معرفی
Matthew Lorincz is a Professor in the Department of Medical Genetics at the University of British Columbia (UBC), Faculty of Medicine. His research focuses on epigenetic mechanisms, including DNA methylation, histone modifications, and chromatin remodeling, particularly in the context of mammalian development and disease. He is affiliated with the Life Sciences Institute and employs cutting-edge technologies like CRISPR/Cas9, low-input ChIP-seq, and allele-specific methylomic analysis.
- Education: PhD in Medical Genetics
Research interests center on:
- Interplay between DNA methylation and histone modifications
- Epigenetic regulation in early embryonic and germline development
- Mechanisms of chromatinopathies and neurodevelopmental disorders
- Role of retrotransposons in genomic imprinting
Recent research trends from his publications (2017–2025) highlight:
- Epigenetic cross-talk during pluripotency
- Lineage-specific imprinting mechanisms
- Transgenerational effects of chromatin regulators
- Transposable element repression in early embryos
- Allele-specific epigenomic analysis
- Technological advancements in low-input profiling
Key projects include:
- Molecular basis of Weaver Syndrome (NSD1/H3K36me2)
- Heritability of histone modifications across fertilization
- Role of H3K9 methyltransferases in transcriptional regulation
- Imprinting establishment via LTR retrotransposons in oocytes
Lorincz's lab utilizes:
- Mouse models for developmental studies
- CRISPR/Cas9 for chromatin factor knockout
- ULI-ChIP-seq, PBAT, RNAseq for genome-wide analysis
- Custom pipelines (e.g., MEA, ALEA) for data integration
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