Andrew C. Adey

Dr. Andrew C. Adey is a Professor in the Department of Genome Sciences at Oregon Health & Science University (OHSU), leading the Adey Lab within the Knight Cancer Institute. His research focuses on developing innovative sequencing technologies and studying epigenetic regulation in health and disease. He completed his Ph.D. at the University of Washington under Jay Shendure, specializing in DNA sequencing and epigenetic analysis.

Education:

• B.S., 2008, University of Texas
• Ph.D., 2014, University of Washington

Research Interests:

• Single-cell epigenomics and chromatin accessibility profiling
• Development of scalable sequencing technologies (e.g., sciMET, sciATAC)
• Epigenetic mechanisms in cancer heterogeneity and tumor progression
• Integration of spatial genomics and multi-omics data

Key Contributions:

• Pioneered transposase-based DNA library preparation and sciMET for single-cell methylation analysis
• Advanced haplotype-resolved genome analysis in aneuploid cells (e.g., HeLa)
• Led development of combinatorial indexing for high-throughput single-cell studies

Awards:

• University of Washington Distinguished Dissertation Award (2014)
• Harold M. Weintraub Graduate Student Award (2014)
• ASHG Early-Career Award (2019)

Lab Focus:

• Epigenetic drivers of cellular heterogeneity in cancer
• Single-cell technologies for precision medicine
• Collaborations in oncology and neuroscience (e.g., cerebral organoids)