جست‌وجوی استاد و پژوهشگر

Craig Melloمشاهده پروفایل

استاد

• RNA Interference
• Molecular Genetics
• Epigenetics
• +۷ مورد دیگر

Craig Mello is a Distinguished Professor and Blais University Chair in Molecular Medicine at UMass Chan Medical School , where he leads research in the RNA Therapeutics Institute within the T.H. Chan School of Medicine . His work spans multiple programs including the Cancer Center and Molecular Medicine. B.S. in Biochemistry (Brown University, 1982) Ph.D. in Cellular/Developmental Biology (Harvard University, 1990) Research Focus Mello investigates RNA-mediated gene regulation mechanisms using Caenorhabditis elegans as a model organism. His lab pioneered RNA interference (RNAi) research, revealing conserved protein pathways that govern genetic information through small RNA-guided regulatory searches. Key projects include: Piwi Argonaute pathways in fertility and epigenetic inheritance Germline determination and cell fate specification CRISPR-based genome editing tools for C. elegans Transgenerational RNA silencing mechanisms Publications Trends Recent work emphasizes piRNA biogenesis, SUMOylation in gene regulation, and CRISPR optimization. His studies span Cell Biology , Molecular Biology , and Genetics with applications in Humans , Animals , and Cells . Awards & Recognition Nobel Prize in Physiology or Medicine (2006) for RNAi discovery Howard Hughes Medical Institute Investigator (2000-) Lab Structure The Mello lab maintains facilities at the Albert Sherman Center, focusing on nematode genetics research and small RNA cloning methodologies. Collaborations span biochemistry, developmental biology, and therapeutics development.

• DNA Repair
• Epigenetics
• DNA Methylation
• +۵ مورد دیگر

Dr. Alexander C. Drohat is a Professor in the Department of Biochemistry and Molecular Biology at the University of Maryland School of Medicine. His research focuses on DNA repair mechanisms and epigenetic regulation through DNA methylation, with particular emphasis on thymine DNA glycosylase (TDG) and its role in maintaining genomic integrity and protecting against cancer. Dr. Drohat received his BS in Aerospace Engineering from the University of Maryland, followed by a PhD in Biochemistry and Molecular Biology from the University of Maryland School of Medicine. He completed his postdoctoral training at Johns Hopkins University School of Medicine, NIST and Center for Advanced Research in Biotechnology. His laboratory investigates how enzymes find and repair DNA lesions through biochemical, biophysical, structural, and molecular approaches. Key research areas include DNA repair mechanisms (particularly TDG and MBD4 enzymes), active DNA demethylation pathways involving oxidation of 5-methylcytosine, and regulation of TDG through SUMO modification. His work has established that TDG rapidly excises 5-formylcytosine and 5-carboxylcytosine, revealing critical mechanisms for epigenetic regulation. Analysis of his recent publications shows consistent focus on nucleotide flipping dynamics, enzyme kinetics of DNA repair proteins, structural characterization of DNA-protein interactions, and regulatory mechanisms involving post-translational modifications. His research bridges fundamental biochemical mechanisms with implications for cancer biology and developmental processes. Fellow, American Association for the Advancement of Science (2022) R35 MIRA Award, National Institute General Medical Sciences (2020-2025) Member, NIH Molecular Genetics A (MGA) study section (2018-2022) Member, DNA Mechanism in Cancer Peer Review Committee, American Cancer Society (2011-2015) Dr. Drohat's laboratory has been continuously supported by NIH funding since 2005, currently through R35GM136225 (Mechanisms of BER in Genomic Integrity and Epigenetic Regulation). His work on TDG's role in excising oxidized bases and epigenetic marks has provided foundational insights connecting DNA repair to epigenetic regulation, with implications for understanding cancer development and embryonic processes. His laboratory maintains extensive collaborations and employs cutting-edge techniques including NMR spectroscopy to investigate molecular mechanisms of DNA maintenance.

• Plant Molecular Biology
• Stress Responses in Plants
• Epigenetic Regulation
• +۳ مورد دیگر

Dr. Dipan Roy serves as a Research Fellow in the Department of Biosciences at Durham University. His research focuses on understanding molecular mechanisms underlying plant stress responses, epigenetic regulation, and developmental signaling. Central to his work is the study of SUMOylation pathways and their roles in integrating environmental cues with cellular signaling. Key research interests include: Epigenetic regulation of stress adaptation Phosphate starvation signaling networks Plant hormone interactions (auxin, ethylene) Protein modification dynamics in developmental processes His recent work has revealed how SUMO modification systems evolve to coordinate development and stress responses in plants. This includes groundbreaking studies on OsPSTOL1 SUMOylation in rice and Arabidopsis, and ROS-regulated auxin signaling pathways. Dr. Roy has also contributed to understanding symbiotic interactions mediated by non-coding RNAs and Polycomb/Trithorax systems. Publications span over a decade, demonstrating sustained focus on: Molecular mechanisms of abiotic stress tolerance Epigenetic regulation of transcription factors Plant hormone crosstalk under environmental stress While no awards are explicitly mentioned, his prolific publication record reflects significant contributions to plant molecular biology. Research has been conducted in collaboration with institutions worldwide, particularly in plant stress biology and epigenetic studies.

Federico Rojas Martinezمشاهده پروفایل

مدرس

• Infection Biology
• Trypanosome Biology
• Ubiquitin-like Modifications
• +۲ مورد دیگر

Dr. Federico Rojas Martinez is Lecturer in Infection Biology at Lancaster University, researching molecular mechanisms of trypanosome differentiation. His work examines ubiquitin-like modifications (including neddylation and ufmylation) regulating developmental transitions in Trypanosoma brucei parasites. Current projects include a long-term study of neddylation in trypanosome biology (2024-2029) and protein ufmylation mechanisms. Recent publication demonstrates SUMO chain depolymerization's role in slender-to-stumpy differentiation in bloodstream parasites. Public engagement includes Campus in the City science outreach activities. Research contributes to understanding evolutionarily distinct human pathogens.

• Pharmaceutical Technology
• Polymer Science
• Drug Delivery Systems
• +۳ مورد دیگر

Anette Larsson is a Professor in pharmaceutical technology at Chalmers University of Technology, leading the Pharmaceutical Technology Group. She holds a PhD and MSc in physical chemistry and chemical engineering from Chalmers. Previously, she worked at AstraZeneca R&D Molndal, gaining industrial experience. Her research focuses on biomaterials, drug delivery systems, and polymer science. She is Cluster Leader in the Vinn Excellence Centre SuMo Biomaterials and part of its management team. Current projects explore lignin compatibility, drug release mechanisms, and sustainable materials like bio-based polymers. She collaborates widely, including with Prof. Sven Engström. Her work bridges academia and industry, emphasizing controlled release systems, biodegradable composites, and structural analysis of polymers. Her group includes five PhD students and an associate professor. Publications highlight advancements in polymer blends, material characterization, and drug delivery technologies. Key themes include lignin processing, thermal properties of biomaterials, and nanocomposite design.

Joel Milnerمشاهده پروفایل

استاد

• Plant-virus interactions
• Host defence responses to virus infection
• Defence signaling in response to pathogens
• +۷ مورد دیگر

Dr. Joel Milner is a Reader in Molecular Biosciences at the University of Glasgow, focusing on plant-virus interactions, host defense responses, and counter-defence strategies by viruses. He is affiliated with the Plant Science research group and has an ORCID: 0000-0003-3702-4295 . Current research investigates plant-pathogen dynamics, defense signaling pathways, and bacteriocin applications for crop protection. He has published extensively on topics including viral protein functions, autophagy mechanisms, and chiral plasmonic nanostructures for biomolecular analysis. Recent Publications highlight trends in plant virology, microbiology, and biotechnology. Key studies include engineering bacteriocins for Pseudomonas syringae resistance and exploring chiral nanostructures to probe protein interactions. Grants from BBSRC, Wellcome Trust, and EPSRC support projects such as potato blackleg disease management and novel bacteriocin-based plant protection strategies. Professional Affiliations include the American Society for Plant Pathology, Association of Applied Biologists, and editorial roles in Molecular Plant Pathology and BBSRC committees.

Emilie Pondevilleمشاهده پروفایل

پژوهشگر

• Mosquito Biology
• Arbovirus Transmission
• Insect Immunology
• +۴ مورد دیگر

Dr. Emilie Pondeville is a Senior Research Fellow at the Centre for Virus Research , part of the University of Glasgow . Her work focuses on mosquito biology and physiology, particularly the reproductive and immune mechanisms that influence arbovirus transmission. Her research explores molecular interactions in mosquito-arbovirus systems, including tissue-specific antiviral strategies, defense pathway crosstalk, and vertical transmission of viruses. She utilizes modern transgenic facilities to manipulate mosquito gene functions. Grants from the Medical Research Foundation , UK Research and Innovation , BBSRC , and European Commission support her work on mosquito-borne disease risks under climate change and control strategies. Her publications span virology, entomology, and molecular biology, with recent articles analyzing NSm protein roles , sugar-feeding immunity , salivary vascular effects , and genetic tools in Aedes and Anopheles mosquitoes. Her group investigates gene expression regulation , transgenic mosquito development , and vector competence to inform control programs for diseases like malaria and dengue.

Yilun Sunمشاهده پروفایل

استادیار

• DNA Repair
• Topoisomerases
• PARP Inhibitors
• +۵ مورد دیگر

Dr. Yilun Sun is an Assistant Professor at the University of Maryland School of Medicine and School of Pharmacy, affiliated with the Greenebaum Comprehensive Cancer Center. His research focuses on molecular mechanisms of DNA repair pathways related to topoisomerase and PARP inhibitors in cancer therapy. Education : BSc in Pharmaceutical Sciences (Capital Medical University), MSc in Biotechnology (Georgetown University), PhD in Biopharmaceutical Sciences (University of Illinois at Chicago) Dr. Sun's lab investigates DNA repair mechanisms induced by topoisomerase inhibitors (e.g., topotecan, irinotecan) and PARP inhibitors (e.g., olaparib), emphasizing their roles in lung, colorectal, and breast cancer models. Key areas include post-translational modifications (ubiquitylation, SUMOylation, neddylation) and enzymatic pathways for resolving DNA-protein crosslinks. Recent publications highlight his development of single-molecule fluorescence assays and immuno-biochemical methods to study TOP-DPCs and PARP-DNA complexes. His work reveals novel repair pathways, including ADP-ribosylation-dependent mechanisms and ubiquitin-mediated proteasomal degradation. Scientific Awards : NCI K99/R00 Award, NIH FARE, AACR Scholar-in-Training Award, NSF Travel Award, W. E. Van Doren Scholarship Dr. Sun serves as Associate Editor for Cell Division and contributes to editorial boards. His research is supported by NIH/NCI grants, including 4R00CA273171-02. The lab collaborates with multidisciplinary teams to advance chemo-immunotherapy strategies and identify novel therapeutic targets.

David C. Schwartzمشاهده پروفایل

استاد

• Genomics
• Computational Biology
• Biotechnology
• +۴ مورد دیگر

David C. Schwartz is the Kellett Professor of Chemistry and Genetics at the University of Wisconsin-Madison, with appointments spanning genomic sciences and biotechnology. His research focuses on developing single-molecule systems for genome analysis, enabling scalable biological insights through advanced statistical and informatic methods. Education: B.A. (1976) from Hampshire College, Ph.D. (1985) from Columbia University His work in genomics and computational biology has revolutionized molecular diagnostics, particularly in cancer genome architecture and personal genomics. He pioneered techniques like optical mapping and pulsed-field gel electrophoresis, advancing DNA sequencing and nanoconfinement studies. Current projects integrate fluidic devices with novel molecular labeling to tackle biological complexity. Scientific contributions include co-authorship on foundational studies in maize genomics, protein modification systems (ubiquitin/SUMO), and biomedical imaging. His recent publications emphasize bioinformatics, genome alignment, and sequencing technologies. Key Awards: Kellett Professorship He leads the Genomic Sciences Training Program, mentoring interdisciplinary research teams. His lab at 5434 Biotech Center (Madison, WI) bridges chemistry, genetics, and engineering to innovate in personal genomics and high-throughput biological analysis.

• Plant Immunity
• Proteomics
• Stress Responses in Plants
• +۴ مورد دیگر

Professor Ari Sadanandom is a faculty member in the Department of Biosciences at Durham University and a member of the Biophysical Sciences Institute Executive Board. His research focuses on plant immunity and stress responses, particularly the roles of the ubiquitin-proteasome system (UPS) and SUMOylation in regulating plant defense mechanisms against pathogens and environmental stresses. He employs interdisciplinary approaches, including genetic, molecular, and biochemical techniques, to study how pathogens manipulate host UPS and how plants adapt to drought, heat, and salinity through SUMOylation. Affiliations: Professor in the Department of Biosciences Biophysical Sciences Institute Biophysical Sciences Institute Executive Board His lab investigates the molecular mechanisms underlying plant-pathogen interactions and stress tolerance. Key areas of research include: SUMOylation's role in signaling pathways related to immunity and environmental stress. Proteomic workflows to study SUMO-modified proteins (the SUMO ylome). Development of stress-resistant crops through understanding post-translational modifications. Recent work highlights SUMOylation's critical role in regulating plant growth, hormone responses, and defense against pathogens such as Fusarium wilt and Septoria tritici. His team collaborates widely, with publications in high-impact journals like Nature , Plant Cell , and New Phytologist . Professor Sadanandom supervises a dynamic research group comprising postdoctoral researchers and PhD students, including notable advisees like Charlotte Walsh, Gary Yates, and Jack Lee. His contributions span from fundamental molecular biology to applied plant science, aiming to enhance agricultural resilience through molecular insights.

• Post-translational modification
• Phosphorylation
• SUMOylation
• +۳ مورد دیگر

Dr. Prakash Bhagat serves as an Academic Visitor in the Department of Biosciences at Durham University. He collaborates extensively with Prof. Ari Sadanandom and has previously worked on the FRASS project alongside Dr. Elaine Fitches and FRASS Industries. He holds a PhD from the National Institute of Plant Genome Research, Jawaharlal Nehru University (JNU), New Delhi (2019), where he studied MAPK signaling in plant growth. His postgraduate research at the University of Lucknow focused on plant defense mechanisms involving peroxidases. His research interests center on post-translational modifications such as SUMOylation and phosphorylation, exploring their roles in plant responses to environmental stimuli. Key areas include epigenetic regulation, plant hormone biology (ABA and auxin), and biotechnological applications of molecular insights. Dr. Bhagat’s recent studies emphasize the interplay between SUMOylation and temperature sensing in plants, as well as light-mediated developmental pathways. His work bridges fundamental research and applied plant science, addressing challenges in crop resilience and growth regulation. Awards: Best Flash Talk award at International Symposium on Plant Photobiology 2024 Best Poster Award at Research Away Day 2024 His research has been supported through collaborative projects like the FRASS initiative. While his profile does not explicitly mention student advisement, his contributions to miRNA biogenesis and stress response studies reflect active engagement in molecular plant biology research. He is affiliated with Prof. Ari Sadanandom’s lab and has participated in interdisciplinary teams focusing on plant signaling mechanisms.

• Plant-Microbe Interactions
• Plant Pathology
• Genetic Diversity
• +۳ مورد دیگر

Dr. Srayan Ghosh is a Postdoctoral Research Associate in the Department of Biosciences at Durham University. His research focuses on plant-microbe interactions, particularly the genetic diversity of Rhizoctonia solani and Xanthomonas campestris pv. campestris. He explores post-translational modifications of defense proteins and their role in plant immune responses. His research interests include molecular mechanisms underlying plant pathogen interactions, with applications in sustainable agriculture. Key areas include SUMO modification systems, pathogen virulence factors, and host specificity. He has developed novel reporter systems and tools to study colonization mechanisms of plant pathogens. Recent publications (2023-2024) highlight his work on Rhizoctonia solani pathogenicity, methionine biosynthesis pathways, and the evolutionary dynamics of SUMO modification in plants. These studies contribute to understanding stress adaptation in crops and disease management strategies. No scientific awards or grants are explicitly mentioned in the provided text. He has no listed advisees or students.

• Plant Biology
• Molecular Biology
• Developmental Biology
• +۳ مورد دیگر

Dr. Dipan Roy is a Post Doctoral Research Associate in the Department of Biosciences. His research focuses on molecular mechanisms underlying plant development and stress adaptation, particularly through SUMOylation pathways. Current studies include evolutionary aspects of SUMO modification in plants and its role in phosphate starvation responses. Publications highlight contributions to understanding how SUMOylation regulates plant stress responses and development. No grants, awards, or lab affiliations are explicitly listed in the provided text.

Justin W. Walleyمشاهده پروفایل

استاد

• Plant Molecular Biology
• Proteomics
• Post-translational Modifications
• +۲ مورد دیگر

Justin W. Walley is a Professor at Iowa State University's Department of Plant Pathology and Microbiology, College of Agriculture and Life Sciences. His research investigates molecular mechanisms in plant growth and stress responses using mass spectrometry-based proteomics to quantify protein modifications. He integrates multi-omics data to study phosphorylation, ubiquitylation, and acetylation in plant systems. His team focuses on: Global proteome quantification in plants Post-translational modification networks Environmental response mechanisms Systems biology approaches to plant adaptation Recent NSF-funded collaborations explore transcription factor function and autophagy regulatory networks. Student Max received a USDA predoctoral fellowship under his mentorship.

Henning D. Mootzمشاهده پروفایل

استاد

• Protein Chemistry
• Biotechnology
• Nonribosomal Peptides
• +۵ مورد دیگر

Henning D. Mootz is a Professor of Biochemistry and Biotechnology at the Institute of Biochemistry, University of Münster. His research focuses on protein chemistry and biotechnology, particularly protein engineering using split inteins and studying posttranslational modifications like ubiquitination and SUMOylation. He has made significant contributions to understanding nonribosomal peptide synthetases and their dynamics, as well as developing tools for site-specific protein modification. Education: Ph.D. (1999) and postdoctoral training at the Philipps-University of Marburg and Rockefeller University. Awards include the Emmy Noether grant (2003) and teaching awards from the Universities of Münster and Dortmund. Research interests span protein engineering, enzyme mechanisms, and applications in biomedicine. His lab has pioneered methods like photoactivatable inteins for controlled protein splicing and light-activatable antibodies (Photobodies). Over 120+ publications highlight his work in Angewandte Chemie, Nature Chemistry, and other top journals.