معرفی
Michael D. Cole is a Professor of Molecular and Systems Biology at the Geisel School of Medicine, Dartmouth College. He leads a research laboratory focused on the genetic events driving cancer development and the molecular basis of diseases, particularly through the lens of eukaryotic gene regulation. His work spans decades, including pioneering studies on the chromosomal translocation between c-myc and the immunoglobulin locus in 1982.
Research Interests: The Cole Lab investigates oncogenic transformation linked to transcription factor families Myc and E2F, emphasizing their role in misregulated gene networks in human cancers. Key research areas include chromatin architecture, distal regulatory elements, epigenetic mechanisms, mRNA cap methylation, and inherited cancer risk. Projects involve CRISPR-based gene editing, allelic expression analysis, and chromatin conformation studies.
Laboratory Members:
- Current Graduate Students: Dustin Elwood, Edmond Feris, Elizabeth Sergison, Jillian Langer, Nadia Cumbal, Valeriya Posternak
- Former Students: Mandeep Kaur (PhD thesis on c-Myc gene repression via PRC2), Scott Turner (studying oncogene transcriptional dynamics)
Publications: The lab has contributed extensively to cancer genetics, though specific titles are not listed here. Research trends focus on chromatin looping, enhancer function, and the interplay between genetic mutations and transcriptional networks.
