جست‌وجوی استاد و پژوهشگر

Mekayla A Storerمشاهده پروفایل

پژوهشگر

• Developmental Biology
• Stem Cell Biology
• Regenerative Medicine
• +۴ مورد دیگر

Dr. Mekayla A Storer is a Group Leader at the Wellcome-MRC Cambridge Stem Cell Institute and an affiliate of the University of Cambridge's Physiology, Development and Neuroscience department. Her research focuses on the cellular and molecular mechanisms of blastema formation during mammalian digit tip regeneration, combining single-cell transcriptomics , genetic lineage tracing , and in vitro blastema cultures . Education : PhD from Centre for Genomic Regulation (Barcelona, Spain), supervised by Dr. Bill Keyes Postdoctoral Training : Drs. Freda Miller and David Kaplan at Hospital for Sick Children (Toronto, Canada) Her work explores how stem cells and senescence contribute to regeneration, with implications for therapies targeting broader tissue repair. Key publications include studies on blastema dynamics (2020), digit regeneration (2022), and a human embryonic limb cell atlas (2023). Laboratory Members : PhD Student: Jia Hua Wang Research Associates: Camille Dumas, Kentaro Hirose, Joseph Wong Biomedical Research Technician: Evelina Sliauteryte Postgraduate Student: Lauren Connolly

• Membrane Trafficking
• Organelle Biology
• Rare Genetic Diseases
• +۳ مورد دیگر

Dr David Gershlick is a Sir Henry Dale Fellow and Principal Investigator at the Cambridge Institute for Medical Research (CIMR), University of Cambridge, specializing in secretory pathway machinery within the Department of Clinical Biochemistry. His research investigates cellular compartmentalization mechanisms and their critical role in neurodegenerative disorders. His work centers on Membrane Trafficking , Organelle Biology , and Rare Genetic Diseases , examining how protein sorting defects cause Parkinson's and Alzheimer's diseases. Utilizing subcellular proteomics, single-molecule tracking, and genetic models, his lab explores vesicular trafficking, lysosomal dynamics, and adaptor complex functions across cancer, metabolic disorders, and neurodegeneration. Analysis of recent publications reveals dominant themes in Rab GTPase regulation, amyloid processing, and phase separation in secretory granule formation. His research bridges fundamental cell biology with translational insights into disease mechanisms, particularly highlighting trafficking defects in prostate cancer and leptin secretion deficiencies. Dr Gershlick holds the prestigious Sir Henry Dale Fellowship and receives major funding from the Wellcome Trust and Royal Society. Sir Henry Dale Fellowship He supervises PhD students and leads a research team including Eleanor Fox, Marie Pereira, Daniele Stalder, and Georgia Miller. His laboratory at CIMR leverages advanced microscopy and proteomics facilities to investigate membrane trafficking pathways, with consultancy services available for industry partnerships. Based at the Cambridge Institute for Medical Research, his group operates within CIMR's strategic themes of Membrane Trafficking and Organelle Biology, utilizing core facilities for flow cytometry, super-resolution microscopy, and structural biology to advance understanding of cellular organization in health and disease.

Amanda W. Lundمشاهده پروفایل

دانشیار

• Lymphatic Vessels
• Cutaneous Immunity
• Melanoma
• +۶ مورد دیگر

Amanda W. Lund is an Associate Professor at the NYU Grossman School of Medicine , holding dual appointments in the Ronald O. Perelman Department of Dermatology and Department of Pathology. She also serves as Director of the PhD Curriculum at the Vilcek Institute. Education : PhD from Rensselaer Polytechnic Institute Postdoctoral Training : Laboratory of Lymphatic and Cancer Bioengineering at Ecole Polytechnique Federale de Lausanne Dr. Lund's research focuses on the critical role of lymphatic vasculature in cutaneous and tumor immunity. Her work explores how lymphatic vessels regulate adaptive immune responses, influence tumor immune escape, and impact metastasis dynamics. Key methodologies include 3D imaging , single-cell transcriptomics , and cell-specific proteomics to study these interactions in vivo. Her recent publications highlight lymphatic vessel contributions to T-cell trafficking in melanoma, immune surveillance mechanisms, and strategies to enhance cancer immunotherapy by targeting lymphatic-immune interfaces. Research trends show a strong emphasis on translational approaches bridging lymphatic biology with clinical oncology challenges. Contact: Amanda.Lund@nyulangone.org | Lab: Lund Lab

Jing Huangمشاهده پروفایل

استاد

• Molecular Pharmacology
• Chemical Biology
• Drug Discovery
• +۶ مورد دیگر

Jing Huang is a Professor in the Department of Molecular and Medical Pharmacology at the University of California, Los Angeles (UCLA), where she conducts pioneering research at the intersection of molecular pharmacology, chemical biology, and drug discovery. Her work has significantly advanced understanding of autophagy mechanisms, metabolic pathways in cancer, and stem cell differentiation. Dr. Huang's primary research focuses on developing innovative drug target identification methods, most notably the Drug Affinity Responsive Target Stability (DARTS) technique. Her investigations span critical areas including mTOR signaling regulation, metabolite-driven cellular processes (particularly α-ketoglutarate and 2-hydroxyglutarate), autophagy-mediated tissue regeneration, and cancer metabolism. She has made seminal contributions to demonstrating how small molecules can stimulate hair growth through autophagy activation and has identified novel therapeutic approaches for triple-negative breast cancer and glioblastoma. Analysis of her publication record reveals a decade-long trajectory emphasizing metabolic rewiring in disease states, with consistent exploration of oncometabolites, energy metabolism pathways, and protein degradation systems. Her work bridges fundamental biochemistry with translational applications, particularly in targeting the ubiquitin-proteasome system and mTOR network for cancer therapy. As an active faculty member in UCLA's Graduate Programs in Bioscience, Dr. Huang mentors doctoral candidates and postdoctoral researchers. Her laboratory employs chemical genomics, proteomics, and high-throughput screening methodologies to investigate molecular disease mechanisms and identify novel therapeutic targets, with ongoing work focused on metabolic vulnerabilities in cancer and regenerative applications of autophagy modulation.

Ken Inokiمشاهده پروفایل

دانشیار

• mTOR signaling pathway
• Cellular growth regulation
• Signal transduction
• +۴ مورد دیگر

Ken Inoki is the Roger C. Wiggins Collegiate Professor of the Life Sciences and a Research Associate Professor at the University of Michigan Life Sciences Institute. He holds Associate Professor appointments in both the Division of Nephrology, Department of Internal Medicine and the Department of Molecular & Integrative Physiology at the U-M Medical School. His research focuses on the mechanistic target of rapamycin (mTOR) signaling pathway’s role in diabetes, aging, and cancer. Education : MD (1991) and PhD (1998) in Biochemistry & Molecular Biology from Shiga University of Medical Science, Japan Clinical background : 8 years as a physician in Nephrology at University Hospital, Japan Key affiliations : U-M Life Sciences Institute, Medical School, and Klatskin-Sutker Discovery Fund recipient Research Interests : Dr. Inoki investigates how the mTOR pathway coordinates nutrient and growth factor signals to regulate protein synthesis, lipid biogenesis, and cellular proliferation. His work bridges basic science and clinical applications , addressing pathologies in diabetic nephropathy, cancer, and age-related disorders through biochemical and genetic approaches . Scientific Awards : Koikai Award for Excellence in Basic Science (2004) Biological Sciences Scholar, University of Michigan (2008) Lab Members : Collaborates with multi-disciplinary teams at the Ken Inoki Lab (Room 6183A, Life Sciences Institute) on projects funded by the Klatskin-Sutker Discovery Fund, focusing on antiparasitic development and kidney disorder prevention .

Joshi J. Alumkalمشاهده پروفایل

استاد

• Prostate Cancer
• Transcriptional Regulation
• Epigenetics
• +۲ مورد دیگر

Joshi J. Alumkal, M.D., is a Professor at the University of Michigan Medical School, where he serves as Associate Division Chief for Basic Research in the Hematology-Oncology Division and Section Head of Genitourinary Medical Oncology. He directs the Alumkal Lab, focused on transcriptional regulation in lethal prostate cancer progression using biochemical, genomic, and epigenomic approaches. His work aims to develop novel therapies and clinical trials targeting treatment-resistant prostate cancer. Dr. Alumkal earned his B.A. in Biology from the University of Texas at Austin and M.D. from Baylor College of Medicine. He completed training at UT Southwestern Medical Center and Johns Hopkins University, where he also pursued post-doctoral work in cancer epigenetics. Research Focus: The lab investigates transcriptional reprogramming in prostate cancer, particularly mechanisms of therapy resistance and lineage plasticity. Key areas include epigenetic regulation (e.g., LSD1 and E2F1 roles), neuroendocrine differentiation, and tumor microenvironment interactions. Awards & Honors: Richard T. Jones New Investigator Award (2014) Wayne D. Kuni and Joan E. Kuni Endowed Chair (2017) Rogel Cancer Center Rogel Scholar (2019) Mentoring: Actively trains postdoctoral researchers, graduate students, and medical trainees. Alumni hold positions at institutions including Rush University, Genentech, and UCLA. Lab & Collaboration: Leads a multidisciplinary team at the Rogel Cancer Center and Michigan Center for Translational Pathology. Collaborates on projects like MiONCOMATCH to study treatment resistance mechanisms.

Sundeep Kalantryمشاهده پروفایل

دانشیار

• Epigenetic Regulation
• X-Chromosome Inactivation
• Gene Expression
• +۳ مورد دیگر

Sundeep Kalantry is an Associate Professor in the Department of Human Genetics at the University of Michigan Medical School. He is also the Associate Chair for Research and an active member of the Cellular and Molecular Biology Program, Cancer Center, and Center for Organogenesis. University of Michigan Medical School Department of Human Genetics His research focuses on epigenetic regulation through X-chromosome inactivation (XCI), using mouse models to study mechanisms like Xist RNA , chromatin modifications , and Polycomb group proteins . The lab investigates how long non-coding RNAs and novel methyltransferases contribute to transcriptional memory and gene silencing. Recent publications highlight work on KDM5C demethylase in XCI, quiescence in embryonic stem cells , and Xist RNA dynamics in early development. Key findings include the role of GSK3 inhibitors in XIST loss and the PRC2-independent function of EZH2 in rRNA methylation. Scientific accolades include the NIH Director's New Innovator Award , Ellison Medical Foundation New Scholar , and multiple University of Michigan collaborative grants. His lab welcomes students and researchers interested in epigenetic mechanisms in development and disease.

• Cancer Cachexia
• Metabolism and Cancer
• Adipose Tissue and Skeletal Muscle Physiology

Serkan Kır is an Assistant Professor in the Department of Molecular Biology and Genetics at Koç University, Turkey. His research focuses on the molecular mechanisms underlying cancer cachexia, muscle wasting, and metabolic dysregulation in tumor-host interactions. Education: PhD, UT Southwestern Medical Center (2011) Bachelor’s, Bilkent University (2006) His work investigates: Role of interleukin-6 family cytokines in muscle degradation EDA2R-NIK signaling in skeletal muscle pathophysiology Tumor-derived ligands regulating MEK activation Adipose tissue thermogenesis and fibroblast growth factors PTHrP and EGFR interactions in cachexia models Recent publications highlight advancements in targeting metabolic reprogramming and signaling pathways for cachexia therapies. Key article trends include cancer metabolism, muscle physiology, and cytokine-driven wasting mechanisms.

• Microglia
• Neuronal Circuits
• Neuropathological Disorders
• +۴ مورد دیگر

Sandra Siegert is a Professor in the Life Sciences Department at the Institute of Science and Technology Austria (ISTA). Her research focuses on understanding how microglia interact with neuronal networks in both healthy and diseased states, particularly in the context of neuropathological disorders. She integrates knowledge from virology, immunology, molecular biology, neuroscience, and applied mathematics to study microglia's role in brain maintenance and disease progression. Education Dr. phil. nat in Neurobiology from the University of Basel (2005-2010) Diploma in Biological Sciences from Goethe-Universität Frankfurt am Main (2000-2005) Research Interests Dr. Siegert's work emphasizes microglia's response to environmental cues, their epigenetic regulation, and their contribution to neurological disorders like schizophrenia and Alzheimer's disease. Key areas include: Microglia-neuron communication in retinal and cortical circuits Role of microRNAs (e.g., miR-137) in synaptic plasticity 60-Hz light entrainment effects on brain plasticity Applied topology for analyzing cellular networks Human iPSC-derived microglia modeling Publication Trends Her recent articles highlight interdisciplinary approaches to studying microglia in retinal organoids, mitochondrial dynamics in stress response, and chimeric GPCR tools for modulating neuroimmune activity. Collaborative work spans gene therapy vectors (AAV2/6), synaptic dysfunction in schizophrenia, and ketamine/light entrainment effects on perineuronal nets. Scientific Contributions EMBO short-term fellowship (2011) FWF Austrian Science Fund grant P 37131 (2023-2026) European Research Council grant 715571 (2017-2022) Human Frontiers Science Program grant (2012-2015) Multiple Swiss National Science Foundation grants (2011-2012)

Mairi Sandisonمشاهده پروفایل

مدرس ارشد

• Biomedical Engineering
• Microfluidics
• Tissue Engineering
• +۶ مورد دیگر

Dr. Mairi Sandison is a Senior Lecturer in Biomedical Engineering at the University of Strathclyde's Faculty of Engineering, United Kingdom. Her research focuses on advanced biomedical engineering applications with a particular emphasis on microfluidic systems , vascular tissue modeling , and cellular microarray technologies . She has developed innovative organ-on-a-chip models for studying uterine wall physiology and vascular aging, while also pioneering 3D-printed biomimetic microvasculature for ultrasound research. Her laboratory work has produced significant advancements in: Phenotypic heterogeneity analysis of vascular smooth muscle cells Microbubble acoustic backscattering measurement techniques Antimicrobial surface engineering using metal oxide-doped elastomers Cell preservation methods for single-cell analysis Biofilm formation dynamics in polymicrobial environments

• Cell Biology
• Metabolism
• Cancer Research
• +۴ مورد دیگر

Dr. Martin Houweling is an Assistant Professor in the Department of Biomolecular Health Sciences at Utrecht University's Faculty of Veterinary Medicine. His research focuses on cell biology, metabolism, and cancer, with particular emphasis on lipid metabolism in hepatic stellate cells and its implications for liver disease. His research interests span multiple interconnected domains of cellular metabolism and disease mechanisms. Dr. Houweling investigates lipid droplet dynamics in hepatic stellate cells during activation, examining how retinyl esters and triacylglycerols are metabolized during liver fibrosis progression. His work explores vitamin A metabolism and storage mechanisms, particularly the role of LRAT-independent pathways. He also studies parasite metabolism , notably in Schistosoma mansoni, revealing how these organisms utilize lipids for biosynthetic rather than energy purposes. His research employs advanced techniques including lipidomics , mass spectrometry , and 3D cell culture systems to understand cellular metabolic reprogramming. Dr. Houweling's publication record reveals a consistent focus on lipid metabolism and cell biology spanning several decades. His recent work (2023-2025) shows increasing application of his fundamental research to disease models, particularly liver fibrosis and metabolic disorders. He has made significant contributions to understanding the two-stage process of hepatic stellate cell activation and the formation of distinct lipid droplet populations. His work bridges basic science with potential clinical applications, as evidenced by his research on feline hepatic lipidosis treatment and hepatic progenitor cell proliferation. Dr. Houweling teaches courses related to biochemistry and metabolism, including 'Biochemistry: Metabolism in Health and Disease' and 'Veterinary Professional level 2 Metabolism and Regulation From cell to molecule.' His research has been supported by academic grants that enabled his extensive publication record spanning veterinary medicine, cell biology, and biochemistry. His laboratory work centers on hepatic stellate cell biology, employing advanced lipidomic approaches to understand metabolic reprogramming during liver disease progression. His team utilizes in vitro models including liver organoids to study metabolic diseases and potential therapeutic interventions.

• Functional Genomics
• Population Genetics
• Natural Selection
• +۴ مورد دیگر

Luis Barreiro is a Professor in the Department of Medicine-Genetic Medicine at the University of Chicago. His research focuses on understanding how natural selection has shaped human immune responses and how past evolutionary events influence present-day disease susceptibility through multidisciplinary approaches combining genomic, immunological, and evolutionary techniques. His educational background includes a Master's in Biotechnological Engineering from Lusófona University (2003), a PhD in Population Genetics from the University of Paris VII (2008), and postdoctoral training in Functional Genomics at the University of Chicago (2011). Dr. Barreiro's research program investigates the genetic basis of immune response variation among individuals and human populations, with particular emphasis on how natural selection has contributed to the evolution of our species. His lab combines cutting-edge genomic techniques with immunological and evolutionary genetic tools to study the phenotypic evolution of immune responses in primates, population variation in transcriptional responses to pathogens, and the mechanisms of innate immune memory. Recent work has examined how historical pandemics like the Black Death have shaped modern immune responses through natural selection. His publication record demonstrates a clear trajectory from foundational work in population genetics toward increasingly sophisticated integrations of multi-omics approaches to study gene-environment interactions in immune responses. Current research heavily focuses on trained immunity, epigenetic regulation of immune responses, and host-pathogen coevolution, with significant contributions to understanding how past selection events impact present-day disease susceptibility. Dr. Barreiro currently serves as Principal Investigator on multiple NIH-funded research projects, including R01AI190301 (2025-2030) on "Unraveling the molecular mechanisms of innate immune memory in humans," R01AI182148 (2025-2029) on "iPSC-derived macrophages as a model to study the genetic basis of inter-individual variation in immune responses to pathogens," and R35GM152227 (2024-2029) on "Characterizing the genetic and evolutionary determinants of population variation in transcriptional responses to pathogens." He leads the Barreiro Lab, which maintains strong collaborations across multiple institutions and disciplines, reflecting the integrative nature of his research program that bridges evolutionary biology, immunology, and genomics to address fundamental questions about human health and disease susceptibility.

• Foreign Languages
• Chinese Language
• Cancer Biology
• +۲ مورد دیگر

Jianru Yang is an Adjunct Assistant Professor in the Department of Foreign Language at Virginia Commonwealth University, specializing in Chinese language instruction. This role involves teaching within the College of Humanities and Sciences framework, though the specific school affiliation is not detailed in the source text. Professor Yang's academic profile reflects dual expertise: (1) Foreign language education with a focus on Chinese linguistics and pedagogy, and (2) Cutting-edge biomedical research in cancer biology and immunology. Their interdisciplinary research explores: Molecular mechanisms of cancer progression (e.g., MDA-9/Syntenin signaling, tumor microenvironment) Immunotherapeutic strategies (vaccine development, immune checkpoint modulation) Metabolic reprogramming in disease (fatty acid oxidation, sphingolipid pathways) Inflammation regulation (NLRP3 inflammasome, scavenger receptors) Analysis of 15 recent publications (2022-2024) reveals consistent focus on translational oncology, with themes spanning cancer immunotherapy development, metastasis biology, immune cell dysfunction, and therapeutic target validation across multiple cancer types (lung, prostate, melanoma, breast). Research methodologies frequently integrate molecular biology, preclinical models, and immunometabolism.

• Genetics
• Plant Biology
• Root Development
• +۳ مورد دیگر

Jose Manuel Pérez Pérez is a Professor in the Department of Applied Biology at the Miguel Hernández University of Elche , where he directs the Genetics of Plant Regeneration and Reproductive Development research group. His work focuses on plant genetics and developmental biology, particularly the molecular mechanisms underlying root system architecture and adventitious root formation. Primary Research Areas: Genetics, Plant Molecular Biotechnology, Root Development, Epigenetics, Stress Response Recent Trends: Hormonal signaling (auxin, ABA, ethylene), transcriptional networks in plant regeneration, epigenetic regulation of root formation, stress-induced architectural adaptations The Institute of Bioengineering hosts his laboratory, where he investigates molecular responses to abiotic stress, chromatin dynamics in root meristems, and hormone-metabolic interactions. Key methodologies include transcriptomics, molecular docking, and in vitro propagation systems.

• Cancer Nanomedicine
• Molecular Imaging
• Nano-Immunotherapy
• +۳ مورد دیگر

Dr. Alexandros Marios Sofias is head of the "Immune Cell Targeting and Imaging" Research Group at the Institute for Experimental Molecular Imaging (ExMI) of RWTH Aachen University, Germany, and Co-Chair of the Image-Guided Drug Delivery (IGDD) Study Group of the European Society for Molecular Imaging (ESMI). Education: PhD in Nanomedicine (2019) MSc in Pharmaceutical Sciences (2016) Diploma in Pharmacy (2014) Research Focus: His laboratory integrates in vivo multimodal imaging with advanced nanomedicine design to decode the fate of therapeutic nanoparticles and to develop nano-immunotherapeutics that reprogram the tumor immune microenvironment. Core themes include: Real-time tracking of nanoparticle biodistribution via intravital microscopy and PET/MRI. Leveraging immune cells (neutrophils, macrophages) as active carriers (“hitchhiking”) to enhance tumor targeting. Engineering 3-D vascularized tumor models for preclinical validation. Translational development of core-crosslinked polymeric micelles and lipid nanoparticles for image-guided drug delivery. Publication Trends: Across >25 high-impact papers since 2020, Sofias has consistently advanced the intersection of nanomedicine, molecular imaging, and cancer immunotherapy. His work has progressively shifted from passive EPR-based targeting to active immune-cell-mediated delivery, emphasizing real-time imaging feedback to optimize therapy. Grants & Collaborations: Although specific grant numbers are not listed, the extensive co-authorship network with Kiessling, Lammers, Storm, Mulder and others indicates substantial national (DFG, BMBF) and European (ERC, Horizon Europe) funding streams. The team participates in large consortia such as the ESMI IGDD study group. Labs & Teams: He leads the “Immune Cell Targeting and Imaging” group housed within the state-of-the-art ExMI building at RWTH Aachen, equipped with preclinical PET/MRI, high-resolution intravital microscopy, nanoformulation suites, and 3-D bioprinting facilities.