جست‌وجوی استاد و پژوهشگر

Brian H. Lowerمشاهده پروفایل

استاد

• Environmental Mineralogy
• Environmental Chemistry
• Environmental Microbiology
• +۴ مورد دیگر

Brian H. Lower is a Professor at The Ohio State University , holding appointments in the School of Environment and Natural Resources and School of Earth Sciences . He earned his Ph.D. in Biochemistry from Virginia Tech (2001) and a B.S. in Zoology (minor in Geography) from Kent State University (1995). His professional journey includes a postdoctoral associate role at Virginia Tech (2001-2004), senior scientist at Pacific Northwest National Laboratory (2004-2008), and faculty roles at Ohio State since 2008. Dr. Lower’s research focuses on Environmental Mineralogy & Chemistry and Environmental Microbiology , with a particular emphasis on magnetotactic bacteria , biomineralization , and mineral-microbe interactions . His work bridges biophysics , nanochemistry , and microbial ecology , exploring how bacteria manipulate magnetic fields and interact with environmental surfaces. The 15 most recent articles highlight his work on magnetotactic bacterial behavior , protein-mediated mineral synthesis , online science education , and biochar impacts on soil ecosystems . These publications span disciplines including biophysics , microbiology , nanotechnology , and environmental engineering . 2007 Pacific Northwest National Laboratory Outstanding Performance Award 2009 Virginia Tech CALS Outstanding Recent Alumni Award 2014–2017: Multiple teaching awards including Ohio State Alumni Award for Distinguished Teaching 2016 APLU-USDA Excellence in College and University Teaching Award As a Principal Investigator , Dr. Lower secures research grants from the National Science Foundation and Department of Energy . His laboratory investigates magnetosome formation , biofilm mechanics , and environmental nanotechnology , collaborating with interdisciplinary teams in geosciences and biomedical engineering.

Steven K. Lowerمشاهده پروفایل

استاد

• Environmental Mineralogy
• Geological Microbiology
• Medical Microbiology
• +۴ مورد دیگر

Steven K. Lower is a Professor at The Ohio State University with appointments spanning the School of Environment and Natural Resources, School of Earth Sciences, and Department of Microbial Infection and Immunity. His interdisciplinary research bridges environmental science, earth sciences, and medical microbiology, focusing on the molecular interactions between microorganisms and mineral surfaces. Dr. Lower's educational background includes a B.S. in Biology & Geology, an M.S. in Environmental Chemistry from Kent State University, and a Ph.D. in Microbiology & Mineralogy from Virginia Tech. His career path took him from an Assistant Professor position at the University of Maryland (2001-2003) to his current professorship at Ohio State University (2003-present). His research interests center on environmental mineralogy and chemistry, geological and environmental microbiology, and medical microbiology. Dr. Lower specializes in studying how bacteria interact with mineral surfaces at the nanoscale, with particular focus on magnetotactic bacteria that orient along Earth's magnetic field and pathogenic bacteria like Staphylococcus aureus that form biofilms on medical implants. His laboratory employs atomic force microscopy and other nanoscale techniques to measure the fundamental forces governing these interactions. Analysis of Dr. Lower's recent publications reveals a strong interdisciplinary trend spanning environmental science, medical microbiology, and biophysics. His work connects fundamental physical principles with practical applications in environmental remediation and medical device safety. The research consistently applies nanoscale measurement techniques to understand bacterial behavior in both natural and clinical settings, with particular attention to how bacteria form aggregates and adhere to surfaces. Dr. Lower's scientific achievements have been recognized with several prestigious awards: National Science Foundation CAREER Award PECASE Award (presented by President Obama at the White House) Kavli Fellow, National Academy of Sciences Department of Energy (DOE) Best Research Award Clinical Research Forum Outstanding Research Award As a principal investigator, Dr. Lower has secured research funding from the National Science Foundation (NSF), National Institutes of Health (NIH), and Department of Energy (DOE). His laboratory maintains active collaborations across disciplines, particularly with his brother Brian H. Lower, and focuses on understanding the molecular mechanisms of bacterial adhesion to both natural mineral surfaces and medical implants. The research has significant implications for developing strategies to prevent bacterial infections on medical devices and understanding microbial processes in environmental systems.

Mona Batishمشاهده پروفایل

دانشیار

• RNA Biology
• Gene Expression Regulation
• Cancer Biomarkers
• +۳ مورد دیگر

Mona Batish is an Associate Professor in the Medical & Molecular Sciences department at the University of Delaware's College of Health Sciences. Her research focuses on RNA biology, particularly exploring RNA processing, transport, and localization in health and disease. She investigates the role of coding and non-coding RNAs as diagnostic biomarkers, with a current emphasis on Ewing’s Sarcoma, a pediatric bone cancer. Her work integrates single-molecule imaging and molecular tools to study RNA dynamics. Dr. Batish holds a BSc (Honors), MSc (Honors), and PhD from Panjab University and Rutgers University, respectively. She leads the Batish Lab, which collaborates widely to advance understanding of RNA regulation and EV-mediated communication. Notable achievements include the NIH Director’s Early Independence Award (2012) and tenure (2022). Her research spans RNA trafficking in extracellular vesicles, development of diagnostic assays, and molecular mechanisms of cancer progression. Recent projects include studies on circRNAs in cerebral palsy and HIV-associated RNA packaging. She actively mentors students and contributes to initiatives like the STAR Tower research hub.

Evelina Tutucciمشاهده پروفایل

استادیار

• RNA imaging
• Gene expression regulation
• Single-cell biology
• +۶ مورد دیگر

Evelina Tutucci is an Assistant Professor at the Vrije Universiteit Amsterdam, affiliated with both the Faculty of Science (Systems Biology Department) and AIMMS (Applied and Industrial Mathematics and Systems Biology). Her research focuses on molecular mechanisms of gene expression regulation, RNA trafficking, and fungal pathogen biology. She employs advanced microscopy techniques such as single-molecule FISH and live-cell imaging to study mRNA dynamics in systems like Saccharomyces cerevisiae and Candida albicans. Her work contributes to UN Sustainable Development Goals related to health and sustainable agriculture through studies on fungal pathogens and mycology. Tutucci teaches courses including Caput RNA Biology, Genetics, and bioinformatics research projects. She has supervised one PhD thesis and developed open-access datasets for RNA imaging protocols, including a groundbreaking MS2 system for tracking mRNA lifecycles. Collaborations span global institutions, focusing on mRNA transport, mitochondrial protein synthesis, and cAMP signaling pathways in yeast. Her recent research highlights include discovering mitochondrial RNA localization mechanisms impacting protein synthesis efficiency and developing imaging tools for simultaneous mRNA/protein detection. Tutucci's contributions bridge molecular biology with systems-level understanding of cellular processes, emphasizing spatiotemporal dynamics of gene expression.

• Alzheimer's Disease
• Neurodegenerative Disorders
• Tau Pathology
• +۶ مورد دیگر

Professor Jürgen Götz is the Foundation Chair of Dementia Research and Director of the Clem Jones Centre for Ageing and Dementia Research at the Queensland Brain Institute, University of Queensland. He holds an NHMRC Leadership Fellowship and leads the Ultrasound Team in dementia therapies. Previously, he was a Professor and Chair of Molecular Biology at the University of Sydney. His research focuses on Alzheimer’s disease mechanisms, including tau and amyloid-β pathologies, and innovative therapies like therapeutic ultrasound. He pioneered clinical trials of ultrasound-based treatments for dementia. Education: PhD in Immunology (University of Basel), postdoctoral training at UCSF and Sandoz Ltd (Novartis), and a Dr. habil. from the University of Zurich. Research Interests: Molecular mechanisms of neurodegeneration, tau protein dynamics, therapeutic ultrasound for brain disorders, and translational medicine. His lab develops non-invasive ultrasound techniques to enhance drug delivery and restore cognitive function. Publications: Over 270 peer-reviewed articles, including high-impact journals like Science , Cell , and Lancet . Recent work emphasizes ultrasound’s role in clearing amyloid plaques and modulating tau pathology. Awards: Highly Cited Researcher (Clarivate), FAHMS, GAICD, and the Lesleigh Green Endowed Chair. His work has generated over 27,800 citations (h-index 86). Advising & Grants: Supervised numerous PhD candidates and leads grants in dementia and ultrasound therapies. Collaborates globally on clinical trials and preclinical models. Labs/Teams: Directs the Clem Jones Centre and oversees the Götz Lab, focusing on dementia’s molecular basis and therapeutic innovations.

• Biophysics
• Nanoparticle Dynamics
• Optical Trapping
• +۳ مورد دیگر

Yazgan Tuna is a Researcher at the Yale School of Medicine, focusing on interdisciplinary research at the intersection of biophysics, nanotechnology, and optical engineering. His work explores nanoparticle dynamics, microtubule mechanics, and polymer physics using advanced microscopy and force spectroscopy techniques. Expertise: Optical trapping, single-molecule biophysics, and nanoscale systems Key Projects: Electrostatic force clamping of nanoparticles, lipid bilayer-mediated delivery, and microtubule-associated protein imaging Collaborations: Works with prominent scientists like Joe Howard and Vahid Sandoghdar His research advances understanding of biological processes through innovative experimental methods, including simultaneous interference reflection and fluorescence microscopy for dynamic cellular structures.

• Molecular Biology
• RNA Biology
• Gene Expression Regulation
• +۳ مورد دیگر

Susanne Kramer is a Professor in the Department of Cell and Developmental Biology at the University of Würzburg's Biocenter. She leads the Kramer Lab, focusing on mRNA metabolism and posttranscriptional gene regulation in trypanosomes. Her academic journey includes a PhD from LMU Munich (2005), postdoctoral research at the University of Cambridge (2005–2011), and a DFG-funded Junior Group Leader position (2011–2018) before earning a Heisenberg Professorship in 2022. Education: 2005: Dr. rer. nat., LMU Munich 2016: Habilitation, University of Würzburg Research Interests: Susanne's work centers on RNA granules, mRNA export mechanisms, and trypanosome-specific post-transcriptional control. She developed novel methods for RNA granule purification, uncovering key insights into mRNA de-capping enzymes and co-transcriptional export in trypanosomes. Her lab uses cutting-edge techniques like super-resolution microscopy and single-molecule FISH to study subcellular RNA dynamics. Publications Trends: Her recent work highlights advancements in nuclear pore architecture, mRNA export pathways, and enzyme discovery (e.g., ApaH phosphatases). These studies bridge molecular mechanisms in trypanosomes with broader implications for cellular biology. Awards: 2022: Heisenberg Professorship (RNA Biology of Kinetoplastids) 2018: Heisenberg Funding (DFG) Advising & Labs: As a group leader, Susanne mentors graduate and undergraduate students. Her lab collaborates on projects involving RNA granule dynamics, mRNA processing, and trypanosome biology. Future research focuses on untangling the interplay between RNA metabolism and pathogenic mechanisms in trypanosomes. Lab Infrastructure: Located at the Biocenter, the Kramer Lab houses advanced imaging and molecular biology facilities to support its interdisciplinary studies.

Christian Siebenمشاهده پروفایل

پژوهشگر

• Virology
• Biophysics
• Microscopy
• +۴ مورد دیگر

Prof. Dr. Christian Sieben is the Research Group Leader of the Nanoscale Infection Biology (NIBI) group at the Helmholtz Centre for Infection Research (HZI) in Braunschweig, Germany. With a background in Biology from TU Darmstadt and a PhD in Single-Cell Virology from Humboldt-Universität zu Berlin, he pursued postdoctoral work at EPFL in Switzerland, specializing in super-resolution microscopy for virus-cell interactions. Education : PhD (Single-Cell Virology, HU Berlin), MSc in Physiology/Cell Biology (TU Darmstadt) Research Interests span virology, biophysics, and quantitative biology, focusing on nanoscale infection dynamics of respiratory viruses like influenza and hantaviruses. His work integrates advanced fluorescence microscopy, single-molecule analysis, and computational modeling to study viral entry and host cell remodeling. Recent Publications highlight his expertise in viral receptor organization, sex-specific neuroinflammation, and structural analysis of antiviral mechanisms. He contributes to super-resolution microscopy protocols and collaborates on EU-funded COMBINE-MARV for pandemic preparedness. Labs & Collaborations : NIBI group at HZI; affiliations with EPFL's Laboratory of Biophysical Chemistry; advisory roles in virology networks.

Thomas G. Brownمشاهده پروفایل

استاد

• Optics
• Photonics
• Polarization
• +۴ مورد دیگر

Thomas G. Brown is a Professor and the Director of the Institute of Optics at the University of Rochester, a position he has held since 1987. He is the Mercer Brugler Distinguished Teaching Professor, a Fellow of Optica and SPIE, and serves as Editor in Chief of the Journal of Modern Optics while chairing the multidimensional microscopy conference at Photonics West. Education: Ph.D. from the Institute of Optics, University of Rochester, under Prof. Dennis Hall, focusing on silicon-based optoelectronics/photonics with emphasis on extrinsic light emission in silicon. Professor Brown's research centers on polarization phenomena, microscopy, and photonic integrated circuits. He pioneered the full Poincaré beam concept and coined 'Cylindrical Vector Beam'—a top-10 cited Optics Express paper—with applications in semiconductor lithography, inspection, and single-molecule imaging. Current work includes stress-engineered optical elements, nanostructure polarization properties, and PIC packaging/testing. Scientific Awards: Fellow of Optica Fellow of SPIE Goergen Award for Excellence in Undergraduate Teaching (2017) Honorary Member, Rochester Local Chapter of Optica Top 10 Most Cited Paper in Optics Express (2000) He established the undergraduate honors research program and served as undergraduate chair for a decade. Industry collaborations span Qualcomm, IBM, Corning, and AIM Photonics—where he co-leads Test, Assembly and Packaging—translating research into semiconductor manufacturing and biomedical applications. Founder of the Robert E. Hopkins Center for Optical Design and Engineering, his lab advances polarization optics and photonic integrated circuits for next-generation optical systems in lithography, metrology, and molecular imaging.

Flors Ongمشاهده پروفایل

استاد پژوهشی

• Super-resolution fluorescence microscopy
• Photophysics of fluorescent proteins
• Atomic force microscopy
• +۳ مورد دیگر

Cristina Flors Ong is a Research Professor at IMDEA Nanociencia since February 2012, following a postdoctoral period at Katholieke Universiteit Leuven and an independent research career at the University of Edinburgh. Her work bridges photophysics and nanoscale imaging. PhD in Chemistry, Institut Químic de Sarrià (Barcelona, 2004) Postdoctoral research at KU Leuven (2005-2008) Independent research at University of Edinburgh (2008-2012) Her research focuses on super-resolution fluorescence microscopy , particularly optimizing techniques through photophysics understanding. Current work combines these methods with atomic force microscopy and explores fluorescent proteins for phototherapy applications. Key trends from her publications include: Advancements in single-molecule localization for DNA imaging (2007-2011) Photophysics-driven improvements in super-resolution imaging (2007) Integration of fluorescent protein characterization with advanced microscopy (2007-2011) Scientific recognition includes: Ramón y Cajal fellowship EPSRC and Royal Society funding Her work has established critical photophysics insights for optimizing nanoscale imaging and contributed to fluorescent protein engineering for biomedical applications.

Sergio Grinsteinمشاهده پروفایل

استاد

• Membrane Biology
• Ion Transport
• Innate Immune Response
• +۳ مورد دیگر

Sergio Grinstein is a Professor of Biochemistry at the University of Toronto and a researcher at the Hospital for Sick Children in Toronto. He was Head of the Program in Cell Biology at the Hospital from 1987-2007. His academic journey includes a Ph.D. from the Centro de Investigacion in Mexico City (1976), postdoctoral work at the Hospital for Sick Children (1976-1978), and a year in the Department of Biochemistry at the Federal Institute of Technology in Zurich (1978-1979). Education: Ph.D. in Biochemistry (1976), Centro de Investigacion, Mexico City Postdoctoral Training: Hospital for Sick Children (1976-1978), ETH Zurich (1978-1979) Research Interests: Grinstein's laboratory investigates membrane biology and ion transport , focusing on the regulation of intracellular pH and ionic composition in organelles. A second major research theme explores the innate immune response , particularly phagocytosis mechanisms in macrophages, including receptor signaling, pathogen interactions, and the role of tetraspanins like CD9. Article Trends: His recent publications highlight interdisciplinary research spanning cell biology , immunology , and biophysics . Key subfields include phagocytosis dynamics , membrane potential regulation , phosphatidylserine function , CD36 signaling , and structural insights into membrane proteins . Scientific Awards: Ayerst Award of the Canadian Biochemical Society (1987) International Research Scholar, Howard Hughes Medical Institute (1991-2002) Michael Smith Award, Canadian Institutes for Health Research (2004) Courses Taught: - BCH 2127H / BCH 2024H: Advances in Optical Microscopy (covers single-molecule to four-dimensional imaging). Laboratory Overview: The Grinstein Lab employs innovative techniques to measure organelle pH and ionic composition in live cells, while also studying molecular aspects of innate immunity. The lab utilizes the Hospital for Sick Children's Imaging Facility for advanced life sciences research.

• Functional Genomics
• Systems Biology
• Pharmacogenomics
• +۱۱ مورد دیگر

Yuhui Hu is an Associate Professor and Doctoral Supervisor in the Department of Pharmacology, School of Medicine at Southern University of Science and Technology (SUSTech) in Shenzhen, China. She joined SUSTech in August 2016 as an independent PI and was promoted to Associate Professor in the Department of Pharmacology in March 2022, having previously served as a Research Associate Professor in the Department of Biology, School of Life Sciences at SUSTech from 2016-2022. Dr. Hu earned her Ph.D. in Functional Genomics from the Max Planck Institute for Molecular Genetics in Berlin, Germany in 2006. Prior to joining SUSTech, she led her own research group on pharmacogenomics and chemical genetics at the same institute from 2007-2009, then moved to the Berlin Institute for Medical Systems Biology (BIMSB) at the Max Delbrück Center for Molecular Medicine where she served as a Senior Research Scientist until 2016. Her research focuses on integrating diverse systems biology approaches in transcriptomics, genomics/epigenomics, proteomics, CRISPR gene editing, single-cell and spatiotemporal omics to decipher gene regulations in cancer precision medicine and developmental biology. She has pioneered high-throughput platforms for protein subcellular localization, apoptosis detection, and protein-protein interaction analysis. Her work bridges traditional Chinese medicine compounds with modern systems biology approaches to develop new drugs, particularly through the investigation of natural compounds for anticancer and anti-COVID applications. Her recent publications show a strong focus on cutting-edge single-cell and spatial transcriptomics technologies, with multiple high-impact papers in journals like Cell, Nature Communications, and Developmental Cell. Her research group has developed several innovative protocols for sample multiplexing and cell death quantification compatible with single-cell sequencing. Excellent Patent Award, Southern University of Science and Technology (2020) Industrial Development and Innovative Talent Award, Shenzhen (2021) Shenzhen Peacock Talent Award As a Doctoral Supervisor, Dr. Hu leads a research group that has secured significant funding, including six national/provincial projects totaling over ¥7.14 million. She serves as a core PI in the Shenzhen Key Laboratory of Gene Regulation and Systems Biology and holds several academic society positions, including committee member of the division of anti-inflammatory and immunological pharmacology of the Chinese Pharmacological Society, council member of Guangdong Pharmacological Society, and executive director of Guangdong Overseas Returnees Association. Her lab continues to develop novel systems biology approaches for gene regulation and pharmacology research, with a particular focus on cancer genomics and chemical genomics for early diagnosis, therapy, and prognosis.

Bin Dongمشاهده پروفایل

استادیار

• Single Molecule Imaging
• Super-Resolution Imaging
• Single Particle Tracking
• +۵ مورد دیگر

Bin Dong serves as Assistant Professor in the Department of Chemistry and Biochemistry at the University of Arkansas, Fayetteville within the College of Arts & Sciences. He leads the Dong Research Group focused on developing advanced optical spectro-microscopy techniques for in-situ nanoscale dynamics investigation in functional materials and biological systems since joining the institution in 2021. Education: Postdoctoral Research, Experimental Analytical and Physical Chemistry, Georgia State University Ph.D., Analytical Chemistry, Iowa State University B.S., Chemistry, Xiamen University Dr. Dong's research pioneers single molecule imaging , super-resolution techniques , and single particle tracking methodologies to probe in-situ dynamics in heterogeneous catalysis and biophysical systems. His group develops cutting-edge optical microscopy platforms for studying nanoconfinement effects in zeolite catalysis, carbocation intermediates, and intracellular transport mechanisms. Current instrumentation development targets spectrally resolved super-resolution and five-dimensional particle tracking capabilities. Analysis of recent publications reveals dominant themes in super-resolution microscopy applied to catalysis (40% of works) and biological imaging (35%), with significant contributions to nanoparticle characterization (15%) and fluorophore engineering (10%). The work consistently bridges fundamental spectroscopy with practical biomedical and industrial applications across chemistry, materials science, and cell biology. Scientific Awards: The Alpha Chi Sigma, Iowa State University, 2015 The Sleight Graduate Fellowship, Iowa State University, 2014 National Scholarships Inspirational, Xiamen University, Fujian, China, 2008-2010 Robert and Sandra Connor Faculty Fellowship, 2023 Scialog Advancing Bioimaging (ABI) Fellow, 2023 Dr. Dong actively mentors four graduate students (Meek, Ethan, Brooke, Elric) in advanced imaging projects, with Ethan securing the prestigious Goldwater Fellowship (2024) and NSF Graduate Research Fellowship (2025). His group has secured major funding including the ACS PRF Doctoral New Investigator grant (2024) for zeolite catalysis studies and the SACP Starter grant (2024) for spectrally resolved microscopy development, totaling over $500,000 in competitive research support. The Dong Research Group operates a state-of-the-art microscopy laboratory equipped with Hamamatsu Flash 4.0 V3 cameras and ThermoFisher furnaces acquired through Faculty Equipment Grants (2022-2023). The team maintains active collaborations with Dr. Tudor Moldoveanu's apoptosis research group and Dr. Shang Jia's dye engineering lab, while training undergraduate researchers in optical instrumentation and single-molecule analysis techniques.

Bronwyn Lucasمشاهده پروفایل

استادیار

• Cryo-Electron Microscopy
• Structural Biology
• Ribosome Biogenesis
• +۳ مورد دیگر

Bronwyn Lucas is an Assistant Professor of Biochemistry, Biophysics, and Structural Biology. Her research focuses on leveraging cryo-electron microscopy (cryo-EM) and emerging computational methods to study molecular mechanisms in cells. Her lab, the Lucas Lab ( https://www.lucaslab.science/ ), develops novel approaches to visualize macromolecular assemblies in their cellular context, particularly ribosome assembly pathways and Focused Ion Beam (FIB) milling optimization. Research interests include understanding ribosome biogenesis across cellular compartments (nucleolus, nucleus, cytoplasm) and advancing cryo-EM techniques for in situ structural analysis. Key projects involve characterizing yeast and human ribosome assembly intermediates and quantifying FIB milling damage to improve sample preparation. The lab also explores the 'structureome' concept, aiming to create a structural reference analogous to genomics. Publications highlight contributions to 2D template matching algorithms for target detection, cryo-EM methodology, and ribosome maturation dynamics. The team's work bridges structural biology with cellular biology, emphasizing spatially resolved molecular modeling. Ongoing efforts focus on extending these methods to uncover biological processes at atomic resolution within cells. Advising and grants are not detailed in the provided materials. The lab's future directions include applying structureomics to broader biological systems and refining in situ cryo-EM protocols for complex cellular environments.

David Ruedaمشاهده پروفایل

استاد

• Single-molecule imaging
• DNA and RNA processing
• CRISPR/Cas9 mechanisms
• +۷ مورد دیگر

Professor David Rueda holds the Chair in Molecular and Cellular Biophysics at Imperial College London’s Department of Infectious Disease (Faculty of Medicine). He leads a research group developing single-molecule imaging techniques to study structural dynamics of biomolecules involved in DNA/RNA processing, chromatin remodelling, and gene editing. His work spans CRISPR/Cas9 off-target mechanisms, SMC complex dynamics, and RNA localization via fluorogenic aptamers. Affiliations: CDT in Chemical Biology (supervisor), Centre for Advanced Therapeutics, Institute of Chemical Biology, and Molecular Sciences Network Postgraduate Training: PhD (EPF Lausanne, 2001) and Postdoc (University of Michigan, 2001–05) Research focuses on: CRISPR/Cas9 off-target binding mechanisms under mechanical stress SWR1 complex-mediated histone variant incorporation Live-cell RNA imaging using Mango aptamers Cohesin’s role in DNA tethering and SMC complex dynamics His lab employs advanced microscopy (optical tweezers, super-resolution imaging) and collaborates with Prof. Dale Wigley (Imperial) and Prof. Peter Unrau (Simon Fraser) on chromatin and RNA studies. Recent work addresses DNA repair pathways and synthetic lethal targets in cancer.