معرفی
Brad Spicer is a Research Fellow in the Department of Biochemistry & Molecular Biology at Monash University. He specializes in structural and functional studies of pore-forming proteins, focusing on the complement system and immune effectors. His work contributes to UN Sustainable Development Goals related to health and innovation. Active projects include molecular characterization of pore-forming proteins for pest control and studying coprinolysin mechanisms.
Research Interests:
- Structural biology of complement proteins (C9, MAC)
- Immune effector mechanisms (MPEG1, perforin-like proteins)
- Pore-forming toxin families (aerolysin, MTX-2)
- Protein self-assembly and membrane interactions
Key Contributions: Recent work includes defining the neoepitope of the complement membrane attack complex (Communications Biology, 2023) and cryo-EM structures of pore-forming immune effectors (Nature Communications, 2019). His research bridges molecular mechanisms with potential applications in disease treatment and pest control.
Grants & Awards: Recipient of the ARC CoE Legacy Award (2020) and Vice-Chancellor Award (2020). Conducted projects funded by the Australian Research Council and Monash University.
