Type III Secretion System Professors and Supervisors

J SIVARAMANمشاهده پروفایل

استاد

National University of SingaporeSingapore

J SIVARAMAN is a Professor in the Department of Biological Sciences at the National University of Singapore (NUS), where he leads the Macromolecular Structure and Function Laboratory. His research program focuses on structural and functional studies of protein targets related to infectious diseases and cancers, employing X-ray crystallography to determine three-dimensional structures and understand functional roles in disease mechanisms. The lab investigates host-pathogen interactions with particular emphasis on bacterial and viral pathogenesis. Professor Sivaraman's research interests center on macromolecular structure and function, with specific focus on proteins involved in infectious diseases and cancer. His laboratory investigates molecular mechanisms of bacterial pathogenesis, particularly studying type III secretion system (T3SS) and type VI secretion systems (T6SS) in Gram-negative bacteria, as well as viral pathogenesis mechanisms of hepatitis E virus (HEV). Additionally, his group studies structural basis for mechanisms of action of cancer-related proteins and their interactions within signal transduction pathways. The long-term goal of his research is to provide new avenues for drug design and development through understanding host-pathogen interactions and cancer mechanisms. His publication record shows a strong focus on structural biology of pathogenic mechanisms, with significant contributions in understanding viral capsid structures, bacterial secretion systems, antibiotic resistance mechanisms, and cancer-related protein interactions. The research spans multiple pathogens and disease mechanisms, demonstrating a comprehensive approach to structural biology with therapeutic applications. Publications appear in high-impact journals including Cell Research, Nature Communications, PNAS, and EMBO Journal. Scientific Recognition: Faculty of 1000 (F1000) recommended his 2011 paper in Nature Protocols as one of the most important articles in biology and medical research Professor Sivaraman's laboratory investigates structural and functional aspects of proteins critical to disease processes, combining structural approaches with in vitro and in vivo functional assays to identify molecular determinants involved in disease mechanisms. His work bridges basic structural biology with potential therapeutic applications, particularly in the areas of infectious disease and cancer. The research has implications for drug design and development targeting specific protein mechanisms in pathogens and cancer cells. The Macromolecular Structure and Function Laboratory is located in Block S3, Level 3, Department of Biological Sciences at NUS (14 Science Drive 4, Singapore 117543), with laboratory contact number 6516 1163 and office number 6779 2486. The lab continues to be active as evidenced by the website being updated as recently as January 25, 2021.

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MOK YU-KEUNG HENRYمشاهده پروفایل

دانشیار

National University of SingaporeSingapore

Yu Keung Mok serves as Associate Professor and Deputy Head of the Department of Biological Sciences at the National University of Singapore (NUS). His research group employs Nuclear Magnetic Resonance (NMR) spectroscopy and X-ray crystallography to elucidate the structure-function relationships of proteins implicated in human diseases, with a focus on allergens and bacterial pathogenesis mechanisms. Dr. Mok's primary research areas include: Structural characterization of dust mite and cockroach allergens (e.g., Blo t 5, Blo t 21, Der f 7) to map IgE epitopes and understand their role in asthma and atopic dermatitis; Investigation of bacterial type III and VI secretion systems, particularly the structural analysis of chaperone-translocator complexes and their regulation by two-component systems (PhoP/PhoQ) in response to environmental cues. His recent publications (2010-2025) demonstrate a strong emphasis on structural biology approaches to study host-pathogen interactions, including dengue virus pathogenesis, bacterial secretion mechanisms, and allergen immunology. The work integrates protein engineering, binding assays, and structural data to inform therapeutic design. Scientific Awards: No major scientific awards were mentioned in the provided text. Dr. Mok's laboratory operates within the Department of Biological Sciences at NUS, utilizing advanced structural biology facilities. His research involves interdisciplinary collaborations with experts in microbiology, immunology, and biochemistry, as reflected in his extensive publication record.

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Georg Busslingerمشاهده پروفایل

پژوهشگر

University of ViennaAustria

Georg Busslinger is a group leader at the Medical University of Vienna, leading the Gastrointestinal Biology Research Group under the Department of Internal Medicine III and Division of Gastroenterology & Hepatology. His research focuses on epithelial cell biology of the human gastrointestinal tract, particularly the esophagus, stomach, and small intestine, using organoid technology and single-cell genomics. University of Vienna (B.S. in Molecular Biology) ETH Zurich (Master’s in Molecular Biology) Rockefeller University (research on epigenetic regulation of interferon response) Research Institute of Molecular Pathology (Ph.D. on cohesin genome localization) Hubrecht Institute (postdoctoral work on organoid biology) His research utilizes CRISPR/Cas9 genome editing and single-cell RNA sequencing to study transcriptional regulation, epithelial differentiation, and disease mechanisms in gastrointestinal organs. He investigates how nutrients and microbiome signals contribute to carcinogenesis and employs organoid models to dissect functional roles of cell types like acid-secreting parietal cells and hormone-producing enteroendocrine cells. Recent publications highlight his work on ulcerative colitis (2025), diet-induced mutations (2023), Barrett’s esophagus progression (2022), and foundational studies on single-cell characterization of gastrointestinal epithelia (2021). Collaborations with clinicians at UMC Utrecht explore organoid applications in precision oncology. Georg Busslinger's lab is funded by the FWF Stand-Alone Program (PAT6421424) and hosts predoctoral fellows including Katharina Kohl, Franziska Langner, Daria Pajak, and Gabriela Vladova. His team also includes Lab Manager Michael Gerstorfer.

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Anna Fahlgrenمشاهده پروفایل

دانشیار

Umea UniversitySweden

Anna Fahlgren is an Associate Professor at Umeå University, affiliated with the Faculty of Medicine and the Department of Molecular Biology. She serves as the Education Manager at the Faculty Office of Medicine, overseeing education, research, and communication initiatives. Her administrative role is based in the Administration Building, while her research ties to molecular biology are centered at the hospital area campus. Her research focuses on microbial pathogenesis , host immune responses , and bacterial infection mechanisms . Key areas include: virulence strategies of pathogens like Yersinia pseudotuberculosis and Campylobacter jejuni , immune evasion tactics, outer membrane vesicle functions, and host-pathogen interactions in gastrointestinal and systemic infections. Recent publications (2012–2024) demonstrate a consistent focus on: Bacterial virulence regulation (e.g., plasmid dynamics, secretion systems) Host immune modulation (e.g., neutrophil interactions, mast cell activation) Co-infections and pathological synergies (e.g., malaria-borrelia models) Molecular mechanisms of persistence and adaptation in infections She collaborates with the Maria Fällman Lab , contributing to research on bacterial pathogenesis. No awards, students, or grant details are mentioned in the provided text.

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Maradona Daouda-Agbanrinمشاهده پروفایل

پژوهشگر

University of TübingenGermany

Maradona Daouda-Agbanrin is a researcher in the Cellular and Molecular Microbiology working group at the Faculty of Mathematics and Natural Sciences. His work focuses on understanding the assembly mechanisms of type III secretion systems (T3SS) in Salmonella , which are critical for the pathogen's ability to manipulate host cells during infection. His research explores the coordination between inner and outer membrane components of the T3SS encoded on Salmonella pathogenicity island 1, with particular emphasis on identifying the stage at which secretion initiates and the needle structure assembles. This work has implications for developing anti-infective drugs targeting bacterial virulence mechanisms. He employs techniques in bacterial genetics, molecular biology, membrane protein biochemistry, and protein-protein interaction analysis to advance these studies.

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Sophie Schminkeمشاهده پروفایل

پژوهشگر

University of TübingenGermany

Sophie Schminke is a researcher at the Cellular and Molecular Microbiology working group within the Faculty of Mathematics and Natural Sciences. Her work focuses on the molecular mechanisms of bacterial pathogens, particularly the membrane insertion dynamics of Salmonella Typhimurium effectors SseF and SseG. Investigating the role of type III secretion systems in bacterial virulence Employing advanced techniques like fluorescent live cell microscopy and subcellular fractionation Exploring protein-protein interactions via in vivo proximity biotinylation (TurboID) Analyzing transmembrane segment functionality in pathogenic protein integration Her research bridges microbiology and cellular biology, aiming to uncover how bacterial effectors hijack host cell membranes.

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Jason McDermottمشاهده پروفایل

دانشیار

Paul Drude Institute for Solid State ElectronicsGermany

Jason McDermott is a senior research scientist and Team Lead for Systems Biology at Pacific Northwest National Laboratory (PNNL), with an Affiliate Associate Professor appointment in the Department of Molecular Microbiology and Immunology at Oregon Health & Science University (OHSU). His work bridges computational and experimental biology, focusing on data integration, network analysis, and systems-level understanding of biological processes. McDermott earned his BA in Biology from Reed College in 1993, PhD in Structural Virology from OHSU in 2000, and completed post-doctoral training in Bioinformatics at the University of Washington in 2006. His research spans cancer biology, host-pathogen interactions, microbiome science, and computational prediction of protein functions. His work integrates high-throughput omics data to develop systems biology models, with particular emphasis on biomarker discovery, network inference, and pathway analysis. Recent publications demonstrate his leadership in applying multi-omics approaches to understand viral infections, soil microbial communities, cancer mechanisms, and metabolic diseases. His research portfolio shows consistent focus on developing computational methods for biological data integration and analysis, with applications across diverse domains from infectious disease to cancer biology and environmental microbiology. 1997 Sears Fellowship Award (OHSU) 1998 Tartar Fellowship Award (OHSU) 2008 Analytics Challenge Winner (Supercomputing 2008) McDermott actively collaborates with experimental biologists, statisticians, and mass spectrometrists to develop and apply computational methods. He has made significant contributions to the Clinical Proteomic Tumor Analysis Consortium (CPTAC), particularly in ovarian cancer research, where he serves as chair of both the biology working group and data analysis working group. His work often involves interdisciplinary teams focused on translating computational insights into biological understanding.

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Lidiya Dubytskaمشاهده پروفایل

دانشیار

Southern University and A&M CollegeUnited States

Dr. Lidiya Dubytska serves as Associate Professor of Biology at Southern University and Agricultural and Mechanical College, Baton Rouge, where she established new research directions in microbiology and pathogen-host interactions since joining in 2017. Her work focuses on bacterial virulence mechanisms and translational applications for disease control, with extensive contributions to understanding Edwardsiella ictaluri and Borrelia burgdorferi pathogenesis. Her academic training includes: MS in Biochemistry from Ivan Franko State University of L'viv, Ukraine, researching TGF-beta effects on fibroblast collagen gel contraction Ph.D. in Molecular Genetics from Ukraine's National Academy of Science (2003), developing Streptomyces strains for anticancer drug production Dr. Dubytska's research examines global virulence regulation through Type Three Secretion Systems, alternative sigma factors, and two-component systems. She investigates how pathogens like Edwardsiella modulate host organelle trafficking and immune responses, with implications for vaccine development and therapeutic interventions against bacterial infections. Publication analysis reveals consistent interdisciplinary work bridging bacterial genomics, host-pathogen dynamics, and molecular pathogenesis. Her recent output emphasizes aquaculture pathogens and spirochetal diseases, demonstrating technical expertise in genome annotation, effector protein characterization, and virulence gene regulation across diverse bacterial systems. Key recognition includes: National Academy of Science of Ukraine prize for best scientific presentation (2002) She has mentored undergraduate researchers like Demetrius McAtee (2nd place biology poster competition, 2019) and secured research funding including an LSU/USDA grant as Co-PI and CEIDER support. Her collaborative network spans Ukrainian institutions, New York Medical College, and Louisiana State University. Dr. Dubytska's laboratory has annotated multiple Edwardsiella genomes and plasmids, contributing to GenBank submissions. She maintains active editorial roles with Advances in Microbiology and BMC Microbiology while advising on microbiological applications textbooks.

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Jeremy Ellermeierمشاهده پروفایل

دانشیار

Midwestern UniversityUnited States

Jeremy Ellermeier, Ph.D. is an Associate Professor in the Department of Microbiology & Immunology at Midwestern University, holding dual appointments in the College of Graduate Studies and College of Veterinary Medicine. His research program focuses on bacterial pathogenesis mechanisms, particularly investigating Salmonella species and their protein secretion systems. Dr. Ellermeier's educational background includes: Ph.D. in Microbiology from the University of Illinois at Urbana-Champaign (2008) M.S. from the University of Illinois at Urbana-Champaign (2004) B.S. in Agronomy from the University of Nebraska-Lincoln (2002) His research interests center on understanding the twin arginine translocation (Tat) system in Salmonella, which exports properly folded proteins from the cytoplasm to the periplasm. His laboratory has demonstrated that bile salts induce tatABC expression and that Tat-deficient strains show increased sensitivity to cell wall-targeting antibiotics. This work addresses fundamental questions about how bacterial pathogens adapt to host environments and the connections between protein secretion and antibiotic susceptibility. Dr. Ellermeier's publication record reveals a consistent research trajectory focused on bacterial virulence mechanisms, with particular emphasis on regulatory networks controlling pathogenicity islands and host-environment sensing. His work spans from foundational studies of transcriptional regulation to investigations of protein secretion systems and their physiological consequences. His scientific contributions include: Elucidating the regulatory mechanisms of SPI-1 type III secretion system Characterizing the role of Tat system in bacterial physiology and antibiotic susceptibility Investigating how host-derived signals (bile, fatty acids) influence bacterial gene expression Exploring connections between cell envelope integrity and antibiotic resistance Dr. Ellermeier teaches across multiple health professions programs at Midwestern University, including Medical Microbiology, Medical Immunology, Veterinary Immunology, and courses for Physician Assistant and Pharmacy students. His regular instruction in Veterinary Immunology (MICRG 1522) demonstrates his commitment to training future veterinarians in immunological principles.

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