Anton A. Komar

Anton A. Komar is a Professor and Director of the Center for Gene Regulation in Health and Disease (GRHD) at Cleveland State University's College of Arts and Sciences. His research focuses on protein synthesis, co-translational protein folding, and translational control of gene expression in eukaryotic cells. He maintains an active laboratory investigating the structure and function of eukaryotic initiation factors and the impact of synonymous mutations on protein function.

Dr. Komar's research interests center on understanding how translation initiation works in eukaryotic cells, particularly focusing on eukaryotic initiation factor eIF2A. His work explores how synonymous codon usage along mRNA modulates protein translation kinetics, providing an active mechanism for coordinating the synthesis, maturation and folding of nascent polypeptides. This research has significant implications for understanding human diseases including diabetes and cancer.

His recent publications demonstrate consistent research activity in protein translation mechanisms, with a particular focus on how ribosome function shapes protein folding. His work spans from fundamental molecular mechanisms to applications in viral genomics and hemophilia research. Dr. Komar has maintained a strong publication record throughout his career, with significant contributions to understanding the relationship between codon usage and protein folding.

As Director of GRHD, Dr. Komar oversees a research center that facilitates collaborative work across disciplines, supporting both basic and translational research in gene regulation. His leadership role indicates his standing within the university's research community.

Dr. Komar mentors several graduate students and postdoctoral fellows, maintaining an active laboratory focused on eukaryotic translation mechanisms. His work has contributed significantly to understanding how translational control plays a pivotal role in development, differentiation, cell cycle progression, cell growth, apoptosis, and stress responses.