David Weisblat

David Weisblat is a Professor in the Department of Molecular and Cell Biology at UC Berkeley's College of Letters & Science. His research focuses on developmental and evolutionary processes in glossiphoniid leeches (e.g., Helobdella), particularly their segmentation mechanisms and molecular phylogeny within Lophotrochozoa. He leads studies integrating embryological, genomic, and genetic approaches to understand how developmental pathways evolved across bilaterian animals.

Research Interests: Weisblat’s work addresses how cell fates and signaling pathways (WNT, NOTCH, TGFβ) shape leech development, with emphasis on the evolutionary origins of segmentation. His lab combines microinjection techniques, transcriptome analysis, and CRISPR mutagenesis to explore stem cell dynamics and conserved developmental programs.

Key Projects: Current efforts investigate grandparental stem cell divisions in segmentation and intercellular signaling during early embryogenesis. The lab’s genomic resources—including BAC libraries and EST databases—facilitate comparative studies across Lophotrochozoan taxa.

Lab Contributions: The Weisblat lab pioneered Helobdella as a model organism, enabling breakthroughs in Evo-Devo. Their findings bridge developmental plasticity and evolutionary innovation, particularly in annelids versus arthropods/deuterostomes.