معرفی
Dr. Andrew Xiao is an Associate Professor in the Department of Genetics at Yale University School of Medicine and a member of the Yale Stem Cell Center and Yale Cancer Center. He leads a research laboratory focused on epigenetic mechanisms in stem cells and development.
- PhD: University of North Carolina at Chapel Hill (2003)
- Postdoctoral Training: The Rockefeller University (2009)
- BS: Peking University Medical Center (1994)
Dr. Xiao's research centers on epigenetic regulation in pluripotent stem cells, with a focus on histone variants, DNA modifications such as N6-methyl-adenine (N6-mA), and retrotransposon control. His work has revealed how epigenetic mechanisms govern stem cell pluripotency and cellular reprogramming. The discovery of N6-mA in mammalian genomes challenged established dogma and opened new frontiers in epigenetics. His lab also investigates how these mechanisms influence early embryogenesis and disease.
Analysis of Dr. Xiao's recent publications reveals a consistent focus on epigenetic modifications—especially N6-mA and m6A—and their roles in gene regulation, stem cell biology, and cancer. His work bridges chromatin dynamics, RNA biology, and developmental genetics, often uncovering novel regulatory pathways with implications for regenerative medicine and oncology.
Dr. Xiao has received several prestigious awards:
- NCI Howard Temin Award in Cancer Research (K99/R00)
- Ellison Medical Foundation New Scholar Award
- Ludwig Family Foundation Outstanding Early Investigator Award
- Blavatnik Innovation Award
- Susan G. Komen for the Cure Fellowship
He mentors students through the Yale Combined Program in the Biological and Biomedical Sciences (BBS) and has secured significant research funding. His lab actively explores the intersection of epigenetics, stem cells, and disease, contributing to both basic science and potential therapeutic applications.
Dr. Xiao leads the Laboratory of Chromatin Structure and Inheritance, part of the Yale Stem Cell Center. His team employs cutting-edge genomic, biochemical, and molecular techniques to dissect epigenetic mechanisms in mammalian systems.
