معرفی
Enric Esplugues is a Research Scientist in the Department of Immunobiology at Yale School of Medicine. He previously held an Assistant Professor position at the Icahn School of Medicine at Mount Sinai and was an Associate Research Scientist at Yale. His research focuses on immunological mechanisms in autoimmune diseases, metabolic inflammation, and cancer immunity.
- PhD, University of Barcelona (2003)
- Postdoctoral Training, Yale School of Medicine (2005–2008)
Dr. Esplugues' research spans immunology and metabolism, with a focus on T cell biology, particularly TH17 and regulatory T cells, and their roles in autoimmunity, atherosclerosis, and cancer. His work investigates how immune cells interact with metabolic pathways in diseases like obesity-induced hepatocellular carcinoma and hypercholesterolemia-driven vascular remodeling. He also studies viral immune evasion mechanisms, including SARS-CoV-2.
His recent publications (2023–2025) emphasize the interplay between lipid metabolism and immune responses, particularly in vascular and tumor microenvironments. Key themes include LXR signaling in smooth muscle cells, ferroptosis in cancer, and endothelial triglyceride metabolism. Earlier work (2017–2020) centered on TH17 cell plasticity, tissue-resident memory T cells, and microbiota-immune interactions in cancer and autoimmunity.
Notable scientific awards include:
- CCFA Senior Award (2014)
- Ramon Margalef Award (2005)
Dr. Esplugues has collaborated extensively with researchers such as Carlos Fernández-Hernando, Yajaira Suárez, and Richard Flavell. While no formal students are listed, his role as a research scientist and former assistant professor implies mentorship of trainees. He leads a research laboratory at Yale, focusing on immune-metabolic interactions in disease.