معرفی
Alexandre Maréchal serves as Full Professor and Associate Director for Graduate Studies and Research in the Department of Biology at the University of Sherbrooke. His laboratory investigates genome stability mechanisms with particular emphasis on cancer biology and therapeutic targeting.
- Ph.D. in Biochemistry, University of Montreal (2009)
- Postdoctoral Fellowship, Harvard Medical School, Massachusetts General Hospital Cancer Center (2010-2014)
Dr. Maréchal's research centers on DNA damage response (DDR) regulation through ubiquitination and telomere maintenance in cancer cells. His work reveals how E3 ubiquitin ligases control DDR pathways and identifies vulnerabilities in Alternative Lengthening of Telomeres (ALT) cancers, which constitute 10-15% of sarcomas and glioblastomas. This research bridges fundamental molecular mechanisms with clinical applications for personalized cancer treatment.
Recent publications (2017-2025) demonstrate consistent focus on ubiquitination-mediated DDR regulation, replication stress at telomeres, and ALT pathway vulnerabilities. Key themes include E3 ligase functions in DNA repair, SMARCAL1 regulation at replication forks, and therapeutic targeting of telomere maintenance mechanisms in cancer cells.
Dr. Maréchal leads an active research laboratory (locations D8-2040/D8-2041) investigating molecular mechanisms of genome stability. His team explores how post-translational modifications maintain genomic integrity, with direct implications for developing novel anti-cancer therapeutics targeting DDR pathways.
