B. Frank Gupton

Dr. B. Frank Gupton is a Professor in the Department of Chemical & Life Science Engineering at Virginia Commonwealth University's College of Engineering. His research focuses on pharmaceutical process development, asymmetric catalysis, and sustainable manufacturing techniques for antiviral and antituberculosis drugs.

• Key research areas: Organic Synthesis, HIV Drug Manufacturing, and Continuous Flow Chemistry
• Specializes in scalable synthetic routes for antiretroviral drugs like Lenacapavir and Nirmatrelvir
• Expertise in carbon-carbon cross coupling reactions using graphene-supported catalysts

Recent work emphasizes protecting-group-free methods, chiral transfer reagents, and flow reactor applications to improve regioselectivity and process economics. His team has published extensively on nanocatalyst design, including Pd/PRGO systems with magnetic recyclability features.

Contributions to global drug access include intensified synthesis routes for HIV medications like nevirapine and dolutegravir sodium. The group's 2024 publications highlight innovations in ruthenium-catalyzed asymmetric transfer hydrogenation and practical indazole synthesis.