Aideen O'Neill

Aideen O'Neill is a Post-Doctoral Researcher and clinical haematologist at the University of Oxford, working in the Haematopoietic Transplantation and Immunotherapy group led by Prof. Ronjon Chakraverty within the Nuffield Department of Clinical Laboratory Sciences.

Her educational background includes:

• Undergraduate Medicine degree from University College London (UCL)
• NIHR Academic Foundation Post at UCL
• Academic Clinical Fellowship at UCL

Dr. O'Neill's research centers on the bone marrow stroma's role in supporting T cells, with a focus on targeting stromal changes to enhance adoptively-transferred T cell therapies and molecular anti-leukaemia treatments. Her work bridges clinical haematology and translational immunology, particularly in haematopoietic stem cell transplantation for blood cancers, utilizing advanced imaging techniques like confocal microscopy of bone marrow microenvironments.

Her publication portfolio reveals consistent expertise in Waldenström Macroglobulinemia and Hodgkin lymphoma, with emphasis on bendamustine-based regimens, graft-versus-leukemia mechanisms, and diagnostic imaging correlations. These works demonstrate her dual focus on optimizing existing therapies while exploring novel stromal targets for immunotherapy enhancement.

Her scientific recognition includes:

• MRC Clinical Research Training Fellowship funding her doctoral research
• Fellowship of the Royal College of Pathologists (FRCPath)

Dr. O'Neill conducts her research within the Chakraverty Group's specialized haematopoietic transplantation framework, where she integrates clinical observations with laboratory investigations to develop stroma-targeted therapeutic strategies. Her ongoing work involves characterizing bone marrow stromal changes during immunotherapy and translating these findings into improved adoptive T cell transfer protocols for leukaemia patients.