معرفی
Matjaz Barboric is a University Researcher in the Department of Biochemistry and Developmental Biology at the University of Helsinki, where he serves as a Supervisor in the Doctoral Programme in Biomedicine. His research is supported by multiple active projects funded by the Academy of Finland, Cancer Foundation, Sigrid Jusélius Foundation, and Magnus Ehrnrooths Foundation, with research extending through 2028.
Dr. Barboric's research program focuses on the fundamental mechanisms of metazoan gene transcription by RNA polymerase II, particularly investigating regulatory factors that modulate transcription at the elongation level. His laboratory studies key cyclin-dependent kinases that stimulate RNAPII elongation and phosphorylate the C-terminal domain of Rbp1 at Serine 2. Using biochemical, genetic, and systems biology approaches, his team explores how transcription elongation connects to pre-mRNA processing events like alternative splicing through Ser2-P CTD modification. A critical aspect of his work examines how deregulation of RNAPII elongation control contributes to cancer development and investigates the significance of transcription elongation kinases in embryonic development.
Analysis of Dr. Barboric's publication record spanning over two decades reveals consistent focus on transcriptional regulation mechanisms, with recent work increasingly connecting fundamental transcription processes to cancer biology. His research demonstrates strong interdisciplinary connections between basic molecular mechanisms and clinical applications, particularly in identifying how transcriptional dysregulation contributes to disease states and potential therapeutic targets.
Dr. Barboric currently leads multiple research projects including 'Combinatorial targeting of transcriptional kinases in cancer' funded by the Academy of Finland (2024-2028), multiple Cancer Foundation projects (2024-2026), and the M&GC. Ehrnrooth Foundation project (2025). He serves as a supervisor for doctoral students in the Biomedicine program, with documented supervision of research on 'Regulation of Pol II polymerase transcriptional response to DNA damage by RBM7 and P-TEFb' in 2020.
