Amanda Lewis

Amanda Lewis is a current researcher at the École polytechnique fédérale de Lausanne (EPFL), affiliated with the LBEM unit within the School of Life Sciences. Her work focuses on neurodegenerative diseases, particularly synucleinopathies like Parkinson’s and Alzheimer’s. She specializes in correlative light and electron microscopy (CLEM) to study protein aggregation and cellular ultrastructure. Key contributions include optimizing CLEM protocols for human brain and skin tissues, elucidating tau pathology maturation stages in Alzheimer’s, and analyzing α-synuclein fibril structures linked to Multiple System Atrophy (MSA).

Her doctoral thesis (2025) explored ultrastructural changes in synucleinopathies using CLEM, revealing novel insights into MSA pathology and peripheral biomarker potential. Lewis collaborates with institutions like Amsterdam UMC and Brigham and Women’s Hospital, leveraging interdisciplinary approaches to advance disease modeling and therapeutic development. Her research emphasizes translational applications, such as iPSC-derived models for studying protein inclusions and drug testing.

Funding sources include the Aligning Science Across Parkinson’s Initiative and the Basque Biobank. Lewis’s work bridges basic science and clinical relevance, addressing urgent needs in diagnostics and disease mechanism understanding.