Alan Roseman

Alan Roseman serves as a Lecturer in Biological Cryo Electron Microscopy within the Division of Molecular & Cellular Function at the University of Manchester. His research integrates advanced cryo-EM techniques with structural biology to investigate protein complexes and molecular mechanisms.

His primary research domains include Cryo-Electron Microscopy, Structural Biology, and Protein Folding, with significant contributions to understanding chaperonin systems (GroEL/GroES) and extracellular matrix components like collagen and fibrillin. His work frequently develops computational methodologies for cryo-EM image processing and 3D reconstruction, bridging experimental and theoretical approaches.

Roseman's publication record demonstrates consistent innovation, with recent work focusing on collagen VI microfibril assembly mechanisms, fibrillin structure-pathology relationships, and viral inactivation techniques. His research shows increasing emphasis on connecting structural insights to genetic disorders and therapeutic applications.

He actively engages with the scientific community through leadership roles including chairing the UK EM Validation Network Workshop and organizing specialized events on cryo-EM modeling. His supervision of 7 students and participation in the university's Structural Biology project highlight his collaborative approach to advancing structural biology research.