معرفی
Dr. Jacqueline Burre serves as an Associate Professor of Neuroscience within the Brain and Mind Research Institute at Weill Cornell Medical College, Cornell University, a role she assumed in 2021. Her research program investigates molecular mechanisms underlying neurodegenerative disorders with emphasis on synucleinopathies including Parkinson's disease and dementia with Lewy bodies, bridging fundamental synaptic biology with translational therapeutic development.
Her academic training includes:
- Ph.D. in Neuroscience from Johann Wolfgang Goethe University, Germany (2006)
- Diploma in Neuroscience from Johann Wolfgang Goethe University, Germany (2003)
Dr. Burre's primary research explores alpha-synuclein's physiological role at the synapse and its pathological transformation in disease. Her laboratory examines how alpha-synuclein interacts with synaptic vesicles, how lipid composition and post-translational modifications (like N-acetylation) regulate these interactions, and how disruptions lead to neurodegeneration. This work extends to STXBP1 encephalopathies and monogenetic epilepsies, employing biochemical, proteomic, and advanced imaging approaches to uncover disease mechanisms.
Analysis of her publication trajectory (2020-2025) reveals progressive focus on alpha-synuclein condensation, synaptic vesicle dynamics, and biomarker discovery for synucleinopathies. Her recent work increasingly integrates lipidomics and proteomics to identify early pathological signatures, with emerging emphasis on therapeutic strategies including pharmacological chaperones and gene therapy approaches for Parkinson's disease and multiple system atrophy.
Dr. Burre currently leads multiple NIH-funded projects as Principal Investigator:
- Changes in synaptic vesicle-binding of alpha-synuclein as an early biomarker for synucleinopathies (NINDS R01, 2024-2029)
- The impact of beta- and gamma-synucleins on alpha-synuclein's synaptic function (NINDS R01, 2022-2026)
- Synaptic vesicle changes in synucleinopathies (NINDS R21, 2022-2025)
- A novel gene therapy approach for multiple system atrophy (NINDS subaward, 2023-2025)
Within the Brain and Mind Research Institute, her laboratory utilizes cutting-edge techniques including super-resolution microscopy, synaptic vesicle proteomics, and electrophysiology to study synaptic dysfunction. She maintains active collaborations with clinicians and basic scientists across Weill Cornell to accelerate translation of mechanistic insights into therapeutic interventions for neurodegenerative conditions.
