جست‌وجوی استاد و پژوهشگر

Vidya Chandrasekaranمشاهده پروفایل

پژوهشگر

• Toxicology
• In Vitro Toxicology
• Stem Cell Research
• +۴ مورد دیگر

Vidya Chandrasekaran is a Researcher at the Vrije Universiteit Amsterdam, affiliated with the Faculty of Science and the Department of Chemistry and Pharmaceutical Sciences. She holds an integrated Master's degree in Industrial Biotechnology from SASTRA University, India (2015), and is completing a PhD focused on iPSC-derived renal proximal tubule models for nephrotoxicity testing. Her research emphasizes developing in vitro systems for toxicity assessment using induced pluripotent stem cells (iPSCs). Key research areas include: iPSC differentiation protocols for kidney cells Nephrotoxicity testing using organoid models Transcriptomic analysis of toxic responses Animal-free chemical safety assessment She contributed to the in3 project , a multidisciplinary initiative for animal-free toxicity testing, alongside Prof. Paul Jennings. Her work has been published in journals like Toxicology in Vitro and Scientific Reports . Current projects involve advancing chronic toxicity prediction models and cadmium exposure mechanisms in renal cells. Collaborations include Harvard Medical School and Brigham and Women’s Hospital, focusing on kidney toxicology and regenerative medicine.

Masmudur Rahmanمشاهده پروفایل

استادیار

• Molecular Virology
• Cancer Biology
• Oncolytic Viruses
• +۳ مورد دیگر

Masmudur Rahman is an Assistant Professor at Arizona State University (ASU), affiliated with the School of Life Sciences and the Biodesign Center for Personalized Diagnostics. He leads research on molecular virology, focusing on oncolytic viruses like myxoma virus (MYXV) to treat cancers, particularly leveraging their ability to target cancer cells with compromised innate immunity. His work combines virology, genetic engineering, microscopy, and bioinformatics. Education highlights include a BSc and MSc from the University of Dhaka, a PhD in Molecular Virology from the Indian Institute of Science (IISc), and postdoctoral research at the University of Western Ontario and University of Florida, studying poxvirus immune modulation. He has received grants from NIH and the Arizona Biomedical Research Commission for projects on cancer virotherapy and virus-host interactions. Research interests span viral host range mechanisms, tumor tropism, and combination therapies (e.g., selinexor + MYXV). His lab develops strategies to enhance viral efficacy using stem cells and explores autosis induction in CAR-T cells. He teaches undergraduate research and honors courses in microbiology and cell biology, emphasizing hands-on training in virology techniques. Grants include NIH-funded studies on overcoming CAR-T resistance via autosis and targeting metastatic cancers with MYXV-selinexor combinations. His work has been published in Viruses , Cancer Research Communications , and International Journal of Molecular Sciences , among others.

• Immunology
• Cancer Therapy
• Oncology
• +۳ مورد دیگر

Angelo Porciuncula is an Associate Research Scientist in the Department of Pathology at Yale School of Medicine, affiliated with the Schalper Lab. He holds a PhD from the University of Navarra. His research focuses on immunology, cancer therapy, and stem cell biology, with a particular emphasis on immune microenvironment modulation in oncology and translational drug development. Key projects include studying STING pathway activation via antibody-drug conjugates (e.g., TAK-500) targeting CCR2-expressing myeloid cells, as well as investigating immunotherapeutic biomarkers in lung cancer and glioblastoma. His work spans clinical-stage drug evaluation, tumor immunology, and epigenetic reprogramming of stem cells. Publications highlight contributions to understanding senescence mechanisms in cancer, pancreatic differentiation of iPSCs, and the role of OX40/OX40L pathways in tumor immunity. Porciuncula collaborates widely, including with Kurt Schalper and teams at Takeda Pharmaceuticals. His research bridges basic science and clinical applications, aiming to advance targeted therapies and regenerative medicine strategies.

• Virology
• Immunology
• Cell Biology
• +۳ مورد دیگر

Xinyan Zhang is a Researcher in the Department of Cell Biology at Yale School of Medicine, Yale University. Her research focuses on understanding the molecular mechanisms of viral infections, particularly cytomegalovirus (CMV), and their interactions with host cellular processes such as autophagy and apoptosis. She investigates how viral infections trigger inflammatory responses and contribute to pathologies in organs like the retina and liver. Her work includes studies on the role of caspase-12 in retinal cell death during CMV retinitis, the impact of autophagy inhibition on viral replication, and the long-term ocular pathologies caused by neonatal CMV infection in mice models. She also explored adipokine involvement in Kawasaki disease and meta-inflammation in obese children during her graduate studies. Zhang collaborates with mentors Dr. Feng Fang (pediatric infectious disease expert) and Dr. Ming Zhang, contributing to interdisciplinary projects at the Su Lab. Her research integrates molecular biology, immunology, and clinical insights to address translational challenges in virology and infectious diseases.

• DNA Damage
• DNA Repair
• Chromatin Structure
• +۵ مورد دیگر

John Rouse is a Professor and Scientific Programme Leader (MRC) of Chromosome Biology at the MRC PPU. His research focuses on DNA repair mechanisms, chromatin structure, and genome maintenance. He leads projects funded by the Medical Research Council (MRC) and other institutions, including collaborative efforts on chromatin remodelling and DNA interstrand crosslink repair. Key roles: MRC QQR Programme Leader (2018–2024), Investigator on multiple collaborative grants. Research interests: Chromosome biology, DNA damage response, histone chaperones, and kinase signaling pathways. His work contributes to understanding genome integrity and has implications for cancer therapy and neurodegenerative diseases. Notable projects include the study of NEK1 kinase in ALS and the development of targeted cancer therapies using PROTAC technology. John has been involved in public engagement activities, such as the Discovery Days 2012 event, promoting science outreach.

• Hepatocellular Carcinoma
• Liver Cancer Stem Cells
• Adiponectin Signaling
• +۶ مورد دیگر

Lionel Hebbard is a Professor in the Department of Molecular and Cellular Biology at James Cook University's College of Medicine and Dentistry. His research spans hepatocellular carcinoma mechanisms, metabolic liver disease, and cancer therapeutics with significant contributions to adiponectin biology and sarcopenia assessment in cardiac surgery. James Cook University (Current) Department of Molecular and Cellular Biology College of Medicine and Dentistry Senior Researcher in Liver Cancer Biology His research focuses on hepatocellular carcinoma pathogenesis , particularly adiponectin signaling pathways and liver cancer stem cells. He investigates non-alcoholic fatty liver disease progression to cancer, metabolic drivers of tumorigenesis, and therapeutic targeting using aptamer-based delivery systems. Recent work explores sarcopenia quantification via CT imaging for cardiac surgery risk prediction, demonstrating clinical translation of his molecular findings. His lab employs advanced techniques including CRISPR screening (TARGET-SL platform), in vitro cancer models, and murine tumor systems. Analysis of his 15 most recent publications reveals strong emphasis on translational liver cancer research (60%), cardiac surgery complications (20%), and emerging biotechnologies (20%). Key trends include adiponectin's dual roles in fibrosis and tumorigenesis, sarcopenia as a surgical biomarker, and aptamer-based targeting of cancer stem cells. His work consistently bridges molecular mechanisms with clinical applications, particularly in hepatocellular carcinoma diagnostics and treatment. He mentors multiple doctoral students and early-career researchers including Rhys Gillman and Miriam Wankell. His research is supported by continuous funding from Australian NHMRC and international collaborations with George Jacob (Westmead Institute), Qiao Liang (Bentham Books), and Ranscht Barbara (T-cadherin studies). He leads the Hepatic Cancer Biology laboratory focusing on: Liver cancer stem cell characterization Adiponectin receptor signaling in HCC Metabolic drivers of tumor progression Novel drug delivery systems for liver cancer Translational sarcopenia assessment tools

Mansoureh Eghbaliمشاهده پروفایل

استاد

• Pulmonary Hypertension
• Myocardial Ischemia-Reperfusion Injury
• Sex Differences in Cardiovascular Disease
• +۳ مورد دیگر

Mansoureh Eghbali, PhD, is a Professor in the Department of Anesthesiology at the David Geffen School of Medicine, University of California, Los Angeles. Her research program investigates molecular mechanisms of cardiovascular and pulmonary diseases with emphasis on sex-specific pathophysiology. She leads an active NIH-funded laboratory focused on pulmonary hypertension, myocardial ischemia-reperfusion injury, and the role of RNA-binding proteins in vascular remodeling. Her research integrates multiomics approaches to explore: Sex chromosome influences (Y-gene Uty) in pulmonary vascular protection MicroRNA regulation of cardiac fibrosis and calcification (e.g., miR-129-5p/Asporin axis) Gut-heart-lung interactions in diet-induced pulmonary hypertension Endothelial subpopulations (TM4SF1+) in disease progression Analysis of her recent publications reveals strong emphasis on: Integrative multiomics in vascular diseases Sex differences in drug responses Novel therapeutic targeting of RNA-binding proteins Cross-organ communication in cardiopulmonary pathologies She directs multiple NIH grants including: R01HL159865: Role of Chromosome Y gene, Uty (2021-2025) R01HL147586: Role of miR125 in pulmonary hypertension (2019-2023) R01HL129051: Role of miR193 in oxidized lipid-induced PH (2016-2021) R01HL131182: Epigenetic regulation by X chromosome (2016-2021)

Dean Bryantمشاهده پروفایل

مدرس

• Computational Cancer Biology
• Hematology
• Genomics
• +۳ مورد دیگر

Dean Bryant is a Lecturer in Computational Cancer Biology at the University of Southampton. He holds a BSc (Hons) and PhD, and is a Fellow of the Higher Education Academy (FHEA). His research focuses on computational approaches to understanding cancer biology, particularly in hematological malignancies such as leukemia and lymphoma. He is affiliated with the Institute for Life Sciences and the Bioinformatics and Genomics research groups. Current research projects include the Early Cancer Research Initiative Network (ECRIN-M3) funded by Cancer Research UK and studies on SDH-deficient gastrointestinal stromal tumors. Dean supervises PhD students in Cancer Sciences and Biomedicine, and actively contributes to research on tumor immunoglobulin sequencing, genomic landscapes, and metabolic alterations in cancer. His academic background includes roles in bioinformatics and cancer genomics, with a strong emphasis on integrating computational methods with experimental biology. Dean collaborates with institutions such as Wessex Medical Research and maintains active research partnerships within Southampton’s academic community.

Antonia Beitzen-Heinekeمشاهده پروفایل

مدرس پزشکی

• Oncology
• Hematology
• Hemostaseology
• +۴ مورد دیگر

Antonia Beitzen-Heineke is a Medical Specialist in Internal Medicine, Hematology, and Oncology at the University Medical Center Hamburg-Eppendorf (UKE). She holds dual affiliations in the II. Medical Clinic and Polyclinic (Center for Oncology) and the Institute of Tumor Biology within the Center for Experimental Medicine. Her expertise spans oncology, hematology, and hemostaseology , with a focus on cardio-oncology, chemotherapy-induced toxicity, and coagulation disorders in cancer patients. Her research emphasizes translational studies in tumor biology, including the molecular mechanisms of coagulation activation in acute myeloid leukemia and the role of AXL inhibition in myeloproliferative neoplasms. She also investigates long-term cardiovascular effects of cancer therapies, leveraging cardiac MRI for early detection of myocardial dysfunction. Publications highlight her work on thrombosis in paroxysmal nocturnal hemoglobinuria, checkpoint inhibitor immunotherapy’s impact on hemostasis, and athlete cardiac adaptations. She collaborates with multidisciplinary teams in radiology, immunology, and pharmacology. Her clinical roles involve managing patients with hematologic malignancies and complex coagulation pathologies. No scientific awards are explicitly noted, but her active research profile underscores contributions to cardio-oncology and thrombosis biology.

Ellen Robeyمشاهده پروفایل

استاد

• Immunology
• Molecular Biology
• Cell Biology
• +۳ مورد دیگر

Ellen Robey is a Professor of Immunology and Molecular Medicine at the University of California, Berkeley, serving as Division Head of the IMM Division. Her research focuses on signaling pathways controlling T cell fate decisions, using mouse models to study T cell development and immune responses, including mechanisms of thymic selection and CD4/CD8 lineage commitment. She employs 2-photon imaging to analyze T cell behavior in situ, particularly during parasitic infections like Toxoplasma gondii . Robey’s lab investigates how self-reactivity influences thymic selection timing and develops collaborative projects combining multi-omics approaches with spatial and temporal analyses of thymic development. Key research areas include understanding negative/positive selection mechanisms in the thymus, immune response dynamics during chronic infections, and the role of unconventional T cell subsets recognizing non-classical MHC molecules. The lab has pioneered studies on Qa1-restricted T cells and their role in host defense against pathogens. Her work bridges basic immunology with cutting-edge imaging and systems biology tools to unravel complex immune processes. Lab collaborations include projects with Nir Yosef and Aaron Streets to create high-resolution thymic developmental maps using single-cell multi-omics. Current efforts also explore how ERAAP downregulation alters antigen presentation, influencing T cell responses. The Robey Lab emphasizes diversity in its team, fostering an inclusive environment for scientific innovation.

David Weisblatمشاهده پروفایل

استاد

• Developmental Biology
• Evolutionary Developmental Biology (Evo-Devo)
• Molecular Phylogenetics
• +۴ مورد دیگر

David Weisblat is a Professor in the Department of Molecular and Cell Biology at UC Berkeley's College of Letters & Science. His research focuses on developmental and evolutionary processes in glossiphoniid leeches (e.g., Helobdella ), particularly their segmentation mechanisms and molecular phylogeny within Lophotrochozoa. He leads studies integrating embryological, genomic, and genetic approaches to understand how developmental pathways evolved across bilaterian animals. Research Interests: Weisblat’s work addresses how cell fates and signaling pathways (WNT, NOTCH, TGFβ) shape leech development, with emphasis on the evolutionary origins of segmentation. His lab combines microinjection techniques, transcriptome analysis, and CRISPR mutagenesis to explore stem cell dynamics and conserved developmental programs. Key Projects: Current efforts investigate grandparental stem cell divisions in segmentation and intercellular signaling during early embryogenesis. The lab’s genomic resources—including BAC libraries and EST databases—facilitate comparative studies across Lophotrochozoan taxa. Lab Contributions: The Weisblat lab pioneered Helobdella as a model organism, enabling breakthroughs in Evo-Devo. Their findings bridge developmental plasticity and evolutionary innovation, particularly in annelids versus arthropods/deuterostomes.

Manuela Truebanoمشاهده پروفایل

مدرس

• Marine Molecular Biology
• Ecophysiology
• Climate Change Adaptation
• +۳ مورد دیگر

Dr Manuela Truebano is a Lecturer in Marine Molecular Biology at the University of Plymouth, affiliated with the School of Biological and Marine Sciences (part of the Faculty of Science and Engineering). She holds a BSc in Marine Biology from the University of Liverpool, an MSc in Shellfish Biology from Bangor University, and a PhD in Molecular Ecophysiology (focusing on thermal stress) from Swansea University and the British Antarctic Survey. Her research group is part of the Ecophysiology and Development Research group within the Marine Biology and Ecology Research Centre. Her teaching portfolio includes module leadership roles in Marine Molecular Biology, Ecophysiology of Marine Animals, Conservation Physiology, and field courses. She has supervised two postgraduate research degrees: Michael Collins (PhD, 2019) and George Mason (ResM, 2021). Dr Truebano’s research focuses on thermal tolerance, hypoxia, and environmental stress responses in marine organisms, particularly invertebrates. She employs molecular and physiological approaches to study climate change impacts, including the development of tools like Dev-ResNet and HeartCV for automated phenotyping. Her work intersects with global sustainability goals, emphasizing organismal resilience to environmental shifts. Her recent publications highlight advancements in understanding transgenerational plasticity, thermal acclimation, and the interplay of multiple stressors. Teaching and learning grants include a 2015 initiative exploring video tutorials for lab skill training. She collaborates extensively in interdisciplinary projects, contributing to both academic and applied marine science.

• Genome Stability
• DNA Repair Mechanisms
• Cancer Biology
• +۳ مورد دیگر

J. Ross Chapman is a Professor of Genome Maintenance Biology at the University of Oxford, affiliated with the MRC Molecular Haematology Unit. He holds fellowships from Cancer Research UK and the Lister Institute, and is part of the EMBO Young Investigator Programme. His research focuses on DNA repair mechanisms, particularly the balance between accurate and mutagenic repair pathways in cancer and immune disorders. Career highlights include roles as a Sir Henry Wellcome Fellow and Principal Investigator. His group studies genetic recombination mechanisms, aiming to develop cancer therapies targeting repair pathway dysfunctions. Key research areas include the role of BRCA1, BARD1, 53BP1, and CST complexes in DNA repair. Awards include CRUK and Lister Institute Fellowships, alongside EMBO recognition. His lab’s work spans genomic stability, immune system development, and cancer therapy strategies. Recent studies explore chronic inflammation in leukemia evolution and synthetic lethality in BRCA-deficient cells.

Thomas Spallekمشاهده پروفایل

پژوهشگر

• Plant Biology
• Parasitic Plant Genetics
• Plant-Microbe Interactions
• +۴ مورد دیگر

Dr. Thomas Spallek is a Junior Group Leader leading the Plant Biotic Interactions Group at Georg-August University Göttingen, Germany. His research focuses on functional genetics of parasitic plants, interspecific signaling, and haustoria formation mechanisms. Previously, he held roles as Project Leader (2019–2022) and Postdoc (2018–2019) at the University of Hohenheim, with postdoctoral experience at RIKEN (Japan) and The Sainsbury Laboratory (UK). Education: PhD in Plant Biology (Max Planck Institute, Cologne, 2011), Diploma in Biology (University of Konstanz, 2008). Research Interests: Parasitic plant genetics and host interactions Cytokinin signaling in plant-pathogen relationships Cellular and molecular mechanisms of haustorium development Publications span plant-parasite signaling, hormonal regulation, and genomic studies of parasitic weeds. Notable collaborations include work on Striga asiatica genome analysis and cytokinin-driven virulence factors. He is affiliated with the International Research Training Group 2172 - PRoTECT and coordinates the Plant Biotic Interactions research group. His work integrates molecular genetics, bioimaging, and computational tools to dissect plant defense and parasitic strategies.

Jean Fanمشاهده پروفایل

استادیار

• Single-cell omics
• Spatial omics
• Computational biology
• +۳ مورد دیگر

Jean Fan, PhD is an Assistant Professor of Biomedical Engineering at Johns Hopkins University, affiliated with the Center for Computational Biology and Institute for Computational Medicine. Her research focuses on developing machine learning methods to analyze spatially resolved and single-cell omics data. Her team, the JEFworks Lab, creates open-source tools for analyzing high-dimensional biological data to understand cellular identity, tissue organization, and disease progression. Dr. Fan's work bridges computational biology with clinical applications, particularly in leukemia and pediatric brain cancers. Education: BS in Biomedical Engineering & Applied Math from Johns Hopkins (2013); PhD in Bioinformatics from Harvard Medical School (2018); Postdoc in Chemical Biology/Physics at Harvard (2018–2020) under Xiaowei Zhuang, focusing on spatial transcriptomics. Research emphasizes spatial genomics and computational tool development, with key contributions to spatial alignment algorithms (STalign), normalization techniques, and cell-type deconvolution methods. Her lab's work has advanced understanding of kidney ischemic injury, glioblastoma spatial dynamics, and CLL pathogenesis. Awards include Forbes 30 Under 30, NSF CAREER Award, and 2025 PECASE. She founded CuSTEMized, a nonprofit providing STEM storybooks for girls. Recent collaborative projects include HuBMAP 3D reference atlas construction and Discovery Award-funded interdisciplinary initiatives. Labs/Teams: JEFworks Lab (primary); active collaborations with Dana-Farber Cancer Institute and Harvard Medical School. Current efforts focus on spatially resolved multi-omic integration and clinical translation of computational tools.