جستجوی استاد راهنمای دانشگاهی

Jeff Shaverمشاهده پروفایل

استاد

• Cell and Molecular Biology
• Genetics
• Plant Physiology
• +۴ مورد دیگر

Jeff Shaver is a Professor in the Department of Biological Sciences at the University of Arkansas - Fort Smith (UAFS), joining the faculty in 2017. His work spans research, teaching, and service, with a focus on cell and molecular biology, genetics, plant physiology, biotechnology, and biology teacher licensure. Ph.D. in Biology, University of Washington (2008) B.S. in Biology, Purdue University (2001) Principal Certification in Education Administration, Angelo State University (2017) Dr. Shaver's research explores microbiomes , antibiotic resistance , and organelle DNA structure , often involving collaborations with UAFS undergraduates. His recent work investigates the interplay between ecosystem restoration and microbial dynamics , as well as novel therapeutic strategies against bacterial infections. He actively contributes to service roles, including serving as President-Elect of the Arkansas Academy of Science, Vice President of the Arkansas Academy of Science, and membership on the Arkansas INBRE Steering Committee. Top Poster Award at 2022 UAFS Student Research Symposium Dr. Shaver mentors students on projects such as the Dictyostelium discoideum host-microbe model, tallgrass prairie restoration, and drug screening for antibiotic resistance. His lab emphasizes interdisciplinary approaches to understanding microbial communities and developing anti-virulence therapeutics.

John Sowellمشاهده پروفایل

استادیار

• Medicinal Chemistry
• Antiviral Research
• Antitumor Research
• +۲ مورد دیگر

John Sowell serves as Assistant Professor at the Dental College of Georgia in the Department of Oral and Maxillofacial Surgery, with a secondary appointment in the Department of Surgery at the Medical College of Georgia. His academic career integrates clinical dental surgery with pharmaceutical research, spanning over three decades of educational and scholarly contributions. His educational credentials include a DDS in Dentistry from Emory University (1974), complemented by Georgia Board of Dentistry certifications (DEN, 1974; GAP, 2006). These qualifications underpin his dual expertise in surgical practice and chemical pharmacology. Dr. Sowell's research focuses on medicinal chemistry targeting antiviral and antitumor applications, with emphasis on synthesizing novel sulfone derivatives. His work bridges organic chemistry and therapeutic development, particularly exploring betaherpesvirus inhibition and cognitive enhancement mechanisms through ranitidine analogs. This interdisciplinary approach connects dental surgery with fundamental pharmaceutical science. His publication record from 1999-2006 reveals consistent innovation in chemical synthesis methodologies and biological evaluation. Key trends include the development of diarylsulfone-based therapeutics for viral and oncological applications, alongside investigations into CNS-active compounds. These works demonstrate a cohesive trajectory from molecular design to functional assessment across virology, oncology, and neuroscience domains.

Chunhong Yanمشاهده پروفایل

استاد

• Cancer Biology
• Transcriptional Regulation
• DNA Damage Response
• +۷ مورد دیگر

Chunhong Yan is a Professor in the Department of Biochemistry and Molecular Biology at the Medical College of Georgia, Augusta University. She is also a member of the Molecular Oncology & Biomarkers Program at the Georgia Cancer Center and affiliated with The Graduate School. Her research focuses on the transcription factor ATF3 and its role in cancer biology, particularly in regulating p53, DNA damage response, and prostate cancer suppression. Research Interests: Regulation of the DNA damage response via ATF3-p53-MDM2 axis Suppression of prostate cancer through inhibition of androgen receptor and Akt signaling Development of transcription-targeted cancer therapies using CRISPR and Flp-in based drug screening platforms Metabolic stress responses in cancer, including serine metabolism and ferroptosis Her recent publications highlight a strong focus on ATF3-mediated regulation of tumor suppression, p53 activation, and novel therapeutic strategies such as MDMX inhibition and mitochondrial uncouplers. The work spans molecular mechanisms, mouse models, and drug discovery, reflecting a translational research approach. Scientific Service: Editor, Genes & Diseases (2018–Present) Dr. Yan mentors a research team of postdoctoral fellows and has developed innovative tools for high-throughput screening of anti-cancer compounds. She teaches BCMB 9010: Seminar in BMB and is actively involved in graduate education and cancer research at Augusta University.

Barbara Campaniniمشاهده پروفایل

دانشیار

• Biochemistry
• Enzymology
• Antimicrobial Drug Discovery
• +۴ مورد دیگر

Barbara Campanini is an Associate Professor of Biochemistry (SSD BIO/10) at the Department of Food and Drug Sciences, University of Parma, where she has held a full-time position since 2016. She obtained her honors degree in Medicinal Chemistry (1998) and PhD in Molecular Biology and Pathology (2002) from the University of Parma, with research conducted at the University of Oklahoma and University of Illinois at Urbana-Champaign. Research Focus: Her work centers on enzyme characterization, particularly pyridoxal 5'-phosphate-dependent enzymes in bacterial and human systems. Key areas include: Bacterial cysteine biosynthesis enzymes as antibiotic targets Heme capture mechanisms in Staphylococcus aureus Human PLP-dependent enzymes for drug development Metabolic pathways in neurological disorders Publications & Trends: Recent articles (2024-2025) demonstrate strong emphasis on antimicrobial strategies targeting bacterial iron acquisition, enzyme inhibition for neurological disorders, and structural analysis of protein interactions. Over 60 peer-reviewed papers reflect interdisciplinary approaches combining biochemistry, biophysics, and medicinal chemistry. Academic Roles: Supervised >30 Master/PhD students PhD program committees: Biochemistry & Molecular Biology (2006-2012), Drugs & Biomolecules (2013-present) Lecturer at international summer schools (ULLA, Paris Sud) Professional Service: Editorial Board member for Scientific Reports , Frontiers in Chemistry , and Frontiers in Molecular Biosciences since 2018; reviewer for major journals including Journal of Medicinal Chemistry . Laboratory: Conducts research at Biochemistry and Molecular Biology Laboratories, Parco Area delle Scienze 23/A, Parma.

• Biochemistry
• Mass Spectrometry
• Proteomics
• +۴ مورد دیگر

Mijoon Lee is a Research Professor at the University of Notre Dame's Mass Spectrometry and Proteomics Facility (MSPF), with a focus on LC/MS and LC/MS/MS methods development for small molecules and peptidoglycan analysis. Her work bridges biochemical characterization of bacterial cell wall enzymes, antibiotic resistance mechanisms, and pharmacological applications. Education: Ph.D. in Chemistry (2002), B.S. in Chemistry (1995) - Pohang University of Science and Technology, Korea Appointments: 2023–present: Research Professor, 2017–2023: Associate Research Professor, 2008–2017: Assistant Professional Specialist - all at University of Notre Dame Her research spans bacterial cell wall turnover, antibiotic resistance pathways, and proteomics. Key collaborations involve structural characterization of enzymes like penicillin-binding proteins, lytic transglycosylases, and amidases, with applications in infectious diseases and wound healing. Articles highlight interdisciplinary work in Microbiology , Pharmacology , and Chemical Biology , focusing on LC/MS methodologies , peptidoglycan analysis , and antibiotic adjuvants . Scientific contributions include mechanistic insights into β-lactam resistance and novel inhibitors for matrix metalloproteinases.

• Antibiotic Therapy
• Biofilm Disruption
• Multi-drug Resistant Bacteria
• +۵ مورد دیگر

Christian Melander is the George & Winifred Clark Professor at the University of Notre Dame's Department of Chemistry and Biochemistry. His research addresses antibiotic therapy failures through synthetic chemistry approaches targeting bacterial biofilms and multi-drug resistant pathogens. Previously, he held professorships at North Carolina State University and conducted postdoctoral research at Scripps Research Institute and Caltech. Education Ph.D. in Chemistry, Columbia University (1998) M.Phil. in Chemistry, Columbia University (1998) M.A. in Chemistry, Columbia University (1995) B.S. in Chemistry, University of California - Davis (1994) Research Focus The Melander Lab develops novel therapeutic strategies against persistent bacterial infections. Primary investigations include: 1) Designing marine natural product-inspired compounds (e.g., 2-aminoimidazole derivatives) to disrupt biofilms in chronic infections like cystic fibrosis and diabetic ulcers; and 2) Creating narrow-spectrum antibiotics and antibiotic adjuvants to combat multi-drug resistant pathogens through resistance mechanism targeting and nanoparticle delivery systems. Publication Trends Recent publications (2024-2025) demonstrate a strong focus on overcoming antibiotic resistance through two primary strategies: adjuvant development to restore efficacy of existing antibiotics (e.g., colistin, β-lactams) against resistant strains, and novel compound synthesis targeting bacterial resistance mechanisms. Work frequently involves mouse infection models, structure-activity relationship studies, and multidisciplinary approaches combining synthetic chemistry with microbiology. Awards North Carolina State University Faculty Scholar (2014-2018) NCSU Entrepreneur of the Year (2012) ACS Southeastern Region Industrial Innovator of the Year (2012) Sigma Xi Faculty Research Award (2009) Laboratory Leads an active research group specializing in synthetic organic chemistry, microbiology, and translational drug discovery. The lab focuses on preclinical development of anti-infectives with collaborations spanning biochemistry, in vivo testing, and mechanistic studies.

Sebastian H. Trippelمشاهده پروفایل

پژوهشگر

• Molecular Physics
• Quantum Dynamics
• Laser-Matter Interaction
• +۳ مورد دیگر

Dr. Sebastian H. Trippel is a Team Leader at the Center for Free-Electron Laser Science (CFEL), part of Deutsches Elektronen-Synchrotron (DESY) in Hamburg, Germany. His research focuses on imaging chemical dynamics, particularly internal rearrangement processes of small molecules in the gas phase using advanced laser and imaging techniques. Education: Dissertation at Albert-Ludwigs-Universität Freiburg (2005-2010) Diploma at Albert-Ludwigs-Universität Freiburg (2003-2005) Dr. Trippel's research centers on quantum-state-selected molecules fixed in space with laser fields, studying processes like cis-trans isomerization and laser alignment dynamics. His work employs Coulomb explosion in combination with velocity-map imaging to probe molecular orientation and structural changes upon laser excitation. He specializes in ultrafast molecular dynamics and imaging techniques, with applications spanning atmospheric chemistry, radiation protection, and materials science. His recent publications demonstrate a strong focus on molecular beam injection systems, water dimer dynamics, polycyclic aromatic hydrocarbons, and advanced detector technologies like Timepix3. His research bridges physics, chemistry, and instrumentation, with significant contributions to understanding fundamental molecular processes through innovative experimental approaches. Dr. Trippel leads research efforts at CFEL/DESY, collaborating with numerous international partners across Europe. His team develops sophisticated experimental setups for molecular imaging and dynamics studies, contributing significantly to the field of ultrafast science and advancing capabilities at European x-ray free-electron laser facilities.

Joshua Heyzaمشاهده پروفایل

استادیار

• DNA Double-Strand Break Repair
• Genome Stability
• Live-Cell Imaging
• +۴ مورد دیگر

Joshua Heyza is an Assistant Professor in the Department of Environmental Health Sciences and Pharmacology at Wayne State University School of of Medicine. His research focuses on genomic stability mechanisms and their implications in cancer biology. He leads the Heyza Lab, which combines genome-editing and live-cell imaging technologies. Current affiliations: Wayne State University School of Medicine Previous affiliations: Michigan State University (postdoc), University of Michigan-Flint (undergraduate) Research Interests center on DNA double-strand break repair, mitotic DNA repair mechanisms, and genome-wide CRISPR screens. His work explores how cells maintain genomic integrity through complex repair pathways and how these mechanisms relate to cancer development and therapeutic responses. Publications highlight his contributions to understanding DNA repair kinetics, chromatin tethering mechanisms, and therapeutic targeting of repair pathways. Key topics include MDC1's PST repeat region, mitotic DSB repair, and platinum resistance mechanisms in lung cancer. Education : B.S. in Biology, University of Michigan-Flint (2014) Ph.D. in Cancer Biology, Wayne State University School of Medicine (2019) Postdoctoral Training at Michigan State University (2019-2025) Lab Members : Shomaila Mehmoood (Postdoc) Cody Phillips (Lab Manager/Research Assistant) Kristen Tran (Ph.D. Student)

• Radiopharmaceuticals
• Theranostics
• Cancer Treatment
• +۵ مورد دیگر

Dr. Janina Baranowska-Kortylewicz is a Research Professor in the Department of Pharmaceutical Sciences at the University of Nebraska Medical Center (UNMC), College of Pharmacy. With over three decades of experience, she has established herself as a leading expert in radiopharmaceutical development and molecular radiotherapy for cancer treatment. She previously directed the UNMC Harry J. Bahr Radiolabeling Facility for more than 15 years, where radioactive drugs and radioimmunoconjugates were prepared for clinical studies. Her educational background includes an MSc from Wrocław University of Science and Technology in Poland and a doctorate from the University of Kentucky. She completed postgraduate research at the Albert B. Chandler Medical Center and Harvard Medical School, establishing a strong foundation in both chemistry and biomedical research. Dr. Baranowska-Kortylewicz's research focuses on the design, synthesis, and evaluation of theranostics—radioactive drugs for targeted molecular radiotherapy and noninvasive cancer diagnosis. Her laboratory specializes in developing theranostics for individualized cancer treatment with particular emphasis on creating radiopharmaceuticals safe for pediatric patients. Ongoing projects include identifying novel tumor-associated biomarkers and developing theranostics that target these markers. Her work bridges chemistry, pharmacology, and oncology to create innovative approaches for cancer diagnosis and treatment. Analysis of her recent publications (2020-2025) reveals a strong focus on breast cancer therapeutics, neuroblastoma treatments, and novel imaging techniques for detecting molecular changes in cancer. Her work consistently emphasizes the development of targeted therapies with reduced side effects, particularly for vulnerable patient populations like children. The research demonstrates sophisticated chemical synthesis approaches combined with rigorous biological evaluation across multiple cancer types. Holds multiple U.S. and international patents Secured FDA approval for an Investigational New Drug application for a radioactive drug developed in her laboratory Serves on the editorial boards of several international journals Member of national and international scientific organizations Recognized as an expert in translational sciences, serving on grant review panels Dr. Baranowska-Kortylewicz lectured in radiation chemistry and biology courses (MITS 438/638N and RSTE 438N) from 1993 until 2019. Her expertise in developing new radioactive drugs and translational sciences has earned her a place on multiple grant review panels. While specific grant details aren't provided in the available information, her patent portfolio and FDA-approved drug development indicate significant research funding support throughout her career. Her research has been conducted through the UNMC Harry J. Bahr Radiolabeling Facility, which she directed for over 15 years. This facility has been instrumental in preparing radioactive drugs and radioimmunoconjugates for clinical studies, serving as a hub for interdisciplinary cancer research at UNMC. Her work continues to advance the field of molecular imaging and targeted radiotherapy, with ongoing projects focusing on pediatric applications and novel biomarker identification.

Rohan Ranasingheمشاهده پروفایل

مدرس

• Nucleic Acids Chemistry
• Multiplexed Assays
• Single-Molecule Fluorescence Spectroscopy
• +۳ مورد دیگر

Rohan Ranasinghe is a Lecturer at the University of Cambridge, affiliated with Sidney Sussex College, where he serves as Admissions Director and Director of Studies since 2015. His research bridges biological chemistry and life sciences, focusing on RNA modifications in antibiotic-resistant bacteria, cancer biomarkers using microfluidic droplets, and protein aggregation in neurodegenerative diseases like Alzheimer’s and Parkinson’s. University: University of Cambridge Academic Rank: Lecturer His research employs single-molecule fluorescence spectroscopy and DNA/RNA probe synthesis to address diagnostic challenges. He emphasizes small-group teaching, fostering critical thinking through Socratic questioning. His supervised undergraduate projects have led to Nature Communications publications and student accolades. Current work explores tau and amyloid-beta aggregation dynamics via super-resolution imaging, with implications for neurodegenerative therapies.

• Cell Biology
• Cancer Research
• Protein Quality Control
• +۷ مورد دیگر

John Christianson is a Professor of Cell Biology at the University of Oxford , affiliated with the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences . His research focuses on protein quality control mechanisms in eukaryotic cells, particularly endoplasmic reticulum (ER)-associated degradation (ERAD) and ubiquitination processes critical for cancer cell survival. Research Interests ER homeostasis and stress response in cancers Ubiquitin ligase complexes in ERAD Targeting proteostasis for therapeutic intervention Regulation of metabolic enzymes by protein quality control Alternative functions of ER-resident ubiquitin ligases Integral membrane protein biogenesis Scientific Awards Cancer Research UK Senior Research Fellow Key Trends in Publications Christianson’s recent work explores the molecular mechanisms of ERAD in organelle homeostasis, therapeutic targeting of ER stress pathways in multiple myeloma, and functional mapping of ubiquitin ligase complexes. His studies integrate proteomics, cell biology, and biochemistry to identify vulnerabilities in cancer cell survival strategies. Lab and Collaborations His lab is part of the Oppermann Group , focusing on epigenetic mechanisms in musculoskeletal disease. The team collaborates on projects targeting ER stress resolution in haematological malignancies, emphasizing the role of non-redundant ubiquitination machinery as potential therapeutic targets.

Alex Manicardiمشاهده پروفایل

دانشیار

• Organic Chemistry
• Bio-Organic Chemistry
• Peptide Nucleic Acids (PNA)
• +۵ مورد دیگر

Alex Manicardi is an Associate Professor in the Department of Chemical, Life and Environmental Sustainability Sciences at the University of Parma's Faculty of Chemistry. His academic responsibilities span multiple degree programs including Biotechnology, Materials Science, Chemistry, and Environmental and Resource Sciences, where he teaches core courses in organic chemistry, bio-organic chemistry, materials-focused chemistry, and chemical safety across undergraduate and graduate levels. Professor Manicardi's research program centers on peptide nucleic acid (PNA) engineering for nucleic acid targeting and therapeutic applications. His laboratory develops innovative chemical tools including furan-modified PNAs, photo-inducible crosslinking systems, and proximity-triggered ligation methodologies. This work bridges synthetic organic chemistry with biomedical challenges in cancer therapy (particularly colorectal cancer and glioblastoma) and genetic disorders like cystic fibrosis, focusing on microRNA modulation and sequence-specific DNA/RNA targeting. Analysis of his 15 most recent publications reveals a clear trajectory from fundamental chemical methodology development toward biomedical translation. Key trends include red light-triggered DNA alkylation for G-quadruplex targeting, microRNA-inhibiting PNAs that induce cancer cell apoptosis, and furan-based systems enabling bio-orthogonal ligation. The research demonstrates strong interdisciplinary integration across organic chemistry, chemical biology, and molecular oncology with significant therapeutic implications.

Katherine Seley-Radtkeمشاهده پروفایل

استاد

• Medicinal Chemistry
• Synthetic Organic Chemistry
• Drug Design
• +۶ مورد دیگر

Katherine Seley-Radtke is a Professor in the Department of Chemistry & Biochemistry at the University of Maryland, Baltimore County (UMBC) and holds a joint appointment with the University of Maryland, Baltimore (UMB) Biochemistry program. With a Ph.D. from Auburn University (1996) and a B.A. from the University of South Florida (1992), her academic career spans institutions like Georgia Tech (1998-2003) and Auburn University (1997-98). She serves on advisory boards for Wayne State University’s NIH FIRST program and Penn State’s NIH T32 training initiative. Education: B.A., University of South Florida (1992) Ph.D., Auburn University (1996) Her research focuses on Medicinal/Synthetic Bioorganic Chemistry , developing fleximer and flex-base nucleoside/nucleotide analogues to combat viral and cancerous diseases. Key projects include: Antiviral agents targeting coronaviruses (SARS-CoV-2, MERS), filoviruses (Ebola), and flaviviruses (Dengue). Anticancer compounds (thiophene-expanded purines, pyrrolo- and thienopyrimidines) showing sub-nanomolar efficacy against lung, colon, leukemia, and breast cancers. Prodrugs for enhanced oral bioavailability of tricyclic nucleosides active against HCV. Her work integrates SAR algorithms , structure-based drug design , and cross-disciplinary chemical biology to overcome drug resistance via molecular flexibility. Honors and Leadership: Baltimore Sun 2021 Women to Watch ISAR Antonín Holý Memorial Award (2020) UMBC Presidential Research Professor (2015-2018) Editor-in-Chief, Annual Reports in Medicinal Chemistry (2022-present) President, International Society for Antiviral Research (2022-2024) Her lab includes 6 graduate students, 3 postdocs, and 4 undergraduates. She has held leadership roles in NIH review panels, Gordon Research Conferences, and the International Society on Nucleosides, Nucleotides & Nucleic Acids (IS3NA).

• Natural Products Chemistry
• Bioactive Substance Isolation and Modification
• Computer-Aided Molecular Modeling (CAMM/CADD)
• +۵ مورد دیگر

Mario V. Zlatovic is a Full Professor at the Faculty of Chemistry, University of Belgrade , specializing in Natural Products Chemistry, Computational Chemistry, and Medical Chemistry. He has held various academic roles since 1988 and currently teaches courses on Chemical Bonding, Molecular Modeling, and Organic Chemistry. Born: 7 April 1963, Šibenik, Croatia Languages: Serbian (native), English, Russian, Croatian Research Focus: His work explores non-covalent interactions in proteins and small molecules, particularly in superoxide dismutases and anion-π systems . He designs antimicrobial and antimalarial agents, emphasizing structure-based drug design and 3D-QSAR analysis . Scientific Contributions: Over 15 years, his publications span materials science (DFT calculations), enzyme inhibition (α-glucosidase), and marine bioconjugates. He combines computational methods with experimental validation in drug discovery. Fulbright Fellow (2009-2010) at National Cancer Institute, USA Supervisor of HemNet (2020-present) Member of Faculty Council and Examination Recognition Commission Teaching: Offers courses on Molecular Modeling, Chemical Informatics, and Project Management. His educational work includes a 2015 publication on homology modeling pedagogy.

Peter Rugg-Gunnمشاهده پروفایل

پژوهشگر

• Epigenetics
• Stem Cell Biology
• Human Developmental Biology
• +۳ مورد دیگر

Dr. Peter Rugg-Gunn is a Group Leader at the Cambridge Stem Cell Institute and Head of Public Engagement at the Babraham Institute . His research focuses on the epigenetic regulation of pluripotency and early human development , investigating how chromatin organization, transcription factors, and non-coding RNA interact to shape cellular identity. Key areas include stem cell-based embryo models , heterochromatin dynamics , and age-related epigenetic changes in neural progenitors. Research Themes : Epigenetic programming in human embryogenesis, stem cell differentiation, and regenerative medicine applications Techniques : Single-cell multi-omics, promoter interactome mapping, chemical reprogramming protocols His work has influenced ISSCR guidelines for stem cell-based embryo models and revealed species-specific differences in X chromosome inactivation mechanisms. Current projects explore chromatin-based lineage barriers and epigenetic stability in human pluripotent stem cells.