معرفی
Peter Shen is an Associate Professor in the Department of Biochemistry at the University of Utah, specializing in protein homeostasis, structural biology, and cryo-electron microscopy. His research focuses on molecular mechanisms governing protein quality control, including synthesis, folding, and degradation pathways essential for cellular health.
Key research areas include:
- Protein synthesis (ribosomes)
- Protein folding (chaperonins)
- Unfolding pathways (AAA+ ATPases)
- Disease mechanisms in cancer and neurodegeneration
Shen's lab utilizes cryo-EM for high-resolution structural analysis of dynamic macromolecular complexes. Recent work highlights structural heterogeneity studies, therapeutic development targeting quality control failures, and viral protein interactions with host machinery.
His publications emphasize cryo-EM methodologies, chaperonin functions, and structural insights into AAA+ ATPases. The lab actively explores viral adaptation mechanisms, transcriptional reprogramming in cancer, and evolutionary structural biology.
