جست‌وجوی استاد و پژوهشگر

• Molecular Biology
• Genetics
• Biochemistry
• +۵ مورد دیگر

Dr. Sukesh R. Bhaumik is a Professor and Distinguished Scholar at Southern Illinois University Carbondale's Department of Biochemistry & Molecular Biology, where he has been appointed since 2003. His academic background includes a B.Sc. from Ramakrishna Mission Residential College (University of Calcutta, 1990), an M.Sc. from the Indian Institute of Technology Bombay (1992), a Ph.D. from the Tata Institute of Fundamental Research (1997), and postdoctoral training at the Howard Hughes Medical Institute, University of Massachusetts Medical School (1998-2003). His research program investigates regulatory mechanisms in eukaryotic systems, with primary focus areas including: Eukaryotic transcription dynamics and proteasome-mediated gene regulation Transcription-coupled DNA repair (TCR) pathways and genome integrity mRNA export mechanisms and nuclear transport regulation Chromatin assembly/disassembly via histone modifications (e.g., H3 Lys56 acetylation) Ubiquitin-proteasome system functions in transcriptional control His publications consistently explore molecular interactions within transcriptional machinery, chromatin remodeling, and DNA damage response. Recent work emphasizes mRNA processing, antisense transcription mechanisms, and regulatory complexes like SAGA, NuA4, and cap-binding complexes. The 19S proteasome's role in transcription initiation remains a recurring theme across his research timeline. Dr. Bhaumik leads an active research laboratory focused on in vivo mechanistic studies of transcription and repair coupling. Current projects examine RNA polymerase II dynamics, FACT complex regulation, and ubiquitin-dependent pathways in gene expression control.

Liang Chenمشاهده پروفایل

استاد

• Computational Biology
• Bioinformatics
• Alternative Splicing
• +۷ مورد دیگر

Liang Chen is a Professor of Quantitative and Computational Biology at the University of Southern California . He leads research efforts in developing advanced statistical and computational frameworks to unravel gene expression regulation mechanisms in eukaryotes, with a focus on post-transcriptional processes and their implications in human diseases. Research Emphasis: Alternative pre-mRNA splicing as a driver of proteomic diversity and disease Advanced RNA-seq data analysis and transcriptome comparison Quantitative trait locus mapping (eQTL, NMD-QTL) Network modeling of splicing regulation Notable Software Contributions: Development of BCseq (single-cell RNA quantification), CellTICS (explainable AI for cell-type identification), and WemIQ (isoform quantification). Current Research Directions: Integrating multi-omics data to study splicing-phenotype relationships, leveraging interpretable machine learning for personalized medicine, and exploring evolutionary conservation of gene regulatory mechanisms. Education: Ph.D. in Computational Biology, Yale University (2006) B.S. in Bioinformatics, Tsinghua University (2001) Ph.D. Advisees: Wei Jiang, Zheyu Li, Qingyang Yin, and Xinyu (Brian) Guo.

Douglas Blackمشاهده پروفایل

استاد

• RNA Processing
• Alternative Splicing
• Neurogenetics
• +۷ مورد دیگر

Douglas Black is a Professor in the Department of Microbiology, Immunology & Molecular Genetics at the University of California, Los Angeles (UCLA) , affiliated with the College of Life Sciences . He investigates RNA processing and alternative splicing , focusing on their roles in neuronal diversity and diseases like cancer and neurodegeneration. Research Focus : Regulation of pre-mRNA splicing, splicing regulators (PTBP1, PTBP2, RBFOX proteins), RNA biology, and transcriptomic impacts on health. Key Contributions : Elucidation of splicing mechanisms (e.g., SF3B1 mutations, LASR complex function) and therapeutic applications (splice-modifying drugs, RNA sensors). Recent Publications highlight mechanisms of splicing in cancer, neurodevelopment (RBFOX1/LASR), GBA1 mutations in neurodegeneration, and RNA localization (Malat1). Awards and education details were not explicitly mentioned.

Peter Scheiffeleمشاهده پروفایل

استاد

• Neuroscience
• Molecular Biology
• Developmental Biology
• +۴ مورد دیگر

Professor Peter Scheiffele, based at the Biozentrum of the University of Basel, Switzerland, is a leading neuroscientist and molecular biologist. His research focuses on neuronal network formation, synaptic specificity, and the molecular basis of neurodevelopmental disorders like autism, using transgenic mouse models and advanced molecular techniques. He has held his current professorship since 2008 and previously served as Assistant Professor at Columbia University (2001-2008). Education: PhD in Biochemistry (1998, EMBL Heidelberg), Postdoctoral Fellowships at UC Berkeley/UCSF (1999-2001). Research Highlights: Investigating synaptic mechanisms in autism, RNA splicing regulation in neuronal circuits, and signaling pathways controlling excitation-inhibition balance. His work bridges basic neuroscience and translational studies for neurodevelopmental disease therapies. Scientific Awards: SNSF Advanced Grant (2020) Robert Bing Prize (2014) Simons Foundation Young Investigator Award (2005) Human Frontiers Science Program Fellowship (1999) He co-founded the spin-off Translation-X (2022) to develop novel therapeutics. His lab employs interdisciplinary approaches including molecular biology, electrophysiology, and computational analysis of neuronal transcriptomes.

Clemens Plaschkaمشاهده پروفایل

استاد پژوهشی

• Molecular Biology
• Structural Biology
• RNA Biology
• +۴ مورد دیگر

Clemens Plaschka serves as Senior Group Leader at the Research Institute of Molecular Pathology (IMP) in Vienna since 2025, previously holding a Group Leader position from 2018-2024. His research program investigates fundamental mechanisms of eukaryotic gene expression with emphasis on mRNA maturation and nuclear export processes. His academic training includes: PhD in Biochemistry from Ludwig Maximilian University of Munich (2015) Postdoctoral research at Max Planck Institute for Biophysical Chemistry (Göttingen, 2015) and MRC Laboratory of Molecular Biology (Cambridge, 2016) The Plaschka Lab employs integrated structural biology to dissect molecular machines involved in pre-mRNA splicing and mRNA export. Using cryo-EM , X-ray crystallography , and complementary biochemical approaches, the lab reveals how dynamic RNA-protein complexes achieve precise regulation of gene expression. Current work focuses on spliceosome quality control mechanisms and the structural basis for selective mRNA packaging and nuclear export. Recent publications (2023-2025) demonstrate consistent leadership in structural RNA biology, with Nature papers establishing mechanistic frameworks for mRNA export and spliceosome disassembly. The work reveals how ATP-dependent conformational changes drive export competence and how spliceosomal remodeling controls splicing fidelity. Key recognitions include: EMBO Young Investigator award The lab maintains robust funding through multiple competitive grants including an ERC Starting Grant and FWF projects. Dr. Plaschka actively supervises graduate students and postdocs, providing training in cutting-edge structural and molecular techniques. The lab participates in the Vienna BioCenter PhD Program and offers direct application routes for motivated researchers. As part of the Vienna BioCenter research ecosystem, the Plaschka Lab collaborates extensively with neighboring institutes while maintaining its distinctive focus on high-resolution structural analysis of RNA-processing machines. The lab culture emphasizes rigorous mechanistic inquiry and technical innovation in structural biology.

Patricia A. Loomisمشاهده پروفایل

استادیار

• Molecular Biology
• Cell Biology
• Auditory System
• +۷ مورد دیگر

Dr. Patricia A. Loomis is a Research Assistant Professor in the Department of Cellular and Molecular Pharmacology at Rosalind Franklin University's Chicago Medical School and School of Graduate and Postdoctoral Studies. She also serves as Director of the Confocal Microscopy Laboratory and Co-director of the Live Cell Imaging Facility, providing critical research infrastructure for cellular imaging studies. Dr. Loomis's research focuses on the molecular mechanisms controlling auditory hair cell stereocilia assembly and maintenance, with particular emphasis on the Espin family of proteins. Her work investigates how alternative splicing of Espin pre-mRNA regulates isoform selection and how these isoforms affect actin cytoskeletal organization in the inner ear. She employs both mouse and zebrafish model systems to study these processes. Analysis of Dr. Loomis's publication record from 1990-2007 reveals a consistent research trajectory focused on cytoskeletal proteins, particularly in neuronal and sensory cells. Her early work examined neurofilaments and tau proteins, while her more recent research has centered on Espin proteins and their role in hearing. Her publications span high-impact journals in cell biology, neuroscience, and molecular biology. Dr. Loomis has made significant contributions to understanding how Espin proteins function as multifunctional actin cytoskeletal regulatory proteins, with implications for deafness and vestibular dysfunction. Her research provides foundational knowledge for potential gene therapy applications in hearing restoration. As Director of the Confocal Microscopy Laboratory and Co-director of the Live Cell Imaging Facility, Dr. Loomis supports a wide range of research activities at Rosalind Franklin University, providing expertise in advanced cellular imaging techniques that are essential for modern cell biological investigations.

Matjaz Barboricمشاهده پروفایل

پژوهشگر

• Transcription Elongation
• RNA Polymerase II
• Gene Expression Regulation
• +۷ مورد دیگر

Matjaz Barboric is a University Researcher in the Department of Biochemistry and Developmental Biology at the University of Helsinki, where he serves as a Supervisor in the Doctoral Programme in Biomedicine. His research is supported by multiple active projects funded by the Academy of Finland, Cancer Foundation, Sigrid Jusélius Foundation, and Magnus Ehrnrooths Foundation, with research extending through 2028. Dr. Barboric's research program focuses on the fundamental mechanisms of metazoan gene transcription by RNA polymerase II, particularly investigating regulatory factors that modulate transcription at the elongation level. His laboratory studies key cyclin-dependent kinases that stimulate RNAPII elongation and phosphorylate the C-terminal domain of Rbp1 at Serine 2. Using biochemical, genetic, and systems biology approaches, his team explores how transcription elongation connects to pre-mRNA processing events like alternative splicing through Ser2-P CTD modification. A critical aspect of his work examines how deregulation of RNAPII elongation control contributes to cancer development and investigates the significance of transcription elongation kinases in embryonic development. Analysis of Dr. Barboric's publication record spanning over two decades reveals consistent focus on transcriptional regulation mechanisms, with recent work increasingly connecting fundamental transcription processes to cancer biology. His research demonstrates strong interdisciplinary connections between basic molecular mechanisms and clinical applications, particularly in identifying how transcriptional dysregulation contributes to disease states and potential therapeutic targets. Dr. Barboric currently leads multiple research projects including 'Combinatorial targeting of transcriptional kinases in cancer' funded by the Academy of Finland (2024-2028), multiple Cancer Foundation projects (2024-2026), and the M&GC. Ehrnrooth Foundation project (2025). He serves as a supervisor for doctoral students in the Biomedicine program, with documented supervision of research on 'Regulation of Pol II polymerase transcriptional response to DNA damage by RBM7 and P-TEFb' in 2020.

• Structural Biology
• Cryo-Electron Microscopy
• Molecular Biology
• +۳ مورد دیگر

Dr. Alexis Caspar Faesen is an academic advisor specializing in structural biology and molecular mechanisms, with a research focus on cryo-electron microscopy applications for studying macromolecular complexes. The advisor has supervised multiple doctoral candidates at what appears to be a German academic institution, as evidenced by the eDiss repository interface containing German language elements. Research interests center around structural analysis of biological macromolecules, particularly in the areas of RNA splicing mechanisms, protein folding and quality control, and chromatin structure. The work employs advanced imaging techniques like cryo-EM to investigate spliceosome assembly, protein-nascent chain dynamics, and histone modifications at molecular resolution. Current research trends show a consistent focus on developing and applying structural biology methodologies to understand fundamental cellular processes. Dr. Faesen has advised eight doctoral students between 2018-2022, with thesis topics spanning cryo-EM methodology development, spliceosome structure and function, protein quality control mechanisms, and chromatin biology. The supervision record indicates active involvement in training the next generation of structural biologists and molecular biologists, with students investigating both methodological advancements and fundamental biological questions using structural approaches.

Joseph Salvinoمشاهده پروفایل

استاد

• Drug Discovery and Development
• Medicinal Chemistry
• Small Molecule Lead Compounds
• +۷ مورد دیگر

Joseph Salvino, Ph.D. is a Professor in the Molecular and Cellular Oncogenesis Program at The Wistar Institute's Ellen and Ronald Caplan Cancer Center. He serves as Scientific Director of the Molecular Screening & Protein Expression Facility. As the first medicinal chemist to join Wistar's staff, Salvino brings over 30 years of experience in drug discovery, including hit-to-lead development, lead optimization, and preclinical development where several drug candidates have successfully completed human clinical trials. Ph.D. in Organic Chemistry, Brown University Postdoctoral Training in Synthetic and Medicinal Chemistry, University of Pennsylvania (mentored by K.C. Nicolaou and Ralph F. Hirschmann) Former Professor, Department of Pharmacology and Physiology, Drexel University College of Medicine Prior Industry Experience: Sterling Winthrop, Rhone-Poulenc Rorer, Aventis, Rib-X Pharmaceuticals, Adolor Corporation, and Cephalon Salvino's research focuses on drug discovery and development, with laboratory work centered on early drug discovery and small molecule tool compounds for in vivo target validation. His medicinal chemistry optimization work focuses on designing new chemical analogs to understand structure-activity relationships critical for optimizing potency and efficacy. Current research projects include compounds blocking HIV and other antivirals, glutamate transporter (EAAT2) stimulators, ACSS2 Inhibitors, PROTACs targeting CDK6, Mdm2, and Tert, small molecules targeting protein-protein interactions, and cancer/gram-negative bacteria targeting pro-drugs. Analysis of Salvino's recent publications reveals a strong focus on cancer therapeutics, particularly targeting metabolic pathways and protein degradation mechanisms. His work spans multiple cancer types including breast cancer, pancreatic cancer, leukemia, and melanoma. The research demonstrates expertise in medicinal chemistry, target validation, and development of novel therapeutic approaches such as PROTACs and transition-state mimetics. Salvino leads an active research laboratory with several postdoctoral fellows including Adi Narayana Reddy Poli, Jitendra Gour, and Nitesh Nandwana. His research is supported by multiple NIH grants (S10OD030245 and P30CA010815), Canadian Institutes of Health Research grant (CIHR PJT-153057), and Commonwealth of Pennsylvania Special Initiatives Grant for COVID-19 research. As Scientific Director of the Molecular Screening & Protein Expression Shared Resource, Salvino oversees facilities that closely align with the lead optimization and hit-to-lead activities ongoing in his laboratory. His recent work on SARS-CoV-2 Mpro inhibitors demonstrates the lab's ability to rapidly respond to emerging health threats through innovative drug discovery approaches.

Qin Liuمشاهده پروفایل

استاد

• Biostatistics
• Cancer Research
• Immunotherapy
• +۵ مورد دیگر

Qin Liu, Ph.D., M.D., is a Professor in the Molecular and Cellular Oncogenesis Program at The Wistar Institute's Ellen and Ronald Caplan Cancer Center. She leads the Biostatistics Unit, providing statistical expertise for translational and pre-clinical cancer research across the institution. Dr. Liu earned her medical degree and master's in health statistics at Shanxi Medical University in China, followed by a Ph.D. in biostatistics from Shanghai Medical University in 1998. She completed a postdoctoral fellowship in biostatistics and epidemiology at the University of Massachusetts, where she also earned a second master's degree in public health and epidemiology. She served as assistant professor in the Department of Cancer Biology at UMMS starting in 2005, then joined the Biostatistical Research Group in 2007. She joined The Wistar Institute in 2011 as an associate professor and was promoted to professor in 2017. Her research applies biostatistics to multiple areas including basic cancer research, clinical trials of cancer immunotherapy, infectious diseases, behavioral and educational intervention research, and health care outcomes. The Biostatistics Unit under her supervision provides statistical support to biological laboratories at The Wistar Institute, including large data management, experiment design, statistical data analysis, and manuscript preparation. Analysis of Dr. Liu's recent publications reveals a strong focus on statistical approaches to complex biological problems, particularly in cancer immunology, HIV research, and biomarker discovery. Her work often involves collaborations across multiple disciplines, combining biostatistical expertise with laboratory and clinical research. Dr. Liu has secured significant funding for collaborative projects, including three NIH P01 Program Project grants on molecular therapies for prostate cancer, melanoma, and EBV-related cancers. Her statistical expertise has contributed to numerous published papers and funded grant proposals for clinical and basic science investigators. The Biostatistics Unit she supervises provides in-house expertise to accommodate the growth in translational cancer research at Wistar. Her team includes scientific programmers and statistical analysts who work closely with laboratory researchers to design experiments and analyze complex biological data.

• RNA-Protein Complexes
• Gene Expression
• Noncoding RNAs
• +۷ مورد دیگر

Joan Steitz is the Sterling Professor of Molecular Biophysics and Biochemistry at Yale School of Medicine, where she has made groundbreaking contributions to RNA biology. She leads the Steitz Lab, which is affiliated with multiple Yale research centers including the Yale Cancer Center, Yale Stem Cell Center, and the Center for RNA Science and Medicine. Yale School of Medicine, Department of Molecular Biophysics and Biochemistry (Primary) Yale Cancer Center Yale Stem Cell Center Yale Combined Program in the Biological and Biomedical Sciences (BBS) Center for RNA Science and Medicine Dr. Steitz earned her BS from Antioch College (1963) and PhD from Harvard University (1967), followed by postdoctoral work at the Medical Research Council Laboratory of Molecular Biology in Cambridge, England. She joined Yale as an assistant professor and progressed to become a Sterling Professor, one of Yale's highest academic honors. Her research focuses on RNA-protein complexes, particularly small nuclear ribonucleoproteins (snRNPs) that play critical roles in pre-mRNA splicing. The lab investigates how these complexes recognize intron signals and assemble into functional spliceosomes. Recent work has explored stress-induced transcriptional readthrough, RNA stability mechanisms involving poly(A) tails, and the functions of viral noncoding RNAs from herpesviruses. Analysis of Dr. Steitz's recent publications reveals a strong emphasis on RNA structure-function relationships, viral-host interactions, and the molecular mechanisms of RNA processing. Her work spans structural biology, virology, and molecular genetics, with applications to understanding human diseases including cancer. Warren Alpert Prize (2021) Wolf Prize in Medicine (2021) Watson Prize (2021) Medal Prize Lecture (2021) Honorary Doctor of Science (2021) Dr. Steitz actively mentors students and postdocs, with numerous trainees appearing as co-authors on her publications. Her lab maintains strong collaborations across Yale and with international researchers, as evidenced by her extensive publication record. She has also been a prominent advocate for gender diversity in STEM fields, co-authoring influential papers on improving representation of women in science. The Steitz Lab maintains active research programs in RNA structure, splicing mechanisms, viral noncoding RNAs, and stress responses, with ongoing projects examining how RNA-protein interactions govern gene expression in both normal and disease states.