معرفی
Bryan Killinger is an Assistant Professor in the Department of Movement Disorders at Rush University's Rush Medical College in Chicago. His work focuses on neurodegenerative diseases, particularly Parkinson's disease and multiple system atrophy, with an emphasis on alpha-synuclein aggregation mechanisms, molecular pathology, and disease progression pathways. His research integrates proteomics, epigenetics, and experimental models to understand synucleinopathies.
Key research interests include the role of alpha-synuclein phosphorylation, the impact of olfactory bulb mitral cells in synucleinopathy onset, and the interplay between gut microbiota and Parkinson's pathology. He has published extensively on topics such as Lewy pathology molecular interactions, autophagy-lysosomal dysfunction, and the appendix's role in PD risk.
Recent studies highlight his exploration of alpha-synuclein interactome differences between MSA and Parkinson's, phosphatase-resistant aggregates, and fibril seeding efficacy across murine models. Collaborations with co-authors like Jeffrey Kordower and Viviane Labrie have advanced understanding of disease mechanisms at the molecular and cellular levels.
