معرفی
Anant Parekh serves as Professor of Physiology and Director of the Centre for Integrative Physiology at the University of Oxford, based within the Department of Physiology, Anatomy and Genetics (DPAG). He maintains a Tutorial Fellowship at Merton College and leads the active Parekh Group research laboratory, focusing on fundamental mechanisms of intracellular calcium signaling and its pathophysiological implications.
His academic foundation includes medical studies, undergraduate training, and doctoral degree (DPhil) at University College, Oxford, followed by postdoctoral research as an Alexander Von Humboldt Scholar at the Max Planck Institute for Biophysical Chemistry in Göttingen.
- Medical student, undergraduate, and DPhil at University College, Oxford
- Alexander Von Humboldt Scholar, Max Planck Institute for Biophysical Chemistry
Professor Parekh's research program centers on store-operated calcium entry (SOCE) mechanisms, particularly CRAC channel function mediated by STIM1-Orai1 interactions. His work examines how spatially restricted calcium microdomains regulate mitochondrial metabolism, gene expression (notably NFAT1 nuclear translocation), and immune cell function, with direct relevance to human diseases including immunodeficiency, atopic dermatitis, asthma, and hypertension. The laboratory employs advanced live-cell imaging, electrophysiology, and molecular techniques to dissect these pathways.
Analysis of his 2019-2024 publications reveals consistent focus on CRAC channel pathophysiology, with emerging themes in mitochondrial-calcium crosstalk, genetic polymorphisms in channel subunits (Orai1), and critical re-evaluation of pharmacological data. Recent work demonstrates increasing translational emphasis on respiratory disorders and therapeutic targeting of calcium signaling pathways.
Major recognitions include:
- Wellcome Prize in Physiology (2002)
- India International Foundation Prize (2009)
- GL Brown Prize from the UK Physiological Society (2012)
- Election to Academia Europaea
- Fellowship in the Academy of Medical Sciences
His career progression includes Wellcome Trust Career Development Fellowship (1997), Lister Institute Senior Research Fellowship, Amersham Medical Fellowship, and Monsanto Senior Research Fellowship, culminating in a proleptic University Lectureship and personal chair (full professorship) in 2002. He chairs editorial boards for the Journal of Physiology, Cell Calcium, and BMC Physiology, and previously served as Chair (2017) of the Gordon Conference on Calcium Signalling.
The Parekh Group operates three integrated research themes: (1) molecular mechanisms of STIM1-mediated CRAC channel activation following ER calcium store depletion; (2) functional consequences of calcium microdomains on mitochondrial metabolism and NFAT-dependent gene expression; and (3) pathophysiological role of CRAC channels in upper/lower airway diseases (nasal polyposis, allergic rhinitis, asthma). Current work investigates Orai1 polymorphisms in atopic dermatitis and mitochondrial regulation of calcium entry, with therapeutic implications for immune and respiratory disorders.
