جستجوی استاد راهنمای دانشگاهی

Jenny PY Ting, PhD, is the William R. Kenan, Jr. Distinguished Professor of Genetics at the UNC School of Medicine and a member of the UNC Lineberger Comprehensive Cancer Center. She serves as Director of the Center for Translational Immunology and Co-Director of the Inflammatory Diseases Institute. Her research focuses on innate immunity, inflammation, and the molecular mechanisms underlying autoimmune diseases, cancer, and neuroinflammation. Dr. Ting's lab investigates the NLR protein family, particularly their roles in inflammasome activation, MHC regulation, and microbial sensing. She has discovered critical functions of NLRC5 and CIITA in immune gene transcription and pioneered studies on plexin-semaphorin signaling in immune cell interactions. Her work on SARS-CoV-2 revealed necroptosis-driven cell death cascades in airway cells, informing therapeutic strategies against cytokine storms. Key Projects: Microbiome-based therapies for multiple sclerosis Targeting NLRP3 inflammasomes in inflammatory diseases Role of plexins in T cell activation and sepsis Awards: National Academy of Sciences member (2022), AAI Distinguished Fellow (2023), ICIS-Pfizer Award (2021). Her lab employs cutting-edge techniques including transcriptomics, proteomics, and murine models. Collaborations span virology, oncology, and neurobiology, with translational goals for immune-based therapies.

• Innate Immunity
• Immunology
• Inflammation
• +۷ مورد دیگر

Andrew L. Goodman, PhD, is the C.N.H. Long Professor and Chair of the Department of Microbial Pathogenesis at Yale School of Medicine. He is also Director of the Yale Microbial Sciences Institute. His research focuses on understanding how gut microbes influence human health, particularly in drug metabolism, host-pathogen interactions, and microbiome ecology. Goodman earned his BA in Ecology and Evolutionary Biology from Princeton University, his PhD in Microbiology from Harvard University, and completed postdoctoral training at Washington University. His lab develops innovative tools such as transposon insertion sequencing (INSeq) and personalized microbiota culture collections. Key contributions include discovering microbiome-driven drug metabolism pathways, mechanisms of bacterial resilience during infection, and bacterial competition strategies. His work has been recognized with awards including the NIH Director’s New Innovator Award and the Presidential Early Career Award in Science and Engineering. Recent research highlights include studies on GPCR-targeted drug modulation by gut microbes (2025), protein-folding mechanisms in bacterial competition (2025), and microbiome responses to time-restricted feeding (2023). Goodman collaborates with institutions like the Diabetes Research Center and Yale Cancer Center, advancing translational microbiome research. Awards: ASPET John J. Abel Award, HHMI Faculty Scholar, Pew Foundation Labs/Teams: Goodman Lab, Yale Microbial Sciences Institute Grants: NIH, Burroughs Wellcome Foundation, HHMI

• Microbial Pathogenesis
• Gut Microbiome
• Drug Metabolism
• +۳ مورد دیگر

Hien Nguyen is the Carl Johnson/Pfizer Professor of Organic Chemistry at Wayne State University, holding joint appointments in the Department of Chemistry and the Department of Oncology's Molecular Therapeutic Program. His research program bridges chemistry and biology to develop novel therapeutic approaches for cancer, Alzheimer's disease, and diabetes through innovative carbohydrate chemistry. His educational background includes: B.S. in Chemistry from Tufts University (1996) Ph.D. in Organic Chemistry from University of Illinois at Urbana-Champaign (2003) NIH Postdoctoral Fellowship at Stanford University (2003-2006) Prof. Nguyen's research focuses on medicinal chemistry, cancer drug discovery, chemical biology, and organic synthesis, with particular expertise in vaccine adjuvant immunotherapy, Alzheimer's disease therapeutics, diabetes treatments, and catalytic stereoselective carbohydrate methods. His lab develops novel methodologies for oligosaccharide assembly and applies them to create carbohydrate-based therapeutics targeting heparanase and other biological pathways involved in disease progression. His recent publications demonstrate a strong focus on phenanthroline-catalyzed stereoselective glycosylations, heparan sulfate mimetics for therapeutic applications, transition-metal catalyzed asymmetric synthesis, and the development of carbohydrate-based inhibitors for heparanase. These works span organic chemistry methodology, medicinal chemistry, and biochemical applications, reflecting his interdisciplinary approach to solving complex biological problems through chemical innovation. Among his notable awards are: 2018 Carl Johnson Endowed Chair 2018 Horace S. Isbell Award for Excellence in Carbohydrate Research 2016 Mitzutani Glycoscience Innovation Award 2012 International Young Carbohydrate Investigator Award Prof. Nguyen has successfully mentored numerous graduate students and postdoctoral fellows who have gone on to successful careers in academia and industry. His research is supported by multiple NIH grants including R01AI169505 "Synthesis and Evaluation of Carbohydrate Vaccine Adjuvants" (2022-2027) and R35GM149213 "Development of Catalytic Glycosylations and Biologically Important Glycosaminoglycans" (2023-2028). His group actively pursues both fundamental methodology development and translational applications of carbohydrate chemistry. The Nguyen research group operates state-of-the-art organic synthesis and biochemical characterization facilities, with strong collaborations across Wayne State University including the School of Medicine. The group maintains active partnerships with researchers at other institutions and pharmaceutical companies to advance their therapeutic discoveries toward clinical applications.

• Medicinal chemistry
• Cancer drug discovery
• Chemical biology
• +۹ مورد دیگر

Hasan Samra is an Assistant Professor at Augusta University’s Medical College of Georgia, specializing in the Department of Pathology with a focus on Clinical Pathology. His academic and clinical work bridges diagnostic pathology with infectious diseases, emphasizing rare and complex infections in immunocompromised populations. Education: MD from Syrian Private University (2014) Certifications: Georgia Professional Licensing (BRD, 2021) Dr. Samra’s research explores emerging infectious diseases, fungal and bacterial pathogenesis, and molecular diagnostics. He investigates rare infections like mucormycosis, listerial peritonitis, and Naegleria fowleri, often in high-risk patients such as those with diabetes, hematologic malignancies, or post-transplant conditions. His work also addresses public health challenges, including undiagnosed AIDS in pediatric monkeypox cases and post-disaster infections. Publications highlight trends in invasive fungal sinusitis, prosthetic joint infections, and rapid diagnostic methods like the Idylla system. His scholarship emphasizes precision medicine, antimicrobial stewardship, and improving diagnostic protocols for challenging cases. He teaches Clinical Pathology (PATH 5009) and contributes to institutional policies on surgical pathology examination standards.

• Infectious Diseases
• Clinical Pathology
• Medical Microbiology
• +۵ مورد دیگر

Martina Damo serves as Assistant Professor in the Department of Medicine, Section of Rheumatology at the University of Chicago School of Medicine, where she joined the faculty in October 2023. She leads a research laboratory investigating immune checkpoint receptors on T cells and their role in immunological tolerance, with particular focus on how checkpoint blockade immunotherapy causes immune-related adverse events (irAEs) in cancer patients. Her work aims to identify druggable tolerance pathways and develop bioengineered therapies for tolerance modulation. Dr. Damo's educational background includes: PhD in Bioengineering from Swiss Federal Institute of Technology in Lausanne (EPFL), 2016 Postdoctoral Fellowship in Immunobiology at Yale University, 2022 Instructor position at Yale University, 2023 Her research centers on T cell immunology in physiological and pathological contexts, with emphasis on peripheral tissue immunity. She investigates mechanisms of immune tolerance in skin and liver environments, neoantigen recognition by T cells, and the pathogenesis of irAEs following cancer immunotherapy. Her laboratory employs advanced techniques including clonal lineage tracing, mouse models of cancer and autoimmunity, and bioengineering approaches for therapeutic development. Analysis of her publication history (2011-2025) reveals an evolving research trajectory from foundational work in antigen-specific tolerance and gene therapy (2011-2015) to contemporary focus on T cell exhaustion, checkpoint biology, and cancer immunotherapy applications (2018-2025). Her most cited works involve CD8+ T cell dynamics in tumors and viral infections, with consistent emphasis on translational applications. Key thematic areas include T cell tolerance mechanisms, irAE pathogenesis, and bioengineered tolerance-inducing therapeutics. Dr. Damo actively mentors within her research laboratory and collaborates extensively with immunology researchers including Jeffrey Hubbell, Thomas Gajewski, and Melody Swartz. Her work has attracted significant attention with multiple publications exceeding 100 citations, substantial social media engagement (over 250 X posts), and patent references (23 patents citing her work). She maintains active research funding supporting her laboratory's investigations into T cell tolerance pathways. Her laboratory operates within the University of Chicago's immunology research ecosystem, collaborating with colleagues in the Department of Medicine including Maria-Luisa Alegre and James Curran. Current projects focus on developing targeted approaches to prevent irAEs while preserving anti-tumor efficacy of checkpoint inhibitors, leveraging her expertise in tissue-specific immune regulation.

• T cell immunology
• Immune tolerance
• Checkpoint inhibitor immunotherapy
• +۵ مورد دیگر

Heather R. Christofk is a Professor in the Department of Biological Chemistry at the David Geffen School of Medicine at UCLA. Her research focuses on the intricate relationship between cellular metabolism and various biological processes, particularly in the contexts of cancer development, stem cell function, and viral infections. Education: PhD in Cell and Developmental Biology from Harvard University (2007) BS in Molecular, Cell, and Developmental Biology from UCLA (2001) Dr. Christofk's research program centers on understanding how metabolic pathways regulate cellular processes in both normal physiology and disease states. Her laboratory has made significant contributions to understanding how cancer cells reprogram their metabolism to support rapid growth and proliferation, with particular focus on glucose metabolism, amino acid utilization, and metabolic adaptations in tumor microenvironments. She has also pioneered work on the metabolic regulation of stem cell function, especially in hair follicle stem cells, demonstrating how metabolic pathways control stem cell activation and differentiation. Her research has important implications for developing novel therapeutic approaches that target cancer metabolism while preserving normal tissue function. Analysis of Dr. Christofk's recent publications reveals a strong focus on metabolic heterogeneity across different biological contexts. Her work spans cancer metabolism (particularly in liposarcoma, melanoma, and hepatocellular carcinoma), stem cell metabolism (especially hair follicle stem cells), viral metabolism (including Epstein-Barr virus and Zika virus), and developmental metabolism (fetal development and organogenesis). A recurring theme is how metabolic pathways serve as regulatory nodes that control cell fate decisions, tumor progression, and therapeutic responses. Selected Research Funding: Metabolic Control of Hair Follicle Stem Cell Homeostasis and Tumorigenesis (NIH R01AR070245, 2018-2023) - Co-Principal Investigator Nutrient regulation of cancer cell growth (NIH R01CA215185, 2017-2022) - Principal Investigator Regulation of the Warburg Effect in Cancer (NIH DP2OD008454, 2011-2016) - Principal Investigator Dr. Christofk's laboratory maintains active collaborations across multiple disciplines, working with clinicians, basic scientists, and computational biologists to address complex questions in metabolism and disease. Her team employs a range of cutting-edge techniques including metabolomics, stable isotope tracing, molecular biology, and in vivo models to investigate metabolic regulation in health and disease.

• Cancer Metabolism
• Stem Cell Metabolism
• Metabolic Regulation of Cell Growth
• +۵ مورد دیگر

Jakob Körbelin is a Principal Investigator at the University Medical Center Hamburg-Eppendorf (UKE), affiliated with the Faculty of Medicine and the II. Medical Clinic and Polyclinic. His research focuses on vascular biology, gene therapy, and neurological disorders, particularly targeting the blood-brain barrier using adeno-associated viral (AAV) vectors. He leads studies on pulmonary hypertension, neurovascular interactions, and genetic diseases like Niemann-Pick type C2. His work bridges basic science and translational medicine, emphasizing AAV engineering and therapeutic applications. Key research interests include endothelial cell biology, neuroinflammation, and the pathophysiology of vascular diseases. Notably, he received the UCCH Hubertus Wald Young Investigator Award 2013 for his contributions. His lab explores mechanisms of vascular dysfunction, gene delivery optimization, and the impact of viral vectors in treating rare diseases. Collaborations span molecular neurobiology, immunology, and translational oncology. Publications highlight breakthroughs in AAV-mediated therapies, such as reversing neurodegeneration in NPC2 models and identifying novel targets for pulmonary hypertension. Ongoing projects address microvascular brain pathology in SARS-CoV-2 infection and the role of transcription factors in vascular diseases.

• Gene Therapy
• Vascular Biology
• Neurology
• +۳ مورد دیگر

Guillaume Bourque is a Professor in the Department of Human Genetics at McGill University's Faculty of Medicine. He serves as an Investigator at the Victor Phillip Dahdaleh Institute of Genomic Medicine and as the Scientific Director of the Canadian Centre for Computational Genomics (C3G). His laboratory is based at 740 Dr Penfield Ave, Room 6103, Montréal, Québec, Canada, H3A 1A4, where he leads research in computational genomics and bioinformatics. Professor Bourque's research focuses on understanding mammalian genomes using comparative genomic and epigenomic analyses. His lab investigates the evolution of regulatory sequences , the role of transposable elements in gene regulation , and the impact of genome rearrangements in evolution and cancer . His team develops computational methods and resources for the functional annotation of genomes with special emphasis on sequencing-based assays including ChIP-seq, RNA-Seq, exome- and whole-genome sequencing, and single-cell analysis. The lab's work involves examining billions of DNA base pairs to interpret how variation impacts basic biology and disease. Recent publications (2024-2025) demonstrate Bourque's leadership in pangenome graph construction , transposable element analysis , epigenomic profiling , and cancer genomics . His work spans multiple disciplines from basic genome evolution to clinical applications in cancer and infectious disease. Notable projects include the development of tools like DeepPolisher for genome assembly polishing and contributions to understanding the genomic basis of long COVID. Bourque's laboratory is actively recruiting postdocs and graduate students with backgrounds in programming or statistics. The lab emphasizes quantitative approaches to biology, requiring applicants to have experience in quantitative biology as a plus. His collaborative work extends across multiple institutions and international consortia, reflecting the interdisciplinary nature of modern genomic research.

• Bioinformatics
• Computational Genomics
• Comparative Genomics
• +۵ مورد دیگر

Rosario B. Jaime-Lara is an Assistant Professor at the University of California, Los Angeles (UCLA) School of Nursing. She holds advanced degrees including a PhD in Nursing from the University of Pennsylvania, MSN from Columbia University, and dual BS degrees in Nursing and Biological Sciences from University of Pennsylvania and UC Davis. Her research focuses on neurophysiological mechanisms of eating behavior, nutritional disparities in Mexican-American communities, and chemosensory science. Key themes include obesity research, sensory neuroscience, and translational clinical studies. She employs rodent models and clinical research methodologies to explore taste/smell physiology and metabolic health. Jaime-Lara has received over 17 honors including the 2022 Hommer Memorial Award and multiple diversity fellowships. Her work spans interdisciplinary collaborations in genomics, microbiome research, and health IT interventions for chronic disease management. Recent publications emphasize olfactory dysfunction in coronaviruses, fat taste mediators, and metabolic profiling. Her research bridges basic science and clinical practice, with particular attention to underserved populations.

• Nutrition
• Neurophysiology
• Obesity Research
• +۵ مورد دیگر

Professor Alexander Breeze is a Chair in the School of Medicine at the University of Leeds, affiliated with the Multidisciplinary Cardiovascular Research Centre. His research focuses on structural biology, drug design, and molecular mechanisms of disease, particularly involving protein-protein interactions and NMR spectroscopy. Key areas include RAS oncogene inhibition, fibroblast growth factor receptors (FGFRs), and amyloid aggregation modulation. Education Background: Details of formal education not explicitly provided in the text, but extensive career history in structural biology and medicinal chemistry suggests advanced degrees in relevant fields. Research Interests: Professor Breeze’s work spans cardiovascular research, cancer biology, and infectious diseases. He develops novel therapeutics targeting oncogenic signaling pathways (e.g., RAS, FGFR) and investigates mechanisms of protein misfolding in amyloid diseases. His lab employs fragment-based drug design, NMR spectroscopy, and computational methods to study protein dynamics and drug interactions. Publications Overview: His recent work highlights advancements in small-molecule inhibitors for RAS proteins, CRACR2A genetic associations with COVID-19 severity, and modulation of amyloid aggregation pathways. Research trends emphasize translational applications, bridging basic science and clinical targets like cancer and neurodegenerative diseases. Awards & Recognition: No specific awards mentioned in the provided text, though his sustained high-impact publications suggest recognition in the field. Grants & Advising: Leadership in multidisciplinary cardiovascular research and training of early-career researchers through collaborative projects. No explicit grant details provided in this dataset. Labs & Teams: Active in the Multidisciplinary Cardiovascular Research Centre, fostering cross-departmental collaborations in cardiovascular and structural biology research.

• Cardiovascular Research
• Structural Biology
• Drug Design
• +۷ مورد دیگر

Enric Esplugues is a Research Scientist in the Department of Immunobiology at Yale School of Medicine. He previously held an Assistant Professor position at the Icahn School of Medicine at Mount Sinai and was an Associate Research Scientist at Yale. His research focuses on immunological mechanisms in autoimmune diseases, metabolic inflammation, and cancer immunity. PhD, University of Barcelona (2003) Postdoctoral Training, Yale School of Medicine (2005–2008) Dr. Esplugues' research spans immunology and metabolism, with a focus on T cell biology, particularly TH17 and regulatory T cells, and their roles in autoimmunity, atherosclerosis, and cancer. His work investigates how immune cells interact with metabolic pathways in diseases like obesity-induced hepatocellular carcinoma and hypercholesterolemia-driven vascular remodeling. He also studies viral immune evasion mechanisms, including SARS-CoV-2. His recent publications (2023–2025) emphasize the interplay between lipid metabolism and immune responses, particularly in vascular and tumor microenvironments. Key themes include LXR signaling in smooth muscle cells, ferroptosis in cancer, and endothelial triglyceride metabolism. Earlier work (2017–2020) centered on TH17 cell plasticity, tissue-resident memory T cells, and microbiota-immune interactions in cancer and autoimmunity. Notable scientific awards include: CCFA Senior Award (2014) Ramon Margalef Award (2005) Dr. Esplugues has collaborated extensively with researchers such as Carlos Fernández-Hernando, Yajaira Suárez, and Richard Flavell. While no formal students are listed, his role as a research scientist and former assistant professor implies mentorship of trainees. He leads a research laboratory at Yale, focusing on immune-metabolic interactions in disease.

• Immunology
• Autoimmune Diseases
• Autoimmunity
• +۱۰ مورد دیگر

Charles Brenner is the Alfred E. Mann Family Foundation Chair in Diabetes and Cancer Metabolism and Professor at the Department of Diabetes & Cancer Metabolism, Beckman Research Institute, City of Hope, Duarte, CA. He previously held leadership roles at the University of Iowa, Dartmouth Medical School, and Thomas Jefferson University. His research focuses on disturbances in nicotinamide adenine dinucleotide (NAD) in metabolic stress-related diseases, including diabetes, cancer, postpartum, coronavirus infection, and neurodegenerative conditions. He pioneered the discovery of nicotinamide riboside as a vitamin precursor of NAD and developed quantitative metabolomic technologies to study NAD system dysregulation. Education: Ph.D. in Cancer Biology, Stanford University (1988-1993) B.A. with honors in Biology, Wesleyan University (1979-1983) Key Research Areas: NAD Metabolomics, Systems Biology, Coronavirus Biology, Postpartum & Lactation, Diabesity, Cancer Targeting. His work spans translational applications of NAD precursors to address metabolic dysfunction in diverse pathological contexts. Scientific Awards: Fellow of the American Association for Advancement of Science (2012) ASBMB Award for Exemplary Contributions to Education (2016) Dartmouth Technology Transfer Innovation Award (2018) American Society of Nutrition Mary Swartz Rose Award (2020) Professional Leadership: He has chaired editorial boards (ASBMB Today), served on publications committees (ASBMB), and co-chaired FASEB conferences on NAD metabolism. His lab at City of Hope continues to explore NAD-based interventions for diseases like fatty liver, diabetes, and cancer.

• NAD Metabolomics
• Systems Biology
• Coronavirus Biology
• +۴ مورد دیگر

Daniel Livingstone is a researcher at The Glasgow School of Art (GSA) specializing in the application of games and 3D technologies to enhance learning and public engagement. His work spans medical visualization, heritage interpretation, and broader educational technology domains. Current PGR supervisee: Shaojie Ni (AR & Gamification in Museums) Email: D.Livingstone@gsa.ac.uk Research Themes : Serious games, virtual reality, 3D anatomical modeling, disease education, digital heritage preservation, and AI-driven simulations. Highlights include AR tools for rheumatology engagement, VR applications in diabetes management, and digital reconstructions of historical surgical instruments. Article Trends : Focus on merging immersive technologies with healthcare education, heritage storytelling, and interdisciplinary applications of game engines. Recurring keywords: Augmented Reality , 3D Visualization , Medical Education , Public Health , Virtual Environments .

• Serious Games
• 3D Visualization
• Medical Education Technology
• +۴ مورد دیگر

Professor Graham Ogg is a leading academic at the University of Oxford, where he serves as Professor of Dermatology and leads the Skin Immunology Group. His research focuses on cutaneous immunity, particularly the role of CD1a-restricted T cells in inflammatory skin diseases. He is affiliated with the MRC Human Immunology Unit and MRC Weatherall Institute of Molecular Medicine, driving translational research on lipid antigen presentation and skin immune responses. Professor Ogg's investigations center on molecular mechanisms of skin inflammation, with emphasis on CD1a-mediated T cell activation and its implications for atopic dermatitis, psoriasis, and vaccine development. His work bridges fundamental immunology with clinical applications, exploring how lipid metabolism influences immune pathways in barrier tissues. Research themes include: CD1a-lipid interactions in cutaneous inflammation Therapeutic modulation of skin-specific T cell responses Translational models for dermatological drug delivery Immune mechanisms in allergic skin disorders Analysis of his recent publications (2024-2025) reveals dominant research streams: 1) Clinical dermatology focusing on systemic therapies for atopic eczema, 2) Immunological studies of dengue pathogenesis and metabolic interactions, 3) COVID-19 sequelae and immunity dynamics, and 4) Fundamental T cell biology in autoimmune/inflammatory contexts. This corpus demonstrates interdisciplinary integration of dermatology, virology, and immunometabolism. His scientific recognition includes: Fellowship of the Academy of Medical Sciences (FMedSci) Professor Ogg directs the Skin Immunology Group at the MRC Weatherall Institute, coordinating translational projects that investigate cutaneous immune circuits. The team employs single-cell analysis, spatial transcriptomics, and immunological profiling to dissect skin-specific immune responses, with ongoing work exploring CD1a-targeted therapeutic strategies.

• Skin Immunology
• T cells
• CD1a
• +۳ مورد دیگر

Xinyan Zhang is a Researcher in the Department of Cell Biology at Yale School of Medicine, Yale University. Her research focuses on understanding the molecular mechanisms of viral infections, particularly cytomegalovirus (CMV), and their interactions with host cellular processes such as autophagy and apoptosis. She investigates how viral infections trigger inflammatory responses and contribute to pathologies in organs like the retina and liver. Her work includes studies on the role of caspase-12 in retinal cell death during CMV retinitis, the impact of autophagy inhibition on viral replication, and the long-term ocular pathologies caused by neonatal CMV infection in mice models. She also explored adipokine involvement in Kawasaki disease and meta-inflammation in obese children during her graduate studies. Zhang collaborates with mentors Dr. Feng Fang (pediatric infectious disease expert) and Dr. Ming Zhang, contributing to interdisciplinary projects at the Su Lab. Her research integrates molecular biology, immunology, and clinical insights to address translational challenges in virology and infectious diseases.

• Virology
• Immunology
• Cell Biology
• +۳ مورد دیگر