جستجوی استاد راهنمای دانشگاهی

Sagiv Shifmanمشاهده پروفایل

استاد

• Genetics of Neurodevelopmental Disorders
• Autism Spectrum Disorders
• Schizophrenia Genetics
• +۷ مورد دیگر

Prof. Sagiv Shifman is a Full Professor at the Department of Genetics , Alexander Silberman Institute of Life Sciences , The Hebrew University of Jerusalem . His research focuses on the genetics of neurodevelopmental and psychiatric disorders , particularly autism spectrum disorders and schizophrenia , utilizing genomic data analysis , mouse models , and CRISPR screening to uncover chromatin regulators , gene expression variation , and sex-specific genetic mechanisms . Academic Leadership : Served as department head (2017-2021), previously leading genetics teaching programs. Research Themes : Mapping genetic variants in brain disorders via computational/experimental methods. Studying gene networks and chromatin regulation in neurodevelopment. Investigating essential genes in stem cells and cancer via CRISPR libraries . Elucidating sex chromosome influences on gene essentiality and disease. Scientific Contributions : 2013 Krill Prize recipient for excellence in Life Sciences. Key discoveries in POGZ deficiency , AUTS2 isoforms , and ASD/Schizophrenia gene overlap . Collaborative Impact : Advancing neurogenetic databases and CRISPR-based disease modeling . Developing tools like ImReP and ROP for immunoglobulin repertoire analysis and RNA-seq read origin detection .

Jing Wangمشاهده پروفایل

استادیار

• Retinal Neurovascular Biology
• Immune-Neuron-Vascular Interaction
• Ischemic Retinopathies
• +۵ مورد دیگر

Jing Wang is an Assistant Professor at the Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University. She serves as Module 1 Director for the P30 Vision Research Core at the James and Jean Culver Vision Discovery Institute. Her research focuses on retinal neurovascular biology, particularly the mechanisms of immune-neuron-vascular interactions in disorders like retinopathy of prematurity (ROP) and age-related macular degeneration (AMD). She investigates Sigma 1 receptor (Sig1R) and its role in retinal vascular development and neuroprotection. Education: PhD: China Agricultural University, Beijing, China, 2004 Post-doc: Retinal Biology, Augusta University, 2013-2015 Post-doc: Molecular Biology, Peking University, 2004-2006 Her research targets novel strategies to create favorable retinal environments for vascular repair and revascularization. Current projects explore Sig1R's role in modulating NRF2 signaling for retinal protection, with translational potential for ROP therapies. She has secured NIH/NEI R01 funding (2023-2028) as Principal Investigator for Sigma 1 receptor-based ROP therapy and collaborates on a P30 Center Core Grant (2020-2025) as Module 1 Director. Scientific Awards: 2023 Travel Award - Harvard AMD Symposium 2020 Career Starter Grant - Knights Templar Eye Foundation Multiple ARVO Distinctions (2017,2015) Various National Natural Science Foundation of China Grants 2008 Marie Curie Scholarship

• Plant Physiology
• Plant Cell Biology
• Plant Development
• +۴ مورد دیگر

Markus Grebe serves as Professor and Head of the Department of Plant Physiology at the Institute of Biochemistry and Biology, University of Potsdam, where he leads a research group investigating fundamental mechanisms of plant cell polarity and development. His laboratory, located in building 20, room 0.08, focuses on molecular processes governing root morphogenesis and cellular organization in Arabidopsis thaliana. Research priorities include: Establishment of planar and tissue polarity in root systems Auxin signaling networks and polarized transport mechanisms Lipid domain organization and membrane dynamics ROP GTPase-mediated cytoskeletal regulation Cell plate assembly during cytokinesis Protein trafficking in polarized growth contexts Analysis of recent publications reveals consistent emphasis on integrating advanced imaging with genetic approaches to dissect how lipid microdomains, cytoskeletal elements, and signaling pathways coordinate to establish cellular asymmetry. The group has pioneered methodologies for visualizing membrane order and protein dynamics during root hair initiation and cell division. Professor Grebe has mentored fifteen graduate students to completion, including nine PhD candidates and four Master's students, while currently supervising two doctoral researchers. His laboratory utilizes state-of-the-art infrastructure including LSM 880 Airyscan microscopy for high-resolution live imaging of developmental processes.

Mads Eggert Nielsenمشاهده پروفایل

پژوهشگر

• Plant Cell Biology
• Plant Immunity
• Vesicle Trafficking
• +۵ مورد دیگر

Mads Eggert Nielsen serves as a Special Consultant in the Department of Plant and Environmental Sciences at the University of Copenhagen's Faculty of Science, specifically within the Section for Plant and Soil Sciences. His research focuses on fundamental cellular processes in plants, particularly those related to defense mechanisms against pathogens. Dr. Nielsen's research interests center on plant cell biology with emphasis on vesicle trafficking pathways, membrane dynamics, and cell wall modifications during plant-pathogen interactions. His work investigates how plants deploy cellular machinery like syntaxins (particularly PEN1 and SYP12 clade proteins) to mount defense responses through papillae formation and other cell wall modifications. He examines the molecular mechanisms of exocytosis in plant defense, including the roles of formins, ROP guanine exchange factors, and secretion regulators in maintaining cell wall integrity during pathogen attacks. Analysis of his recent publications reveals consistent focus on plant immunity mechanisms, particularly how vesicle trafficking pathways contribute to defense-related cell wall modifications. His research spans from molecular studies of specific proteins like MONENSIN SENSITIVITY1 in barley to broader evolutionary analyses of syntaxin-mediated immunity across plant species. The work demonstrates strong integration of cell biology, molecular genetics, and plant pathology approaches. Dr. Nielsen has delivered academic presentations including a notable lecture on how the PEN1 syntaxin links lipid rafts and endocytosis to plant innate immunity in 2009. His research has garnered attention across multiple platforms, being referenced in patents, picked up by news outlets, and shared across social media and academic networks. His laboratory work appears to focus on membrane trafficking in plant defense responses, particularly investigating syntaxin-mediated pathways that contribute to immunity against filamentous pathogens. The research employs advanced techniques including split-GFP systems for membrane protein topology analysis and detailed studies of protein mobility and functional specialization in model systems like Arabidopsis.

• Plant Cell Biology
• Signal Transduction
• Cell Polarity
• +۵ مورد دیگر

Dr. Philipp Denninger serves as a Group Leader at the Chair of Plant Systems Biology within the TUM School of Life Sciences at Technical University of Munich. Appointed in July 2019, he leads an independent research group focused on plant cell polarity mechanisms under the supervision of Prof. Dr. Claus Schwechheimer. His habilitation process in Plant Cell Biology began in March 2022, marking his progression toward a professorial qualification in the German academic system. Dr. Denninger's research centers on understanding cell polarity and signal transduction in plants, particularly investigating the RhoGTPases (ROP) and their activating guanine nucleotide exchange factors (ROPGEFs). His laboratory employs model systems including Arabidopsis thaliana , Marchantia polymorpha , and Zea mays to study pollen tube growth, cell division, and other polarization events. The group utilizes advanced techniques such as confocal microscopy, image analysis, and quantitative protein-protein interaction studies (MST, FRET) to unravel the spatiotemporal composition of ROP signaling complexes during polar growth. Analysis of Dr. Denninger's publication record reveals a consistent focus on ROP signaling mechanisms across multiple plant developmental contexts. His work demonstrates how specific ROPGEFs establish polar membrane domains that drive processes like pollen germination and root hair outgrowth. The research trajectory shows progression from identifying individual ROPGEF functions to understanding the dynamic repositioning of polarity domains and the negative regulation of polar growth pathways. 2019: Otto Schmeil Award from the Schmeil Foundation Heidelberg for an excellent dissertation 2013: Master's Prize from the Biochemistry Center Regensburg 2012: DAAD scholarship for research at Carnegie Institution of Science, Stanford University Dr. Denninger's laboratory operates within the Chair of Plant Systems Biology, collaborating with international research groups across Europe and North America. His research program integrates in vivo imaging approaches with in vitro biochemical techniques to address fundamental questions about how plants establish and maintain cellular polarity during development. Current projects focus on determining how polarity domain positions are established and how uncontrolled polar growth is regulated to ensure normal plant development.