معرفی
Aladin M Boriek is a faculty member at the Department of Medicine, Baylor College of Medicine. His research focuses on mechanical signal transduction in skeletal muscles, particularly the anisotropic regulation of mechanosensitive genes like Ankrd2 and Sirt1. He investigates how mechanical stretch activates distinct signaling pathways (Akt/NF-kappaB vs. Ras-GTP/Erk1/2) and their roles in eliminating ROS and modulating muscle function.
Notably, he studies respiratory muscle mechanics in mouse models of muscular dystrophy, including the Ttnmdm/mdm mutation affecting titin's N2A region. His collaborative work with Dr. Rolf Hubmayr (Mayo Clinic) and former advisee Dr. Michael Lopez (PhD thesis) highlights structural-functional relationships in diaphragm mechanics. Current projects involve modeling respiratory muscle dynamics and geodesic fiber properties.
