معرفی
Bradley Backes, PhD, is an Associate Professor in the School of Medicine at the University of California, San Francisco (UCSF). His research focuses on understanding and modulating endoplasmic reticulum (ER) stress pathways, particularly the role of IRE1α in disease. His work spans cell biology, molecular biology, and pharmacology, with applications in fibrosis, diabetes, immunology, and oncology. He has held leadership roles in multiple NIH-funded projects, including grants targeting retinal degeneration, diabetes, and neurodegenerative diseases.
Research Interests:
- IRE1α signaling and its therapeutic potential in fibrosis and diabetes.
- Mechanisms of ER stress-induced cell death and inflammation.
- Development of small molecule inhibitors targeting IRE1α and related pathways.
Grants and Funding:
- Principal Investigator (PI) of NIH grants R41EY026370 (IRE1α inhibitors for retinal diseases) and R41DK108377 (IRE1α inhibitors for diabetes).
- Co-PI of NIH R01DK100623 (UPR modulators for β-cell protection).
- Co-Investigator of NIH P01HL108794 (pulmonary fibrosis).
Labs/Teams: His lab investigates ER stress pathways and translational therapies, collaborating with experts in protein biology, drug development, and clinical medicine.
