جست‌وجوی استاد و پژوهشگر

Steven Clarkeمشاهده پروفایل

استاد

• Protein Methylation
• Aging
• Biochemical Mechanisms of Disease
• +۴ مورد دیگر

Steven Clarke is a Distinguished Professor in the Department of Chemistry and Biochemistry at UCLA, where he has been a faculty member since 1978. He directs the UCLA Cellular and Molecular Biology Training Program and investigates protein methylation's role in aging and disease states. His work spans biochemical, genetic, and molecular approaches across organisms including Saccharomyces cerevisiae , Caenorhabditis elegans , and Arabidopsis thaliana . Clarke earned his Ph.D. in Biochemistry and Molecular Biology from Harvard University, where he worked with NSF Fellow Peter Mitchell at Glynn Research Laboratories on mitochondrial amino acid transport. He completed postdoctoral work as a Miller Fellow at UC Berkeley with Dan Koshland, studying bacterial chemotaxis receptors. His research has identified key methyltransferases like protein L-isoaspartyl repair methyltransferase and PRMT9, while exploring connections between methylation, insulin signaling, and longevity pathways. His laboratory has produced over 250 publications since 2000, focusing on protein methylation (PRMT7/9), aging mechanisms (isoaspartyl damage, methionine addiction), ribosomal modification , and stress response pathways . Recent work examines PCMTD1/2 in proteostasis, COQ5 in coenzyme Q biosynthesis, and novel methyltransferases in Trypanosoma brucei. Current graduate students include Eric Pang (biochemistry/structural biology) and Cindy Wang (biochemical-computational hybrid). Undergraduates Celeste Medina-Seymour, Elizabeth Oroudjeva, Olivia Pacheco, and Jasmine Winter contribute to projects involving yeast, plant, and nematode models. His team's interdisciplinary approach combines biochemical assays, mass spectrometry, and computational methods to uncover methylation's impact on cellular function.

Janne Ravanttiمشاهده پروفایل

مدرس

• Bioinformatics
• Structural Bioinformatics
• NGS Analysis
• +۲ مورد دیگر

Janne Ravantti is a University Lecturer at the University of Helsinki, affiliated with the Molecular and Integrative Biosciences Research Program and the Doctoral Programme in Integrative Life Science. His research focuses on bioinformatics, structural bioinformatics, NGS analysis, computational methods for Cryo-EM, and BioPython. He has contributed to collaborations in structural biology, virology, and cancer research. Department: Molecular and Integrative Biosciences Research Program Supervision: Co-supervisor for PhD theses and member of thesis committees Collaborations: Center of Excellence in Virus Research (CoE_VIRRES), Okinawa Institute of Science and Technology (OIST) Ravantti's recent publications examine topics such as giant virus characterization, cancer risk factors, and RNA processing mechanisms. He has co-authored studies on colorectal cancer, viral structural analysis, and epidemiological modeling of disease incidence. His activities include participation in academic conferences, peer review for journals, and collaborative projects with international researchers. He has also served as a preliminary reviewer and committee member for doctoral dissertations.

Rui Chenمشاهده پروفایل

استاد

• Human Genetics
• Genomics
• Molecular Biology
• +۵ مورد دیگر

Rui Chen is a Professor of Ophthalmology at University of California Irvine and a Visiting Professor in Molecular and Human Genetics at Baylor College of Medicine . His research bridges Human Cell Atlas methodologies with clinical genetics to decode the functional consequences of genomic variants in neural degenerative diseases, particularly retinal disorders. Education : BS (Tsinghua University, 1994), PhD (Baylor College of Medicine, 1999), Post-Doctoral Fellowship (BCM, 2002) Rui Chen's research interests span: Genetic variant discovery in Mendelian and complex visual diseases Single-cell omics for retinal development and disease modeling Therapeutic innovation via CRISPR, gene therapy, and neural regeneration His publications highlight interdisciplinary approaches combining next-generation sequencing , retinal organoids , and machine learning to address inherited and age-related retinal degenerations. The Chen Lab at Baylor College of Medicine leads efforts in Human Cell Atlas construction for the visual system, fostering collaborations with institutions globally.

Stephen Raderمشاهده پروفایل

استاد

• Pre-mRNA splicing
• Spliceosome structure and function
• Evolutionary biology of splicing
• +۴ مورد دیگر

Stephen Rader is a Professor of Chemistry at the University of Northern British Columbia (UNBC) in Prince George, British Columbia. His laboratory investigates the biological function and mechanism of pre-mRNA splicing, with a particular focus on the extremophile red alga Cyanidioschyzon merolae , which thrives in volcanic hot springs at temperatures up to 60°C and pH as low as 0.5. Dr. Rader's research program examines fundamental questions about pre-mRNA splicing from an evolutionary perspective, including how splicing helps cells adapt to environmental changes, the pressures leading to intron loss in certain lineages, and the minimal set of splicing machinery necessary for cell viability. His lab has made significant discoveries, including that C. merolae completely lacks the U1 snRNP typically responsible for 5' splice site recognition. His recent publications (2012-2022) demonstrate a consistent research trajectory focused on spliceosome structure, function, and evolution across diverse organisms. The work spans molecular biology, structural biology, and evolutionary genomics, with particular emphasis on how reduced spliceosomes function in extremophile organisms. His research combines biochemical, genetic, and structural approaches to understand splicing mechanisms. Dr. Rader actively trains graduate students and postdoctoral researchers, welcoming enthusiastic and well-prepared students to join his dynamic team in Prince George. His laboratory has produced numerous publications in high-impact journals including PNAS, RNA, Journal of Molecular Biology, and Frontiers in Genetics.

Beatrix Suessمشاهده پروفایل

استاد

• Synthetic RNA biology
• Regulatory RNAs
• Aptamer engineering
• +۵ مورد دیگر

Prof. Dr. Beatrix Suess is a Professor at Technische Universität Darmstadt, Fachbereich Biologie, leading the Suess Lab. Her research focuses on synthetic RNA biology, particularly regulatory RNAs like aptamers and riboswitches, with applications in synthetic biology, medicine, and biotechnology. She holds an Emmy-Noether-Habilitationspreis (2007) and other notable awards. Education: Diploma (Biology, 1994), Ph.D. (1998), Postdoc (1999-2006) Research: Engineering synthetic riboswitches, studying non-coding RNAs in Streptomyces, developing biosensors Key research interests include RNA structure-function relationships, aptamer design for genetic control, and applications in drug development. Her lab has pioneered RNA Capture-SELEX methods and engineered riboswitches for gene regulation in diverse organisms.

Klemens J. Hertelمشاهده پروفایل

استاد

• Alternative Splicing
• RNA Processing
• Molecular Genetics
• +۳ مورد دیگر

Klemens J. Hertel is a Professor and Chair of the Department of Microbiology & Molecular Genetics at the University of California, Irvine School of Medicine. His research focuses on the molecular mechanisms of RNA splicing, particularly the regulation of alternative splicing events such as NAGNAG splicing and their implications in cancer and cellular processes. He has contributed extensively to understanding spliceosome dynamics, RNA processing, and the interplay between splicing and gene regulation. Key research areas include the influence of genetic and epigenetic factors on splicing efficiency, the role of RNA-binding proteins in splice site selection, and the impact of metabolic signals on alternative splicing. His work integrates biochemical assays, high-throughput sequencing, and computational modeling to uncover fundamental mechanisms in molecular genetics. Recent studies highlight his exploration of splicing defects in cancer progression, the regulatory networks governing spliceosome assembly, and the functional consequences of alternative polyadenylation. He has published over 50 peer-reviewed articles, with notable contributions to journals like Nucleic Acids Research and Molecular and Cellular Biology. Dr. Hertel’s grants include NIH funding (R01 GM062287, R21 CA149548) for projects on splicing regulation and cancer biology. His lab is at the forefront of developing in vitro splicing systems and tools for studying RNA processing. Mentorship of students and postdocs in molecular genetics and biochemistry underscores his commitment to training future scientists.

Brenda Templeمشاهده پروفایل

دانشیار

• Structural Bioinformatics
• Computational Structural Biology
• Molecular Modeling
• +۷ مورد دیگر

Brenda Temple is an Associate Professor at the University of North Carolina at Chapel Hill School of Medicine , affiliated with the Departments of Biochemistry & Biophysics and Pharmacology . She serves as the Director of the RLJ Structural Bioinformatics Core, providing computational expertise in structural biology to support interdisciplinary research. Her research interests focus on structural bioinformatics , molecular dynamics , and homology modeling , enabling collaborative studies in histone modifications , RNA processing , viral oncogenesis , and chromatin biology . She supports experimental studies through computational modeling, molecular docking, and drug design. The RLJ Structural Bioinformatics Core, under her leadership, offers access to advanced computational tools like PyMOL, AMBER, and AlphaFold. Collaborations span diverse labs studying epigenetics , neurodegenerative diseases , cell cycle regulation , and viral pathogenesis , with core resources funded by the NIH grant P30CA016086.

Daniel Semlowمشاهده پروفایل

استادیار

• DNA Replication
• DNA Repair
• Nucleic Acid Chemistry
• +۴ مورد دیگر

Daniel Semlow is an Assistant Professor of Biochemistry at the California Institute of Technology (Caltech) and a Ronald and JoAnne Willens Scholar. He earned his B.S. from the University of Illinois, Urbana (2005) and his Ph.D. from the University of Chicago (2015). He served as a Visiting Associate at Caltech from 2019–2020 before joining as a faculty member in 2020. His research focuses on DNA replication and repair mechanisms, particularly those involving nucleic acid chemistry and genome maintenance. Education: B.S. in Biochemistry, University of Illinois, Urbana (2005) Ph.D. in Biochemistry, University of Chicago (2015) The Semlow Lab employs biochemical, genetic, and analytical methods to investigate how cells tolerate and repair DNA damage during replication. They also develop tools to identify novel DNA lesions and elucidate their origins. These studies aim to advance understanding of DNA repair pathways and potentially inform therapeutic strategies for cancer and genetic disorders. His publications highlight research on DNA interstrand crosslink repair, spliceosome dynamics, and RNA ligase deoxyribozymes. Key themes include DNA damage response, RNA processing, and enzyme activity. Collaborations with researchers like James C. Walter and others underscore interdisciplinary approaches to genome stability. Scientific Awards: Ronald and JoAnne Willens Scholar (2021–) As an instructor, Semlow contributes to Caltech’s BMB/Bi/Ch 174 course on advanced topics in biochemistry and molecular biophysics (2021–2024). He emphasizes literature analysis and synthesis of biochemical research.

Gideon Dreyfussمشاهده پروفایل

استاد

• RNA-binding proteins
• SMN complex
• Spinal Muscular Atrophy
• +۶ مورد دیگر

Gideon Dreyfuss is the Isaac Norris Professor in the Department of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania. He maintains an active research laboratory focusing on RNA biology and its implications for human disease. His work bridges basic molecular mechanisms with therapeutic applications, particularly in neurodegenerative disorders. Dr. Dreyfuss received his B.Sc. in Chemistry from The Hebrew University in Jerusalem (1973), M.Sc. in Biochemistry from Tel Aviv University (1975), and Ph.D. in Biological Chemistry from Harvard University (1978). His educational background provided the foundation for his pioneering work in RNA-protein interactions. His research primarily focuses on RNA-binding proteins, the Survival of Motor Neurons (SMN) complex, and their roles in spinal muscular atrophy and other neurodegenerative diseases. Dr. Dreyfuss has made seminal contributions to understanding the assembly and transport of RNA-protein (RNP) complexes, the exon-junction complex, and U1 snRNP telescripting. His laboratory employs high-throughput screening approaches to identify potential therapeutics for spinal muscular atrophy. The keywords that define his research include RNA, RNPs, SMN, spinal muscular atrophy, high throughput screening, neurodegeneration, and nuclear transport. Analysis of his recent publications (2013-2025) reveals a consistent focus on RNA-protein interactions, with particular emphasis on U1 snRNP functions in transcription regulation and telescripting. His work has evolved from basic characterization of RNA-binding proteins to therapeutic applications for neuromuscular diseases, demonstrating a clear trajectory from fundamental science to clinical relevance. Dr. Dreyfuss leads an active laboratory with numerous research associates, postdoctoral fellows, and specialists working on various aspects of RNA biology. His laboratory has been consistently funded through competitive grants, supporting research on SMN complex composition, function, and therapeutic targeting for spinal muscular atrophy. The Dreyfuss laboratory maintains a robust team structure with specialized personnel focusing on different aspects of RNA biology. Current lab members include research associates, postdoctoral fellows, and specialists working on SMN complex structure, U1 snRNP functions, and high-throughput screening for therapeutic compounds. The laboratory has established sophisticated methodologies for studying RNA-protein interactions and their implications for human disease.

Joshua A Ribackمشاهده پروفایل

استادیار

• Biological Condensates
• Biophysics
• Cell Biology
• +۶ مورد دیگر

Joshua A Riback is an Assistant Professor in the Department of Molecular and Cellular Biology at Baylor College of Medicine. His research focuses on the biophysical principles governing biological condensates, including their roles in cellular processes, disease mechanisms, and macromolecular assembly. He leads the Cellular Physical Chemistry Group (Riback Lab), which bridges biology and physics to study condensate dynamics in health and disease. Education: B.A. in Biophysics from Johns Hopkins University Ph.D. in Biophysical Sciences from the University of Chicago Postdoctoral Fellowship in Chemical and Biological Engineering at Princeton University Research Interests: Dr. Riback investigates how biological condensates reorganize biomolecules in response to cellular signals, particularly during differentiation, oncogenesis, and aging. His lab explores the thermodynamics of phase separation, condensate-driven macromolecular assembly (e.g., ribosomes, spliceosomes), and the impact of compositional changes on disease pathways like cancer and neurodegeneration. Labs/Teams: The Riback Lab at Baylor College of Medicine fosters interdisciplinary collaboration, combining tools from molecular biology, biophysics, and computational modeling. Current projects address condensate formation mechanisms, chaperone roles in macromolecular assembly, and therapeutic vulnerabilities in NPM1-mutant leukemias.

• Hematology
• Oncology
• Molecular Biology
• +۷ مورد دیگر

Rahul Roy is a Researcher in the Department of Medical Oncology and Hematology at Yale University’s Yale School of Medicine. His work focuses on molecular mechanisms underlying hematologic malignancies, transcriptional regulation defects, and translational applications in cancer therapy. Key research areas include splicing factor mutations in myelodysplastic syndromes (MDS), chromatin organization dynamics, DNA repair pathways, and microbiome-driven disease mechanisms. Research Interests Investigating SF3B1 mutations' impact on chromatin architecture and transcription elongation Developing biomarkers for Mucorales infections using nanotechnology Exploring tight junction proteins as novel therapeutic targets in cancer and inflammation Characterizing gut microbiome signatures in severe liver diseases and colorectal cancer His recent studies highlight transcriptional defects in splicing factor-mutant MDS and identify potential therapeutic targets via chromatin landscape alterations. Work on nanotextured drug-delivery systems demonstrates innovative approaches to osteogenesis and anti-cancer applications. Collaborative projects span molecular diagnostics, epigenetic regulation, and microbiome-driven pathology. No scientific awards have been listed for this researcher. Grants & Advising No information available on current grants or advisees. No active lab teams or collaborative groups are explicitly mentioned in the provided profile.

Weilong Haoمشاهده پروفایل

دانشیار

• Bioinformatics
• Comparative Genomics
• Evolution
• +۴ مورد دیگر

Weilong Hao is an Associate Professor in the Department of Biological Sciences at Wayne State University, affiliated with the College of Liberal Arts and Sciences. His research focuses on understanding dynamic genomic changes and their functional consequences using comparative genomics, next-generation sequencing, and bioinformatics. Key areas include genome structure evolution, mutation mechanisms, and mitochondrial genetics. Education: Ph.D. in Bioinformatics from McMaster University, with a Certificate in Effective College Instruction (2018). Awards include an NSERC Postdoctoral Fellowship and NSF grant #1838291. Research Interests: Comparative genomics of yeast, bacteria, and plants Mechanisms of mutation and genome plasticity Evolutionary dynamics of AT-rich genomes Horizontal gene transfer and recombination Recent Work Trends: Publications emphasize genomic mechanisms in yeast mitochondria, antibiotic resistance in urban environments, and evolutionary transitions in fungi. Themes include mutation bias, recombination-driven genome evolution, and functional genomic innovations. Grants & Awards: Active NSF funding supports pathogen genome research. Teaching includes courses in evolution (BIO2700) and bioinformatics (BIO5280/BIO7280). Labs/Teams: Directs the Hao Lab (haolab.wayne.edu), focusing on integrative genomic approaches to evolutionary biology and microbial genomics.

• Epigenetic mechanisms in human disease
• Novel epigenetic modifications and modulators
• Cancer epigenetics
• +۴ مورد دیگر

Dr. Chen Hao is an Assistant Professor at the School of Medicine, Southern University of Science and Technology (SUSTech), where he serves as a doctoral supervisor. Previously, he completed postdoctoral training at Boston Children's Hospital, Harvard Medical School. His research focuses on epigenetic mechanisms in human disease, particularly tumor development and metabolic disorders such as diabetes and obesity. Dr. Chen received his academic training at prestigious Chinese institutions: PhD in Molecular Biology & Disease Proteomics, Fudan University (2013) B.S. in Biology, Wuhan University (2008) Dr. Chen's research program investigates epigenetic mechanisms underlying human diseases, with a particular focus on novel epigenetic modifications and their regulatory enzymes. His lab employs biochemical techniques combined with multi-omics approaches to identify and characterize RNA/DNA epigenetic modification enzymes. Key research areas include: Epigenetic mechanisms in cancer development Novel RNA/DNA epigenetic modifications and their modulators Metabolic disease epigenetics (diabetes, obesity, hypertension) mRNA translation mechanisms and mRNA drug development Analysis of Dr. Chen's recent publications reveals a strong focus on RNA epigenetics, particularly m6A methylation and related modifications. His work spans structural biology of methyltransferases (METTL4, METTL5, METTL15), functional studies of RNA modification enzymes, and exploration of how epigenetic dysregulation contributes to diseases including cancer, metabolic disorders, and cardiovascular conditions. His research often bridges basic molecular mechanisms with potential clinical applications. Dr. Chen has received several prestigious awards and honors: Guangdong Province "Pearl River Talent" Young Top-notch Talent Shenzhen "Peacock Plan" Overseas High-level Talent National Scholarship from Chinese Ministry of Education (2012) Magna cum Laude from Fudan University (2013) F1000 recommended paper for METTL4 research Dr. Chen has secured significant research funding, serving as principal investigator for National Natural Science Foundation of China projects and as sub-project leader for National Key R&D Program initiatives. His collaborative research spans multiple disciplines, connecting epigenetics with cancer biology, metabolic disease, and stem cell research. He actively mentors graduate students and postdoctoral fellows in his laboratory. Dr. Chen leads a research group focused on epigenetic mechanisms at SUSTech, utilizing advanced biochemical and multi-omics approaches. His team works at the intersection of basic epigenetic research and translational applications, seeking to identify novel epigenetic targets for therapeutic intervention in cancer and metabolic diseases.

Richard I. Gregoryمشاهده پروفایل

استاد

• RNA regulation
• Stem cell biology
• MicroRNA biogenesis
• +۷ مورد دیگر

Richard I. Gregory, PhD is a Professor in the Department of Biological Chemistry and Molecular Pharmacology, and Department of Pediatrics at Harvard Medical School. He serves as the Stem Cell Biology Endowed Chair for Boston Children's Hospital Department of Pediatrics and is Co-Director of the HMS Initiative for RNA Medicine. His laboratory at Boston Children's Hospital focuses on RNA regulation mechanisms in stem cell pluripotency, development, cancer, and neurological diseases. Dr. Gregory's research program bridges RNA biochemistry/molecular biology and stem cell research, with a focus on the regulation of microRNAs (miRNAs), messenger RNAs (mRNAs), and long non-coding RNAs (lncRNAs). His lab has made significant contributions to identifying key molecular mechanisms of stem cell biology, including the regulation of let-7 miRNAs by the RNA-binding protein and pluripotency factor LIN28. His work spans several critical areas: RNA biogenesis & decay pathways in human disease RNA methylation in gene regulation and cancer (epitranscriptomics) MicroRNA stem cell biology Development of novel therapeutic approaches for cancer Dr. Gregory's laboratory has pioneered the field of epitranscriptomics and cancer, providing the first functional evidence linking RNA modifications with cancer development. His innovative research strategy addresses new, unexplored areas of RNA metabolism and disease, with a focus on developing small molecule inhibitors targeting RNA regulatory pathways as potential cancer therapies. The laboratory has published extensively in top journals including Nature, Cell, and Molecular Cell, with recent work focusing on m6A and m7G RNA modifications in cancer. His laboratory has received significant recognition: Stem Cell Biology Endowed Chair for Boston Children's Hospital Department of Pediatrics (2018) Dr. Gregory has mentored numerous postdoctoral fellows who have gone on to establish successful careers in academia and industry. His laboratory is supported by multiple grants from the National Institutes of Health, including the National Institute of General Medical Sciences (NIGMS), National Cancer Institute (NCI), and the National Institute of Mental Health (NIMH). The Gregory Laboratory continues to be at the forefront of RNA biology research with implications for understanding and treating cancer and degenerative diseases.

Eileen K. Bridgeمشاهده پروفایل

دانشیار

• Virology
• Molecular Biology
• Cell Biology
• +۷ مورد دیگر

Eileen K. Bridge is an Associate Professor in the Department of Microbiology at Miami University, where she is affiliated with the Cell, Molecular and Structural Biology Graduate Program. Her research and teaching are centered on virology, molecular biology, and host-pathogen interactions. Ph.D. in Biology, Johns Hopkins University (1990) B.A. in Natural Science, Bennington College (1981) Her research interests lie at the intersection of virology and cellular molecular mechanisms, focusing on how adenovirus manipulates the host's DNA damage response to facilitate replication. This work has implications for cancer biology, particularly in developing strategies to sensitize cancer cells to chemotherapy and radiation. She investigates viral regulation of ATM and DNA-PK pathways, viral DNA replication, and the role of early viral proteins in gene expression and cell cycle control. The analysis of her recent publications (2022–2000) reveals a sustained focus on adenovirus early region 4 (E4) mutants and their impact on host DNA damage responses, cell cycle arrest, and viral gene expression. The studies employ molecular, cellular, and imaging techniques to dissect kinase signaling (ATM, DNA-PK), viral replication centers, and nuclear organization of RNA and splicing factors. These works collectively contribute to understanding viral hijacking of cellular machinery and potential oncolytic applications. Her scientific contributions are reflected in numerous peer-reviewed publications in journals such as Virology , Journal of Virology , and Experimental Cell Research . While specific awards are not listed, her long-standing research program and publication record indicate significant scholarly impact. Dr. Bridge has advised numerous students and researchers, as evidenced by her collaborative publications. She teaches a wide range of courses including MBI 255 (Modern Microbiology Applications), MBI111 (Microorganisms and Human Disease), and advanced seminars in molecular biology and virology. She also contributes to graduate training through seminars in microbiology and molecular biology. Her laboratory appears to focus on viral-host interactions using adenovirus as a model system, with an emphasis on DNA damage response modulation, nuclear organization of viral replication, and RNA processing. The team employs techniques such as fluorescence in situ hybridization, immunostaining, and molecular virology assays.