Aladin M. Boriek

Aladin M. Boriek is a Professor of Medicine and Integrative Physiology and Biophysics at Baylor College of Medicine, and an Adjunct Professor of Mechanical Engineering at Rice University. He holds tenured positions and has adjunct roles across multiple departments, including Mechanical Engineering and Biomedical Engineering at Rice. His research focuses on mechanical signal transduction in skeletal muscles, the role of Sirt1 in muscle physiology, and respiratory muscle dysfunction in muscular dystrophy. He has extensive collaborations with institutions like Mayo Clinic and The W.M. Keck Center for Computational Biology.

Education includes a Ph.D. in Computational Mechanics from Rice University (1990), followed by postdoctoral training in Respiratory Muscle Mechanics at Baylor College of Medicine. His professional experience spans over three decades, with roles in computational biology, mechanical engineering, and molecular physiology.

Research interests include anisotropic regulation of mechanosensitive genes (e.g., Ankrd2), Sirt1’s antioxidative role under mechanical stress, and diaphragm mechanics in dystrophic models. His work bridges biomechanics and molecular biology, with implications for muscle diseases and aging.

Publications span topics like mechanotransduction pathways, muscle dysfunction in genetic models, and respiratory mechanics. His lab investigates the structural and functional basis of respiratory muscle performance, leveraging interdisciplinary approaches.

Grants and advising include training students like Michael Lopez (PhD thesis on titin mutations), and collaborations on projects funded by NIH and other agencies. He contributes to academic boards and serves as a visiting scientist at the Mayo Clinic.