جست‌وجوی استاد و پژوهشگر

Andrzej Dziembowskiمشاهده پروفایل

استاد

• RNA Biology
• Posttranscriptional Regulation
• Gene Expression
• +۴ مورد دیگر

Professor Andrzej Dziembowski serves as Head of the Laboratory of RNA Biology - ERA Chairs Group at the International Institute of Molecular and Cell Biology in Warsaw (IIMCB), while maintaining a 25% appointment as Associate Professor at the University of Warsaw's Faculty of Biology. Appointed Professor by the President of Poland in 2014, he leads a multidisciplinary team investigating posttranscriptional regulation of gene expression in metazoans. His laboratory focuses on two primary research areas: Analysis of processive ribonucleases that shape transcriptomes through RNA degradation, with implications for multiple myeloma (where DIS3 mutations are frequent) Analysis of cytoplasmic poly(A) and poly(U) polymerases, particularly the TENT5 family's role in bone formation, immune response, and cancer Professor Dziembowski's recent work demonstrates how cytoplasmic polyadenylation regulates diverse biological processes, from LINE-1 retrotransposition restriction to proper bone development. His team employs transgenic mouse models generated through their CRISPR/Cas9 facility (crisprmice.eu), which has produced over 20 mouse lines in three years. Notable recognition includes: EMBO Membership (2018) Corresponding Member of Polish Academy of Sciences (2020) Multiple Foundation for Polish Science awards Knight's Cross of the Order of Polonia Restituta (2013) He has supervised ten PhD students to completion and currently mentors six doctoral candidates. His laboratory comprises senior researchers, postdoctoral fellows, technicians, and undergraduate students working across multiple research projects including the GRIEG-funded study on cytoplasmic polyadenylation in neuronal translation.

Anton A. Komarمشاهده پروفایل

استاد

• Protein Synthesis
• Co-translational Protein Folding
• Translational Control of Gene Expression
• +۵ مورد دیگر

Anton A. Komar is a Professor and Director of the Center for Gene Regulation in Health and Disease (GRHD) at Cleveland State University's College of Arts and Sciences. His research focuses on protein synthesis, co-translational protein folding, and translational control of gene expression in eukaryotic cells. He maintains an active laboratory investigating the structure and function of eukaryotic initiation factors and the impact of synonymous mutations on protein function. Dr. Komar's research interests center on understanding how translation initiation works in eukaryotic cells, particularly focusing on eukaryotic initiation factor eIF2A. His work explores how synonymous codon usage along mRNA modulates protein translation kinetics, providing an active mechanism for coordinating the synthesis, maturation and folding of nascent polypeptides. This research has significant implications for understanding human diseases including diabetes and cancer. His recent publications demonstrate consistent research activity in protein translation mechanisms, with a particular focus on how ribosome function shapes protein folding. His work spans from fundamental molecular mechanisms to applications in viral genomics and hemophilia research. Dr. Komar has maintained a strong publication record throughout his career, with significant contributions to understanding the relationship between codon usage and protein folding. As Director of GRHD, Dr. Komar oversees a research center that facilitates collaborative work across disciplines, supporting both basic and translational research in gene regulation. His leadership role indicates his standing within the university's research community. Dr. Komar mentors several graduate students and postdoctoral fellows, maintaining an active laboratory focused on eukaryotic translation mechanisms. His work has contributed significantly to understanding how translational control plays a pivotal role in development, differentiation, cell cycle progression, cell growth, apoptosis, and stress responses.

• Cancer Biology
• Tumor Heterogeneity
• Glioblastoma Research
• +۳ مورد دیگر

Michalina Janiszewska is an Assistant Professor at the University of Florida leading the SR-MM-JANISZEWSKA LAB, where her research focuses on intratumor heterogeneity dynamics in aggressive brain tumors. Her work bridges molecular oncology and translational research to uncover mechanisms driving therapy resistance in glioblastoma and other cancers. Her educational background includes a Ph.D. in Life Sciences from the University of Lausanne (2012), a Master's of Science in Medical Biotechnology from the University of Wroclaw (2007), and a Bachelor's of Science in Biotechnology from the University of Wroclaw (2005). Dr. Janiszewska's research centers on how subclonal cancer cell populations interact with tumor microenvironments to drive disease progression. Her lab employs single-cell genomics, spatial transcriptomics, and molecular techniques to investigate RNA-binding proteins (particularly IMP2), epigenetic regulators like HDACs and EZH2, and vascular niche organization in glioblastoma. Key interests include cancer stem cell maintenance, mutation-dependent heterogeneity, and microenvironmental influences on therapeutic response. Analysis of her recent publications reveals a cohesive focus on tumor heterogeneity across multiple dimensions: spatial organization in recurrent glioblastoma, single-cell genomic variations in breast cancer, and epigenetic vulnerabilities in cancer evolution. Her work consistently connects molecular mechanisms to clinical resistance patterns, with strong emphasis on RNA biology and microenvironmental interactions as therapeutic targets. Dr. Janiszewska currently manages three active research grants: Principal Investigator for "Oncofetal protein as a therapeutic target in pediatric brain tumors" (FL DEPT OF HLTH LIVE LIKE BELLA, June 2024) Principal Investigator for "Scott R. MacKenzie Foundation Final Grant application" (UF FOUNDATION via SCOTT R MACKENZIE FOUNDATION, December 2023) Project Manager for "American Cancer Society Institutional Research Grant" (AMERICAN CANCER SOCIETY, January 2022) These projects support her lab's mission to translate heterogeneity research into clinical applications. The SR-MM-JANISZEWSKA LAB specializes in dissecting intratumor heterogeneity in brain tumors through advanced molecular techniques. The lab investigates cancer stem cell regulation, RNA-protein interactions, and spatial tumor architecture to develop strategies targeting therapy-resistant subclones. Current work emphasizes perivascular niches in glioblastoma recurrence and leveraging collateral lethality for precision interventions.

• RNA-Targeted Therapeutics
• Precision Medicine
• Chemoinformatics
• +۷ مورد دیگر

Matthew Disney is an Associate Professor of Chemistry at Scripps Research with a distinguished career in RNA-targeted drug discovery. His laboratory has pioneered approaches to design selective therapeutics directly from genome sequence, bridging chemoinformatics and RNA structural biology to develop precision medicines for challenging diseases. Dr. Disney's research interests center on RNA-targeted therapeutics, focusing on developing rational approaches to design small molecules that selectively target disease-causing RNAs. His work spans multiple disease areas including neuromuscular disorders, neurodegenerative diseases (Alzheimer's, ALS), difficult-to-treat cancers (breast, pancreatic, prostate), and infectious diseases. He has developed the proprietary Inforna platform that merges chemoinformatics and RNA structure to identify lead compounds targeting disease-associated RNAs, and has pioneered RIBOTACs (Ribonuclease-Targeting Chimeras) technology for catalytic RNA degradation. His recent publications reveal a strong focus on covalent RNA targeting, transcriptome-wide binding site mapping, and the development of orally bioavailable compounds for neurological disorders. The research demonstrates increasing sophistication in RNA-targeted drug design, with emphasis on selectivity, potency, and clinical translation. ACS 2022 Nobel Laureate Signature Award for Graduate Education in Chemistry Raymond and Beverly Sackler International Prize in Chemistry (2019) NIH Director's Pioneer Award (2015) Tetrahedron Young Investigator Award in Bioorganic and Medicinal Chemistry (2016) Eli Lilly Award in Biological Chemistry (2013) Dr. Disney's research is supported by numerous active grants from NIH, foundations including the Rainwater Charitable Foundation, and industry partners like AstraZeneca and Astellas Pharma. His laboratory trains the next generation of scientists in RNA-targeted drug discovery while advancing multiple therapeutic candidates toward clinical development. Current research includes the Druggable Transcriptome Project, which aims to systematically identify and target disease-relevant RNAs across the human transcriptome.

• Single-Cell Genomics
• Computational Biology
• Multi-Omic Integration
• +۲ مورد دیگر

Kelly Street is an Assistant Professor of Population and Public Health Sciences in the Division of Biostatistics at the Keck School of Medicine, USC. His research develops computational methods for high-dimensional genomic data with focus areas in: Single-cell RNA sequencing trajectory analysis Multi-omic integration of chromatin structure and gene expression Cancer immunology and tumor microenvironment profiling Dr. Street created widely-used tools like Slingshot for cell lineage inference. Recent work includes spatial analysis of immune exhaustion in transplant rejection and normalization frameworks for ATAC-seq data.

James Daleمشاهده پروفایل

استاد

• Biofortification of bananas
• Plant disease resistance (e.g., Fusarium wilt, viruses)
• Molecular farming
• +۳ مورد دیگر

Distinguished Professor James Dale is a Professor in the School of Biology & Environmental Science at Queensland University of Technology (QUT). He holds a PhD and BScAgr from the University of Sydney. As Program Leader (Banana Biotechnology) and inaugural Director of QUT’s Centre for Tropical Crops and Biocommodities (CTCB), he leads global research in agricultural biotechnology, focusing on disease-resistant and nutrient-enhanced crops like bananas and sugarcane. His research interests span biofortification (e.g., vitamin A-enriched bananas), genetic engineering for disease resistance (Fusarium wilt, viruses), and molecular farming for medical proteins. He has pioneered transgenic solutions for tropical crops and collaborates internationally, including with African institutions like Uganda’s National Agricultural Research Organisation. Key achievements include developing GM banana varieties with biofortification and disease resistance traits, leading a Bill & Melinda Gates Foundation-funded project, and commercializing biotech innovations through ventures like Leaf Energy. Awards include an Order of Australia (AO) and ATSE Fellowship. He has supervised over 25 PhD students and secured major grants, advancing sugarcane biofuel technologies and tropical crop improvement. His work bridges lab-to-field translation, emphasizing socio-economic impacts in developing regions.

Stephanie Hicksمشاهده پروفایل

دانشیار

• Single-cell genomics
• Spatial transcriptomics
• Computational methods development
• +۳ مورد دیگر

Dr. Stephanie Hicks is an Associate Professor in Biomedical Engineering and Biostatistics at Johns Hopkins University, with affiliations in multiple centers including the Malone Center for Engineering in Healthcare and the Center for Computational Biology. Her research focuses on developing computational methods and open-source software for analyzing single-cell and spatial transcriptomics data to enhance understanding of human health and disease. She holds a PhD from Rice University and completed postdoctoral training at Dana-Farber Cancer Institute and Harvard. Education: B.S. Mathematics (LSU), M.A./Ph.D. Statistics (Rice University), Postdoc in Biostatistics/Data Science (Dana-Farber/Harvard). Research interests span scalable computational methods, machine learning, and biomedical data science. Notable contributions include tools like SpotSweeper for spatial transcriptomics quality control and the spatialLIBD package for spatial data visualization. Awards include Fellow of the American Statistical Association, COPSS Emerging Leader Award, and Myrto Lefkopoulou Lectureship. She co-hosts the Corresponding Author podcast and actively promotes open science through initiatives like R-Ladies Baltimore. Labs/Teams: Leads the Hicks Lab, collaborates across departments at Johns Hopkins, and engages in interdisciplinary projects in spatial genomics and computational biology.

• Protozoan Parasitology
• Sphingolipid Biosynthesis
• Antileishmanial Drug Discovery
• +۳ مورد دیگر

Professor Paul Denny is a Professor in the Department of Biosciences and the Department of Chemistry at Durham University. He is also a Fellow of the Wolfson Research Institute for Health and Wellbeing. His research focuses on protozoan parasites, particularly Leishmania , aiming to understand lipid biosynthesis and membrane trafficking in host-parasite interactions to identify therapeutic targets. He has held significant roles, including being the MRC Global Network for NTDs Lead and has received notable awards such as the Royal Society of Biology Fellowship. His research interests span Cell Biology, Lipid Biochemistry, Molecular Biology, and Parasitology. Central to his work is the study of sphingolipid biosynthesis pathways in parasites like Leishmania and Toxoplasma gondii , aiming to discover novel drug targets and therapies for neglected tropical diseases. His lab investigates antileishmanial compounds, drug delivery mechanisms, and the molecular basis of parasitic resistance to existing treatments. Key scientific achievements include the MRC Outstanding Team Impact Prize (2024) for leading a global network addressing Leishmaniasis and Chagas disease, and the COMSTECH Distinguished Scholar award (2025). He has organized numerous workshops and training programs in countries like Kenya, Brazil, and Pakistan, focusing on drug discovery and capacity building in endemic regions. Professor Denny supervises multiple PhD students, including Amy Wiseman, Davide Cazzola, and others, and has secured grants supporting collaborative research across continents. His lab collaborates with institutions globally, emphasizing equitable partnerships in scientific research. Notable contributions include developing nanoparticle drug delivery systems and identifying clemastine fumarate analogues as effective antileishmanials. He is actively involved in public engagement, such as the Pint of Science event on 'flesh-eating parasites,' and serves on editorial boards including Parasitology and Frontiers in Cellular and Infection Microbiology . His recent work highlights the role of sphingolipid metabolism in parasite survival and the application of advanced sequencing technologies for rapid pathogen genotyping.

Uladzimir Karniychukمشاهده پروفایل

استاد مدعو

• Emerging and Re-emerging Infectious Diseases
• Viral Pathogenesis
• Animal Models of Viral Diseases
• +۳ مورد دیگر

Uladzimir Karniychuk is an Adjunct Professor in the Department of Veterinary Microbiology at Ohio State University and leads Zika virus research at VIDO-Intervac (University of Saskatchewan). He holds a DVM from Vitebsk State Academy of Veterinary Medicine (2005) and a PhD in Veterinary Medicine from Ghent University (2012), focusing on porcine reproductive and respiratory syndrome virus (PRRSV) pathogenesis. His research spans emerging infectious diseases, viral host interactions, and vaccine development using animal models. Key areas include: Design and validation of humanized mouse and ferret models for HIV-1 and influenza Mechanisms of Zika virus infection in utero and fetal outcomes Development of CpG-recoded Zika virus vaccine candidates Pathogen persistence in reproductive tissues Publications highlight innovative strategies in viral attenuation, molecular footprints of persistent infections, and cross-species transmission dynamics. His work bridges basic virology with translational applications in veterinary and human medicine.

• Molecular Biology
• Parasitology
• Trypanosome Biology
• +۳ مورد دیگر

Lisa Bergmann is a Lecturer in Romance Studies Didactics at the Institute of Modern Languages and Romance Studies , University of Würzburg , Germany. Her research focuses on parasitology, particularly the cellular mechanisms and genetic regulation in trypanosomes, as evidenced by her publications in molecular biology, phylogenetics, and membrane trafficking. University : University of Würzburg Faculty : Faculty of Philosophy Department : Romance Studies Rank : Lecturer Her work explores: Molecular Biology of trypanosomes, including endocytosis and exocytosis pathways. Phylogenetic analysis of trypanosome species using 18S rDNA/RNA sequencing. Cellular dynamics , such as flagellar pocket function and organelle replication. Recent publications (2024) investigate actomyosin systems in Trypanosoma brucei, transcriptional profiles in Trypanosoma cruzi, and the discovery of continuous endosomes in membrane trafficking. Earlier studies (2022-2014) address endocytosis requirements for cargo entry, GPI anchor biochemistry, and Brazilian fish trypanosomes.

Teresa Rappمشاهده پروفایل

استادیار

• Inorganic Synthesis
• Ruthenium Photochemistry
• Hydrogels
• +۳ مورد دیگر

Dr. Teresa Rapp is an Assistant Professor in the Department of Chemistry and Biochemistry at the University of Oregon. She leads the Rapp Lab, which focuses on developing light-responsive ruthenium-based biomaterials for applications in drug delivery, tissue engineering, and photocaging of biomolecules. Her research integrates inorganic chemistry with biomedical engineering, emphasizing the use of visible and near-IR light to control material properties and biological processes. Dr. Rapp holds a B.S. from Cal Poly San Luis Obispo, a Ph.D. from the University of Pennsylvania, and completed postdoctoral training at the University of Washington as a Washington Research Foundation Postdoctoral Fellow. Her work has led to innovations in ruthenium-polypyridyl complexes for hydrogel design, visible-light responsive materials, and self-illuminating drug delivery systems. Her lab’s current projects include tricolor wavelength-selective hydrogels, bioluminescence-driven cargo release, and photocaging of previously inaccessible molecules. These efforts aim to address challenges in light penetration depth and precision in biomedical applications. The Rapp Lab actively engages undergraduate and graduate students in research through programs like the RuPROBE initiative, fostering a collaborative environment for trainees at all levels.

• Ruminant Nutrition
• Nutritional Physiology
• Feed Efficiency
• +۵ مورد دیگر

Andrew Foote is an Associate Professor in the Department of Animal & Food Sciences at Oklahoma State University, where he was promoted from Assistant Professor in July 2024. Previously, he served as a Research Physiologist at the USDA Agricultural Research Service's US Meat Animal Research Center from 2012-2018. He oversees the ruminant nutrition laboratories and teaches graduate courses in ruminant nutrition and research methods. Dr. Foote earned his PhD in Animal Sciences from the University of Kentucky in 2013, following B.S. and M.S. degrees from Tarleton State University where he studied phosphorus absorption in dairy cows. His research program focuses on nutritional physiology and feed efficiency of growing and finishing beef and dairy cattle. His research interests span ruminant nutrition, gut physiology, metabolism, and nutritional physiology, with particular emphasis on improving feed efficiency in cattle production systems. His work addresses important agricultural sustainability issues related to resource utilization, including Sustainable Development Goals related to Zero Hunger, Good Health and Well-Being, Affordable and Clean Energy, and Responsible Consumption and Production. Dr. Foote's recent publications (2023-2025) demonstrate a strong focus on feed efficiency mechanisms, rumen physiology, and nutrient metabolism in beef and dairy cattle. His research spans molecular approaches (gene expression, transcriptomics), physiological measurements (glucose metabolism, hormone profiles), and practical feeding studies (distillers grains, reduced-lignin alfalfa, forage supplementation). A significant portion of his work investigates the relationship between metabolic processes and feed efficiency. Associate Editor for Domestic Animal Endocrinology Editorial Board Member for Journal of Animal Science Board of Directors for ASAS (American Society of Animal Science) Dr. Foote actively advises graduate students through Master's Research and Thesis and Doctoral Research and Dissertation courses. His research program addresses practical challenges in beef and dairy production while contributing to fundamental understanding of ruminant nutrition and physiology. He has secured research funding to support his laboratory work on nutritional physiology and feed efficiency. His laboratory work focuses on ruminant nutrition, with particular attention to the physiological mechanisms underlying feed efficiency differences in cattle. His research integrates molecular, physiological, and production approaches to address challenges in sustainable livestock production.

Mudassar Iqbalمشاهده پروفایل

مدرس ارشد

• Gene Regulatory Networks
• Machine Learning
• Bioinformatics
• +۴ مورد دیگر

Mudassar Iqbal holds the position of Senior Lecturer in Health Data Sciences within the Division of Informatics, Imaging & Data Sciences. His research focuses on integrating computational methods with biological data to study gene regulatory networks, circadian rhythms, and cancer biology. He earned a Doctor of Philosophy from the University of Kent in 2009, specializing in machine learning applications for protein-protein interaction prediction. His work contributes to UN Sustainable Development Goals related to health and innovation. Key research interests include spatial transcriptomics, single-cell multiomics analysis, and computational modeling of biological systems. His recent studies explore age-related gene networks in AML, chronotype associations with psoriasis, and algorithm development for integrating imaging and genomic data. He collaborates internationally on projects analyzing gene expression, circadian biology, and cancer genomics. His methods like CellPie and TriTan advance scalable tools for spatial and multi-omics data analysis. Research affiliations include the Digital Futures, Lydia Becker Institute, and Christabel Pankhurst Institute. He has supervised three academic works and published widely in journals like Nucleic Acids Research and eLife , focusing on bioinformatics-driven discoveries in health and disease.

Sebastian Bauerمشاهده پروفایل

استاد

• Translational Cancer Research
• Soft-Tissue Sarcoma
• Gastrointestinal Stromal Tumor (GIST)
• +۷ مورد دیگر

Prof. Dr. Sebastian Bauer is a leading oncologist and academic researcher at the University of Duisburg-Essen, affiliated with the Medical Faculty and the West German Cancer Center (WTZ) at University Hospital Essen. He leads the Translational Sarcoma Research group, focusing on soft-tissue sarcomas, particularly gastrointestinal stromal tumors (GIST). His work integrates molecular oncology, preclinical modeling, and clinical trials to advance targeted therapies. Research Interests: His research spans translational cancer research , oncogenetic signaling pathways , tyrosine kinase inhibitors , preclinical cancer models , and drug development . He investigates mechanisms of resistance in GIST and evaluates novel therapeutic agents in clinical settings. The recent publication trends highlight a strong focus on targeted therapies (e.g., avapritinib, ripretinib), biomarker discovery (ctDNA, neoantigens), and combination therapies in sarcomas. His work frequently appears in high-impact journals such as Nature Communications and Clinical Cancer Research , reflecting significant contributions to clinical oncology and molecular therapeutics. Scientific Awards: No specific awards mentioned in the provided text. Advising and Grants: While specific student names are not listed, Prof. Bauer leads a research group and participates in PhD programs through the ZMB (Center for Molecular Biomedicine), indicating active mentoring. His research is supported by national and international collaborations, including DFG, EU programs, and industry partnerships, particularly in drug licensing and clinical trials. Labs and Teams: He heads the Translational Sarcoma Research group at WTZ Essen, collaborating closely with institutions like TU Dortmund and the Max Planck Institute. His team works on drug discovery, proteogenomics, and clinical trial design, contributing to the development of novel therapies for rare cancers.

Liran Carmelمشاهده پروفایل

استاد

• Ancient DNA Analysis
• Human Evolution
• Paleo-epigenetics
• +۵ مورد دیگر

Prof. Liran Carmel is a Professor of Genetics at the Hebrew University of Jerusalem's Alexander Silberman Institute of Life Sciences (Faculty of Science). His lab focuses on ancient DNA analysis to study human evolution, paleo-epigenetics, and molecular evolution. Recent work includes reconstructing Denisovan anatomy through epigenetic maps and analyzing Bronze Age population dynamics in the Southern Levant. Research Interests: Decoding genetic and epigenetic changes driving human evolution Reconstructing ancient DNA methylation patterns Studying RNA biology mechanisms like splicing and nonsense-mediated decay Developing computational tools for paleogenomics (e.g., RoAM, Gene ORGANizer) Key Achievements: Identified Denisovan morphological traits through epigenomic analysis Discovered Neolithic-era metabolic adaptations via ancient methylation studies Received the 2021 Massry Prize and 2020 Science Breakthrough award Lab Activities: Current members: 4 PhD students, 1 MSc student, lab managers, and programmers Alumni include 19 researchers now in academia and industry roles worldwide Hosts annual retreats and collaborates internationally on projects like the Punic genome study