جست‌وجوی استاد و پژوهشگر

Valentina Perissiمشاهده پروفایل

دانشیار

• Genomic Regulation of Metabolism
• Nuclear-Mitochondria Communication
• Transcriptional Regulation
• +۵ مورد دیگر

Valentina Perissi serves as Associate Professor in the Department of Biochemistry at Boston University School of Medicine, where she leads the Perissi Laboratory focused on transcriptional regulation mechanisms. Her research integrates molecular, cellular, and physiological approaches to study metabolic and stress responses. Her primary research interests explore genomic regulation of metabolism, nuclear-mitochondria communication, and cellular stress responses. The lab investigates how signal transduction pathways and chromatin remodeling enzymes fine-tune transcriptional regulation during metabolic changes, hormonal stimulations, and differentiation processes. Current work centers on the NCoR/SMRT corepressor complex's role in cellular bioenergetics and stress adaptation using multidisciplinary approaches including biochemical assays, mouse models, and next-generation sequencing. Her laboratory has produced significant publications on mitochondrial retrograde signaling, ubiquitin-mediated regulation, and metabolic disease mechanisms. Key findings include GPS2's role in mitochondria-to-nucleus communication and AKT signaling regulation in metabolic tissues. Peter Paul Career Development Professorship Dr. Perissi mentors several researchers including Senior Postdoctoral Fellow Sahana Mitra (specializing in unfolded protein response and mitochondrial stress signaling) and MS student Ting-Yu (Claire) Fan. Her research is supported by multiple NIH grants (NIDDK, NIGMS), the Boston Nutrition and Obesity Center, US Department of Defense, and Grunebaum Cancer Foundation. The Perissi Lab maintains active collaborations with Boston University's core facilities and participates in the Adipose Tissue Biology and Metabolism Core.

Mitchell Turkerمشاهده پروفایل

دانشیار مهمان

• Gene Inactivation
• Cancer Biology
• Aging Mechanisms
• +۴ مورد دیگر

Mitchell Turker is a Visiting Associate Professor in the Department of Genetics and Development at Columbia University, with prior academic roles at the University of Kentucky (Assistant/Associate Professor in Pathology and Microbiology/Immunology) and the University of Washington. His research focuses on abnormal gene inactivation mechanisms in cancer and aging, particularly DNA mutations and methylation under radiation or oxidative stress. Education: PhD in Pathology (University of Washington, 1984), JD in Law (Lewis and Clark, 2008) Key Collaborations: NASA Space Radiation Laboratory, Columbia University Research Themes Turker’s work bridges radiation biology , epigenetics , and aging , using mouse models (e.g., Aprt gene) to study how environmental factors like space radiation alter DNA methylation and mutation rates, increasing cancer risk. His team also explores circadian rhythm epigenetics and space radiation’s cognitive effects . Publications & Trends His publications (1984–2023) emphasize space radiation genomics , epigenetic instability , and oxidative stress in aging . Recent studies (2017–2023) analyze how Galactic cosmic rays and heavy ions affect fear memory and genomic integrity. Awards Jefferson Science Fellow, US Department of State (2010–2011) Institute of Medicine Committee (2014–2015) on Vietnam veterans’ herbicide exposure

Yassine Sassiمشاهده پروفایل

استادیار

• Cardiovascular Physiology
• Pulmonary Arterial Hypertension
• Pulmonary Fibrosis
• +۷ مورد دیگر

Yassine Sassi, Ph.D., is an Assistant Professor at the Fralin Biomedical Research Institute at VTC, the Department of Biomedical Sciences and Pathobiology at the Virginia-Maryland College of Veterinary Medicine, and the Department of Internal Medicine at the Virginia Tech Carilion School of Medicine. His research focuses on understanding the molecular mechanisms of cardiovascular and pulmonary diseases, particularly the roles of coding and non-coding RNAs and cyclic nucleotide pathways. Research Interests: Dr. Sassi's work centers on pulmonary arterial hypertension, pulmonary fibrosis, cardiac hypertrophy, and fibrosis. His lab investigates how RNA molecules and signaling pathways contribute to disease progression and seeks to identify novel therapeutic targets. The research integrates molecular biology, cell culture, and animal models to uncover disease mechanisms and test potential treatments. Publication Trends: His recent publications span high-impact journals such as Circulation , Nature Communications , and Science , reflecting a strong focus on RNA biology, epigenetics, and signal transduction in heart and lung diseases. The work increasingly emphasizes therapeutic development and molecular mechanisms of fibrosis and vascular remodeling. Transformational Project Award, American Heart Association, 2021 Innovative Project Award, American Heart Association, 2018 Career Development Award, American Heart Association, 2017 Early Career Best Science Award Winner (1 st place), American Heart Association, 2014 Best Poster Award (1 st place), Dutch-German Joint Meeting of Molecular Cardiology, 2013 Advising and Grants: Dr. Sassi mentors a multidisciplinary team of postdoctoral associates, graduate students, and medical students in the Sassi Lab. His research is supported by prestigious awards from the American Heart Association, enabling innovative projects in cardiovascular and pulmonary therapeutics. He has led and contributed to numerous collaborative studies, demonstrating strong leadership in both basic and translational research. Labs and Teams: The Sassi Lab is part of the Center for Vascular and Heart Research at the Fralin Biomedical Research Institute. The lab fosters collaboration across disciplines and institutions, contributing to a vibrant research environment focused on advancing understanding and treatment of chronic heart and lung diseases.

Bimal N. Desaiمشاهده پروفایل

استاد

• Ion Channels
• Calcium Signaling
• Immunology
• +۷ مورد دیگر

Bimal N. Desai is a Professor in the Department of Pharmacology at the University of Virginia School of Medicine, where he leads a research program at the intersection of immunology, physiology, and molecular pharmacology. His work focuses on ion channels and calcium signaling in inflammation, immunity, and tissue homeostasis. Dr. Desai earned his PhD in Immunology from Harvard University. His research explores how electrical signals, particularly through ion channels like TRPM7 and pannexins, regulate macrophage function, efferocytosis, and inflammatory responses in non-excitable cells. His research interests include: Ion Channel Biophysics Calcium Signaling in Immune Cells Macrophage and Myeloid Cell Physiology Neuroimmunology Molecular Mechanisms of Inflammation Metabolic-Electrical Coupling in Immunity Analysis of his recent publications reveals a strong focus on TRPM7 and pannexin channels as key regulators of macrophage function, mitochondrial metabolism, and intercellular communication during inflammation. His work increasingly integrates immunometabolism, aging (inflammaging), and translational pharmacology, with implications for autoimmune and neurodegenerative diseases. Scientific contributions and recognitions include: Editorial leadership in Frontiers in Immunology (2021) High-impact publications in Nature Aging , Nature Communications , Immunity , and Science Signaling Development of novel TRPM7 inhibitors with in vivo anti-inflammatory effects Dr. Desai actively mentors trainees and collaborates across disciplines, securing co-authorships with experts in neuroscience, metabolism, and vascular biology. His lab utilizes advanced techniques including live-cell imaging, electrophysiology, and mouse transgenics. While specific grants are not listed, his sustained productivity suggests robust external funding. He is involved in collaborative research on pannexin channels and inflammatory signaling, often partnering with groups in immunology and physiology. His laboratory functions as a multidisciplinary team investigating the 'electrical symphony of life' in immune cells, combining chemical biology, imaging, and genetic models to dissect signaling circuits in health and disease.

Joshua D. Currieمشاهده پروفایل

استادیار

• Regenerative Biology
• Developmental Biology
• Cell Biology
• +۷ مورد دیگر

Joshua D. Currie is an Assistant Professor in the Department of Biology at Wake Forest University, where he leads the Currie Lab focused on regenerative and developmental biology. His lab is located at Wake Downtown in Winston-Salem, NC, within the Innovation Quarter, adjacent to the Wake Forest School of Medicine and the Wake Forest Institute for Regenerative Medicine (WFIRM), fostering interdisciplinary collaboration. Dr. Currie earned his Ph.D. from the University of North Carolina at Chapel Hill and completed postdoctoral research at the Center for Regenerative Therapies in Dresden, Germany. His research centers on understanding how tissues regenerate, using the Mexican axolotl ( Ambystoma mexicanum ) as a model system. He investigates the spatiotemporal coordination of cells during limb and tail regeneration, particularly the formation and function of the blastema—a mass of progenitor cells that rebuilds missing structures. His lab combines live imaging , CRISPR/Cas9 genome editing , ex vivo cell biology , and single-cell transcriptomics to uncover the molecular and cellular mechanisms of regeneration. A key goal is to compare regenerative processes in axolotls with fibrotic wound healing in mammals to identify therapeutic targets for improving human tissue repair. The recent publications of Dr. Currie reflect a strong trend in regeneration biology , cell dynamics , and molecular control of tissue morphogenesis . His work spans from fundamental cell biological mechanisms in Drosophila to cutting-edge regeneration studies in vertebrates, demonstrating a deep integration of model systems and methodologies. The interdisciplinary nature of his research bridges developmental biology, cell biology, and translational regenerative medicine. Scientific Awards: No awards explicitly mentioned in the text. Dr. Currie advises graduate and undergraduate researchers in his lab, though specific student names are not listed. His lab receives research funding that supports advanced imaging and molecular biology work, likely through federal or private grants, though specific grants are not detailed. He actively recruits new team members and emphasizes core values such as collaboration, rigor, and inclusivity. The Currie Lab is embedded in a vibrant research ecosystem at Wake Forest, with strong ties to regenerative medicine initiatives. The lab’s location in the Innovation Quarter enables close interaction with clinicians and engineers, enhancing the translational potential of their discoveries. The lab also promotes open science through shared resources and protocols.

Manuel Collado Rodríguezمشاهده پروفایل

پژوهشگر

• Cellular Senescence
• Cancer Biology
• Aging Mechanisms
• +۴ مورد دیگر

Dr. Manuel Collado Rodríguez is a researcher at the University of Santiago de Compostela (USC), leading the ColladoLab within the Center for Research in Molecular Medicine and Chronic Diseases (CIMUS). He holds a PhD from the Autonomous University of Madrid (1997), focusing on HIV-1 immunology under Dr. Mariano Esteban Rodríguez. His research centers on cellular senescence's role in cancer and aging, with particular emphasis on tumor suppression mechanisms, epigenetic regulation, and senescence-associated secretory phenotypes. His lab investigates these processes through in vivo models and explores therapeutic applications such as senolytic compounds and cellular reprogramming. Collaborations include institutions like i3S in Porto, Portugal, and involvement in international conferences like the Wiggers-Bernard Conference on Cellular Senescence. Research Focus: His work spans molecular mechanisms of senescence, oncogene-induced senescence, and the interplay between senescence and cancer progression. Key areas include SOX2 regulation in cancer, p53 signaling pathways, and extracellular vesicle biology. His lab also engages in translational research, such as evaluating diet's impact on tumor microenvironments and exploring CRISPR-Cas13d for antiviral therapies. Publications Trends: Recent articles emphasize guidelines for senescence experimentation, epigenetic reprogramming in tumors, and senescence's dual role in cancer control and promotion. His work bridges basic science and clinical applications, addressing aging-related diseases and cancer therapies. Lab Activities: The ColladoLab hosts students and researchers, with ongoing projects funded by GAIN-Xunta de Galicia and other initiatives. Projects include studying senescence in zebrafish models, senotherapies for cancer, and investigating senescence biomarkers in clinical settings.

• Plant Pathology
• Microbial Genetics
• Plant-Microbe Interactions
• +۳ مورد دیگر

Dr. Jessica Erickson is a Junior Group Leader at the University of Tübingen’s Center for Integrative Biological Signaling Studies (ZMBP), within the Department of General Genetics. Her research focuses on bacterial pathogens’ manipulation of plant apoplast environments, particularly through secreted proteins like those from Xanthomonas . She leads the Bacterial Apoplast Modulators Lab, studying virulence mechanisms and plant immune responses. Academically, she holds a Ph.D. from Martin Luther University Halle-Wittenberg and postdoctoral experience at the Leibniz Institute of Plant Biochemistry. Her career includes independent project leadership funded by the DFG’s Walter Benjamin Program. Current projects leverage molecular biology, biochemistry, and computational approaches, using Arabidopsis and Nicotiana benthamiana as model systems. Research interests include effector protein function, microtubule dynamics, and stromule formation in plant cells. Her lab collaborates broadly, with publications in PLOS Pathogens , Plant Cell Physiol , and Plant Physiology . Open positions exist for bachelor/master’s theses, emphasizing plant-bacteria interaction studies. Key grants include DFG support for her independent research and infrastructure for multiplex gene editing. The lab’s future work aims to dissect how bacterial proteins reprogram plant apoplast environments to enable disease progression.

Eli Zunderمشاهده پروفایل

دانشیار

• Stem Cell Biology
• Single Cell Mass Cytometry
• High-Dimensional Data Modeling
• +۵ مورد دیگر

Eli Zunder, Ph.D., is an Associate Professor in the Department of Biomedical Engineering at the University of Virginia. His research focuses on analyzing stem cell fate using single-cell mass cytometry and high-dimensional modeling of cell lineage trajectories. He holds a B.A. from Dartmouth College (2002) and a Ph.D. in Biophysics from UCSF (2008), followed by postdoctoral training in Garry Nolan’s lab at Stanford University. His work has developed novel methods for cell barcoding in mass cytometry, mapping immune system organization, and identifying therapeutic targets in cancer and stem cell reprogramming. Research Interests: Biotechnology and Biomolecular Engineering, Computational Systems Biology, stem cell differentiation, immune system dynamics, and high-dimensional data analysis. His lab explores mechanisms controlling stem cell behavior in development and disease, with applications in regenerative medicine and drug discovery. Grants & Projects: Current research includes in vitro differentiation studies to define principles of pluripotency and lineage commitment. His lab develops experimental and computational tools for tracking cell populations at single-cell resolution, such as the FLOW-MAP trajectory mapping algorithm and ensemble clustering methods like ESCHR. Projects focus on neurodevelopment, immune system plasticity, and disease models like ALS and idiopathic pulmonary fibrosis. Labs & Teams: The Zunder Lab at the University of Virginia collaborates across disciplines to integrate cutting-edge cytometry techniques with systems biology approaches. Key collaborations include work on immune signaling dynamics and metabolic pathways in neurodegenerative diseases.

• Transcription Factors
• Nuclear Reprogramming
• Catenin
• +۵ مورد دیگر

Sebastian Wild is a Research Associate (Hynes Research Fellowship) in the Department of Life Sciences at the University of Bath. His research focuses on molecular mechanisms of cell reprogramming and liver development for therapeutic applications in Type 1 Diabetes. Education: PhD in Life Sciences, University of Bath, 2024 Wild's research spans Transcription Factors, Nuclear Reprogramming, Catenin, Liver Development, Wnt Signaling, Pancreas, and Transdifferentiation. He investigates transcription factor-mediated conversion of liver to pancreas to generate therapeutic beta cells for diabetes, with emphasis on molecular pathways driving cellular identity changes. His publications reveal a strong emphasis on Wnt signaling in liver development and the molecular basis of cell reprogramming. This work bridges developmental biology and regenerative medicine, with significant implications for diabetes therapy through liver-pancreas transdifferentiation approaches. Scientific awards: Hynes Research Fellowship Wild completed his PhD under Professors Tosh and Walko, focusing on refining liver-derived beta cells for Type 1 Diabetes Mellitus. He has not yet supervised students. He is an active member of Professor Tosh's research team, contributing to projects on liver-pancreas transdifferentiation and Wnt signaling in organ development and homeostasis.

Yaakov Nahmiasمشاهده پروفایل

استاد

• Metabolic Engineering
• Liver Tissue Engineering
• Hepatitis C Virus Research
• +۴ مورد دیگر

Prof. Yaakov Nahmias is a Professor and Managing Director at the Hebrew University of Jerusalem's Silberman Institute of Life Sciences, Department of Genetics. His research focuses on bioengineering applications in metabolism, tissue engineering, and drug discovery. His lab develops organ-on-chip systems, sensors for toxicity studies, and cultivated meat technologies. Key projects include metabolic control of viral infections, kidney nephrotoxicity mechanisms, and cost-effective bioprocessing for cultured meat. Research Interests: Metabolic programming and nuclear receptor control Liver tissue engineering and HCV infection Organ-on-chip platforms for drug discovery Cultivated meat production and bioprocessing innovations Scientific Awards: AIMBE Fellow, ERC Consolidators Grant (2015), Rosetrees Trust Prize (2017), and Rappaport Prize (2014). Lab Members: Includes researchers like Mohammad Ghosheh and Aaron Cohen. Collaborations span Grass Center for Bioengineering and Tissue Dynamics.

Kurt R. Zinnمشاهده پروفایل

استاد

• Molecular Imaging
• Cancer Diagnosis and Therapy
• Neuroimaging
• +۳ مورد دیگر

Kurt R. Zinn is a Professor in the Department of Biomedical Engineering at Michigan State University. Previously, he held roles at the University of Alabama, including Professor of Radiology, Director of the Laboratory of Multimodality Imaging, and Director of Radiology’s Division of Advanced Medical Imaging Research. He earned a D.V.M., M.S. in Chemistry, and Ph.D. in Biochemistry from the University of Missouri-Columbia. Dr. Zinn’s research focuses on molecular imaging for cancer diagnosis/therapy and neuroimaging of drug delivery to the brain. His work includes developing PET radiotracers, targeted radioimmunotherapy, and novel drug delivery systems. Notable contributions include over ten phase I clinical trials and the Distinguished Investigator Award from the Academy of Radiology Research (2015). His research spans PET imaging agent design, alpha-particle therapy for cancers (e.g., ovarian, breast), and advanced imaging techniques like simultaneous PET/MRI. He also investigates glymphatic system clearance in the brain and primate brain drug delivery via nasal routes. His work integrates 3D-printed biomedical tools and AI-driven image analysis for precision medicine applications. Dr. Zinn’s labs focus on translational research bridging preclinical models and clinical applications. He collaborates extensively on imaging biomarkers, therapeutic efficacy evaluation, and multimodality imaging platforms. His team’s innovations aim to improve diagnostic accuracy and treatment efficacy in oncology and neurology.

Pierre Mattarمشاهده پروفایل

استادیار

• Neurodevelopment
• Neurodegeneration
• Retinal Biology
• +۶ مورد دیگر

Pierre Mattar is an Assistant Professor in the Department of Cellular and Molecular Medicine at the University of Ottawa and a Senior Scientist in the Regenerative Medicine program at the Ottawa Hospital Research Institute (OHRI). He holds the Gladys and Lorna J. Wood Chair for Research in Vision. His research focuses on understanding how genome remodelling regulates neurodevelopment and neurodegeneration, particularly in the retina and cerebral cortex. Key goals include identifying mechanisms to regenerate neural tissue and combat retinal degenerative diseases like glaucoma and macular degeneration. Dr. Mattar’s academic roles include teaching in graduate courses such as HMG8105 and NSC8103. His research employs advanced techniques in epigenetics, genomics, and model organisms. He collaborates with institutions like the University of Ottawa and OHRI, leveraging interdisciplinary approaches to address vision-related disorders. His work bridges basic science with translational medicine, aiming to translate discoveries into therapeutic strategies for blindness and neurodevelopmental disorders. Notable achievements include studies on chromatin remodelling factors (e.g., ADNP, Chd4) and their roles in neurodevelopmental disorders. His team investigates lamin A’s role in photoreceptor degeneration and employs mouse models to study Sifrim-Hitz-Weiss syndrome. Dr. Mattar’s research is supported by grants and affiliations with major institutions, positioning him as a leader in retinal neuroscience and regenerative medicine.

Benedikt Berningerمشاهده پروفایل

استاد

• Neurodevelopment
• Neurogenesis
• Cellular Reprogramming
• +۳ مورد دیگر

Professor Benedikt Berninger is a Professor of Developmental Neurobiology at King's College London, affiliated with the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) and the Centre for Developmental Neurobiology. He leads a research group focusing on neurogenesis and cellular reprogramming, particularly converting glial cells into neurons. His work is supported by major grants like the ERC Advanced Grant (2021). Affiliations: King's College London, Francis Crick Institute (Satellite Group Leader) Education: PhD in Neurochemistry from Ludwig Maximilian University of Munich (1996) His research explores mechanisms to regenerate the diseased brain through reprogramming support cells into neurons. Key interests include neural stem cells, astrocyte biology, and regenerative medicine. Recent breakthroughs include reprogramming astroglia into functional interneurons and reducing epileptic seizures via glial conversion. Awards: ERC Advanced Grant (2021). Grants and collaborations: IMAGINE (EU project), Neuro-ReprOm (EU project), and partnerships with institutions like the Francis Crick Institute.

• Epigenetics
• Plant Reproduction
• Speciation Mechanisms
• +۴ مورد دیگر

Gerardo Del Toro-De León is a Researcher at the Max Planck Institute of Molecular Plant Physiology, Germany, specializing in the epigenetic mechanisms underlying plant reproduction and speciation. He holds a PhD in Plant Biotechnology from Langebio-CINVESTAV (Mexico) and a BS in Biology from UNAM (Mexico). His current role combines postdoc and scientific leadership within Department 2 under Prof. Köhler, focusing on imprinting dynamics and reproductive barriers in plant endosperm. Research interests center on the interplay between epigenetics, reproductive processes, and evolutionary mechanisms. His work explores how RNA decay regulation safeguards embryo development, maternal transcriptome biases in embryogenesis, and transposon mobilization effects on epigenetic stability. Key contributions include defining imprinting's role in postzygotic isolation and characterizing endosperm-specific transcriptomic landscapes. Notable achievements include an EMBO Postdoctoral Fellowship (2018-2020) and collaborative work with institutions like the Swedish University of Agricultural Sciences. His research bridges fundamental plant biology with evolutionary implications, using advanced molecular tools like the INTACT system for tissue-specific analysis.

• Cancer immunotherapy
• Oncolytic virotherapy
• Vaccine development
• +۵ مورد دیگر

Manlio Fusciello is a Postdoctoral Researcher at the Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki. He serves as Supervisor for the Doctoral Programme in Drug Research and is affiliated with the ImmunoViroTherapy Lab. His research focuses on developing innovative cancer immunotherapies and oncolytic viral platforms for personalized medicine applications. Dr. Fusciello's research spans cancer immunotherapy , oncolytic virotherapy , and vaccine development with particular emphasis on adenoviral vector engineering and personalized approaches. His work investigates how viral vectors can be optimized to deliver therapeutic agents and stimulate robust immune responses against various cancers, with significant focus on combination therapies that integrate viral treatments with epigenetic modulators and checkpoint inhibitors. His recent publication record (2022-2025) demonstrates increasing sophistication in vaccine platform development, with particular attention to delivery systems like microneedle patches, immune receptor engagement mechanisms, and personalized approaches based on tumor antigen profiles. His research bridges fundamental virology with practical therapeutic applications, showing strong translational potential. VETURI DATA-INDUCTOR (2025-2028, Business Finland) JAES Cerullo consortium (2023-2026, Jane ja Aatos Erkon säätiö) As a doctoral programme supervisor, Dr. Fusciello guides the next generation of pharmaceutical researchers in drug development and cancer therapeutics. His work in the ImmunoViroTherapy Lab focuses on creating novel viral-based cancer vaccines and immunotherapies that target the complex interplay between tumors and the immune system.