جست‌وجوی استاد و پژوهشگر

Alice Telesnitskyمشاهده پروفایل

استاد

• Retrovirology
• RNA Biology
• HIV-1 Research
• +۳ مورد دیگر

Alice Telesnitsky is a Professor at the Department of Microbiology and Immunology, University of Michigan Medical School. Her research focuses on HIV-1 RNA biology, including transcription start site heterogeneity, genome packaging, and epigenetic mechanisms of viral persistence. BS in Genetics, University of California, Davis (1979) PhD in Biochemistry, University of California, Berkeley (1988) Postdoctoral fellowship at Columbia University Her work reveals how HIV-1 employs diverse RNA isoforms with distinct functions in replication and pathogenesis. Recent studies highlight RNA structural plasticity, cap-sequestration mechanisms, and transcriptional start site dynamics in viral RNA fate. Collaborated on 20+ publications on HIV-1 replication and RNA structure Led research on transcription start site heterogeneity and its role in viral evolution Co-authored studies on APOBEC3H antiviral activity and UBQLN2 protein toxicity As an MCIDT Affiliate, she investigates HIV-1 genome packaging with collaborators like Michael Summers and James Munro, contributing to understanding HIV therapeutics targets via RNA structural analysis.

Trung Nghia Vuمشاهده پروفایل

پژوهشگر

• Bioinformatics
• Computational Biology
• Cancer Genomics
• +۵ مورد دیگر

Trung Nghia Vu is a Principal Researcher at the Department of Medical Epidemiology and Biostatistics at Karolinska Institutet in Stockholm, Sweden. His research group focuses on developing and applying statistical and bioinformatics methods for molecular biology and medicine, with particular emphasis on cancer genomics and pharmacogenomics. Dr. Vu received his PhD from the Department of Mathematics and Computer Science at the University of Antwerp, Belgium (2009-2014), following an MSc in Computer Engineering from Korea Aerospace University (2006-2008) and a BSc in Technology from Vietnam National University in Hanoi (2000-2004). His research focuses on developing statistical and bioinformatics methodologies for analyzing high-throughput omics data, with specific interests in single-cell sequencing analysis, characterization of cancer omics, and pharmacogenomics. His group has developed 20 statistical and bioinformatics tools available through Biostat Wiki Primary research areas include gene/isoform quantification, detection of abnormal RNAs, single-cell RNA-seq analysis, and drug response prediction Current projects focus on breast cancer and Acute Myeloid Leukemia (AML) Analysis of Dr. Vu's recent publications reveals a strong focus on cancer genomics, particularly in AML and breast cancer. His work bridges computational biology with clinical applications, developing methods for spatial transcriptomics, drug synergy prediction, and circular RNA analysis. The research demonstrates a clear trajectory toward precision medicine applications, with increasing emphasis on personalized drug response prediction and pathway activation modeling. Dr. Vu actively supervises multiple students and researchers, including both completed PhD students (Quang Thinh Trac, Lu Pan, Wenjiang Deng) and ongoing supervisees (Gulser Caliskan, Meghana Alugunoolla, Yuying Li, Aron Arzoomand). His research is supported by significant grants from the Swedish Research Council, CancerFonden, and Karolinska Institutet. He leads the Computational Medicine and Bioinformatics research group at Karolinska Institutet, which collaborates with international clinical and systems-biology researchers. The group maintains active development of bioinformatics tools and maintains the Biostat Wiki platform for academic use. Dr. Vu also contributes to teaching through master's and doctoral courses in biostatistics and R programming at Karolinska Institutet.

• Food Science
• Microbiology
• Biochemistry
• +۳ مورد دیگر

Maria Leticia Miranda Fernandes is a Researcher at the Polytechnic Institute of Bragança , with a focus on food science, microbiology, and biochemical characterization of beekeeping by-products. Her work spans 30 years and includes 283 publications , with extensive collaborations across Brazil and Portugal. Research Interests Food safety and microbiology Antioxidant and antimicrobial mechanisms Chemical profiling of natural products High-pressure food processing Stingless bee product applications Pharmacological evaluation of plant extracts Scientific Awards Highly Cited Researcher (Cross-Field) - Web of Science (2018-2023) Stanford University Top 2% Scientists (2020-2023) Multiple 'Prémio Inventor' awards from CINOVA/UFRB (2015, 2019) Best Poster Awards (2010, 2013) Her research has been supported by grants from Fundação para a Ciência e Tecnologia (FCT) and institutional partnerships with Brazilian universities. She leads studies on mead production, propolis applications, and foodborne pathogen control.

Domenico Praticòمشاهده پروفایل

استاد

• Clinical Pharmacology
• Oxidative Biology
• Alzheimer's Disease
• +۴ مورد دیگر

Domenico Praticò, MD, FCPP is a Professor in the Department of Neural Sciences at Lewis Katz School of Medicine, Temple University, and the Founding Director of the Alzheimer's Center at Temple. His research focuses on clinical pharmacology, oxidative biology, and neurodegeneration. MD, University of Rome "La Sapienza" (1986) Internship, Residency, and Fellowship at University of Rome "La Sapienza" Cardiovascular Science Fellowship, University of Dublin (1994) Dr. Praticò investigates the role of bioactive oxidized lipids, oxidative stress, and neuroinflammation in aging, Alzheimer's disease, and cardiovascular disorders. His lab employs cellular and animal models to translate findings into human disease understanding. Recent publications highlight his work on Alzheimer's disease mechanisms involving non-coding RNAs, endosomal trafficking, lipid metabolism, autophagy, and vascular contributions. His studies bridge neurobiology, cardiovascular research, and translational medicine. Fellow of the Center for Clinical Pharmacology (FCPP) His lab integrates in vitro systems and transgenic mouse models to study APP processing, Aβ metabolism, tau pathology, and synaptic dysfunction. The Pratico Lab emphasizes drug discovery for neurotherapeutics and biomarker identification.

Anthea Letsouمشاهده پروفایل

استاد

• Developmental Biology
• Neurogenetics
• Molecular Genetics
• +۵ مورد دیگر

Anthea Letsou is a Professor of Human Genetics at the University of Utah, with a research focus on using Drosophila melanogaster to model human developmental and neurodegenerative diseases. Her work spans two primary areas: embryonic morphogenesis and neurometabolic disorders. Education: B.A., Harvard University; Ph.D., Yale University Research Interests: Dr. Letsou’s laboratory investigates the molecular mechanisms underlying dorsal closure during embryonic development, focusing on evolutionarily conserved pathways like JNK and Dpp signaling. She also develops Drosophila models for Adrenoleukodystrophy (ALD), a fatal neurodegenerative disorder caused by VLCFA accumulation, aiming to elucidate disease etiology and identify therapeutic targets. Publication Trends: Her research integrates genetic, biochemical, and pharmacological approaches in Drosophila , emphasizing conserved mechanisms relevant to human health. Key themes include signal transduction pathways, epithelial morphogenesis, lipid metabolism, and neurodegeneration. Lab Activities: Dr. Letsou’s lab employs double mutant studies to explore gene redundancy in VLCFA metabolism, characterizes dorsal closure dynamics, and screens for neuroprotective drugs using Drosophila models.

Koushik Royمشاهده پروفایل

استادیار

• Immunological Memory
• Protein Design
• Vaccine Development
• +۶ مورد دیگر

Koushik Roy is an Assistant Professor of Microbiology & Immunology at the University of Utah School of Medicine , specializing in B cell fate decisions, immunological memory, and vaccine development. His research bridges molecular biology, systems immunology, and chemical biology to address fundamental and translational challenges in infectious diseases and cancer. Education: M.S., Jadavpur University Ph.D., CSIR-Indian Institute of Chemical Biology Postdoctoral Research, University of California, Los Angeles Research Focus: Dr. Roy's lab investigates the molecular mechanisms governing B cell differentiation into plasma cells and memory B cells, particularly how pathogens disrupt these processes. His work combines systems biology (omics, microscopy, mathematical modeling) and chemical biology (peptide design) to develop therapeutic strategies for B cell lymphomas and vaccines against infectious diseases. Key Projects: 1. NFkB signaling in B cell fate: Deciphering how NFkB dynamics regulate proliferation-differentiation transitions. 2. Quantitative B cell responses: Modeling immune dysregulation in infectious diseases. 3. Peptide-based immunomodulators: Engineering synthetic peptides for vaccine enhancement and cancer therapy. Scientific Recognition: F1000 Faculty Recommended - New Finding (2019) F1000 Faculty Recommended - Interesting Hypothesis (2013, 2016) Laboratory Philosophy: Emphasizes rational thinking, open feedback, self-criticism, diversity, and mental health awareness in scientific mentorship.

• Cancer Biology
• Epigenetics
• Glioblastoma
• +۳ مورد دیگر

William Alexander Flavahan is an Assistant Professor at UMass Chan Medical School, affiliated with the T.H. Chan School of Medicine and the Morningside Graduate School of Biomedical Sciences. His primary department is Molecular, Cell and Cancer Biology, with additional appointments in Systems Biology, Biochemistry and Molecular Biotechnology, Cancer Biology, and translational science programs. He holds a BE in Biomedical Engineering and a PhD in Molecular Medicine, both from Case Western Reserve University. Dr. Flavahan's research focuses on epigenetic plasticity, tumorigenesis, and the role of cancer stem cells in therapeutic resistance. His work investigates chromatin remodeling, insulator dysfunction in gliomas, metabolic adaptations in tumor microenvironments, and the interplay between epigenetic dysregulation and oncogene activation. Key areas include glioblastoma biology, cancer metabolism, and developing strategies to overcome treatment resistance. His publications demonstrate a consistent focus on epigenetic mechanisms in cancer, particularly glioblastoma and gastrointestinal stromal tumors. Recent work explores metabolic dependencies of tumor-initiating cells, chromatin topology alterations in SDH-deficient cancers, and RNA metabolism in radiation resistance. The research integrates genomics, epigenetics, and cancer biology to identify novel therapeutic vulnerabilities. Dr. Flavahan collaborates extensively within cancer biology networks, co-authoring with researchers specializing in epigenetics, stem cell biology, and neuro-oncology. His work involves studying tumor microenvironments, myeloid-derived suppressor cells, and chromatin remodeling complexes.

Webster H. Pilcherمشاهده پروفایل

استاد

• Neurosurgery
• Epilepsy
• Brain Tumors
• +۷ مورد دیگر

Dr. Webster H. Pilcher is a Professor and Chair of Neurosurgery at the University of Rochester Medical Center (URMC), where he holds the Ernest & Thelma Del Monte Distinguished Professorship in Neuromedicine. He completed his MD/PhD in Neuroscience/Anatomy at URMC, trained in neurological surgery at Rochester, and pursued epilepsy/brain tumor research at the University of Washington. Education: MD/PhD, University of Rochester School of Medicine/Dentistry (Neuroscience/Anatomy) Undergraduate, Colgate University Dr. Pilcher specializes in epilepsy surgery, brain/spinal tumors, and neurodegenerative diseases. His research includes brain mapping , neurosurgical oncology , and cost-effective care models . Recent publications focus on single-cell genomics , mobile stroke units , and functional connectivity studies . Scientific Awards: Merit Award (2008) Upjohn Surgical Research Award (1987) Resident Research Award (1986) Alpha Omega Alpha (1983) As a clinician-scientist, Dr. Pilcher expanded URMC Neurosurgery to national prominence with $7.9M+ annual funding. He leads the Rochester Neurosurgery Partners initiative and resides in Honeoye Falls, NY, with his family.

Mani S. Mahadevanمشاهده پروفایل

استاد

• Human genetics
• Molecular genetics
• Myotonic dystrophy
• +۴ مورد دیگر

Mani S. Mahadevan, M.D. is a Professor of Pathology at the University of Virginia School of Medicine, where he directs a prominent research program focused on the molecular genetics of myotonic dystrophy (DM), the most common inherited neuromuscular disorder in adults. His work has established fundamental understanding of the disease mechanisms and continues to drive therapeutic development. Dr. Mahadevan received his medical degree from the University of Ottawa in 1986, followed by clinical training including an internship at Victoria Hospital in London, Ontario (1986-1987), residency at the University of Ottawa (1987-1991), and a research fellowship at the Children's Hospital of Eastern Ontario (1991-1995). This comprehensive background bridges clinical medicine with deep molecular investigation. His laboratory made seminal contributions to the field by cloning the DM gene and identifying the mutation as a CTG trinucleotide repeat expansion in the 3' untranslated region of the DMPK gene. Current research focuses on RNA-protein interactions, muscle regeneration in RNA toxicity models, and identifying therapeutic targets. His team has demonstrated that mutant DMPK 3'UTR mRNA forms distinct nuclear foci and inhibits normal muscle differentiation, establishing critical disease mechanisms. Analysis of Dr. Mahadevan's publication record reveals a consistent trajectory from fundamental gene discovery to sophisticated investigations of RNA toxicity mechanisms and therapeutic development. His recent work shows particular emphasis on muscle regeneration pathways, novel therapeutic targets like the TWEAK/Fn14 pathway, and the role of RNA-binding proteins in disease pathology. This evolution reflects both maturation of the field and strategic research direction. Dr. Mahadevan has established a productive research program that has generated significant insights into myotonic dystrophy pathogenesis. His laboratory has developed important cellular and animal models that serve as platforms for therapeutic testing. Through his mentorship and collaborative efforts, he has contributed to training researchers in neuromuscular disorders, with his work continuing to shape our understanding of molecular mechanisms underlying this complex disorder.

Jeffrey K. Mooreمشاهده پروفایل

دانشیار

• Microtubule networks
• Cell biology
• Molecular motors
• +۷ مورد دیگر

Jeffrey K. Moore is an Associate Professor in the Department of Cell and Developmental Biology at the University of Colorado Anschutz Medical Campus. He also serves as the Director of the Graduate Program in Cell Biology, Stem Cells and Development. His research focuses on understanding how microtubule networks organize cells and regulate crucial cellular processes, with implications for human diseases including cancer and neuropathies. Dr. Moore received his Ph.D. from the University of Rochester in 2006. His academic journey has led him to specialize in cellular organization mechanisms, particularly how the microtubule cytoskeleton controls organelle positioning during cell division and migration. His work bridges fundamental cell biology with potential clinical applications. Dr. Moore's research interests center on the molecular mechanisms that regulate microtubule dynamics and function. His laboratory investigates how molecular motors interact with microtubule tracks, how mitosis is coordinated with cell polarity during asymmetric cell divisions, and how cells develop resistance to microtubule-targeting cancer drugs. His work combines powerful yeast genetics with quantitative microscopy and protein biochemistry to uncover fundamental principles of cellular organization. The laboratory's research has significant implications for understanding human diseases where microtubule dysfunction plays a critical role. Dr. Moore's publications reveal how specialized microtubules serve different cellular functions through tubulin isotypes and post-translational modifications. His work on the 'tubulin code' has advanced understanding of how microtubule networks can be differentially regulated in various cellular contexts. Recent publications examine α-tubulin regulation, tubulin isotype specialization, and the role of microtubule-based forces in genome stability. As Director of the Graduate Program in Cell Biology, Stem Cells and Development, Dr. Moore mentors numerous graduate students in the Department of Cell and Developmental Biology. His research program is supported by grants from the National Institutes of Health and other funding agencies focused on understanding fundamental cellular processes with implications for human health. The Moore Lab at the University of Colorado Anschutz Medical Campus utilizes the budding yeast Saccharomyces cerevisiae as a primary model system. The lab brings together researchers with expertise in genetics, cell biology, biochemistry, and quantitative imaging to tackle questions about cellular organization. Their collaborative approach has led to important insights into how cells manipulate their internal architecture for proper function, with findings relevant to understanding disease mechanisms and potential therapeutic approaches.

Yi Panمشاهده پروفایل

استاد

• Parallel and Cloud Computing
• Wireless Networks
• Bioinformatics
• +۳ مورد دیگر

Dr. Yi Pan is a Distinguished University Professor and Chair of the Department of Computer Science at Georgia State University. He holds a B.Eng. and M.Eng. from Tsinghua University (China) and a Ph.D. from the University of Pittsburgh (USA). His research focuses on parallel computing, wireless networks, bioinformatics, and machine learning, with over 330 publications and 39 authored/edited books. Dr. Pan has organized international conferences and delivered over 40 keynote speeches globally. Education: B.Eng., Computer Engineering, Tsinghua University, 1982 M.Eng., Computer Engineering, Tsinghua University, 1984 Ph.D., Computer Science, University of Pittsburgh, 1991 Research Interests: Dr. Pan’s work spans parallel and cloud computing, wireless networks, and bioinformatics. His contributions include scalable algorithms for functional module discovery in protein networks, self-defense mechanisms for cyber threats, and efficient routing protocols for sensor networks. Recent efforts integrate AI into healthcare, such as lesion localization in OCT imaging and autism spectrum disorder diagnosis via EEG analysis. Awards & Recognition: IEEE Distinguished Speaker (2000–2002) Yamacraw Distinguished Speaker (2002) Listed in Who’s Who in America and Who’s Who in Computational Science Awards from NSF, AFOSR, IBM, and Mellon Foundation Advising & Leadership: As department chair, Dr. Pan oversees interdisciplinary collaborations between Computer Science and Computer Information Systems. He has advised numerous students and holds editorial roles in 15 journals, including several IEEE Transactions. His grants focus on advancing AI-driven healthcare, cybersecurity, and computational biology. Labs & Teams: Leads research initiatives in bioinformatics, medical AI, and parallel computing, collaborating with industry partners like IBM and Shell Oil. Active in organizing conferences such as the IEEE International Conference on Bioinformatics and Biomedicine.

Jeremy Birdمشاهده پروفایل

استادیار

• Gene Expression Regulation
• Transcription Mechanisms
• RNA Polymerase Function
• +۳ مورد دیگر

Jeremy Bird is an Assistant Professor in the Department of Biological Sciences at the University of Delaware’s College of Arts & Sciences. His research focuses on the interplay between cellular metabolism and transcriptional regulation, particularly the role of non-canonical initiating nucleotides (NCINs) in RNA capping. He holds a BS from Loyola University in Maryland, a PhD from Cornell University, and completed post-doctoral research at Rutgers University’s Waksman Institute of Microbiology. Dr. Bird’s work investigates how metabolic states influence transcription by RNA polymerases, with emphasis on mitochondrial RNAPs and their use of NAD(H) and dpCoA as capping metabolites. His lab employs genetic, biochemical, and next-generation sequencing approaches to study transcription initiation, elongation, and termination dynamics. Key discoveries include NAD-cap-dependent regulation of RNA stability and its redox-state sensitivity, suggesting a novel epitranscriptomic regulatory layer. Recent projects explore functional implications of metabolite caps, metabolic/transcriptional crosstalk, and applications to mitochondrial dysfunction in diseases. His research has been published in high-impact journals, with a focus on mechanistic studies of transcriptional regulation across prokaryotes and eukaryotes.

Trey Westbrookمشاهده پروفایل

استاد

• Cancer Genetics
• Breast Cancer Therapeutics
• Oncogene-Induced Stress Pathways
• +۳ مورد دیگر

Trey Westbrook is a Professor at Baylor College of Medicine, holding joint appointments in the Department of Molecular and Human Genetics and the Department of Biochemistry & Molecular Biology. He also serves as Director of the Cell-Based Assay Screening Shared Resource at the Dan L Duncan Comprehensive Cancer Center and holds the McNair Scholar position. His research focuses on cancer genetics, oncogene-induced stress pathways, and translational therapies for aggressive cancers like triple-negative breast cancer (TNBC). Education: B.S. from Allegheny College (1997), Ph.D. from the University of Rochester School of Medicine and Dentistry (2003), and postdoctoral training at Harvard Medical School (2007). Research Interests: Mechanisms of oncogene-induced cellular stresses, functional genetic screens for cancer genes, and drug resistance pathways. Key projects include exploiting stress pathways for therapy development, identifying tumor suppressor networks in TNBC, and dissecting RNA processing stress in cancer. Publications highlight discoveries such as REST tumor suppressor networks, Myc-driven vulnerabilities, and mTOR signaling in immunosuppression. His work bridges basic science with clinical translation, aiming to improve targeted therapies and patient outcomes. Labs/Teams: Leads the Westbrook Lab at Baylor, emphasizing collaborative research in cancer biology, functional genomics, and translational oncology.

Katherine Alexanderمشاهده پروفایل

استادیار

• Gene regulation
• Nuclear speckles
• Chromatin organization
• +۴ مورد دیگر

Katherine Alexander is an Assistant Professor at Cold Spring Harbor Laboratory (CSHL) and a member of the CSHL Cancer Center. She joined the institution in August 2024 after completing her Ph.D. at Cornell University in 2016 and her B.A. at Carleton College in 2010. Dr. Alexander leads the Alexander Laboratory, which focuses on understanding the fundamental mechanisms of gene regulation as mediated by nuclear speckles. Dr. Alexander's research centers on nuclear speckles, which are prominent gene-activating substructures within cell nuclei. Her work investigates two major levels of gene regulation by nuclear speckles: 1) regulation of what DNA is positioned next to speckles (mediated by DNA-binding transcription factors), and 2) regulation of speckle state, which varies in human cancer and correlates with survival and drug responsiveness. She seeks to build textbook models for nuclear-speckle-based gene regulation and apply these paradigms to improve disease outcomes and patient quality-of-life. Analysis of Dr. Alexander's recent publications reveals a strong focus on the relationship between nuclear speckles and cancer biology, particularly kidney cancer. Her work demonstrates how nuclear organization influences gene expression programs in both normal and pathogenic processes, with significant implications for understanding cancer progression and developing new therapeutic approaches. Her research bridges molecular biology, cell biology, and cancer research, creating a unique interdisciplinary approach to studying gene regulation. Dr. Alexander's work has received significant media attention, including features in CSHL's "At the Lab" series and "Cocktails & Chromosomes" segments, where she discusses the potential implications of nuclear speckle research for cancer care. Her research on nuclear speckles influencing kidney cancer patient outcomes was highlighted in January 2025 as "A speckle of hope for cancer patients."

Lucas Cheadleمشاهده پروفایل

دانشیار

• Neuroscience
• Neuroimmunology
• Brain Development
• +۶ مورد دیگر

Lucas Cheadle is an Associate Professor at Cold Spring Harbor Laboratory (CSHL) and a Cancer Center Member. Appointed as Assistant Professor in 2020 and promoted to Associate Professor in November 2024, he leads the Cheadle Lab focusing on neuro-immune mechanisms of brain development, plasticity, and function. As a Howard Hughes Medical Institute Freeman Hrabowski Scholar (2023), his work bridges neuroscience and immunology to understand how environmental experiences shape brain connectivity. Dr. Cheadle's research interests center on how sensory experiences engage immune cells, particularly microglia, to shape neural circuit development and function. His lab investigates how impairments in neuro-immune communication contribute to neurodevelopmental disorders like autism and neurodegenerative conditions including Alzheimer's disease. Using the mouse visual system as a model, his team employs cutting-edge approaches including two-photon live imaging, single-cell transcriptomics, and electrophysiology to study the molecular mechanisms through which environmental stimuli converge upon the microglial genome to shape neural circuits. Analysis of Dr. Cheadle's recent publications reveals a strong focus on oligodendrocyte precursor cells (OPCs), microglial function, and synaptic plasticity. His work demonstrates how sensory experiences alter gene and protein expression in brain immune cells, allowing them to interact with neurons to strengthen, maintain, or eliminate synaptic connections. This research has significant implications for understanding both normal brain development and neurological disorders across the lifespan. Scientific Awards: MIND Prize (2025) from The Pershing Square Foundation ($750,000) HHMI Freeman Hrabowski Scholar (2023) NIH Director's New Innovator Award (2022) Rita Allen Scholar Award (2021) Klingenstein-Simons Neuroscience Fellowship (2021) McKnight Scholar Award (2021) Emerging Scholar by Diverse: Issues In Higher Education (2022) Dr. Cheadle actively mentors students through CSHL's graduate program, teaching courses on visual system development. His lab emphasizes diversity, equity, and inclusion, with a stated commitment that 'diverse teams do better science and are more productive.' The Cheadle Lab develops innovative tools and approaches to define contributions of immune cells to brain development and function, with parallel investigations into how inflammatory signals contribute to neurological disorders from autism to Alzheimer's disease. Their current MIND Prize-funded project explores oligodendrocyte precursor cells as potential therapeutic targets for maintaining synaptic integrity in Alzheimer's disease.