Zhandong Liu

Zhandong Liu is an Associate Professor at Baylor College of Medicine with joint appointments in the Department of Pediatrics and Department of Neurology. He serves as Chief of Computational Sciences at Texas Children's Hospital and co-directs the Quantitative & Computational Biosciences Graduate Program at Baylor.

• Education:
  • B.S. in Computer Science, Nankai University (2001)
  • M.S. in Computer Science, Wayne State University (2003)
  • Ph.D. in Genomics and Computational Biology, University of Pennsylvania (2010)

Dr. Liu's research integrates genomics, machine learning, and bioinformatics to advance understanding of neurological diseases. His work focuses on:

• Multi-omics data integration for disease mechanism discovery
• Development of cloud-based CRISPR analysis tools like CRISPRcloud
• Augmented reality platforms for biomedical data visualization
• Identification of disease genes through computational models
• Alternative splicing analysis in cancer and neurodegeneration
• Single-cell and spatial transcriptomics algorithms

His recent publications emphasize Alzheimer's disease, MECP2 syndromes, and computational therapy prediction across multiple domains. Scientific awards include the 2018 Outstanding Service Award from the International Association for Intelligent Biology and Medicine. He has secured major grants from NIH, CPRIT, and NSF for projects including:

• NSF grant #199977 (2018-2020): Augmented reality therapy platforms
• CPRIT grant #RP170387 (2016-2019): Network-guided cancer analysis
• NIH #1R01AG057339 (2017-2022): Alzheimer's disease networks

As head of the Liu Lab, he leads teams developing tools like:

• MARRVEL: Human-model organism gene variant integration
• CRISPRcloud: Secure CRISPR screen analysis platform
• CrypSplice: Cryptic splicing detection algorithm