جست‌وجوی استاد و پژوهشگر

Alexandra Piotrowski-Daspitمشاهده پروفایل

استادیار

• Gene Therapy
• Biomaterials
• Nanoparticle Delivery
• +۳ مورد دیگر

Dr. Alexandra Piotrowski-Daspit is an Assistant Professor in the Biomedical Engineering department and Internal Medicine – Pulmonary and Critical Care Medicine at the University of Michigan Medical School. She is a chemical/biological engineer with expertise in polymeric biomaterials for gene therapies, focusing on in vivo behavior of delivery vehicles and strategies to optimize biodistribution. Education: Ph.D. in Chemical/Biological Engineering Her research bridges polymer chemistry, gene delivery, and translational medicine, emphasizing in utero interventions and pulmonary targeting. Key areas include nanoparticle surface engineering, macrophage decoys, and computational pharmacokinetic modeling. Recent publications highlight systemic in utero gene editing for cystic fibrosis, poly(amine-co-ester) nanoparticle tunability, and mucosal vaccination platforms. She also explores miRNA therapies for congenital diaphragmatic hernia and triplex-forming PNAs for CFTR correction. PhRMA Foundation Awardee (2024) Her work involves interdisciplinary collaborations, DEI initiatives, and translational projects from postdoc foundations in W. Mark Saltzman’s lab. Labs like Saltzman and SCGE teams support her research.

Andrew Bassettمشاهده پروفایل

پژوهشگر

• Genome Engineering
• Neurodegenerative Diseases
• Stem Cell Research
• +۵ مورد دیگر

Dr. Andrew Bassett serves as Head of the Cellular and Gene Editing Research group at the Wellcome Sanger Institute, where he develops cutting-edge genome engineering techniques using human pluripotent stem cells to investigate neurodegenerative diseases including Alzheimer's and Parkinson's. His work focuses on scaling genetic screening approaches and improving CRISPR specificity for modeling complex disease mechanisms. His academic training includes: PhD at the MRC Laboratory of Molecular Biology (MRC-LMB) with Andrew Travers on chromatin remodelling in heterochromatin formation Postdoctoral research with David Baulcombe at the University of Cambridge studying small RNA roles in chromatin modification Additional postdoctoral work with Chris Ponting at the MRC Functional Genomics Unit (MRC-FGU) in Oxford, where he pioneered CRISPR applications in Drosophila Bassett's research program centers on developing advanced genome engineering methodologies for precise modulation of gene expression networks during development and neurodegeneration. His group specializes in creating complex editing events (SNPs, paired knockouts, enhancer perturbations) within iPSC-derived models, with particular emphasis on epigenetic regulation and transcriptional control. Current projects integrate single-cell 'omics and phenotypic assays to decode genetic causes of neurodegenerative disorders through the OpenTargets consortium. Analysis of his 15 most recent publications reveals dominant trends in CRISPR technology development (35%), neurodegenerative disease modeling (30%), and single-cell functional genomics (25%). His work consistently bridges methodological innovation with disease mechanism studies, increasingly incorporating multi-omics approaches and expanding into cancer immunology and infectious disease applications since 2022. As group leader, Bassett mentors postdoctoral researchers and PhD students while securing major funding for genome engineering initiatives. His team operates within the Sanger Institute's Cellular Operations division and maintains critical partnerships with the OpenTargets consortium for therapeutic target validation. The laboratory specializes in high-throughput screening platforms using iPSC-derived neural and microglial models, with recent methodological advances including scSNV-seq and ONE-STEP tagging systems that significantly enhance precision genome editing capabilities.

Yuri Y. Glebaمشاهده پروفایل

استاد

• Plant genetics
• Plant physiology
• Plant cell biology
• +۳ مورد دیگر

Yuri Y. Gleba is a renowned academic scientist affiliated with the Institute of Cell Biology and Genetic Engineering at the Ukrainian Academy of Sciences in Kiev, Ukraine. As Founder and Director (1989–2010) and current Honorary Director, he has shaped plant biotechnology research through pioneering work in transient expression systems and molecular farming. Key Roles: Founder and Director of Institute of Cell Biology and Genetic Engineering (1989–2010), Honorary Director (2010–present) Research Interests Plant genetics , plant physiology , and biotechnology underpin his work in genetic engineering , viral vector systems , and transgenic plant applications . His innovations include the Magnifection platform for rapid plant-based vaccine production and methods for RNA silencing enhancement in molecular farming. Scientific Recognition includes membership in six international academies (World Academy of Arts and Science, Academia Europaea, Leopoldina, Ukrainian Academy of Sciences, Lithuanian Academy of Science, Bavarian Academy of Sciences) and prestigious awards like the Koerber Prize , A. von Humboldt Prize , and state prizes from the USSR and Ukraine. His work has appeared in top journals including Proceedings of the National Academy of Sciences USA and FEBS Letters . Publications : Gleba's 15 most recent articles (2004–2010) focus on plant biotechnology applications, viral vector engineering, and molecular farming. Key trends include plant-based pharmaceutical production , transient expression systems , and transgene containment strategies . Laboratory and Collaborations : Founded and led the Institute of Cell Biology and Genetic Engineering, fostering international collaborations in plant biotechnology and genetic engineering research.

Jonathan Bonesمشاهده پروفایل

دانشیار

• Analytical Chemistry
• Biopharmaceutical Manufacturing
• Mass Spectrometry
• +۳ مورد دیگر

Dr. Jonathan Bones is an Associate Professor in the School of Chemical and Bioprocess Engineering at University College Dublin (UCD) and Principal Investigator of the Characterisation and Comparability Group at NIBRT. His research focuses on analytical methods for biopharmaceuticals, including liquid chromatography-mass spectrometry (LC-MS) for protein characterization, glycomics, and process optimization. He holds a BSc and PhD in Analytical Chemistry from Dublin City University. His work has been recognized through inclusion in the Medicine Maker Power List. He leads a team of 18 researchers, supported by SFI, EI, and industry partnerships. Education: BSc in Analytical Science (Chemistry), Dublin City University PhD in Analytical Chemistry, Dublin City University Research Interests: Development of advanced LC-MS platforms for glycomics, proteomics, and bioprocess analysis. Key areas include: Quantitative proteomics/metabolomics for bioprocess monitoring Liquid phase separations for complex bioanalysis Process analytical technology (PAT) His group collaborates with ThermoFisher Scientific on analytical workflows for biopharmaceutical characterization. Articles Trends: Recent work emphasizes analytical methods for AAV vector characterization, biosimilar comparability via MAM/iMAM, and process clearance of excipients. Over 126 publications highlight his contributions to biopharmaceutical quality control and process understanding. Awards: Medicine Maker Power List (2023): Top 100 influential scientists in biopharmaceutical manufacturing and analysis Advising & Grants: Supervises PhD students in bioprocessing and analytical chemistry Funding from Science Foundation Ireland (SFI), Enterprise Ireland (EI), and EU FP7 Industry collaborations with ThermoFisher Scientific and Bristol Myers Squibb Labs & Teams: Leads the Characterisation and Comparability Lab at NIBRT, focused on cutting-edge analytical tools for bioprocess development and product quality assurance.

• Bioprocess Engineering
• Industrial Biotechnology
• Downstream Processing
• +۱۱ مورد دیگر

Alois Jungbauer is a full Professor and Head of the Institute of Biochemical Engineering at the University of Natural Resources and Life Sciences Vienna (BOKU), within the Department für Biotechnologie und Lebensmittelwissenschaften. He is a leading expert in bioprocess engineering, with a focus on downstream processing, continuous manufacturing, and sustainable biopharmaceutical production. Doctorate, University of Natural Resources and Life Sciences Vienna Habilitation, 1991 His research interests center on advanced purification technologies for biologics, including monoclonal antibodies, viral vectors, virus-like particles (VLPs), and gene therapy products. He is a pioneer in continuous integrated biomanufacturing, real-time process monitoring, and the development of platform processes for non-mAb proteins. His work integrates computational modeling, digital twins, and process intensification to improve efficiency and reduce environmental impact. He has made significant contributions to affinity chromatography, membrane adsorbers, and non-chromatographic separation methods. Recent publications highlight trends in continuous downstream processing, water conservation, in-situ buffer preparation, and the purification of complex biomolecules like secretory IgA and VLPs. His work spans both fundamental biophysical studies and industrial applications, reflecting a strong industry-academia interface. His scientific awards include: ISMR Thermo Fischer Award for Affinity Technologies (2011) Bia Separations Award (2000) Fulbright Award, Austrian-American Fulbright Commission (1996) Award of Japanese Society for Promotion of Science (1994) Golden Award 93 Professor Jungbauer actively supervises university theses and leads a dynamic research group. He has delivered numerous lectures and keynotes worldwide, indicating active engagement in knowledge transfer. His research is supported by ongoing projects and collaborations, with a strong emphasis on environmental and economic modeling of bioprocesses. He is affiliated with the Institute of Biochemical Engineering at BOKU, a hub for innovation in bioprocessing and industrial biotechnology.

David Latulippeمشاهده پروفایل

استاد

• Membrane Science
• Bioprocessing
• DNA Purification
• +۴ مورد دیگر

David Latulippe is a Professor in the Department of Chemical Engineering at McMaster University. He joined McMaster in 2012 after postdoctoral work at Cornell University and a PhD at Penn State University, focusing on membrane filtration for DNA purification. His industrial experience includes roles at ZENON Environmental (now GE Water) in hollow-fiber membrane design for water treatment. Research interests include Membrane science and technology Bioprocessing of therapeutic viruses Microscale systems for biological applications Environmental engineering solutions for water treatment Current projects involve collaborations with industry partners like Ceapro and Aevitas, and the development of a biomanufacturing automation lab with Sartorius. Recent publications highlight advancements in Nanofiltration and microfiltration for viral vectors Conductive membranes for electrochemical applications Microfluidic systems for DNA analysis Environmental monitoring of biocides and microplastics Scientific recognition includes the Young Membrane Scientist Award (2014). Teaching activities focus on Fluid Mechanics (CHEMENG 2O04) and Industrial Separation Processes (CHEMENG 4M03).

Hongbo Zhangمشاهده پروفایل

استاد

• Functional Materials
• Drug Delivery
• Biomedical Engineering
• +۴ مورد دیگر

Professor Hongbo Zhang is a leading academic at Åbo Akademi University , affiliated with the Faculty of Natural Sciences and Engineering and the InFLAMES (Innovation Ecosystem based on the Immune System) flagship program. With over 227 publications and 21 active/completed projects since 2006, his research spans Functional Materials , Drug Delivery , and Clinical Translation . Research Interests: His work focuses on Engineering nanostructures for blood-brain barrier penetration Microfluidics-enabled biomedical devices Antimicrobial resistance solutions Cellulose-based sustainable materials Mitochondrial delivery systems Theranostic hydrogels Scientific Awards: Fellow of the Royal Society of Chemistry (2024) MDPI Pharmaceutics Young Investigator (2020) Chinese Orthopedic Association 1st Prize (2019) Best Oral Drug Formulation (Control Release Society, 2014) 10 Leading Chinese Talents in Europe (2023) Collaborative Network: Actively hosts international researchers and contributes to EU/Nordic-funded projects like NAP4DIVE and Printed Intelligence Infrastructure . His recent publications demonstrate expertise in nanomedicine, biocomposites, and lignin valorization.

• Clinical sciences
• Neurosciences
• Medical physiology
• +۲ مورد دیگر

Jinhong Meng is a Senior Research Fellow at the Department of Genetics & Genomic Medicine, University College London (UCL), focusing on neuromuscular disorders and gene therapy. He earned his PhD and Bachelor’s degrees from the Fourth Military Medical University. Education: Doctor of Philosophy, Fourth Military Medical University (2000) Bachelor, Fourth Military Medical University (1995) Research Interests: Jinhong Meng’s work centers on Duchenne Muscular Dystrophy (DMD), Spinal Muscular Atrophy (SMA), and gene therapy techniques including CRISPR, lentiviral vectors, and antisense oligonucleotides. His studies explore immune responses to dystrophin, vascular defects in SMA, and dystrophin correction via viral and non-viral delivery systems. Publication Trends: Over the past eight years, Jinhong Meng has published extensively on DMD and SMA, with a focus on gene editing, dystrophin restoration, and cellular therapies. His collaborative work spans lentiviral vectors, foamy virus transduction, and necroptosis mechanisms in muscle degeneration. Labs & Collaborations: He works within UCL’s Genetics & Genomic Medicine Department, collaborating on projects involving dystrophic muscle engraftment, circadian signaling, and RNA editing for genetic mutations.

Zhandong Liuمشاهده پروفایل

دانشیار

• Bioinformatics
• Big Data analysis
• Machine Learning
• +۵ مورد دیگر

Zhandong Liu is an Associate Professor at Baylor College of Medicine with joint appointments in the Department of Pediatrics and Department of Neurology . He serves as Chief of Computational Sciences at Texas Children's Hospital and co-directs the Quantitative & Computational Biosciences Graduate Program at Baylor. Education: B.S. in Computer Science, Nankai University (2001) M.S. in Computer Science, Wayne State University (2003) Ph.D. in Genomics and Computational Biology, University of Pennsylvania (2010) Dr. Liu's research integrates genomics , machine learning , and bioinformatics to advance understanding of neurological diseases. His work focuses on: Multi-omics data integration for disease mechanism discovery Development of cloud-based CRISPR analysis tools like CRISPRcloud Augmented reality platforms for biomedical data visualization Identification of disease genes through computational models Alternative splicing analysis in cancer and neurodegeneration Single-cell and spatial transcriptomics algorithms His recent publications emphasize Alzheimer's disease , MECP2 syndromes , and computational therapy prediction across multiple domains. Scientific awards include the 2018 Outstanding Service Award from the International Association for Intelligent Biology and Medicine. He has secured major grants from NIH, CPRIT, and NSF for projects including: NSF grant #199977 (2018-2020): Augmented reality therapy platforms CPRIT grant #RP170387 (2016-2019): Network-guided cancer analysis NIH #1R01AG057339 (2017-2022): Alzheimer's disease networks As head of the Liu Lab , he leads teams developing tools like: MARRVEL : Human-model organism gene variant integration CRISPRcloud : Secure CRISPR screen analysis platform CrypSplice : Cryptic splicing detection algorithm

Pam J. McLeanمشاهده پروفایل

استاد

• Neurodegenerative Diseases
• Parkinson's Disease
• Dementia with Lewy Bodies
• +۱۲ مورد دیگر

Pam J. McLean, Ph.D. is a Professor of Neuroscience and Consultant in the Department of Neuroscience at Mayo Clinic, Jacksonville, Florida . She leads the Neurobiology of Parkinson's Disease and Related Disorders Laboratory , focusing on the molecular mechanisms of neurodegenerative diseases such as Parkinson’s disease and dementia with Lewy bodies. Primary Appointment: Consultant, Department of Neuroscience Institution: Mayo Clinic, Jacksonville, FL Research Affiliations: APDA Center for Advanced Research, Center for Clinical and Translational Science (CCaTS), Discovery and Translation Labs: Brain Research, Lewy Body Dementia Center Without Walls Dr. McLean’s research centers on alpha-synuclein , a key protein involved in neurodegeneration. Her lab investigates how alpha-synuclein misfolds, aggregates, and propagates in a prion-like manner across neurons, contributing to disease progression. She employs human induced pluripotent stem cell models, viral vector-based systems, and animal models to study these processes. Key research themes include: Prion-like propagation of alpha-synuclein Biomarker discovery using extracellular vesicles in blood Copathologies in neurodegenerative diseases Development of gene therapies and small molecules targeting alpha-synuclein Her recent publications highlight work on alpha-synuclein seeding assays, transcriptional differences between Lewy body disease and Alzheimer’s, and novel methods for isolating plasma-derived extracellular vesicles for diagnostic use. These reflect a strong trend toward translational neuroscience, aiming to bridge molecular insights with clinical applications. Dr. McLean is actively funded through multiple NIH grants, including from the National Institute on Aging and the National Institute of Neurological Disorders and Stroke. She serves as Principal Investigator on projects related to functional assessment of pathological species in Lewy body dementia and contributes to the Mayo Alzheimer’s Disease Research Center. Her lab is committed to patient-centered research and training the next generation of neuroscientists, offering postdoctoral fellowships and research education programs. She collaborates extensively with experts in neuropathology, neurology, and translational biology.

Christopher S. Sullivanمشاهده پروفایل

استاد

• Virology
• Non-coding RNA Biology
• RNA Interference
• +۵ مورد دیگر

Christopher S. Sullivan is a Professor in the Department of Molecular Biosciences within the College of Natural Sciences at the University of Texas at Austin. He directs an active research laboratory focused on viral non-coding RNA biology and host-pathogen interactions, with continuous funding evidenced by publications spanning 2005-2025. His work bridges molecular virology, immunology, and RNA biology through investigations of tumor viruses and host defense mechanisms. Research interests center on the role of non-coding RNAs in viral infection and host defense pathways, with particular emphasis on viral microRNAs , RNA interference mechanisms , and host-pathogen coevolution . His lab studies diverse virus families including Polyomaviridae, Herpesviridae, Retroviridae, and avipoxviruses, with key discoveries regarding viral miRNA functions in tumorigenesis and immune evasion. Research approaches integrate molecular virology, next-generation sequencing, and computational analysis to dissect RNA-based regulatory networks. Publications reveal consistent focus on viral non-coding RNA functions, particularly how viruses exploit host RNA machinery (notably DUSP11 phosphatase) to modulate immune responses. Recent work (2021-2025) expands into viral shedding dynamics, SARS-CoV-2 diagnostics, and circular RNA biology in polyomaviruses, demonstrating evolving yet cohesive research trajectory in RNA-virus interactions. Scientific contributions include: Pioneering identification of viral microRNAs across multiple virus families Discovery of DUSP11's critical role in RNA triphosphate regulation during infection Mechanistic insights into viral evasion of RNAi and innate immunity Development of novel RNA-based detection methods The Sullivan lab maintains active collaborations through the Center for Systems and Synthetic Biology, John Ring LaMontagne Center for Infectious Disease, and Interdisciplinary Life Sciences Graduate Programs. Lab culture emphasizes collective scientific inquiry with stated mission to 'increase understanding of pathogen-host interactions while enjoying the company of fellow lab members.' Current research directions include viral exploitation of RNA modification pathways and identification of novel host defense mechanisms using viruses as 'molecular divining rods.'

Amir Shmuelمشاهده پروفایل

استاد

• Neuroimaging
• fMRI
• Visual Perception
• +۵ مورد دیگر

Amir Shmuel is a Professor at McGill University's Faculty of Medicine, holding appointments in the Department of Neurology and Neurosurgery, Department of Biomedical Engineering, and Department of Physiology. He serves as Director of the Brain Imaging Signals Lab and Core Faculty at the McConnell Brain Imaging Centre of the Montreal Neurological Institute. His leadership includes chairing the 2018 International Society for Brain Connectivity conference and securing an $18.7M Canada Foundation for Innovation grant for Quebec's first large-bore 7 Tesla MRI scanner. Dr. Shmuel's research focuses on understanding neuronal mechanisms underlying functional brain imaging signals and visual information processing. His integrative approach combines fMRI, optical imaging, multi-channel neurophysiological recordings, and optogenetics across multiple spatial and temporal scales. Current research priorities include resting-state functional connectivity mechanisms, cortical lamina-resolved neurophysiology, and computational modeling of brain signals. His lab emphasizes parallel model development with experimental data acquisition. Recent publications demonstrate strong trends in multimodal neuroimaging integration, with emphasis on high-resolution fMRI techniques (especially 7T applications), resting-state connectivity analysis across species, and computational modeling of neurovascular coupling. Key subfields include laminar-specific activity mapping, artifact detection in medical imaging using deep learning, and cross-species functional connectivity frameworks. Dr. Shmuel's research is currently funded by the Canadian Institutes of Health Research (CIHR), Natural Sciences and Engineering Research Council of Canada (NSERC), and the US Department of Defense. His lab maintains active collaborations through initiatives like the International Society for Brain Connectivity and the PRIME-DE database consortium. Operating within the Brain Imaging Signals Lab at the Montreal Neurological Institute, Shmuel's team develops and applies advanced multimodal techniques including simultaneous fMRI-electrophysiology, voltage-sensitive dye imaging, and computational modeling frameworks. The lab maintains strong ties with the McConnell Brain Imaging Centre and participates in major open-science initiatives including the Tanenbaum Open Science Institute.

Jonathan Weissmanمشاهده پروفایل

استاد

• Protein Folding
• Systems Biology
• Genomics
• +۶ مورد دیگر

Jonathan Weissman is a Professor of Biology at the Massachusetts Institute of Technology (MIT) and a Member of the Whitehead Institute. He is also an Investigator of the Howard Hughes Medical Institute and the Landon T. Clay Professor of Biology. His research spans protein folding mechanisms, ribosome profiling, CRISPR-based tools (CRISPRi/a), and genetic interaction mapping. Whitehead Institute Member MIT Professor HHMI Investigator Co-founder, Maze Therapeutics & KSQ Therapeutics Research Interests focus on: Protein folding in cellular contexts Endoplasmic reticulum (ER) function and stress responses Genome-wide CRISPR screening for gene regulation High-density genetic interaction maps in mammals Mitochondrial protein targeting and quality control Epigenomic engineering with synthetic tools Scientific Awards include: Protein Society Irving Sigal Young Investigator Award (2004) Raymond & Beverly Sackler Prize (2008) National Academy of Sciences election (2009) NAS Award for Scientific Discovery (2015) Genetics Society of America Ira Herskowitz Award (2020) Labs & Collaborations : Leads the Weissman Lab at MIT/Whitehead Institute, co-leads the Laboratory for Genomic Research with GlaxoSmithKline, and chairs the Stowers Institute Scientific Advisory Board.

Ype P. de Jongمشاهده پروفایل

استادیار

• Viral Hepatitis
• Hepatology
• Liver Disease
• +۷ مورد دیگر

Dr. Ype P. de Jong is an Assistant Professor of Medicine at Weill Cornell Medical College of Cornell University and an Attending Physician at New York-Presbyterian Hospital. He completed his medical and doctoral training at the University of Amsterdam, followed by internal medicine and gastroenterology fellowships at Mount Sinai Hospital, New York. His research focuses on hepatitis virus immune evasion, liver disease modeling, and gene therapy applications. Education M.D., University of Amsterdam Faculty of Medicine (2003) Ph.D., University of Amsterdam (2002) Research Interests Dr. de Jong investigates hepatitis virus persistence mechanisms, develops advanced liver disease models, and explores gene therapy applications for hemophilia and liver conditions. His work bridges clinical hepatology with translational research on viral immune evasion and hepatocyte engineering. Scientific Awards Cum Laude (PhD thesis), University of Amsterdam (2002) Hippocrates Prize (Best Medical Thesis in Netherlands), Leiden University (2003) Appointments Assistant Professor of Medicine, Weill Cornell Medical College Attending Physician, New York-Presbyterian Hospital Visiting Clinical Fellow, The Rockefeller University

Patrick M. Tarwaterمشاهده پروفایل

استاد

• Infectious Disease Epidemiology
• Traumatic Brain Injury Rehabilitation and Sleep
• Biostatistical Methods in Comparative Pathobiology
• +۱ مورد دیگر

Patrick M. Tarwater is a Professor in the Department of Epidemiology & Biostatistics at Texas A&M University, with research spanning infectious disease epidemiology, traumatic brain injury rehabilitation, sleep science, biostatistical methods, and environmental health impacts on child development. His work integrates clinical, laboratory, and computational approaches to address complex public health challenges. His educational foundation includes: PhD in Biometry from University of Texas Health Science Center at Houston (1999) MS in Mathematics from Texas Tech University (1992) BA in Mathematics from Texas Tech University (1990) Tarwater's research in Infectious Disease Epidemiology features extensive work on HIV/SIV pathogenesis using non-human primate models, SARS-CoV-2 variant dynamics, and microbial risk assessment in environmental settings. His Traumatic Brain Injury and Sleep research includes innovative interventions like the OSABI sleep hygiene protocol and objective sleep monitoring methodologies for rehabilitation patients. The Environmental Health focus centers on the ECHO program's investigation of maternal nutrition and child health outcomes, alongside risk assessments for oil spill contaminants and recreational water safety. Analysis of his 2018-2024 publications reveals three dominant trajectories: (1) viral pathogenesis mechanisms using advanced animal models, (2) neuroimmunological consequences of infections and injuries, and (3) environmental exposure risk modeling. His work consistently employs sophisticated biostatistical techniques and translational approaches bridging laboratory findings to clinical applications. While no specific awards are documented in the source material, Tarwater's prolific publication record in high-impact journals demonstrates significant scholarly contributions. His teaching portfolio includes foundational courses in epidemiology and biostatistics, plus advanced instruction in cohort analysis and epidemiologic inference.