Sagiv Shifman

Prof. Sagiv Shifman is a Full Professor at the Department of Genetics, Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem. His research focuses on the genetics of neurodevelopmental and psychiatric disorders, particularly autism spectrum disorders and schizophrenia, utilizing genomic data analysis, mouse models, and CRISPR screening to uncover chromatin regulators, gene expression variation, and sex-specific genetic mechanisms.

• Academic Leadership: Served as department head (2017-2021), previously leading genetics teaching programs.

Research Themes:

• Mapping genetic variants in brain disorders via computational/experimental methods.
• Studying gene networks and chromatin regulation in neurodevelopment.
• Investigating essential genes in stem cells and cancer via CRISPR libraries.
• Elucidating sex chromosome influences on gene essentiality and disease.

Scientific Contributions:

• 2013 Krill Prize recipient for excellence in Life Sciences.
• Key discoveries in POGZ deficiency, AUTS2 isoforms, and ASD/Schizophrenia gene overlap.

Collaborative Impact:

• Advancing neurogenetic databases and CRISPR-based disease modeling.
• Developing tools like ImReP and ROP for immunoglobulin repertoire analysis and RNA-seq read origin detection.