Haider Samiمشاهده پروفایل
پژوهشگر
Haider Sami is a researcher at the University of Vienna , affiliated with the Faculty of Life Sciences and the Department of Pharmaceutical Sciences . He works in the Macromolecular Cancer Therapeutics (MMCT) laboratory under Professor Manfred Ogris, focusing on RNA-based therapeutics and nanocarrier delivery systems . His research addresses critical challenges in splice-switching oligonucleotide (SSO) delivery , particularly regarding endosomal escape , nuclear targeting , and systemic biodistribution . Haider Sami's research expertise spans nanocarrier design for RNA splicing modulation , with a particular emphasis on redox-responsive polymers like disulfide cross-linked polyethylenimine (cLPEI) . He has pioneered methods for accelerated endosomal release and hepatic splice correction , validated through transgenic mouse models expressing split-luciferase reporters . His work demonstrates that cLPEI-SSO polyplexes significantly improve in vivo bioavailability while reducing renal excretion and enhancing tumor accumulation . Key research contributions include disulfide crosslinking strategies for endosomal escape enhancement , one-step nanoparticle synthesis using Brij-linkers , and spatiotemporal delivery tracking via NIR fluorescence imaging and X-ray computed tomography . These studies have direct implications for monogenic disease therapies and cancer treatment applications. Haider Sami has authored 24 publications since 2014, with recent work (2023-2025) emphasizing biocompatible delivery systems , quantitative biodistribution analysis , and functional protein restoration in multiple organ systems including liver, lung, kidney, and bladder.








