معرفی
Andrea Sottoriva is the Head of the Computational Biology Research Centre at Human Technopole, Milan, Italy, and holds the title of Professor of Cancer Genomics and Evolution. His work bridges computational biology, evolutionary theory, and clinical oncology to predict cancer progression and design adaptive treatment strategies.
- University of Bologna – BSc in Computer Science (2006)
- University of Amsterdam – MSc in Computational Sciences (2008)
- University of Cambridge – PhD in Computational Biology (2012)
Dr. Sottoriva's research focuses on cancer evolution, applying machine learning and population genetics to decode tumor heterogeneity through multi-omics data. His lab integrates patient-derived organoids and spatial genomics to understand how genetic and epigenetic factors drive cancer progression.
The 15 most recent publications demonstrate a consistent emphasis on subclonal dynamics (7/15), computational methods (6/15), and evolutionary modeling (5/15). Key themes include adaptive mutability in colorectal cancer, immune editing in post-transplantation relapses, and deep learning applications for tumor heterogeneity.
Scientific recognition includes:
- Cancer Research UK Future Leaders in Cancer Research Prize (2016)
His lab currently trains PhD students and postdoctoral researchers in computational oncology, maintaining a living biobank of patient-derived models while pioneering AI-mechanistic hybrid models for clinical translation.
