معرفی
Professor Alice Vrielink is a Professor of Structural Biology at the University of Western Australia (UWA), within the School of Molecular Sciences. She holds academic leadership roles, coordinating units such as BIOC3002 - Structural and Functional Biochemistry. Her career spans research roles at McGill University (1994–2001) and the University of California, Santa Cruz, before joining UWA in 2007.
Education:
- Bachelor of Science in Chemistry (University of Calgary, 1982)
- Masters of Science in Physical Chemistry (University of Calgary, 1985)
- PhD in Physics (Imperial College London, 1989)
- Diploma in Crystallography (Imperial College of Science and Technology, London)
Research Interests: Prof. Vrielink specializes in structural biology using protein crystallography and electron microscopy. Key areas include:
- Enzyme mechanisms in redox catalysis and bacterial pathogenesis
- Bacterial membrane biosynthesis (e.g., endotoxin biosynthesis in Neisseria species)
- Structural studies of transcription factors in mesothelioma
- Neutron crystallography of flavoenzymes like cholesterol oxidase
- Capsule transport machinery in pathogenic bacteria
Grants & Collaborations: She leads 35 active and completed grants, including ARC and NHMRC-funded projects. Key collaborators include Prof. Charlene Kahler (Microbiology), Assoc. Prof. Keith Stubbs (Chemistry), and Dr. Flora Meilleur (Oak Ridge National Laboratory). Recently, her team developed ADR3, an anti-RANKL i-body targeting bone resorption disorders.
Labs & Teams: Her lab focuses on structural biology with interdisciplinary collaborations in drug discovery, microbiology, and biomedicine. Ongoing projects address mesothelioma therapies and antivirulence strategies against multidrug-resistant bacteria.
