جست‌وجوی استاد و پژوهشگر

• Pulmonary vasculature
• Heart Failure
• Cardiopulmonary Immunology

Michael Yeager, PhD, serves as an Associate Clinical Professor in the School of Medicine at the University of Colorado Denver, focusing on cardiopulmonary pathophysiology with emphasis on pulmonary hypertension and heart failure mechanisms. He completed his PhD at the University of Colorado Health Sciences Center in 2002, establishing foundational expertise in vascular biology. His research program investigates immunological and molecular drivers of pulmonary vascular disease, particularly the roles of autoantibodies, fibrocytes, and inflammatory cascades in disease progression. Analysis of his 14 publications (2012-2015) reveals consistent exploration of biomarker discovery, vascular remodeling, and immune dysregulation across pediatric and adult pulmonary hypertension. Key methodological approaches include proteomics, animal modeling, and molecular interrogation of cellular stress responses, with significant translational implications for personalized therapeutic strategies. Professional recognitions include: Outstanding Faculty award from Tau Beta Pi (2019) Chancellor's Teaching Recognition Award from the University of Colorado (2016) Dr. Yeager maintains active clinical research collaborations at Children's Hospital Colorado while mentoring within the medical school curriculum. His work bridges basic science discovery with clinical application through ongoing investigations into endothelial dysfunction and inflammatory mediators. Affiliated with the Department of Medicine, he contributes to pulmonary vascular research initiatives and participates in professional societies including the American Thoracic Society, American Heart Association, and T21 Research Society.

Priya Ramanمشاهده پروفایل

دانشیار

• Molecular mechanisms of vascular smooth muscle cell phenotypic switching
• Non-lipid causes of vascular disease in metabolic syndrome
• Mechanistic links between metabolic syndrome, vascular dysfunction, and Alzheimer’s disease
• +۳ مورد دیگر

Priya Raman, Ph.D., FCVS, is an Associate Professor of Integrative Medical Sciences at Northeast Ohio Medical University (NEOMED). She holds tenure and serves as Co-Director of the Basic and Translational Biomedicine (BTB) Graduate Program and Chair of the Kent State University-Biomedical Sciences Pharmacology Graduate Program. Her academic roles include teaching in NEOMED’s medical curriculum, focusing on pharmacology, cardiovascular systems, and clinical therapeutics. Raman’s research explores molecular mechanisms linking metabolic disorders (e.g., diabetes, metabolic syndrome) to vascular dysfunction and Alzheimer’s disease, using mouse models and cellular/molecular techniques. She has published extensively on thrombospondin-1, O-GlcNAc signaling, and atherosclerosis pathogenesis. Education: B.Pharm. and M.Pharm. (India), Ph.D. in Pharmacology (University of Louisiana at Monroe). She has over 25 years of postdoctoral and faculty experience, including roles at the Cleveland Clinic and Indiana University School of Medicine. Raman serves on editorial boards for journals like International Journal of Cardiology and Frontiers in Cardiovascular Medicine , and reviews grants for the American Heart Association and NIH. Research focus areas include: (1) Vascular smooth muscle cell phenotypic switching in metabolic diseases, (2) Non-lipid mechanisms of vascular disease in metabolic syndrome, and (3) Interactions between metabolic disorders and neurodegeneration. Her lab employs biochemical assays, mouse models (e.g., ApoE-/-, KKAy), and advanced imaging techniques to study these pathways. Notable recent work includes discovering that O-GlcNAc transferase deletion reduces atherosclerosis in hyperglycemic mice and identifying thrombospondin-1’s role in leptin-driven vascular pathology. She has also linked metabolic syndrome-induced O-GlcNAc deficits to Alzheimer’s-like cognitive impairment in aging mice. Raman is actively involved in interprofessional education and mentoring, directing graduate programs and teaching courses in pharmacology, molecular signaling, and diabetes/vascular disease. Her work bridges basic science and clinical applications, aiming to develop novel therapies for metabolic syndrome-related vascular complications.

Guizhen Zhaoمشاهده پروفایل

استادیار

• Cardiovascular Diseases
• Epigenetics
• Molecular Biology
• +۶ مورد دیگر

Guizhen Zhao is an Assistant Professor at the University of Houston College of Pharmacy , Department of Pharmacological and Pharmaceutical Sciences. Her research focuses on epigenetic and molecular mechanisms in cardiovascular diseases (CVD), particularly aortic aneurysm, dissection, and atherosclerosis, with a goal to drive drug discovery innovations. Major research areas: Metaboloepigenetic properties of vascular cells, chromatin remodeling, vascular cell crosstalk Methodologies: bulk RNA-seq, single-cell RNA-seq, ChIP-seq, ATAC-seq, spatial transcriptomics, metabolomics Ongoing projects include studying BAF60c-dependent epigenetic modifications in smooth muscle cell biology, BAF60c-mediated iPSC differentiation, BAF60a in endothelial dysfunction, and vascular cell interactions in CVD development. Scientific contributions include 15+ publications on abdominal aortic aneurysm, atherosclerosis, and chromatin remodeling mechanisms, with recent work on adenosine kinase inhibition and KLF11 as therapeutic targets. 2023-25: Career Development Award, American Heart Association 2021-22: Postdoctoral Fellowship, American Heart Association 2019: Young Investigator Award, American Heart Association

• Stem Cell Biology
• Cardiovascular Medicine
• Tissue Engineering
• +۵ مورد دیگر

Yibing Qyang is a Professor of Medicine (Cardiovascular Medicine) at Yale University School of Medicine (YSM), affiliated with the Department of Internal Medicine. He serves as Director of the Yale Stem Cell Research Forum since 2010. His expertise spans stem cell biology, cardiovascular disease modeling, and regenerative medicine. Qyang holds a B.S. from Nanjing University, an M.S. from Chinese Academy of Sciences, and a Ph.D. from the University of Texas M.D. Anderson Cancer Center. He completed postdoctoral training at UC San Diego and Harvard Medical School. Research Interests: The Qyang Lab focuses on engineering vascular tissues using induced pluripotent stem cells (iPSCs), elucidating cardiovascular disease mechanisms, and developing therapeutic strategies. Key areas include: Vascular tissue engineering for graft development Stem cell-derived models of diseases like supravalvular aortic stenosis Cardiac progenitor cell therapies for heart repair Biomechanical signaling in hypertrophic cardiomyopathy Preclinical porcine models for translational research Key Achievements: Developed immunocompatible 'universal donor' vascular grafts using CRISPR-engineered iPSCs Pioneered iPSC-derived vascular smooth muscle and endothelial cells for tissue engineering Identified elastin-based therapies for supravalvular aortic stenosis Grants & Awards: Connecticut Stem Cell Program Established Investigator Awards (2011, 2015) ISSCR Membership (2007–Present) Highlighted in Yale News for groundbreaking discoveries in heart disease and vascular grafts Lab Team & Collaborations: The lab includes researchers and students from institutions worldwide, with collaborations at Harvard, UCSD, and Yale’s Cardiovascular Research Center. Projects span iPSC differentiation, biomechanical modeling, and preclinical trials. Future Directions: Expanding studies on universal donor grafts, cardiac tissue engineering, and clinical translation of iPSC-derived therapies.

• Oxygen Transport
• Vascular Physiology
• Skeletal Muscle Metabolism
• +۳ مورد دیگر

Russell Richardson is a tenured Professor at the University of Utah , holding joint appointments in the Department of Internal Medicine (Division of Geriatrics) and the Department of Exercise and Sport Science . He directs the Utah Vascular Research Laboratory (UVRL) at the Salt Lake VA Medical Center. Education: Fellowship (University of California San Diego), Doctoral Training (University of Utah), PhD (Colorado State University), MS (Loughborough University), PGCE (West London Institute of Higher Education) His research focuses on oxygen transport from air to tissue , with a current emphasis on the link between vascular and skeletal muscle function , particularly how oxidative stress regulates skeletal muscle metabolism and vascular control. He has authored numerous studies on aging, vascular dysfunction, and exercise hemodynamics. Recent publications highlight work on mitochondrial respiration, passive limb movement techniques, antioxidant interventions, and age-related vascular decline. His lab employs both in vivo and ex vivo methodologies to investigate these mechanisms. Collaborations span clinical and physiological domains, including studies in chronic obstructive pulmonary disease (COPD), heart failure, and breast cancer. His work integrates gerontology , exercise physiology , and vascular biology . Notable affiliations include the Salt Lake VA Medical Center and contributions to understanding the interplay between physical activity, aging, and vascular plasticity.

Cam Ha Tranمشاهده پروفایل

استادیار

• Neuroscience
• Cardiovascular Physiology
• Neurovascular Coupling
• +۴ مورد دیگر

Cam Ha Tran is an Assistant Professor in the Department of Physiology and Cell Biology at the University of Nevada, Reno, affiliated with the Institute of Neuroscience. Her research focuses on neurovascular unit interactions, particularly how blood flow regulation impacts brain function under health and disease conditions such as stroke and dementia. She employs advanced techniques like two-photon imaging, optogenetics, and electrophysiology to study astrocyte-endothelial communication and vascular reactivity. Education: PhD in Cardiovascular and Respiratory Sciences from the Cumming School of Medicine, University of Calgary (Canada); Master of Biomedical Technology and Bachelor of Science from the University of Alberta (Canada). Research emphasizes understanding how astrocytes and endothelial cells coordinate to maintain cerebral blood flow, with implications for neurological disorders. Her recent work explores TRPA1 channels in neurovascular coupling, astrocyte dysfunction in Alzheimer’s, and seizure-induced vascular changes. Techniques include in vivo imaging and chemogenetic approaches to dissect cellular mechanisms. Key contributions include uncovering astrocyte roles in functional hyperemia and identifying therapeutic targets for cerebrovascular diseases. Her lab’s findings bridge basic science and clinical applications, aiming to improve diagnostics and treatments for stroke and neurodegenerative conditions.

• Neurosciences
• Physiology
• Microbiology
• +۵ مورد دیگر

Professor Elisa Hill is a distinguished academic at RMIT University where she serves as a Professor in the Department of Health and Biomedical Sciences within the College of Science. She leads the Gut-Brain Axis Laboratory and holds the significant position of Deputy Chair of the Academic Board at RMIT University. Her career spans prestigious institutions including The University of Melbourne and research collaborations in Paris, France. Professor Hill earned her PhD in Neuroscience from The University of Melbourne in 2002. She subsequently undertook a CNRS postdoctoral position in Paris studying cortical neuronal diversity. Returning to Melbourne in 2006 as an NHMRC Howard Florey Centenary Fellow, she joined Prof Steve Petrou's laboratory to investigate neuronal networks in genetic mouse models of epilepsy. In 2009, she imported the Neuroligin-3R451C mouse model of autism to Australia, establishing herself as a pioneer in gut-brain axis research. Her research program focuses on three interconnected areas: identifying causes of gut dysfunction in transgenic mouse models of neurological disease, determining how neurons communicate with the lymphoid system and inflammation, and understanding interactions between the nervous system and bacteria. Professor Hill has demonstrated that gene variations associated with autism alter neuron populations in the mouse enteric nervous system, affecting gut motility, permeability, microbiome composition, and behavior. Her laboratory has developed sophisticated capabilities including video-imaging assays for gut motility, immunofluorescence for neuronal and immune cell analysis, and whole-cell patch clamp electrophysiology for neuronal activity profiling. Analysis of her recent publications reveals a strong focus on the gut-brain axis in autism, with particular attention to the Neuroligin-3R451C mouse model. Her work spans neuroimmunology, gastrointestinal physiology, microbiome interactions, and behavioral neuroscience, demonstrating an increasingly interdisciplinary approach that integrates molecular, cellular, and systems-level perspectives. A notable trend is the expansion of her research into translational applications, including biomaterial development for urogynaecological health. NHMMRC Howard Florey Centenary Fellowship ARC Future Fellowship RMIT Senior Vice Chancellor's Research Fellowship Professor Hill actively supervises numerous PhD students including Vic Lin, Yuansong Li, and Mohammed Al Alamoudi, among others. Her research has been supported by major funding bodies including NHMRC, US Department of Defense CDMRP, CNRS, ARC, and RMIT. She leads the Gut-Brain Axis Laboratory, which collaborates extensively with researchers across institutions, particularly with Prof Ashley Franks at La Trobe University. The laboratory employs a multidisciplinary team with expertise in neuroscience, microbiology, immunology, and gastrointestinal physiology, utilizing advanced techniques to investigate the complex interactions between the nervous system, immune system, and gut microbiome.

Thomas Longdenمشاهده پروفایل

دانشیار

• Brain blood flow
• Neurovascular coupling
• Functional hyperemia
• +۱۲ مورد دیگر

Thomas Longden is an Associate Professor in the Department of Physiology at the University of Maryland School of Medicine. He leads a research group focused on neurovascular interactions in health and disease, with particular emphasis on understanding how blood flows through the brain under normal conditions and how this process is disrupted in diseases like Alzheimer's. Dr. Longden received his B.Sc (Hons) and Ph.D. in Pharmacology from the University of Manchester in the UK (2006 and 2010), followed by postdoctoral training at the University of Vermont under Professor Mark Nelson (2011-2015). He was promoted to Assistant Professor at Vermont in 2015 before joining the University of Maryland in February 2019. His research focuses on the control of blood flow in the brain, particularly the mechanisms of neurovascular coupling where neuronal activity triggers changes in blood flow. His lab has made significant discoveries including identifying the brain's capillary network as a 'sensory web' that translates neural activity into vasodilatory electrical signals, and demonstrating how pericytes function as metabolic sentinels that control blood flow through KATP channel-dependent mechanisms. Analysis of Dr. Longden's recent publications reveals a strong focus on pericyte function in neurovascular coupling, electrical signaling in the capillary network, and how these mechanisms are disrupted in Alzheimer's disease and other dementias. His work increasingly incorporates advanced imaging techniques, computational approaches, and innovative tools to study vascular plasticity. 2023: Fellow of the American Physiological Society Cardiovascular Section 2020: NIH Director's New Innovator Award 2017: American Heart Association Scientist Development Grant Multiple travel awards and postdoctoral fellowships Dr. Longden currently mentors several graduate students and postdoctoral fellows in the Longden Lab, which is supported by multiple NIH grants including an NINDS New Innovator Award and an NIA R01 grant. His lab develops and employs advanced techniques including multiphoton microscopy, electrophysiology, optogenetics, and molecular biology to study vascular cells in the brain. The lab is particularly focused on understanding vascular signaling plasticity and how pericytes control brain blood flow in health and Alzheimer's disease.

Richard W. Grossمشاهده پروفایل

استاد

• Analytical Chemistry
• Biological Membranes
• Lipidomics
• +۴ مورد دیگر

Dr. Richard W. Gross is Professor of Medicine and Developmental Biology at Washington University School of Medicine and Professor of Chemistry. He holds a PhD from Washington University, MD from New York University Medical School, and BA from Columbia College. His research focuses on the chemical biology of membranes in health and disease, specializing in lipidomics, metabolomics, and membrane signaling. He pioneered shotgun lipidomics technology for direct identification and quantification of lipid molecular species in biological systems. Developed novel shotgun lipidomics technology combining intrasource separation, multidimensional MS, and array analysis Investigates phospholipase regulation and membrane signaling complexes Studies altered lipid metabolism in obesity, diabetes and cardiovascular disease

Gary K. Owensمشاهده پروفایل

استاد

• Cardiovascular Biology
• Atherosclerosis
• Smooth Muscle Cell Biology
• +۴ مورد دیگر

Dr. Gary K. Owens is a Professor in the Department of Molecular Physiology and Biological Physics at the University of Virginia , with a secondary appointment in the Department of Medicine, Division of Cardiology. He serves as Director of the Robert M. Berne Cardiovascular Research Center and leads groundbreaking research on vascular smooth muscle cell (SMC) dynamics in atherosclerosis. His work challenges conventional paradigms about SMC roles in plaque stability and thromboembolic events. Primary Affiliation: University of Virginia Key Titles: Robert M. Beirne Professor of Cardiovascular Research, Professor, Director of CVRC Research Themes include: Cardiovascular Biology Atherosclerosis Pathogenesis Smooth Muscle Cell Plasticity Epigenetic Regulation Inflammatory Signaling Tumor Metastasis Mechanisms Publication Trends (2015–2024) reveal expertise in Nature Medicine and Circulation studies, focusing on SMC gene regulation (Klf4/Oct4), plaque stability, and cross-talk between vascular cells and tumors. His work demonstrates that SMCs account for >80% of advanced lesion cells and that Klf4 inhibition reduces metastasis by >70%. Lab Leadership includes mentoring PhD students Anita Salamon and Victoria Milosek , alongside senior scientists and postdocs. Collaborations span with Dr. Gwen Randolph (Washington University) and Dr. Rosey Kaplan (NIH) on IL1β signaling and metastasis.

Gregory Dickمشاهده پروفایل

استاد پژوهشی

• Coronary Circulation
• Ion Channel Physiology
• Vascular Tone Regulation
• +۳ مورد دیگر

Gregory Dick, PhD, is a Research Professor in the Department of Physiology & Anatomy at the University of North Texas Health Science Center's College of Biomedical and Translational Sciences. His research focuses on ion channel regulation in coronary arteries, particularly how potassium channels control vascular tone under normal and pathological conditions (e.g., obesity, diabetes). He has led multiple NIH-funded projects exploring coronary vascular dysfunction and metabolic signaling. Education: Bachelor of Science in Physiology, Oklahoma State University Doctor of Philosophy in Physiology, University of Missouri Research Interests: Electro-metabolic signaling in coronary vasodilation Role of K+ channels in coronary blood flow regulation Impact of metabolic syndrome and obesity on cardiovascular health Vascular smooth muscle plasticity in disease states Key Projects (2024–2026): Role of potassium as a coronary metabolic vasodilator (Principal Investigator) Disentangling the Mechanisms of Coronary Dysfunction (Co-Investigator) Grants & Funding: NIH R01 Grant: Mineralocorticoid Receptor-Dependent Coronary Vascular Dysfunction in Obesity Multiple collaborative grants with University of Michigan and University of Missouri Collaborations: Active partnerships with institutions studying coronary autoregulation, metabolic syndrome, and swine models of cardiovascular disease.

Andrew Braunمشاهده پروفایل

استاد

• KCa Channels
• Nitric Oxide
• Calcium Signaling
• +۷ مورد دیگر

Andrew Braun is a Professor at the University of Calgary, affiliated with the Libin, Hotchkiss Brain Institute, and Snyder Institute. His research focuses on vascular physiology, particularly the role of potassium channels in regulating blood flow and pressure, with applications in diabetes and neurodegenerative diseases. He utilizes advanced techniques like patch clamping and arterial pressure myography. His work explores KCa channels , nitric oxide signaling , and calcium dynamics in vascular cells, aiming to develop novel therapies for endothelial dysfunction. He investigates how these channels affect myogenic tone , vasodilation , and coronary circulation in diseased states such as Type 2 Diabetes and Alzheimer's. The 15 most recent publications highlight his focus on pharmacological targeting of KCa channels to treat vascular complications in diabetes, aging, and atherosclerosis. Key subfields include platelet aggregation , genetic mutations in IP3 receptors , glycation effects on vascular function , and sex-dependent cerebrovascular defects . Contact information: Email abraun@ucalgary.ca. Administrative Assistant: Theresea Connolly (tconnoll@ucalgary.ca, 403-220-3018).

Xi-Long Zhengمشاهده پروفایل

استاد

• Vascular Smooth Muscle Biology
• Atherosclerosis
• Vascular Disease Mechanisms
• +۴ مورد دیگر

Xi-Long Zheng is a tenured Professor in the Department of Biochemistry and Molecular Biology and Department of Physiology and Pharmacology at the Cumming School of Medicine, University of Calgary. He holds additional appointments as a Member of the Libin Cardiovascular Institute and Associate Member of both the Snyder Institute for Chronic Diseases and Arnie Charbonneau Cancer Institute. His research focuses on vascular smooth muscle biology and its role in cardiovascular diseases. Doctor of Medicine, Hunan Medical University (1986) M.S. in Pharmacology, Hunan Medical University (1989) Doctor of Philosophy in Pharmacology, University of Calgary (1997) Dr. Zheng's research centers on vascular smooth muscle cell differentiation, proliferation, and phenotypic switching in vascular diseases. His laboratory investigates mechanisms of vascular smooth muscle dedifferentiation in atherosclerosis, abdominal aortic aneurysms, and vascular stiffness. Current work explores ferroptosis, epigenetic regulation (particularly BRD4), and PCSK9 functions in vascular pathologies. His studies integrate molecular, cellular, and in vivo approaches to identify novel therapeutic targets for cardiovascular diseases. Analysis of his recent publications reveals strong emphasis on cell death mechanisms (ferroptosis, cuproptosis), epigenetic regulation, lipid metabolism, and immune-vascular interactions in atherosclerosis. His work demonstrates increasing focus on translational applications targeting vascular smooth muscle phenotypic switching and plaque stability. Alberta Innovates ‒ Health Solutions Senior Scholar Award (2008-2015) Heart & Stroke Foundation New Investigator Award (2001-2006) CIHR/Hypertension Society Scholarship Award (2001-2004) Heart & Stroke Foundation Fellowship Award (1999-2001) AHFMR Independent Investigator Award (2008) Dr. Zheng serves on grant panels for Canadian Institutes of Health Research and Heart and Stroke Foundation of Canada. He is an editorial board member for Biochemical Journal and other scholarly publications. His laboratory receives funding from CIHR and NSERC for projects including smooth muscle PCSK9 in abdominal aortic aneurysm pathogenesis, smooth muscle autophagy in vascular aging, and epigenetic regulation of smooth muscle plasticity. The Zheng Lab investigates vascular smooth muscle functions across multiple organ systems including blood vessels, gastrointestinal tract, bladder, and uterus. His research has established critical mechanisms in vascular smooth muscle differentiation and cell cycle regulation, contributing over 100 peer-reviewed publications in high-impact journals including PNAS, ATVB, Diabetologia, JBC, and Hypertension.

John Eberthمشاهده پروفایل

دانشیار

• Cardiovascular Engineering
• Biomechanics
• Mechanobiology
• +۹ مورد دیگر

Dr. John F. Eberth is an Associate Professor at Drexel University's School of Biomedical Engineering, Science and Health Systems. As a cardiovascular engineer with expertise in mechanical controls, continuum biomechanics, and hydrogel-based extracellular matrix mimetics, he leads the Applied Biomechanics and Mechanobiology Lab (ABML) to investigate vascular behavior under mechanical stimuli. PhD in Biomedical Engineering from Texas A&M University (2008) MS in Mechanical Engineering from Clemson University (2004) BS in Mechanical Engineering from Clarkson University (2001) His research focuses on vascular pathology and mechanobiology, including: Aortopathy and aneurysm mechanics Endothelial dysfunction and arterial stiffening Hydrogel-based vascular grafts Calcification chelation therapy Coronary artery disease Perfusion tissue culture Recent publications demonstrate expertise in vascular imaging techniques, mechanical modeling, and therapeutic interventions. Key themes include drug-coated balloon development, collagen fiber mechanics, and bioreactor systems for vascular conditioning.

Mansoureh Eghbaliمشاهده پروفایل

استاد

• Pulmonary Hypertension
• Myocardial Ischemia-Reperfusion Injury
• Sex Differences in Cardiovascular Disease
• +۳ مورد دیگر

Mansoureh Eghbali, PhD, is a Professor in the Department of Anesthesiology at the David Geffen School of Medicine, University of California, Los Angeles. Her research program investigates molecular mechanisms of cardiovascular and pulmonary diseases with emphasis on sex-specific pathophysiology. She leads an active NIH-funded laboratory focused on pulmonary hypertension, myocardial ischemia-reperfusion injury, and the role of RNA-binding proteins in vascular remodeling. Her research integrates multiomics approaches to explore: Sex chromosome influences (Y-gene Uty) in pulmonary vascular protection MicroRNA regulation of cardiac fibrosis and calcification (e.g., miR-129-5p/Asporin axis) Gut-heart-lung interactions in diet-induced pulmonary hypertension Endothelial subpopulations (TM4SF1+) in disease progression Analysis of her recent publications reveals strong emphasis on: Integrative multiomics in vascular diseases Sex differences in drug responses Novel therapeutic targeting of RNA-binding proteins Cross-organ communication in cardiopulmonary pathologies She directs multiple NIH grants including: R01HL159865: Role of Chromosome Y gene, Uty (2021-2025) R01HL147586: Role of miR125 in pulmonary hypertension (2019-2023) R01HL129051: Role of miR193 in oxidized lipid-induced PH (2016-2021) R01HL131182: Epigenetic regulation by X chromosome (2016-2021)