معرفی
Angelika Doetzlhofer is an Associate Professor in the Solomon H. Snyder Department of Neuroscience at Johns Hopkins University School of Medicine. Her research focuses on understanding the molecular mechanisms that govern cell specification and differentiation in the mammalian auditory system, with a strong emphasis on hair cell and supporting cell development and regeneration.
Research Interests: Her work spans developmental neuroscience, cellular and molecular neuroscience, and the neurobiology of disease. Key areas include the role of Notch, LIN28B/let-7, and Activin/Follistatin signaling pathways in cochlear development, as well as the epigenetic and transcriptional regulation of sensory cell fate. A major goal is to identify molecular barriers to hair cell regeneration in mammals, aiming to develop therapeutic strategies for hearing loss.
The recent publications highlight a consistent focus on regenerative mechanisms in the inner ear, particularly how supporting cells can be reprogrammed or induced to generate new hair cells. Themes across these works include developmental timing, signaling gradients, and post-transcriptional control of gene expression.
Scientific Awards:
- No awards listed in the provided text.
Advising and Grants: Dr. Doetzlhofer mentors several graduate students and postdoctoral fellows, including Charles Morgan, Elannah Venhaus, River Huang, and Zia Rehman. Her research is supported by active funding, as evidenced by ongoing high-impact publications, though specific grants are not mentioned in the text.
Labs and Teams: She leads an active research laboratory at Johns Hopkins, utilizing mouse genetic models, conditional gene targeting, and in vitro culture systems to study inner ear development and regeneration. Her team includes a lab manager (Kimberly Smith), graduate students, and postdoctoral researchers.
