M. Andres Blanco

M. Andres Blanco is an Assistant Professor at the Department of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine. He is also affiliated with the Institute for Regenerative Medicine and the Abramson Cancer Center, both at the Perelman School of Medicine. His research focuses on epigenetics, chromatin biology, and cellular identity, particularly in the context of cancer progression and metastasis.

• Epigenetics
• Chromatin Biology
• Cellular Identity and Differentiation
• Cancer Epigenetics
• Transcriptional Regulation in Cancer
• Metastasis Mechanisms

Blanco’s recent work explores the interplay between epigenetic regulation and cellular differentiation in cancers such as AML and pancreatic cancer. His research highlights the role of chromatin-state barriers in irreversible cell fate decisions, and the impact of LSD1 and WNT pathway perturbations on AML differentiation. He has also contributed to understanding how epigenetic and metabolic treatments can overcome differentiation blockades in leukemia.

His publications span topics like histone modifications, nucleosome mapping, and epigenetic marks such as N6-adenine DNA methylation in C. elegans. He has collaborated with researchers across institutions like Harvard Medical School and Boston Children’s Hospital, and has contributed to studies involving epigenetic inhibitors for cancer treatment.

Blanco received his PhD in Molecular Biology from Princeton University (2011) and a BA in Biological Sciences and Philosophy from Cornell University (2004)