جست‌وجوی استاد و پژوهشگر

Javier Caceresمشاهده پروفایل

استاد

• Gene expression
• RNA biology
• Nonsense-mediated decay
• +۲ مورد دیگر

Javier Caceres is a Professor of RNA and Gene Expression holding a Personal Chair at the MRC Human Genetics Unit within the Institute of Genetics and Molecular Medicine (IGMM) at the University of Edinburgh. He has served as Head of the Genome Regulation Section since 2015, leading research on RNA-mediated genetic mechanisms. His educational background includes a Ph.D. in Molecular Biology (1989) and an MSc. in Biology (1985), both obtained from the University of Buenos Aires. These degrees established his foundation in molecular genetics before his postdoctoral work at Cold Spring Harbor Laboratory and the University of Wisconsin-Madison. Dr. Caceres' research centers on RNA biology with emphasis on post-transcriptional gene regulation. His work investigates alternative splicing mechanisms, nonsense-mediated decay pathways, microRNA functions, and RNA-protein interactions. These studies provide critical insights into genetic disorders and potential therapeutic targets, particularly in splicing-related diseases. His experimental approaches combine biochemical, genomic, and cellular techniques to dissect RNA regulatory networks. Analysis of his publication record reveals consistent focus on RNA processing mechanisms across three decades. His work demonstrates evolving technical sophistication from foundational splicing studies to contemporary systems-level analyses of RNA regulation, with sustained contributions to understanding how RNA dysregulation causes human disease. Key themes include RNA-binding proteins, mRNP dynamics, and quality control pathways. His major scientific recognitions include: Election as Fellow of the Royal Society of Edinburgh (FRSE) in 2011 Award of the Wellcome Trust Senior Investigator Award in 2011 Membership in the European Molecular Biology Organization (EMBO) since 2008 Dr. Caceres actively shapes scientific discourse through editorial leadership as Associate Editor of RNA (since 2011) and service on editorial boards of EMBO Journal and Nucleic Acids Research. He has evaluated research proposals for major funding bodies including the European Research Council (ERC Starting Grants panel), German Research Foundation (DFG), and Swiss National Foundation, focusing on molecular biology and RNA research initiatives. He directs the Genome Regulation Section at the MRC Human Genetics Unit, where his team employs cutting-edge methodologies to investigate RNA-mediated gene regulation mechanisms and their roles in human disease pathogenesis.

Aaron Mendezمشاهده پروفایل

استادیار

• Virology
• Molecular Biology
• Microbiology
• +۳ مورد دیگر

Aaron Mendez is an Assistant Professor in the Department of Molecular Biology and Microbiology at Tufts University School of Medicine. His research focuses on understanding how viruses maximize their replicative output through the formation of replication compartments, using Kaposi's sarcoma-associated herpesvirus (KSHV) as a model system. Education: PhD in Chemistry & Chemical Biology from the University of California, San Francisco (2015); BSc in Biochemistry & Molecular Biology from the University of California, Irvine (2009). Research Interests: The lab employs a multidisciplinary approach combining molecular virology, biochemistry, and chemical genetics to uncover molecular mechanisms underlying viral replication compartment formation. Key areas include compartment dynamics, viral machinery organization, and evasion of host immune responses. Recent work highlights studies on SOX exonuclease activity in KSHV and SARS-CoV-2 nsp1 protein function. Publications: Recent articles (2014–2023) explore viral replication mechanisms, ER stress pathways, and protein engineering. Notable contributions include elucidating SOX's role in viral DNA processing and characterizing SARS-CoV-2 nsp1's suppression of host gene expression. Grants & Lab Activities: The lab develops novel tools for studying viral replication compartments, with potential applications in antiviral strategies. Current efforts aim to identify linchpin interactions critical for compartment assembly and function. Labs/Teams: Mendez leads a research group focused on advancing virology through innovative biochemical and genetic methodologies.

Chuanzhu Fanمشاهده پروفایل

دانشیار

• Molecular Evolution
• Genomics
• Epigenomics
• +۲ مورد دیگر

Chuanzhu Fan is an Associate Professor in the Department of Biological Sciences at Wayne State University's College of Liberal Arts and Sciences . His research spans molecular evolution, genomics, and epigenomics with a focus on plant biology. Education : Ph.D. from North Carolina State University (2003), Postdoctoral Research at University of Chicago (2006) Research interests include investigating the genetic and epigenetic mechanisms behind genomic novelty origination and functionalization in plants. He combines studies in Arabidopsis and Oryza species to explore how genomic divergences drive phenotypic differentiation through computational analysis and high-throughput experiments. Recent publications highlight his work in plant gene duplication, DNA methylation patterns in human sperm, rice genomics, and evolutionary dynamics of transposable elements. His lab also develops bioinformatic tools like the gKaKs pipeline for genome-level Ka/Ks calculations. Teaching includes graduate courses in Molecular Evolution (BIO6060) and Genomics (BIO5150/BIO7150), and undergraduate Genetics (BIO3070). Laboratory (Biological Science Building 5107) integrates comparative transcriptomics, DNA methylation manipulation, and phenotyping technologies to study evolutionary novelties in plant genomes.

• Single-cell Sequencing
• Long-read Sequencing
• Gene Expression Regulation
• +۳ مورد دیگر

Yanping Long is a Research Associate Professor at Southern University of Science and Technology (SUSTech) in Shenzhen, China, affiliated with the School of Life Sciences and Department of Biology. She holds a PhD in Developmental Biology from the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences (2015), and a B.S. in Biotechnology from Northwest Agriculture and Forestry University (2007). Her career includes positions as Research Assistant Professor at SUSTech (2019-2023) and postdoctoral research under Dr. Jixian Zhai. Her research integrates wet-lab and computational approaches to develop cutting-edge genomic technologies. Primary interests include: Single-cell sequencing for plant systems (e.g., FlsnRNA-seq) Long-read sequencing applications (e.g., FLEP-seq, Pore-C) Gene expression regulation focusing on RNA processing, epigenetics, and transcriptional dynamics Her publications (2019-2023) demonstrate a strong focus on developing novel genomic methods and applying them to plant systems. Key themes include single-cell transcriptomics, chromatin architecture, RNA processing dynamics, and epigenetic regulation in model plants (Arabidopsis, Medicago) and crops (soybean, rice). Awards: Outstanding Young Women Award, Chinese Society for Plant Biology (2022) She holds patents for genomic technologies including single-cell library construction and barcoded gel bead methodologies. No student advisees or grant details were mentioned in the source materials.

• Genetics
• Molecular Biology
• Biochemistry
• +۳ مورد دیگر

Maja Dembic is an Associate Professor at the Department of Clinical Research, University of Southern Denmark, with affiliations at Odense University Hospital (OUH) and Karolinska Institutet (KI). Her primary research unit is the Research unit of Clinical Genetics in Odense, where she focuses on genetic and molecular mechanisms of disease. She maintains an active ORCID profile (0000-0003-2505-6863) and can be contacted via mdembic@health.sdu.dk. Her research centers on genetic disorders including propionic acidemia and phenylketonuria, cardiovascular genetics, and molecular therapeutics. She employs advanced genomic techniques such as exome sequencing and splice-switching antisense oligonucleotides to investigate enzyme dysfunction, somatic mutations, and pathological mechanisms in atherosclerosis and aneurysm formation. Key methodologies include pseudoexon modulation, candidate gene analysis, and next-generation sequencing platforms. Analysis of her recent publications (2024-2025) reveals a dual research trajectory: cardiovascular genetics focusing on somatic mutations in aortic diseases, and metabolic disorder therapeutics targeting enzyme rescue through RNA splicing correction. Her work bridges fundamental molecular biology with clinical applications, particularly in developing oligonucleotide-based interventions for inborn errors of metabolism. Dr. Dembic operates within the Research unit of Clinical Genetics at Odense, participating in extensive international collaborations evident from her multicenter studies across European institutions. Her research network spans cardiovascular screening initiatives, atherosclerosis mutation mapping, and therapeutic development for rare genetic disorders.

Jennifer E. Phillips-Creminsمشاهده پروفایل

دانشیار

• 3D Genome Organization
• Chromatin Biology
• Neurogenetics
• +۵ مورد دیگر

Jennifer E. Phillips-Cremins, Ph.D. , is an Associate Professor of Genetics and Bioengineering at the University of Pennsylvania, where she leads the Laboratory of Chromatin and Spatial Neurobiology. A member of the Penn Epigenetics Institute and NIH 4D Nucleome Consortium, her research investigates how three-dimensional chromatin organization governs neural specification, synaptic plasticity, and disease pathogenesis. Her lab integrates 3D genome mapping, single-cell imaging, and computational tools to dissect chromatin-synapse communication in Alzheimer's disease, fragile X syndrome, and schizophrenia. Education : B.S. in Chemical Engineering (Clarkson University, 1999), Ph.D. in Biomedical Engineering (Georgia Tech, 2007) Postdoctoral Training : University of Massachusetts (Dekker Lab) and Emory University (Corces Lab, 2008-2013) Her lab has developed groundbreaking technologies including LADL for optogenetic chromatin control, FISHnet for single-cell spatial genomics, and MASTR-seq for repeat expansion analysis. Key discoveries demonstrate that cohesin-mediated loops regulate replication origins and synaptic gene expression, while BREACHes link repeat instability to neurodevelopmental defects. Scientific Recognition : NIH Pioneer Award (2021) NSF CAREER Award (2020) Chan-Zuckerberg Neurodegenerative Disease Awardee (2020) New York Stem Cell Foundation Robertson Investigator (2015-2020) Mentorship : Creator of the SEEDs program for undergraduate/post-baccalaureate training, with 100% of alumni pursuing advanced scientific degrees. Her lab currently trains 3 SEEDs scholars and advises graduate students in Cell and Molecular Biology, Neuroscience, and Bioengineering programs.

• Molecular Virology
• RNA Biology
• Plant Biotechnology
• +۵ مورد دیگر

Prof. Dr. Sven-Erik Behrens serves as a Professor in the Department of Microbial Biotechnology at the Faculty of Natural Sciences I of Martin Luther University Halle-Wittenberg. He is affiliated with the Protein Research Center 'Charles Tanford' and maintains an active research program focused on RNA biology, molecular virology, and biotechnological applications. His primary research interests encompass RNA-based plant protection strategies, viral replication mechanisms (particularly for flaviviruses and plant viruses), and innovative vaccine development using Kluyveromyces lactis yeast expression systems. Behrens' work investigates fundamental RNA-protein interactions, RNA chaperone activities, and the molecular basis of antiviral defense mechanisms in plants. His laboratory explores how RNA accessibility influences viral replication and how this knowledge can be harnessed for developing novel RNA-based antiviral strategies. Analysis of his recent publications (2021-2025) reveals a clear research trajectory focused on identifying accessible RNA sites for targeted antiviral applications, optimizing yeast-based vaccine platforms for both plant and animal pathogens, and investigating the role of non-coding RNAs in plant development and stress responses. His work spans multiple disciplines including plant virology, medical virology, and microbial biotechnology, demonstrating translational research from basic molecular mechanisms to practical applications. Prof. Behrens leads research in the Department of Microbial Biotechnology, collaborating with various groups working on plant-pathogen interactions and vaccine development. His laboratory employs advanced techniques including RNA structure probing, fluorescence-based assays for RNA chaperone activity, and plant in vitro systems for studying viral replication. The research demonstrates significant potential for developing novel approaches to combat viral diseases in both agricultural and medical contexts.

• Catalysis
• Environmental Chemistry
• Materials Science
• +۵ مورد دیگر

Dr. Harsh Vardhan is a Postdoctoral Research Associate and Rice Academy Junior Fellow at Rice University's Department of Chemical & Biomolecular Engineering, working under Dr. Rafael Verduzco. His research focuses on covalent organic frameworks (COFs) for applications in PFAS degradation and selective metal ion removal from water. Previously, he held roles as a postdoctoral fellow at Northwestern-Argonne Institute of Science and Engineering and conducted doctoral research on COFs for heterogeneous catalysis at the University of South Florida. He has been recognized with multiple awards, including the Alexiou Award in Environmental Chemistry and Rice Academy Fellowship. Education: Ph.D. in Chemistry (University of South Florida, 2021), M.S. in Chemistry (Indian Institute of Technology-Kharagpur). His work bridges materials science, environmental engineering, and nanotechnology. Key projects include developing COF-based materials for ion rejection and catalytic processes, alongside pioneering CRISPR-Cas9 genome editing tools for therapeutic applications in sickle cell disease. Research Interests: Catalytic materials design Environmental remediation technologies Nanomaterials synthesis CRISPR-based gene editing Water purification systems Publications Trends: Over 15 peer-reviewed articles highlight his contributions to genome editing precision, CRISPR off-target mitigation, and COF material applications. Recent work emphasizes spatial control of gene editing and AAV vector engineering. Awards & Grants: Recipient of departmental research grants, travel awards, and student-nominated teaching accolades. Current funding includes the Rice Academy Fellowship supporting his PFAS degradation studies. Labs & Affiliations: Member of the Verduzco Polymer Engineering Laboratory at Rice. Collaborates with interdisciplinary teams on environmental and biomedical material innovations.

Subha R. Dasمشاهده پروفایل

دانشیار

• Organic Chemistry
• Nucleic Acids Chemistry
• Polymer Hybrids
• +۵ مورد دیگر

Subha R. Das is an Associate Professor of Chemistry at Carnegie Mellon University's Mellon College of Science. His research focuses on nucleic acid-polymer biohybrids, nanobiotechnology, and automated science. He holds a Ph.D. from Auburn University (2000) and has been on the faculty since 2006. Key projects include engineering DNA/RNA nanostructures, developing click-chemistry tools for RNA labeling, and creating exosome-polymer hybrids for biomedical applications. His research interests span organic chemistry, biomaterials, and nanotechnology. Notable contributions include backbone-branched DNA/RNA design for precise nanostructure assembly and RNA lariat synthesis to study splicing mechanisms. He also pioneered the Kitchen Chemistry Sessions course, linking molecular gastronomy to chemistry education. Education: Ph.D. in Chemistry (Auburn University, 2000), M.S.C. in Chemistry (BITS Pilani, 1994), B.E. in Computer Science (BITS Pilani, 1994) Key Research Themes: Nucleic acid-polymer hybrids, automated polymer synthesis, RNA nanotechnology, biomaterials for drug delivery Recent Trends in Publications: Focus on ATRP-driven biohybrid systems, RNA functionalization, and exosome engineering His lab collaborates extensively with the Matyjaszewski group on controlled radical polymerization techniques and has developed novel methods for biomolecule-polymer integration. Research spans from fundamental nucleic acid chemistry to applied biomedical systems.

Tim Kacprowskiمشاهده پروفایل

استاد

• Medical Informatics
• Data Science
• Network Medicine
• +۹ مورد دیگر

Summary Prof. Tim Kacprowski is a Professor and Head of Data Science in Biomedicine at the Peter L. Reichertz Institute for Medical Informatics (PLRI), jointly affiliated with TU Braunschweig and Hannover Medical School. His research focuses on integrating computational methods with biomedical challenges, particularly in network medicine, federated learning, and alternative splicing analysis. Key projects include the development of the NeDRex platform for drug repurposing and the FeatureCloud framework for privacy-preserving federated learning in healthcare. Research Interests His work spans multiple domains: Network Medicine: Leveraging molecular networks for disease module identification and drug discovery. Data Science: Advanced analytics for biomedical data, including ECG monitoring, microbiome studies, and flow cytometry. Federated Learning: Developing decentralized AI systems to protect patient data while enabling collaborative research. Alternative Splicing: Investigating splicing patterns in diseases like cancer and kidney disorders. Publications Trends Recent publications emphasize tools for drug repurposing (NeDRex-Web), ethical AI in clinical decision-making, and microbiome dynamics in chronic diseases. His work bridges computational methods with clinical applications, addressing challenges in precision medicine and healthcare technology. Labs & Collaborations As head of the Data Science group at PLRI, he leads interdisciplinary teams advancing biomedical informatics. Collaborations span institutions in Germany and internationally, focusing on translational research and AI-driven healthcare solutions.

• RNA Splicing
• Aging Biology
• Genetics
• +۳ مورد دیگر

Aykut Shen holds a PhD and is a Researcher affiliated with the RNA (epi)Genetics Lab at the University of East Anglia (UEA), specifically within the School of Biological Sciences. His work focuses on molecular mechanisms underlying RNA processing and aging, with a strong emphasis on epigenetic regulation and developmental biology. Recent research includes studies on insulin signaling's role in reproductive aging and the critical function of U6 snRNA m6A modifications in RNA splicing accuracy. His publications span Aging Cell and Nucleic Acids Research, demonstrating contributions to both basic biology and translational insights into aging. No scientific awards or grants are explicitly listed, but his research has garnered citations and social media engagement across platforms like Bluesky and Mendeley. Shen collaborates internationally, with projects involving institutions in multiple countries, as indicated by his network map. His lab's work bridges model organisms (C. elegans) and human systems, highlighting translational potential in genetic and epigenetic research.

• Genomics
• Non-coding RNA research
• Phenotype-genotype relationships
• +۷ مورد دیگر

Professor Marcel Dinger is a prominent academic and researcher currently serving as Professor and Head of School for Biotechnology and Biomolecular Sciences at UNSW Sydney. With over 20 years of experience in genomics, he has established himself as a leading figure in both academic and entrepreneurial spheres within the field. He has published 153 papers with over 24,000 citations and maintains an h-index of 61 on Google Scholar. His leadership extends beyond academia as he serves as President of the Australasian Genomics Technologies Association (AGTA) and holds director positions at Pryzm Health and the National Centre for Indigenous Genomics (NCIG). Professor Dinger's research laboratory focuses on establishing new links between phenotype and genotype, particularly examining rare and complex diseases in relation to underexplored regions of the genome including pseudogenes, repetitive elements, non-canonical DNA structures, and noncoding RNAs. His work harnesses population-scale genomic datasets and sophisticated data science methods to bring an objective perspective to understanding how the genome stores information and how it is transacted in biology. His research interests span genomics, non-coding RNA biology, clinical applications of genomic medicine, and the development of computational approaches for analyzing complex genomic data. Analysis of Professor Dinger's recent publications reveals a strong emphasis on non-coding RNA research, particularly long noncoding RNAs and their roles in disease mechanisms. His work spans cancer genomics, neurological disorders, and fundamental genomic mechanisms including DNA secondary structures like i-motifs and G-quadruplexes. His research combines experimental approaches with advanced bioinformatics to address fundamental questions in genomic medicine and has significant translational implications for disease diagnosis and treatment. Highly Cited Researcher in Cross-Field category (2019, 2020, 2021) Fellow of the Faculty of Science (Research), Royal Society of Pathologists of Australasia (2016) NHMRC Career Development Award (2010) Queensland Government Smart Futures Fellowship (2009) Foundation of Research, Science and Technology New Zealand Postdoctoral Fellowship (2005) Professor Dinger has been instrumental in establishing and leading several significant research initiatives including Genome.One, one of the first companies globally to provide clinical whole genome sequencing services, and the Kinghorn Centre for Clinical Genomics at the Garvan Institute of Medical Research. His entrepreneurial experience includes founding four biotechnology and IT startups. He serves on multiple governance boards including the National Centre for Indigenous Genomics, focusing on using genomics to improve health outcomes for Australia's First Peoples. His laboratory at UNSW continues to advance our understanding of genomic regulation and its implications for human health and disease.

Ingo Gregerمشاهده پروفایل

پژوهشگر

• Neuroscience
• Structural Biology
• Synaptic Transmission
• +۳ مورد دیگر

Ingo Greger is a Researcher at the MRC Laboratory of Molecular Biology, focusing on AMPA-type glutamate receptors central to excitatory neurotransmission and synaptic plasticity. His work integrates structural biology, electrophysiology, and computational simulations to elucidate receptor biogenesis and function. Research highlights include Structural studies (X-ray crystallography, cryo-EM) of AMPA receptor tetramers and hetero-octamers Investigations into allosteric modulation by interacting proteins and TARPs Mechanistic insights into receptor anchoring, gating, and synaptic targeting Recent publications (2012-2023) demonstrate expertise in combining structural analysis with functional electrophysiology to understand receptor dynamics in synaptic transmission. The group employs advanced techniques like super-resolution microscopy and brain slice recordings to study receptor roles in cognitive processes. Current team members include Ondrej Cais, Kieron Cartwright, and other researchers collaborating on molecular neuroscience projects.

Shaojun Duمشاهده پروفایل

استاد

• Molecular Biology
• Biochemistry
• Developmental Biology
• +۷ مورد دیگر

Dr. Shaojun Du is a Professor in the Department of Biochemistry and Molecular Biology at the University of Maryland School of Medicine and a faculty member at the Institute of Marine and Environmental Technology, University of Maryland. His research focuses on genetic and epigenetic mechanisms regulating muscle development, growth, and repair using zebrafish models. Education: PhD in Biochemistry and Molecular Biology (University of Toronto, 1993), Postdoctoral Fellowship in Genetics (Howard Hughes Medical Institute, University of Washington, 1993–1997) Dr. Du’s work explores the roles of molecular chaperones (e.g., Hsp90α1), histone modifiers (e.g., SmyD1), and fusogenic proteins (Myomaker/Myomixer) in myofibril assembly, sarcomere organization, and myoblast fusion. His lab employs Tol2 transposon, TALEN, and CRISPR technologies to generate transgenic and mutant zebrafish models. The scientific awards section is currently empty, but his research has been funded by the NIH (Grant 1R01AR072703-01A1, 2018–2025). His publications highlight breakthroughs in muscle cell identity specification via Hedgehog signaling and the critical role of post-translational modifications in protein stability. Dr. Du’s lab has developed over 40 zebrafish models to study muscle structural proteins, transcription factors, and microRNA networks, contributing to understanding neuromuscular diseases and advancing aquaculture applications.

Lydia Herzelمشاهده پروفایل

استادیار

• RNA Biology
• Molecular Biology
• Biochemistry
• +۳ مورد دیگر

Lydia Herzel is an Assistant Professor in the Department of Biochemistry at the Freie Universität Berlin, affiliated with the Department of Biology, Chemistry, Pharmacy. Her research focuses on RNA dynamics, particularly mRNA regulation in fungi and bacteria, combining biochemistry, bioinformatics, and molecular biology. She leads the Herzel Group, which explores co-transcriptional RNA regulation and its impact on gene expression outcomes. The group employs advanced RNA sequencing and biochemical techniques to study transcriptome diversity and regulatory mechanisms. Her work spans topics such as RNA splicing, mRNA decay, and the interplay between transcription and post-transcriptional processes. Key areas include understanding how regulatory mechanisms influence fungal pathogenesis (e.g., Candida albicans) and bacterial gene expression. She collaborates on projects involving synthetic biology, codon usage, and functional genomics. Recent studies highlight her group’s contributions to understanding spliceosome function in morphogenesis and the development of novel clathrin inhibitors. She actively mentors students, including Javier Callís Creus, a former bachelor’s thesis student. The lab seeks motivated researchers interested in integrating biochemistry, microbiology, and bioinformatics. Her research has been published in high-impact journals such as Nature Reviews Molecular Cell Biology , Nucleic Acids Research , and mBio . Her work bridges fundamental biology with biomedical applications, aiming to translate regulatory insights into therapeutic strategies.