جست‌وجوی استاد و پژوهشگر

Maureen E. Murphyمشاهده پروفایل

استاد

• Cancer genetics
• p53 tumor suppressor protein
• Genetic variants in ethnic populations
• +۳ مورد دیگر

Maureen E. Murphy, Ph.D. serves as Deputy Director of the Ellen and Ronald Caplan Cancer Center and Ira Brind Professor at The Wistar Institute, where she also leads the Molecular and Cellular Oncogenesis Program and holds the position of Associate Vice President for Faculty Affairs. Additionally, she maintains adjunct professor appointments at Drexel University College of Medicine and The Perelman School of Medicine at the University of Pennsylvania. Dr. Murphy's research program centers on the genetics of the p53 tumor suppressor protein, with particular focus on genetic variants prevalent in populations of African-descent (P47S and Y107H) and Ashkenazi Jewish descent (G334R). Her laboratory investigates how these variants impact cancer risk and therapy efficacy, aiming to develop personalized medicine approaches for affected populations. She also conducts significant research on the cancer-survival protein HSP70, developing novel inhibitors for melanoma and colorectal cancer therapy. Her work has direct clinical relevance for improving cancer prognosis and treatment outcomes for African and Ashkenazi Jewish Americans. Dr. Murphy's publications reveal a research trajectory focused on understanding the functional consequences of p53 variants, identifying predictive gene signatures for cancer risk assessment, exploring connections between p53 and cell death mechanisms like ferroptosis, and developing targeted cancer therapies. Her recent work demonstrates increasing sophistication in connecting genetic variants to specific therapeutic approaches, with significant emphasis on addressing health disparities in cancer treatment. 2024 Woman of Influence (The Philadelphia Business Journal) Dr. Murphy mentors several predocotoral fellows including Kaitlyn Casey, Maya Foster, Giulia Pantella, Kelsey Salcido, and Andrea Valdespino. Her laboratory collaborates with the Salvino laboratory at Wistar to develop HSP70 inhibitors for clinical application and works with computational biologists like Andrew Kossenkov to apply machine learning approaches to cancer risk prediction. Her research is supported by NIH grants CA102184 and CA238611, with additional funding for trainees through T32 fellowships and Wistar Accelerator Postdoctoral Awards.

• Hematology
• Oncology
• Sickle Cell Disease
• +۳ مورد دیگر

Siayareh Rambally, M.D., serves as an Associate Professor in the Department of Internal Medicine at UT Southwestern Medical Center, specializing in non-malignant blood disorders within the Division of Hematology/Oncology. Her clinical expertise focuses on complex hematologic conditions requiring multidisciplinary management. Her educational journey includes a bachelor's degree in biochemistry from Southern Methodist University, an M.D. from UT Southwestern Medical Center, internal medicine residency at Baylor College of Medicine, and hematology/oncology fellowship training at the same institution. Board-certified by the American Board of Internal Medicine in hematology and oncology, she joined the faculty in 2013. Dr. Rambally's research centers on sickle cell disease and bleeding disorders, with significant contributions to understanding thrombotic thrombocytopenic purpura mechanisms and coagulation abnormalities. Her work integrates clinical observations with laboratory investigations to develop novel therapeutic approaches for refractory hematologic conditions, emphasizing patient-specific treatment strategies. Analysis of her 13 publications (2007-2021) reveals consistent focus on thrombotic microangiopathies, coagulation testing methodologies, and genetic erythrocytosis. Key trends include innovative applications of immunomodulatory agents (rituximab, infliximab) for refractory cases, diagnostic algorithms for bleeding disorders, and molecular mechanisms underlying rare coagulation factor deficiencies. Her professional recognition includes: Eugene P. Frenkel Teaching Award (2020) for excellence in medical education Dr. Rambally actively mentors medical students, residents, and fellows while serving on the Anticoagulation Safety Workgroup at Parkland Memorial Hospital. She maintains active membership in the Texas Medical Association and American Society of Hematology, contributing to national hematology guidelines and educational initiatives. Her clinical practice integrates with research through participation in institutional committees focused on anticoagulation safety protocols and multidisciplinary tumor boards addressing complex hematologic cases.

Laurence BLANCHARDمشاهده پروفایل

استاد پژوهشی

• Structural biochemistry
• Molecular microbiology
• Gene expression regulation
• +۳ مورد دیگر

Laurence BLANCHARD serves as Deputy Team Leader and CNRS Research Director (Directrice de Recherche) at the Biosciences and Biotechnology Institute of Aix-Marseille (BIAM - UMR 7265), part of CEA Cadarache/City of Energy in Saint-Paul-lez-Durance, France. She leads research within the MEM Team (Mécanismes Moléculaires et Physiopathologie de la Radio-Résistance) focusing on molecular mechanisms of radiation resistance. Her educational background includes a Doctorate in Biochemistry and Cell Biology from the Institute of Microbiology of the Mediterranean (IMM, CNRS) in Marseille (1994) and a Habilitation to Supervise Research (HDR) from Joseph Fourier University in Grenoble (2006). BLANCHARD's research expertise spans structural biochemistry, molecular microbiology, gene expression regulation mechanisms, and repair of damaged proteins after oxidative stress. Her work particularly investigates how radiation-resistant bacteria like Deinococcus radiodurans survive extreme conditions through specialized DNA repair pathways and stress response systems. She has published extensively on redox signaling, zinc activation in radiation response, and SOS-independent DNA repair regulation. Her recent publications reveal a strong focus on bacterial radiation resistance mechanisms, with particular attention to oxidative stress response proteins, DNA repair gene regulation, and the molecular basis of extreme radioresistance in Deinococcus species. The research demonstrates sophisticated understanding of how these organisms maintain genomic integrity despite massive DNA damage. BLANCHARD has held research positions at the Institute of Structural Biology in Grenoble (1998-2006) and completed postdoctoral research at the University of Sheffield, UK (1994-1997). Her current work continues to advance understanding of molecular mechanisms that enable life to survive in extreme environments.

• Protein Oxidation
• Biochemical Reactions in Crowded Environments
• Protein Glycation
• +۳ مورد دیگر

Eduardo Fuentes Lemus serves as a Guest Researcher in the Department of Biomedical Sciences at the University of Copenhagen's Faculty of Health and Medical Sciences. He joined the Protein Oxidation group (IMOX section) in August 2020 through a prestigious Marie Skłodowska-Curie Actions Individual Fellowship (CASMOX project, number 890681). His research investigates protein oxidation mechanisms in biologically relevant crowded environments, with particular emphasis on dairy protein systems and their nutritional implications. Dr. Fuentes Lemus specializes in understanding how hydrophilic microdomains, membraneless compartmentalization, and altered viscosities modulate radical-mediated and photo-oxidation pathways of proteins. Using experimental models like casein micelles and crowded solutions, he employs advanced techniques including mass spectrometry, fluorescence spectroscopy, and electron microscopy. His work reveals critical insights into how concentrated protein environments exacerbate oxidative damage, directly impacting food quality assessment in dairy processing. Analysis of his 31 research outputs shows consistent focus on redox biology and protein chemistry, with significant contributions to understanding casein oxidation pathways. Key findings demonstrate that crowded conditions enhance radical chain reactions in milk proteins, leading to essential amino acid loss and aggregate formation—findings with direct applications for the $6 billion dairy industry. Scientific awards: Marie Skłodowska-Curie Actions Individual Fellowship (Horizon 2020, project 890681) His CASMOX project secured substantial EU grant funding to investigate oxidative modifications in casein micelles, generating industry-relevant methodologies for quality assessment. This research has established long-lived biomarkers for monitoring nutritional value in dairy products and fostered collaborations across international research teams. Dr. Fuentes Lemus operates within the Protein Oxidation research group of the Inflammation, Metabolism and Oxidation (IMOX) section, contributing to a multidisciplinary team that examines oxidative processes in biological systems using state-of-the-art biochemical and biophysical approaches.

• RNA Biology
• Molecular Biology
• Redox Signaling
• +۲ مورد دیگر

Nanna Bach Poulsen is a Researcher at the Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, affiliated with the Transcription, RNA, and Gene Medicine Program. Her research focuses on RNA biology, molecular mechanisms of redox signaling, and gene medicine. She investigates the roles of $$ ext{NOX}2$$ and $$ ext{SOD}3$$ in macrophage trafficking and redox signaling, bridging immunology and cell biology to understand immune cell regulation and therapeutic applications. Her recent publication in Antioxidants (2021) reviews converging pathways of $$ ext{NOX}2$$ and $$ ext{SOD}3$$ in macrophage redox signaling, highlighting emerging trends in redox biology and immunology with implications for oxidative stress-related diseases. She contributes to the Transcription, RNA, and Gene Medicine Program, which advances RNA-based therapeutic strategies and gene medicine research through interdisciplinary collaboration.

• Mycobacterium tuberculosis
• Bacterial Metabolism
• Antibiotic Resistance
• +۳ مورد دیگر

Luiz Pedro Sorio de Carvalho is a Professor at the University of Florida, leading the Carvalho Lab at the Scripps Research campus in Jupiter, Florida. His research focuses on mycobacterial pathogenesis and metabolism, with emphasis on Mycobacterium tuberculosis adaptation to human hosts and novel therapeutic strategies against antibiotic-resistant infections. His educational background includes a Ph.D. in Biochemistry from Albert Einstein College of Medicine (2006), an M.Sc. in Cell and Molecular Biology from Federal University of Rio Grande do Sul (2001), and a Pharmacy Degree from the same institution (1999). Ph.D. Biochemistry, Albert Einstein College of Medicine (2006) M.Sc. Cell and Molecular Biology, Federal University of Rio Grande do Sul (2001) Pharmacy Degree, Federal University of Rio Grande do Sul (1999) Carvalho's research centers on evolutionary adaptation of soil-dwelling mycobacteria to human pathogens, with key contributions in mycobacterial metabolism , antibiotic resistance mechanisms , and drug discovery . His group pioneered the discovery of target-mediated antibiotic inactivation, mapped nitrogen metabolism in M. tuberculosis , and identified itaconate catabolism pathways critical for virulence. Current work leverages chemical biology approaches to develop novel small-molecule therapeutics against tuberculosis. His 15 most recent publications demonstrate consistent focus on metabolic vulnerabilities in mycobacteria, with recurring themes in itaconate dissimilation , amino acid metabolism , enzyme inhibition mechanisms , and structural characterization of drug targets . Key trends include elucidating metabolic pathways for host adaptation and developing innovative screening strategies for antitubercular compounds. Notable scientific awards include: ACS Infectious Diseases/Biological Chemistry Division Young Investigator Award (2021) American Chemical Society Horizon Award (2021) Royal Society of Chemistry Irving S. Sigal Memorial Award (2014) American Society for Microbiology New Investigator Award (2014) Wellcome Trust MRC Centenary Early Career Award (2012) Carvalho currently holds NIH/NIGMS funding (Apr 2023–Apr 2025) for Probing SNARE assembly and disassembly in vitro and live cells . His Carvalho Lab operates at the intersection of chemical biology and infectious disease research, with emphasis on translating metabolic insights into therapeutic interventions for tuberculosis and related mycobacterial diseases.

Stanislav Koprivaمشاهده پروفایل

استاد

• Plant Nutrition
• Sulfur Metabolism
• Mineral Nutrition
• +۵ مورد دیگر

Professor Stanislav Kopriva leads a research group at the Institute for Plant Sciences, University of Cologne, where he serves as a faculty member and contributes significantly to the Cluster of Excellence on Plant Sciences (CEPLAS). As speaker of the Competence Area 'Food Security,' he actively works to embed CEPLAS research within broader societal contexts and promote knowledge transfer to countries in the Global South. His research group is firmly established within the university's infrastructure at Zülpicher Str. 47b in Cologne, Germany, with contact information readily available for collaboration. Professor Kopriva's research focuses on three interconnected areas: molecular mechanisms of sulfur homeostasis and its integration with general plant metabolism; alterations in mineral nutrition between C3 and C4 plants; and metabolic signals in plant-microbe interactions that contribute to plant nutrition. His group employs biochemical, genetic, and physiological approaches while exploiting natural variation to understand how plants integrate mineral nutrient uptake with environmental demands. This work has significant implications for improving nutrient use efficiency in crop plants and addressing food security challenges. The publication record shows a clear trajectory of research focusing on sulfur metabolism, plant nutrition, and plant-microbe interactions. Recent work increasingly examines the role of secondary metabolites in shaping root microbiomes, the molecular mechanisms of sulfur homeostasis across evolutionary time, and adaptations in nutrient metabolism under changing environmental conditions. The research spans model organisms like Arabidopsis thaliana to crop species, with growing emphasis on translating basic findings to agricultural applications, particularly regarding C4 crops and food security under climate change. Professor Kopriva actively collaborates with researchers across Europe and maintains a productive research program with numerous publications in high-impact journals. His group participates in multiple collaborative projects through CEPLAS and maintains connections with international research networks focused on plant nutrition and metabolism. While specific grant details aren't provided in the source material, his ongoing publication record and institutional affiliations indicate sustained research funding supporting his laboratory's activities. The research group operates within the Institute for Plant Sciences at the University of Cologne, contributing to CEPLAS research areas 1 and 2. They utilize various facilities including the Plant Metabolism and Metabolomics Facility and Imaging Platform mentioned in the CEPLAS infrastructure. The group's work integrates experimental approaches with computational modeling to understand complex plant-microbe-nutrient interactions, positioning them at the forefront of plant systems biology research.

Matias Zurbriggenمشاهده پروفایل

استاد پژوهشی

• Synthetic Biology
• Optogenetics
• Plant Biology
• +۵ مورد دیگر

Matias Zurbriggen is a Research Professor at the Institute of Synthetic Biology, Heinrich Heine University Düsseldorf, where he leads a pioneering research group at the interface of engineering and life sciences. His work focuses on developing theoretical-experimental synthetic biology approaches to understand and control eukaryotic signaling processes with quantitative and spatiotemporal precision. Dr. Zurbriggen's research interests center on synthetic biology principles applied to biological signaling systems, with particular emphasis on optogenetics. He pioneered cellular optogenetics - engineering synthetic photoswitches to control molecular processes with high precision, minimal toxicity, and non-invasive methods. His group has successfully overcome the fundamental challenge of implementing optogenetics in plants, which normally require light for growth, opening new possibilities for plant engineering. His research spans microbial, yeast, mammalian, and plant systems, with applications in tissue engineering, biomedical research, and crop improvement. His recent publications demonstrate significant advances in optogenetic tools, including genetically-stable optogenetic switches for 3D tissue cultures, image-guided optogenetic patterning, and specialized biosensors for plant hormones. These innovations enable precise spatiotemporal control of cellular processes using light of different colors, with applications spanning from fundamental biological research to practical agricultural improvements. Selected by Nature Methods as one of the top methods of 2023 Dr. Zurbriggen's research program integrates synthetic biology with advanced imaging and computational approaches to reconstruct semisynthetic signaling and metabolic networks. His group performs de novo engineering of genetic circuits, biosensors, and synthetic metabolic pathways, including intracellular and cell-cell communication systems. The work has significant implications for understanding developmental processes, metabolic regulation, and creating novel biotechnological applications in medicine and agriculture.

• Vascular Biology
• Angiogenesis
• Cardiovascular Research
• +۳ مورد دیگر

Emma Ristori is an Associate Research Scientist in Cardiovascular Medicine at Yale University School of Medicine. She holds a PhD in Biochemistry and Molecular Biology from the University of Siena (2021), an MSc in Behavioral Biology from the University of Florence (2011), and a BSc in Biology (2008). Her research focuses on vascular biology, angiogenesis, mitochondrial dysfunction, and developmental biology in disease contexts. Research interests include mechanisms of vascular permeability regulation, neurovascular interactions, and mitochondrial stress responses in oocytes and somatic cells. She has contributed to studies on Syndecan-2’s role in VEGF signaling, PPIL4’s essentiality in brain angiogenesis, and Akt’s role in artery specification using zebrafish models. Her work bridges molecular mechanisms and translational applications in cardiovascular and neurodegenerative diseases. Key contributions include identifying novel therapeutic targets for aneurysms and developing CRISPR-based tools for miRNA research. Collaborations span interdisciplinary teams at Yale and international institutions, emphasizing vascular biology, cancer angiogenesis, and mitochondrial pathophysiology.

• Structural Biology
• Biophysics
• Membrane Proteins
• +۳ مورد دیگر

Robert Bosman is a Professor affiliated with the University of Hamburg's Medical Faculty, Department of Structural Biology. His research focuses on elucidating molecular mechanisms of membrane proteins and light-driven processes using advanced structural biology techniques such as X-ray crystallography, XFEL-based methods, and time-resolved spectroscopy. Key areas of interest include protein dynamics, photoactive proteins (e.g., rhodopsins, phytochromes), and enzymatic catalysis in metalloproteins. Affiliation: University of Hamburg Medical Faculty Key Techniques: Serial femtosecond crystallography (SFX), synchotron/XFEL applications, time-resolved studies Highlighted Research: Structural basis of sensory rhodopsin photocycles, dynamics of cytochrome c oxidase, photosynthetic reaction centers, and phytochrome photoactivation

Brian Smithمشاهده پروفایل

دانشیار

• Epigenetics
• Bromodomain Proteins
• Sirtuins
• +۵ مورد دیگر

Dr. Brian Smith is an Associate Professor in the Department of Biochemistry at the Medical College of Wisconsin (MCW) and serves as Associate Director of the Program in Chemical Biology and the Structural Genomics Unit at the Mellowes Center for Genomic Sciences and Precision Medicine. He holds a PhD from the University of Wisconsin-Madison and a BS from the University of Illinois at Urbana-Champaign. His research focuses on epigenetic signaling pathways, particularly the roles of bromodomain and sirtuin proteins in inflammation-related diseases such as diabetes, cancer, and heart disease. Dr. Smith has led groundbreaking work in developing chemical probes and inhibitors targeting BET bromodomains and sirtuins. His lab employs techniques including NMR spectroscopy, X-ray crystallography, and cellular assays. Key achievements include identifying novel epigenetic readers of histone modifications and demonstrating the therapeutic potential of bromodomain inhibitors in autoimmune diabetes. Dr. Smith has received notable awards, including NIH R35 and R01 grants, and MCW's Outstanding Faculty Service and Educator awards. His lab has trained numerous graduate students and postdocs, fostering a collaborative environment. Current research emphasizes translating epigenetic discoveries into therapies for metabolic and inflammatory diseases. Notable grants include a $1.95 million NIH R35 grant for studying tandem bromodomain selectivity and a $1.56 million NIH R01 grant targeting bromodomain inhibition in β-cells. His work bridges basic science and clinical applications, with ongoing projects in drug discovery and epigenetic mechanism elucidation.

Sabine Zachgoمشاهده پروفایل

استاد

• Molecular Developmental Genetics
• Redox Processes in Plant Development
• Evolutionary Adaptations
• +۳ مورد دیگر

Prof. Dr. Sabine Zachgo is a Professor and Director of the Botanical Garden at the University of Osnabrück, leading the Division of Botany. Her research focuses on molecular mechanisms driving plant diversity, particularly the genetic regulation of plant development and adaptation. She uses model organisms like Arabidopsis thaliana , Marchantia polymorpha , and Riccia fluitans to study redox processes in developmental pathways and evolutionary transitions. Key areas include transcription factor networks, stress responses, and the evolution of terrestrial plant life. Her work integrates genetics, biochemistry, and advanced microscopy techniques such as superresolution imaging and FRET-FLIM. She has contributed to landmark studies on liverwort genomics and the Chara genome, advancing understanding of plant terrestrialization. As Botanical Garden director, she oversees conservation initiatives and public engagement in plant science. Publications highlight her expertise in developmental genetics, redox signaling, and evolutionary biology. Current projects explore developmental plasticity in amphibious liverworts and the role of redox regulation in adaptation. She collaborates internationally and mentors early-stage researchers, welcoming BSc/MSc students and PhD candidates.

• Molecular Immunology
• Antigen Presentation
• T Cell Activation
• +۴ مورد دیگر

Lawrence Stern is a Professor of Pathology at UMass Chan Medical School and holds academic positions across multiple departments within T.H. Chan School of Medicine and Morningside Graduate School of Biomedical Sciences, including Biochemistry and Molecular Biotechnology, Immunology, and Translational Science. He earned his B.A. in Chemistry from Cornell University (1983) and Ph.D. in Biochemistry from MIT (1989), followed by postdoctoral training at Harvard and MIT. His research focuses on molecular mechanisms of immune recognition, particularly antigen presentation by MHC proteins and T cell activation signaling. Key research areas include: Structural biology of MHC-peptide complexes and their role in T cell activation Antigen presentation pathways in dendritic cells and microglia Role of MHC class II-associated proteins (HLA-DM, HLA-DO) in peptide editing Development of MHC oligomer reagents for T cell detection in infectious diseases Mechanisms of TCR clustering-induced signaling via cytoplasmic domain conformational changes Immunopeptidome analysis in viral infections and autoimmune disorders Recent work highlights discoveries about extracellular antigen presentation pathways, conformational dynamics of MHC proteins, and allosteric regulation of aminopeptidases critical for antigen processing. Current research combines structural, biochemical, and cellular approaches to unravel fundamental immunological processes with implications for vaccine design and immune therapies. Laboratory affiliation: Stern Lab focuses on structural immunology and translational research in antigen presentation mechanisms. Collaborations span virology, cancer immunology, and autoimmune disease modeling.

• Exercise Physiology
• Sports Nutrition
• Human Performance
• +۴ مورد دیگر

Dr Stephen Bailey is a Professor in Human and Exercise Physiology at the School of Sport, Exercise and Health Sciences, Loughborough University. He holds a PhD in Exercise Physiology from the University of Exeter and has been affiliated with Loughborough since 2016. His research focuses on exercise physiology, sports nutrition, and health-related performance, with a particular interest in dietary supplements like nitrate and their effects on athletic performance and physiological responses. Education Background: BSc in Sport and Exercise Science (2006), University of Wales Institute Cardiff MSc in Sport and Exercise Science (2008), University of Wales Institute Cardiff PhD in Exercise Physiology (2011), University of Exeter Research interests span sports nutrition, thermoregulation, oxidative stress, and the impact of dietary interventions on exercise performance. His work often examines gender differences in physiological responses, elite athlete physiology, and the efficacy of supplements such as tetraselmis chuii and cannabidiol. Scientific Awards: Fellow of the Higher Education Academy (FHEA) Advising and grants: No formal advising details are provided in the text, though his extensive publication record suggests active involvement in research projects and collaborations.

Andrew Pieperمشاهده پروفایل

استاد

• Neuroscience
• Neurodegenerative Diseases
• Neuroprotection
• +۴ مورد دیگر

Dr. Andrew Pieper is a Professor and Morley Mather Chair in Neuropsychiatry at Case Western Reserve University's Department of Psychiatry, affiliated with University Hospitals Cleveland Medical Center and the Louis Stokes Cleveland VA Medical Center. He leads the Center for Brain Health Medicines at the Harrington Discovery Institute. His research focuses on neurodegeneration, neuropsychiatric disorders, and developing neuroprotective therapies for conditions like Alzheimer's disease and traumatic brain injury (TBI). Dr. Pieper earned his MD and PhD in Neuroscience from Johns Hopkins University, followed by residency and internship there. His lab investigates translational strategies to combat neurodegeneration, emphasizing tauopathy, mitochondrial dysfunction, and neuroinflammation. Key achievements include the Staglin Family Rising Star Research Award and election to the American Society for Clinical Investigation. His recent work explores AI-driven drug discovery, P7C3 compounds for TBI, and neuroprotective mechanisms like biliverdin reductase and hydrogen sulfide signaling. Lab members include graduate students (e.g., Emiko Miller, Preethy Sridharan) and postdoctoral fellows (e.g., Kalyani Chaubey), focusing on projects like cystic fibrosis-related neurodegeneration and Alzheimer's pathophysiology. Collaborations extend to network medicine and endophenotype-based therapeutic discovery.