جست‌وجوی استاد و پژوهشگر

Tune H Persمشاهده پروفایل

دانشیار

• Metabolism Research
• Genomics
• Metagenomics
• +۵ مورد دیگر

Tune H Pers is an Associate Professor at the Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR) within the Faculty of Health and Medical Sciences at the University of Copenhagen. He leads the Pers Group, which focuses on human genomics and metagenomics in metabolism, integrating systems biology approaches to understand metabolic diseases and their underlying mechanisms. Dr. Pers earned his PhD in Integrative Systems Biology from the Technical University of Denmark in 2011, supervised by Søren Brunak and Thorkild I.A. Sørensen. He completed both his MSc in Bioinformatics (2008) and BSc in Computer Science (2005) at the University of Copenhagen, establishing a strong foundation at the intersection of computer science and biological sciences. His research spans metabolism, genomics, metagenomics, diabetes, obesity, gut microbiome, and systems biology. Dr. Pers' work uniquely bridges computational approaches with experimental validation, investigating how gut bacteria influence host metabolism and how neural circuits regulate energy balance. His group employs advanced genomic, transcriptomic, and high-dimensional profiling techniques to unravel the complex relationships between microbiome composition, host genetics, and metabolic health. Analysis of Dr. Pers' recent publications reveals a strong trajectory in understanding the molecular mechanisms of metabolic disorders, with particular emphasis on the gut-brain axis, microbial contributions to metabolism, and novel therapeutic targets for obesity and diabetes. His work frequently appears in high-impact journals including Nature, Nature Metabolism, and Nature Microbiology, demonstrating both scientific rigor and translational relevance. Sapere Aude Scholarship, Danish Research Council for Independent Research (2011) Lundbeck Foundation Fellowship (2015) Honorary Medal for Researchers below 40 Years, Jakobiner Society (2017) Sapere Aude Starting Grant, Danish Research Council for Independent Research (2019) Young Investigator Award, Danish Diabetes Academy (2019) Dr. Pers maintains significant research collaborations across institutions, evidenced by his previous positions as Senior Scientist at Statens Serum Institut (2015-2018) and Senior Research Fellow at Boston Children's Hospital (2011-2015). His research program is supported by multiple Danish research councils and foundations, enabling comprehensive investigations into metabolic disease mechanisms. The Pers Group actively mentors students and collaborates with both computational and experimental researchers to advance understanding of metabolic health. The Pers Group operates at CBMR, a world-leading center for metabolic research, where they investigate the complex interplay between human genomics, gut metagenomics, and metabolic regulation. Their work combines cutting-edge computational approaches with physiological validation to identify novel mechanisms and potential therapeutic targets for metabolic disorders.

Steven Vollmerمشاهده پروفایل

استاد

• Evolutionary Genomics
• Ecological Genomics
• Coral Immunology
• +۴ مورد دیگر

Steven Vollmer serves as Director of the School of Environmental, Coastal, and Ocean Sustainability and Professor in the Department of Biological Sciences at Florida Atlantic University, having joined FAU in 2025 after 18 years as Professor of Marine and Environmental Science at Northeastern University where he directed the Bioinformatics program and served as Associate Director of the Marine Science Center. His postdoctoral research was conducted at the Smithsonian Tropical Research Institute in Panama. Education: B.S., Colorado State University, Fort Collins, CO M.S., California State University, Northridge, CA Ph.D., Harvard University, Boston, MA Dr. Vollmer is an evolutionary and ecological genomicist specializing in reef corals, with primary research focus on coral adaptation mechanisms against disease infection and thermal bleaching. His laboratory employs integrated field experiments, tank-based studies, and advanced genomic techniques to investigate coral immunity, host-pathogen dynamics, and microbial community interactions at molecular and organismal levels. This work directly informs marine conservation strategies and environmental sustainability initiatives for endangered coral ecosystems. Analysis of his 2021-2025 publications reveals a concentrated research trajectory centered on White Band Disease in Caribbean staghorn coral (Acropora cervicornis), leveraging genome-wide association studies, machine learning pathogen identification, and whole-genome assembly to uncover disease resistance mechanisms. His work bridges fundamental genomics with applied conservation, addressing urgent threats to coral reef resilience. Scientific Awards: National Academy of Science Kavli Fellow Advising and Grants: The source text does not specify doctoral advisees or grant funding details, though his research program implies active supervision of graduate students and secured external funding for genomic and disease ecology projects. Laboratory and Team: Dr. Vollmer leads a multidisciplinary research group integrating evolutionary genomics, bioinformatics, and marine ecology to study coral host-microbe-symbiont systems. His team conducts fieldwork across Caribbean and Indo-Pacific reefs while maintaining controlled tank experiments to simulate environmental stressors and disease challenges.

• RNA-targeted therapeutics
• Precision Medicine
• Chemoinformatics
• +۷ مورد دیگر

Matthew Disney is an Institute Professor and Chair of the Department of Chemistry at the University of Florida. His research program focuses on developing rational approaches to design selective therapeutics from genome sequence data, with particular emphasis on RNA-targeted drug discovery. He leads a highly productive research group that has pioneered innovative approaches in chemical biology and drug design. Dr. Disney's primary research interests include RNA-targeted therapeutics, precision medicine, chemoinformatics, RNA structure analysis, and drug design for neuromuscular and neurodegenerative diseases. His work bridges chemistry, biology, and medicine to develop novel treatments for conditions including muscular dystrophy, Alzheimer's, ALS, and difficult-to-treat cancers. His research has established that RNA can be effectively targeted with small molecules, challenging previous assumptions in the field. His recent publications demonstrate a strong focus on RNA-targeted therapeutics, with key advances including sequence-based drug design across the human transcriptome, development of RIBOTACs (ribonuclease-targeting chimeras) for catalytic RNA degradation, and creation of tools like Chem-CLIP for studying RNA-ligand interactions. The research spans from fundamental RNA structure studies to preclinical animal models, showing exceptional translational potential. The ACS 2022 Nobel Laureate Signature Award for Graduate Education in Chemistry (2021) The Raymond and Beverly Sackler International Prize in Chemistry (2019) BioFlorida's Weaver H. Gaines Entrepreneur of the Year (2018) NIH Director's Pioneer Award (2015) American Chemical Society's Eli Lilly Award in Biological Chemistry (2013) Dr. Disney's laboratory has trained numerous scientists who have gone on to successful careers in academia and industry. His research has been supported by substantial funding from the National Institutes of Health and other organizations. The Disney lab maintains strong collaborations across multiple disciplines, enhancing the impact of their RNA-targeted therapeutic approaches. The Disney group operates the Druggable Transcriptome Project and has developed the Inforna platform, which merges chemoinformatics and RNA structure to identify lead compounds targeting disease-associated RNAs. Their work on RIBOTACs represents a major advance in RNA-targeted therapeutics, enabling catalytic and substoichiometric degradation of disease-causing RNAs.

• Neuronal diversity and connectivity
• Mouse visual cortical circuit
• Brain circuitry
• +۷ مورد دیگر

Hongkui Zeng serves as Executive Vice President and Director of the Allen Institute for Brain Science, a position she assumed in 2020 after joining the institute in 2006 and leading its Structured Science Division from 2016-2020. She directs one of the world's leading neuroscience research organizations focused on creating comprehensive brain atlases and accelerating neuroscience discovery through open science principles. Dr. Zeng earned her Ph.D. in molecular and cell biology from Brandeis University studying circadian clock mechanisms in fruit flies, followed by postdoctoral research at MIT investigating hippocampus-dependent plasticity and learning. Her scientific journey has evolved toward systematic understanding of brain circuitry through large-scale, multidisciplinary approaches. Her research program centers on understanding neuronal diversity and connectivity in the mouse visual cortical circuit, employing a combined molecular, anatomical, and physiological approach. She has pioneered the development of multiple research platforms including single-cell transcriptomics, electrophysiology, 3D neuronal reconstruction, brain-wide connectivity mapping, and neuronal activity imaging to characterize neuronal cell types and their interconnections. Analysis of her recent publications (2023-2025) reveals a strong emphasis on creating multi-scale brain atlases that integrate transcriptomic, epigenomic, morphological, and connectivity data. Her work demonstrates increasing sophistication in mapping brain organization from molecular to circuit levels, with significant contributions to understanding healthy aging, cortical architecture, and cell-type-specific brain organization. Leading the BRAIN Initiative Cell Census Network Developing the Allen Mouse Brain Connectivity Atlas Creating comprehensive cell-type taxonomies Establishing standardized physiological survey methods As Director, she oversees major research programs, mentors scientific staff, and guides strategic direction for large-scale neuroscience projects that produce foundational resources for the global neuroscience community. Her leadership has positioned the Allen Institute at the forefront of systematic brain mapping initiatives that are transforming how we understand brain structure and function.

James M Reecyمشاهده پروفایل

استاد

• Animal Genetics
• Genomics
• Bioinformatics
• +۵ مورد دیگر

Dr. James M Reecy is a Professor and Associate Vice President for Research at Iowa State University, specializing in Animal Science. He holds a PhD in Animal Science from Purdue University (1995), preceded by an MS from the University of Missouri-Columbia (1992) and a BS from South Dakota State University (1990). His affiliations include the Bioinformatics Coordination Program, National Animal Genome Research Program, and National Beef Cattle Evaluation Consortium. Education: BS in Animal Science, South Dakota State University (1990) MS in Animal Science, University of Missouri-Columbia (1992) PhD in Animal Science, Purdue University (1995) Dr. Reecy’s research focuses on Animal Genetics and Genomics , integrating Transcriptomics , Epigenetics , and Microbiome Analysis to enhance livestock production. His work explores feed efficiency in Bos indicus , dietary impacts on Sus scrofa physiology, and genomic diversity in global cattle/goat breeds. He leads initiatives for genomic data curation and systems biology in animal health. Recent publications highlight his contributions to Livestock Genomics , including genome-wide association studies (GWAS) for growth traits in goats, integrative analysis of miRNA-microbiome interactions in cattle, and functional annotation of the bovine genome. His work bridges Computational Biology with agricultural practice, focusing on data infrastructure and precision livestock farming. Dr. Reecy’s affiliations with programs like the National Animal Genome Research Program underscore his role in advancing genomics for animal production. He also emphasizes practical applications of High-throughput Phenotyping and Big Data Analytics in livestock systems.

Louis C. Gerstenfeldمشاهده پروفایل

استاد

• Skeletal Tissue Biology
• Bone Histomorphometry
• Cell Biology of Skeletal Tissues
• +۵ مورد دیگر

Louis C. Gerstenfeld is a Professor in the Department of Orthopaedic Surgery and Research Professor in the Department of Biochemistry & Cell Biology at Boston University's Chobanian & Avedisian School of Medicine. He also holds affiliations with the Center for Regenerative Medicine and Evans Center for Interdisciplinary Biomedical Research. His expertise spans skeletal tissue biology, bone histomorphometry, and fracture healing mechanisms. Gerstenfeld earned a PhD from Boston University School of Medicine and dual undergraduate degrees (BA and BS) from Pennsylvania State University. His research focuses on genomic and transcriptomic factors influencing bone quality, fracture healing diagnostics, and extracellular matrix proteins. He has led over 35 funded grants, including NIH and DOD projects on osteoporosis, bone regeneration, and systems genetics. His work integrates molecular biology, bioengineering, and clinical research to address skeletal repair challenges. Key contributions include pioneering osteoblast culture techniques, cloning bone matrix proteins, and developing serum-based fracture healing diagnostics. Current efforts explore genetic determinants of bone strength and regenerative therapies. Gerstenfeld has served on NIH review panels and collaborated with NASA/DOD on skeletal biology research. His lab investigates osteogenesis, angiogenesis, and the role of metabolic pathways in bone repair. He maintains active partnerships with industry (e.g., Acceleron Pharma) and academic institutions.

• Bioinformatics
• Genomics
• Computational Biology
• +۳ مورد دیگر

Jason Liu is a Researcher in the Department of Molecular Biophysics and Biochemistry at Yale University’s Yale School of Medicine. His work focuses on computational genomics, epigenetics, and the development of bioinformatics tools for analyzing genomic and regulatory data. He collaborates extensively on projects such as the ENCODE and EN-TEx initiatives, contributing to resources for cancer genomics and multi-tissue epigenome analysis. His research integrates machine learning, functional genomics assays, and systems biology approaches to study gene regulation, transcriptional networks, and the impact of genetic variants in diseases like cancer and psychiatric disorders. Key research interests include single-cell genomics, regulatory network modeling, and the application of AI to wearable health data. Notable contributions include SCAN-ATAC-Sim (a single-cell ATAC-seq simulation tool), the RADAR framework for RNA-binding protein variant analysis, and the DiNeR model for network rewiring analysis. His work bridges computational methods with experimental biology to advance personalized medicine and functional genomics. Liu has published over 15 peer-reviewed articles in journals like Nature, Nature Communications, and Genome Biology. His recent studies explore digital phenotyping via wearable devices, single-cell brain genomics, and multi-tissue epigenome integration. While no awards or grants are explicitly listed, his publications reflect significant contributions to bioinformatics and genomic medicine.

• Ovarian Cancer Epidemiology
• Breast Cancer Risk Factors
• Genetic Susceptibility to Cancer
• +۴ مورد دیگر

M. A. Rossing is a cancer epidemiology researcher at the German Cancer Research Center (DKFZ) in Heidelberg, Germany, with significant contributions to ovarian and breast cancer research. As evidenced by 56 publications in the DKFZ database, Dr. Rossing is an active researcher with extensive collaborations through the Ovarian Cancer Association Consortium (OCAC) and other international research networks. Dr. Rossing's research focuses on understanding the genetic and epidemiological factors influencing ovarian and breast cancer risk and outcomes. Their work spans multiple areas including genome-wide association studies, polygenic risk modeling, biomarker development, and investigation of reproductive risk factors. Recent publications demonstrate expertise in molecular subtyping of ovarian cancer and the development of clinically applicable risk prediction tools. The publication record shows a consistent output of high-impact research in leading oncology and genetics journals including Nature Communications, Journal of Clinical Oncology, American Journal of Human Genetics, and JAMA Oncology. The research demonstrates a strong emphasis on translating genetic findings into clinically relevant risk assessment tools. Extensive work on ovarian cancer genetic susceptibility Development of polygenic risk models for cancer prediction Investigation of reproductive factors in cancer etiology Analysis of molecular subtypes and their prognostic value Dr. Rossing's collaborative approach is evident through authorship on numerous multi-institutional studies involving researchers from North America, Europe, and beyond. This collaborative network enables the large-scale analyses necessary for meaningful discoveries in cancer epidemiology.

• Prostate Cancer
• Oncology
• Genomics
• +۶ مورد دیگر

Dr. Adnan Ali is a leading researcher in prostate cancer genomics and clinical oncology at the Australian National University's Genome Sciences and Cancer Division. His work focuses on genomic profiling of prostate cancer progression, radiation therapy efficacy, and drug development strategies. Ali has contributed to major clinical trials such as STAMPEDE, evaluating treatments like abiraterone and radiotherapy for metastatic prostate cancer. His research bridges basic science (e.g., microRNA regulation) and clinical applications, with a strong emphasis on personalized medicine. Key research areas include metastatic prostate cancer management, genomic biomarkers for treatment response, and understanding mechanisms behind castration-resistant disease. He collaborates widely on international trials and publishes in high-impact journals like The Lancet and Cell Reports . Ali's work has garnered over 2,200 citations and an h-index of 14, reflecting significant contributions to oncology research. Notable projects include: Leading genomic analyses of metastatic prostate cancer subtypes Evaluating radiotherapy outcomes in newly diagnosed metastatic cases Developing biomarker strategies for treatment selection His studies often involve large-scale genomic sequencing and clinical trial data integration, advancing both scientific understanding and clinical practice in prostate cancer care.

Nicholas Ingoliaمشاهده پروفایل

دانشیار

• Post-transcriptional Regulation
• Ribosome Profiling
• RNA-Binding Proteins
• +۴ مورد دیگر

Nicholas Ingolia is an Associate Professor in the Department of Molecular and Cell Biology at the University of California, Berkeley. His research focuses on understanding post-transcriptional regulation of gene expression, particularly mRNA translation and stability. He leads the Ingolia Lab, which develops high-throughput techniques like ribosome profiling and APEX-Seq to study translational control mechanisms. Key contributions include characterizing RNA-binding proteins, ribosome rescue pathways, and the role of alternate translation initiation sites. Education and affiliations are not explicitly detailed, but his work spans molecular biology, biochemistry, and genetics. Recent advancements include CRISPRi-based functional genomics (CiBER-seq) and studies on calcium-dependent protein interactions. The lab collaborates widely, including with Helen Bateup and Ruixuan Gao, and supports graduate students and postdocs in MCB, Computational Biology, and Biophysics programs. Research interests emphasize translating fundamental discoveries into tools for studying cellular processes. Notable techniques include improved ribosome profiling protocols and proximity labeling for RNA-protein complex analysis. The lab’s work has been published in Nature , Molecular Cell , and Science , among others.

Andrea Doseffمشاهده پروفایل

استاد

• Cell Biology
• Cancer Biology
• Pharmacology
• +۳ مورد دیگر

Andrea Doseff is a Professor in the Department of Physiology at Michigan State University (MSU) and Director of the Graduate Program in Physiology. Previously, she held a Professorship at Ohio State University, beginning her academic career there as an Assistant Professor. Her research focuses on apoptosis mechanisms, cell fate regulation, and the role of phytochemicals in cancer and immune function. She earned her Ph.D. through a joint program at SUNY Stony Brook and Cold Spring Harbor Laboratory, followed by postdoctoral training at Cold Spring Harbor Laboratory. Research Interests Dr. Doseff’s lab employs genome-wide analyses, proteomics, and cellular/animal models to study how cell death proteins and phytochemicals (e.g., apigenin) influence cancer resistance, immune function, and metabolic pathways. Key areas include functional foods enhancing phytochemical efficacy for cancer prevention, and plant-derived compounds’ anti-inflammatory effects in obesity and chronic diseases. Advising & Grants While specific grant details are not detailed here, her work involves collaborative research on plant metabolites and cancer biology. Her lab’s advancements in apigenin’s cancer-inhibiting mechanisms and flavonoid bioengineering reflect interdisciplinary grant-funded efforts. Labs/Teams As head of the Doseff Lab, she leads a team focused on translational research bridging plant biology and human health, emphasizing functional foods and molecular mechanisms of disease.

Gregor Bucherمشاهده پروفایل

استاد

• Evolutionary Developmental Biology
• Insect Genetics
• Neurogenesis
• +۳ مورد دیگر

Gregor Bucher is Professor of Evolutionary Developmental Genetics at the University of Göttingen, where he leads research on insect development using the red flour beetle (Tribolium castaneum) as a model system. His laboratory investigates the genetic and cellular mechanisms underlying insect head formation, brain development, and evolutionary diversification. Bucher developed the iBeetle RNAi screening platform that enables genome-wide functional analysis in Tribolium. Research spans three interconnected areas: (1) Genetic control of insect head development, (2) Evolution of insect brain structures with focus on the central complex, and (3) Application of RNA interference for pest control. The laboratory employs CRISPR/Cas9 genome editing, transgenic tools, and comparative approaches to study evolutionary developmental processes. Recent publications demonstrate increasing focus on RNAi applications for agricultural pest control and comparative brain development. Work from 2022-2025 shows methodological innovations in dsRNA design, genome-wide screening for pest control targets, and comparative analyses of neurodevelopmental timing between beetles and flies. Bucher contributes to graduate education through the Göttingen Graduate Center for Neurosciences, Biophysics, and Molecular Biosciences, training PhD students in functional genomics and evolutionary biology.

Abderrahim Oussalahمشاهده پروفایل

استاد

• Inborn Errors of Metabolism
• Cobalamin (Vitamin B12) Metabolism
• Epigenetics
• +۵ مورد دیگر

Abderrahim Oussalah is a Professor and MD at the University of Lorraine, Faculty of Medicine, based at Campus Brabois Santé in Vandoeuvre-lès-Nancy. His research focuses on inborn errors of metabolism, particularly cobalamin (vitamin B12) metabolism, epigenetics, and biomarker discovery for liver/kidney disorders and genetic diseases. His research interests center on inborn errors of metabolism with emphasis on cobalamin metabolism disorders (cblC, cblG), epigenetic mechanisms in diseases like hepatocellular carcinoma, and biomarker development for conditions including cirrhosis, sepsis, and inflammatory bowel disease. His work integrates multi-omics approaches to correlate molecular findings with clinical phenotypes. Recent publications reveal strong trends in genetic diagnostics (exome sequencing for Mendelian disorders), epigenetic signatures (DNA methylation for cancer detection), and clinical biomarker validation (pro-adrenomedullin for bacterial peritonitis, calprotectin for ulcerative colitis). His research bridges basic science with clinical applications, particularly in rare metabolic diseases. Scientific contributions include: Discovery of epi-cblC disorder (transgenerational epimutation) Development of epigenomic signatures for hepatocellular carcinoma Validation of novel biomarkers for sepsis and renal dysfunction in cirrhosis Expansion of genetic spectrum for Tatton-Brown-Rahman syndrome His collaborative work involves multi-institutional studies on vitamin B12 metabolism, with technical platforms including functional genomics, bioinformatics, and specialized cell culture. Current projects focus on epigenome-wide alterations in metabolic disorders and translation of biomarkers to clinical practice.

Andrew C. Adeyمشاهده پروفایل

استاد

• Single-Cell Epigenetics
• Sequencing Biotechnology
• Quantitative Oncology
• +۴ مورد دیگر

Dr. Andrew C. Adey is a Professor in the Department of Genome Sciences at Oregon Health & Science University (OHSU), leading the Adey Lab within the Knight Cancer Institute. His research focuses on developing innovative sequencing technologies and studying epigenetic regulation in health and disease. He completed his Ph.D. at the University of Washington under Jay Shendure, specializing in DNA sequencing and epigenetic analysis. Education: B.S., 2008, University of Texas Ph.D., 2014, University of Washington Research Interests: Single-cell epigenomics and chromatin accessibility profiling Development of scalable sequencing technologies (e.g., sciMET, sciATAC) Epigenetic mechanisms in cancer heterogeneity and tumor progression Integration of spatial genomics and multi-omics data Key Contributions: Pioneered transposase-based DNA library preparation and sciMET for single-cell methylation analysis Advanced haplotype-resolved genome analysis in aneuploid cells (e.g., HeLa) Led development of combinatorial indexing for high-throughput single-cell studies Awards: University of Washington Distinguished Dissertation Award (2014) Harold M. Weintraub Graduate Student Award (2014) ASHG Early-Career Award (2019) Lab Focus: Epigenetic drivers of cellular heterogeneity in cancer Single-cell technologies for precision medicine Collaborations in oncology and neuroscience (e.g., cerebral organoids)

• Plant Genetics
• Quantitative Trait Loci (QTL) Mapping
• Polyploid Biology
• +۳ مورد دیگر

Dr. Peter Bourke is an Assistant Professor in Plant Breeding at Wageningen University & Research. His research focuses on polyploid genetics, quantitative trait loci (QTL) mapping, and genomic resources for crops such as rose, kiwifruit, and potato. He specializes in developing genetic mapping tools for higher ploidy species and improving breeding strategies for agricultural resilience. Bourke collaborates internationally on projects addressing genetic diversity in food systems and disease resistance in crops. Research Interests: Polyploid biology, QTL analysis, genomic resources for ornamental and agricultural plants, sustainable breeding practices. Key Projects: Tetraploid rose genomics, kiwiberry fruit quality QTL mapping, potato pollen genetics. Tools Developed: polymapR software for polyploid linkage analysis, high-density SNP arrays. His work bridges basic genetics and applied breeding, with contributions to understanding tetraploid inheritance patterns and genomic applications in diverse crop species. Bourke also advocates for biodiversity-positive agricultural systems to enhance resilience against environmental challenges.