Stefan Feske

Stefan Feske, MD, the Jeffrey Bergstein Professor of Medicine at NYU Grossman School of Medicine, is a leading researcher in calcium signaling and ion channels in immune cells. His work bridges immunology, calcium channel biology, and autoimmune diseases.

• Key Roles: Vice Chair for Research, Department of Pathology; Director of the Ion Channels & Transporters in Immunity (ICTI) program at NYU Langone.
• Education: MD from University of Hamburg/Freiburg (Germany), Postdoctoral training at Harvard Medical School and Max-Planck-Institute.

His research focuses on CRAC channels (ORAI/STIM proteins) and their role in T cell activation, macrophage function, and primary immunodeficiencies. He discovered CRAC channelopathy, a novel disease caused by ORAI1/STIM1 mutations, and co-founded CalciMedica to develop CRAC inhibitors for immune diseases.

Recent publications highlight his lab’s work on ion channels in cancer immunity (e.g., LRRC8C in T cell function), calcium-metabolic crosstalk (e.g., SOCE-lipolysis links), and neuroimmunology (e.g., presenilin-CRAC interactions). He mentors a multidisciplinary team including

• MD/PhD students (e.g., Anthony Tao)
• Postdoctoral fellows (e.g., Yinhu Wang)
• Bioinformaticians (e.g., Maxwell MacDermott)