معرفی
Alex Ivetic is a Reader in Cardiovascular Biology at King's College London, affiliated with the School of Cardiovascular Sciences and Medicine and the London Centre for Nanotechnology. His research focuses on molecular mechanisms of leukocyte adhesion and recruitment in cardiovascular inflammation and sterile injury contexts.
Education:
- BSc in Biochemistry, Imperial College London (1993)
- PhD in Analysis of MCM proteins from Drosophila Melanogaster, Institute of Cancer Research, University of London (1998)
Research Interests: Ivetic investigates the Leukocyte Adhesion Cascade with emphasis on sterile injury models (myocardial infarction, venous thrombosis). His work integrates intravital microscopy, molecular biology, and immunology to elucidate leukocyte homing mechanisms and develop therapeutic interventions for inflammatory cardiovascular conditions.
Publication Trends: Recent work (2021-2024) centers on endothelial-leukocyte interactions, redox signaling (Nox enzymes), and adhesion molecules (L-selectin, ezrin/radixin/moesin family). Key themes include oxidative stress in cardiac fibrosis, endothelial permeability regulation, and translational applications for cardiovascular therapeutics.
Scientific Awards:
- Research Career Development Award, Wellcome Trust
Advising and Grants: As Postgraduate Research Lead for ~100 PhD students and primary supervisor for 10 PhD projects (8 completed), Ivetic actively mentors doctoral candidates. His grant portfolio includes multiple British Heart Foundation awards (BHF 4-year PhD programmes, ESCALATE project) and King’s College Hospital Charity funding, totaling over £2M in active research support.
Labs and Collaborations: He leads a cardiovascular biology research group at King's with international partnerships including Paul Kubes (Calgary), Michael Hickey (Monash), and the University of Göttingen's Heart Centre, fostering multidisciplinary approaches to inflammation research.
