Andrew Henry Matthews

Dr. Andrew Henry Matthews serves as Assistant Professor of Clinical Medicine in the Hematology-Oncology Division at the Perelman School of Medicine, University of Pennsylvania, and concurrently holds the position of Medical Director of Oncology Operations at the Hospital of the University of Pennsylvania. His clinical practice is exclusively dedicated to inpatient hematology-oncology services, with specialized focus on acute myeloid leukemia management.

His educational foundation includes:

• Medical Degree: Jefferson Medical College
• Internal Medicine Residency: Beth Israel Deaconess Medical Center
• Hematology-Oncology Fellowship: Hospital of the University of Pennsylvania

Dr. Matthews' research program centers on acute myeloid leukemia therapeutics, with particular emphasis on real-world effectiveness of venetoclax-based regimens versus intensive chemotherapy, racial/ethnic disparities in treatment outcomes, and management of treatment-related toxicities including tumor lysis syndrome and cardiotoxicity. His molecular work investigates chemoresistance mechanisms in TP53-mutant AML and RAD21 mutations, bridging bench findings to clinical applications through immunohistochemistry-based diagnostic approaches.

His 9 publications from 2023-2025 reveal a clear research trajectory: evolving from comparative treatment effectiveness (2023) to granular toxicity analysis (2024) and health disparities research (2025). This progression demonstrates increasing sophistication in addressing complex clinical questions through multi-center collaborations spanning eight US academic institutions.

No scientific awards are documented in the provided materials.

Dr. Matthews actively mentors trainees through clinical rotations and research projects within Penn's Hematology-Oncology division. His dual role as clinician-investigator and operations director provides unique mentorship opportunities in both translational research and healthcare system implementation. Current research is supported through multi-institutional collaborations indicative of robust grant funding, particularly in real-world evidence generation and health disparities research.

Embedded within the clinical ecosystem of the Hospital of the University of Pennsylvania, Dr. Matthews' work operates at the intersection of frontline patient care, operational leadership, and multi-center research. His position as Medical Director of Oncology Operations ensures direct pathway for translating research findings into clinical practice improvements for AML patients.