جست‌وجوی استاد و پژوهشگر

Miler T. Leeمشاهده پروفایل

دانشیار

• Gene Regulation
• Developmental Biology
• Computational Genomics
• +۹ مورد دیگر

Miler T. Lee is an Associate Professor at the University of Pittsburgh , focusing on gene regulation during early embryonic development through high-throughput experimental and computational genomics. He earned his Ph.D. in Genomics and Computational Biology in 2009 from the University of Pennsylvania under Dr. Junhyong Kim, followed by postdoctoral work with Dr. Antonio Giraldez at Yale University. Joining the university in 2016, his research spans maternal-to-zygotic transition (MZT), RNA stability, pluripotency networks, and evolutionary developmental biology, utilizing model organisms like zebrafish, Xenopus, and Hydractinia symbiolongicarpus. Key Research Themes: Maternally inherited RNA dynamics during embryogenesis Mechanisms of RNA degradation and transcriptome remodeling Evolution of pluripotency networks in hybrid species Role of zinc signaling in fertilization barriers Computational tools for RNA regulation and sensing Scientific Awards: Pan-American Society for Evolutionary Developmental Biology Junior Faculty Award (2024) Outstanding New Investigator – International Xenopus Board (2023) Basil O'Connor Scholar – March of Dimes (2017-2019) Recent publications highlight his work on enhancer classification, RNA degradation mechanisms, and cross-species MZT comparisons. His lab develops innovative methods like RESA for regulatory sequence analysis and studies evolutionary divergence in RNA localization patterns. While the articles span computational and experimental approaches, they consistently address RNA's role in cellular identity, developmental timing, and evolutionary adaptation. Applications include understanding pluripotency, designing RNA biosensors, and elucidating fertilization barriers. Prospective Ph.D. students are encouraged to contact him for opportunities in gene regulation, development, evo-devo, and computational genomics.

James Manleyمشاهده پروفایل

استاد

• Gene Expression Regulation
• mRNA Processing
• RNA Splicing and Polyadenylation
• +۳ مورد دیگر

James Manley is the Julian Clarence Levi Professor of the Life Sciences at Columbia University, with extensive research in gene expression regulation. His work spans transcription, RNA splicing, and polyadenylation mechanisms in human cells, connecting these processes to neurodegenerative diseases (ALS/FTD) and cancers. Affiliation: Columbia University, Department of Biological Sciences Contact: jlm2@columbia.edu Research Interests: Dr. Manley's laboratory investigates nuclear processes including: Transcriptional control via RNA polymerase II CTD modifications Alternative splicing regulation by hnRNP and SR proteins Polyadenylation dynamics in cell cycle and differentiation Disease mechanisms in spliceosome mutations (SF3B1, SRSF2) RNA-protein interactions in stress responses Publication Trends: Recent work focuses on disease-associated mutations affecting RNA processing, non-canonical RNA functions, and immune regulation via polyadenylation. Articles span molecular oncology, neurodegeneration, and RNA surveillance mechanisms. Scientific Recognition: Member, American Academy of Arts & Sciences Member, National Academy of Sciences Key Collaborations: Studies involve interdisciplinary work with neurology, cancer biology, and immunology teams. His lab employs biochemical assays, structural analysis, and genetic models to dissect RNA processing pathways.

Mikhail Gelfandمشاهده پروفایل

استاد

• molecular evolution
• comparative genomics
• systems biology
• +۷ مورد دیگر

Mikhail Gelfand is a Full Professor and Director of the Center for Molecular and Cellular Biology at Skolkovo Institute of Science and Technology (Skoltech), where he also serves as Vice President for Biomedical Research. His distinguished career spans multiple prestigious institutions including Lomonosov Moscow State University and the Higher School of Economics. His educational background includes: 1985: MSc in mathematics (functional analysis) 1993: PhD in physics-mathematics (biophysics) 1998: DSc in biology (molecular biology) 2007: full professor (bioinformatics) Professor Gelfand's research focuses on molecular evolution, comparative genomics, systems biology, and metagenomics. His work examines eukaryotic processes including alternative splicing, mRNA editing, and chromatin structure, as well as bacterial genome evolution and transcription regulation. His lab combines data on three-dimensional chromatin structure, epigenetic states, and gene expression to obtain an integrated view of genome functioning across diverse organisms from humans to amoebae. One major research direction focuses on the evolution of transcript splicing and editing, while comparative analysis of bacterial genomes yields functional annotations of novel enzymes, transporters, and transcription factors. His recent publications demonstrate a strong focus on RNA editing in cephalopods, bacterial genome analysis, and computational approaches to understanding chromatin structure. The work spans molecular biology, evolutionary biology, and bioinformatics, with particular emphasis on how RNA editing contributes to adaptation and molecular evolution across metazoans. His research shows how edited adenines are more frequently substituted with guanine in evolution than their unedited counterparts, suggesting RNA editing may enhance adaptation. His notable awards include: The President of Russian Federation's Award for Young Doctors of Science (2000) The "Best Scientist of the Russian Academy of Sciences" award (2004) A. A. Baev Prize in Genomics and Genoinformatics (2007) Member of Academia Europaea (2010) As Director of the Center for Molecular and Cellular Biology, Professor Gelfand leads a research group that combines computational and experimental approaches to study genome function and evolution. His lab's work has significant implications for understanding molecular mechanisms of evolution and adaptation across diverse biological systems, from bacteria to complex eukaryotes. His research on metagenomics extends to practical applications in areas including coral disease, aphids, and oil wells.

Guillaume Chanfreauمشاهده پروفایل

استاد

• RNA metabolism
• RNA splicing
• RNA decay pathways
• +۵ مورد دیگر

Guillaume Chanfreau is a Professor in the Department of Chemistry and Biochemistry within the College of Letters and Science at the University of California Los Angeles (UCLA). His research focuses on fundamental mechanisms of RNA metabolism, with particular emphasis on RNA splicing, decay pathways, and ribonuclease functions. His work spans molecular biology, biochemistry, and genetics, utilizing yeast as a primary model organism to investigate conserved RNA processing mechanisms. Professor Chanfreau's research interests center on understanding how RNA processing pathways regulate gene expression. His work examines transcription termination, RNA splicing fidelity, RNA decay mechanisms, and the role of ribonucleases in cellular RNA homeostasis. He investigates how these processes are interconnected and how they respond to cellular stress conditions. His laboratory has made significant contributions to understanding how RNA quality control mechanisms prevent the accumulation of aberrant transcripts and maintain cellular health. Analysis of Chanfreau's recent publications (2020-2025) reveals a strong focus on RNA splicing mechanisms, RNA decay pathways, and ribonuclease functions. His work frequently employs yeast genetics combined with advanced RNA sequencing techniques. A notable trend is the increasing use of long-read sequencing technologies to analyze RNA isoforms and decay intermediates. His research consistently bridges fundamental molecular mechanisms with potential implications for understanding human diseases related to RNA processing defects. Professor Chanfreau has been continuously funded by the National Institutes of Health, with his current grant R35GM130370 (2019-2023) titled 'The Control of Gene Expression by Eukaryotic Ribonucleases' and previous long-term funding through R01GM061518 (2000-2019). His research program has supported numerous graduate students and postdoctoral researchers who have contributed to his extensive publication record spanning over two decades.

• Physiology
• Sports Science
• Molecular Biology
• +۳ مورد دیگر

Tommy Lundberg is a Senior Lecturer and Docent in Physiology at Karolinska Institutet. He works at the Department of Laboratory Medicine, Division of Clinical Physiology. His email address is tommy.lundberg@ki.se, and his postal address is H5 Laboratoriomedicin, H5 Klinisk Fysiologi Gustafsson, 141 52 Huddinge. Lundberg is affiliated with the university library and has held positions since 2022. Research Interests: Lundberg's research focuses on skeletal muscle mass and function adaptation, particularly in athletic performance, disease contexts, aging, and transgender individuals undergoing hormone therapy. He investigates molecular, metabolic, morphological, and functional responses to resistance and aerobic exercises. His work also explores biological maturity selection biases in youth sports, bio-banding applications in soccer and ice hockey, and the impact of anti-inflammatory drugs on muscle hypertrophy. Article Trends: Lundberg's recent publications (2025–2024) cover topics like sex differences in disc golf, muscle atrophy in space exposome, longitudinal hormone therapy effects in transgender individuals, and bio-banding in youth sports. Earlier works delve into molecular pathways in muscle hypertrophy, concurrent training effects, mitochondrial function, and imaging techniques (CT/MRI) for muscle assessment. Scientific Recognition: Most prominent young researcher in Sport Science, Swedish Central Association for Sport Promotion (SCIF), 2017 Teaching and Editorial Roles: Lundberg teaches human physiology and sports science in nursing, physiotherapy, and biomedical analytics programs. He leads a contract education course in advanced exercise physiology and contributes to a PhD course on scientific writing. He is an Associate Editor for Frontiers in Physiology - Exercise Physiology (2022) and a member of the editorial board for Translational Exercise Biomedicine (2024). Collaborations and Expertise: He collaborates with the Swedish Football Association and Swedish Ice Hockey Association on bio-banding studies. Lundberg served as an invited speaker at the ACSM Annual Meeting (2024) on transgender athletes and as an expert panelist for World Rugby's transgender workshop (2020). His supervision includes Andrea Tryfonos (2021) and thesis evaluations at Mid Sweden University and Linköping University.

Aaron Hoskinsمشاهده پروفایل

استاد

• Pre-mRNA splicing
• Spliceosome assembly
• Single-molecule fluorescence microscopy
• +۳ مورد دیگر

Aaron Hoskins is a full-time Professor of Biochemistry and Chemistry at the University of Wisconsin–Madison, where he leads an active research program focused on pre-mRNA splicing, spliceosome assembly, and single-molecule biophysics. He is affiliated with the Department of Biochemistry and the Hoskins Group laboratory, located in the Biochemical Sciences Building. Education: B.S., 2000 – Purdue University Ph.D., 2006 – Massachusetts Institute of Technology Postdoctoral Fellow, 2006–2011 – Brandeis University and UMass Medical School His research centers on understanding the molecular mechanisms of pre-mRNA splicing and spliceosome assembly in eukaryotes. Using single-molecule fluorescence microscopy, his lab investigates how the spliceosome recognizes RNA targets, how ribonucleoproteins are assembled, and how splicing fidelity is maintained or disrupted in disease. His work integrates genetics, chemical biology, and biophysical approaches to dissect spliceosome dynamics and to develop new tools for studying RNA processing. Aaron Hoskins has published over 80 peer-reviewed articles since 2004, with recent work appearing in RNA , eLife , Structure , and Cell Chemical Biology . His research trends include the structural dynamics of spliceosomal snRNPs, cancer-associated mutations in splicing factors, and the development of splicing inhibitors as potential therapeutics. His lab also explores translational applications, including the use of humanized yeast strains for drug screening. He is supported by multiple NIH grants (R01 GM053007, R01 GM112735, R01 GM081648) and has collaborated extensively with UW-Madison colleagues David Brow and Samuel Butcher. His lab is equipped with custom-built fluorescence microscopes for single-molecule imaging and is actively training the next generation of scientists in RNA biology and biophysics.

Michael Thompsonمشاهده پروفایل

استاد

• Semiconductor Physics
• Materials Science
• Laser Processing
• +۷ مورد دیگر

Professor Michael Thompson is a tenured faculty member in the Department of Materials Science and Engineering at Cornell University's College of Engineering. He holds the Dwight C. Baum Professorship in Engineering and specializes in advanced materials processing, particularly semiconductor materials under pulsed laser exposure. His research focuses on transient thermal processing (nanosecond to sub-second timescales) for material property modification and characterization, with applications in semiconductors, EUV lithography, and photonic materials. Thompson has authored over 120 papers and 20 patents, emphasizing industrial challenges like front-end junction formation and flexible electronics. Education: B.S. in Physics (CalTech, 1979), M.S./Ph.D. in Physics (Cornell, 1982/1984). He has received prestigious awards including the North American Award for Technical Contribution to the Semiconductor Industry (2009), multiple Cornell Excellence in Teaching Awards, and the Stephen H. Weiss Presidential Fellow designation (2021). His teaching focuses on thermodynamics and electronic properties, with a commitment to making abstract concepts accessible through real-world examples. Service: Leads curriculum development, ABET accreditation, and industry outreach. His lab develops novel methods for autonomous materials discovery using AI-driven approaches. Current projects include laser spike annealing for semiconductor doping and high-throughput synthesis of metastable materials.

• Molecular Biology
• Biochemistry
• Cell Biology
• +۵ مورد دیگر

Dr. Maruf Ali is an Associate Professor in Molecular and Structural Biology at Imperial College London's Department of Life Sciences, part of the Faculty of Natural Sciences. He holds affiliations with the Centre for Structural Biology, Electron Microscopy Centre, and Membrane Biology. His research focuses on understanding molecular mechanisms of protein quality control during cellular stress, particularly in cancer and neurodegenerative diseases. Research interests include the Unfolded Protein Response (UPR), ER stress signaling pathways, and therapeutic interventions targeting these mechanisms. His multidisciplinary approach combines structural biology, biochemistry, and cellular techniques to study proteins and complexes involved in ER stress responses. Notable affiliations include the Membrane Biology and Molecular Mechanisms of Disease groups. His work explores how the UPR is activated and propagated, with implications for developing novel treatments for diseases linked to protein misfolding. Recent studies emphasize drug repurposing strategies targeting RSK4 to combat chemoresistance in cancers like lung and bladder cancer, as well as identifying key regulators of ER stress pathways such as IRE1 and PERK. Laboratory activities are centered at the Ali Lab (http://www.imperial.ac.uk/ali-lab), where research integrates structural insights with functional studies to advance understanding of cellular stress responses and their therapeutic applications.

• Respiratory diseases
• Epigenetics
• Molecular Biology
• +۵ مورد دیگر

Senani N.H. Rathnayake is a Research Fellow at the University of Technology Sydney (UTS), Faculty of Science. He completed his PhD at UTS (2019-2024) and held a Postdoctoral Fellowship at the University of Groningen (2023-2024). His primary research focuses on respiratory diseases, particularly the molecular mechanisms of smoking-induced lung damage, COPD, and asthma. Key areas include gene expression profiling, epigenetic changes, and cellular responses to cigarette smoke exposure. Research Interests: Transcriptomic and epigenetic alterations in lung diseases Smoking cessation effects on airway biology Genetic regulation of COPD biomarkers (e.g., sRAGE) Sex chromosome influences on respiratory disease susceptibility Awards & Fellowships: 2023 TSANZ Past Presidents Scholarship Award 2022-2023 European Respiratory Society Short-Term Fellowship Recent Research Trends: His articles emphasize smoking's impact on bronchial epithelial cells, including transcriptomic shifts, mucus barrier dynamics, and CRISPR-based gene-editing applications. Recent work explores Y-chromosome effects on COPD and asthma pathogenesis. Professional Engagement: Co-chair of the 2023 TSANZ Annual Scientific Conference Member of Australian Society for Medical Research, European Respiratory Society, and Thoracic Society of Australia and New Zealand

Virginia W. Cornishمشاهده پروفایل

استاد

• Synthetic Biology
• Protein Engineering
• Chemical Biology
• +۵ مورد دیگر

Virginia W. Cornish is the Helena Rubinstein Professor in the Departments of Chemistry and Systems Biology at Columbia University. She is a pioneer in synthetic biology, focusing on engineering yeast for diagnostic and therapeutic applications. Her research integrates chemical synthesis and genetic tools to expand cellular capabilities, including yeast biosensors and protein engineering. Education: B.A. in Biochemistry, Columbia University (1991) Ph.D. in Chemistry, University of California, Berkeley (1996) Postdoctoral Fellow, MIT (1996–1999) Research Interests: Her work spans synthetic biology, directed evolution, and live-cell imaging. Key areas include: Development of yeast biosensors for pathogen detection Engineering yeast communities for therapeutic applications Expanding the genetic code for noncanonical amino acid incorporation Chemical tagging for protein visualization and manipulation Recent Article Trends: Recent work emphasizes yeast-based biosensors for clinical diagnostics, scalable peptide-GPCR communication systems, and advances in fluorescent tagging for multiplex imaging. Her group also explores genetic code expansion to study protein dynamics and function. Awards: NSF Career Award (2000) Sloan Fellowship (2003) Protein Society Sigal Award (2009) ACS Pfizer Enzyme Chemistry Award (2009) HHMI Gilliam Adviser (2021) Advising & Grants: She advises a dynamic lab of ~20 students/postdocs. Active grants include NIH, NSF, and DARPA funding for synthetic biology and therapeutics. Her team collaborates on projects like vaccine development and metabolic engineering. Labs & Teams: Her lab at Columbia focuses on translational synthetic biology, with facilities for genetic engineering, imaging, and bioassays. Collaborations include projects on yeast-based diagnostics and protein engineering with groups at Harvard, MIT, and Memorial Sloan Kettering.

Ralf Zimmerمشاهده پروفایل

استاد

• Bioinformatics
• Systems Biology
• Machine Learning
• +۵ مورد دیگر

Ralf Zimmer is a Full Professor for Practical Informatics and Bioinformatics at Ludwig Maximilian University of Munich (LMU) since 2001, affiliated with the Department of Informatics in the Faculty of Mathematica, Informatics and Statistics. He concurrently serves as Head of Section III and Head of the Research Group Network Regulation and Modeling / Machine Learning at the Leibniz Institute for Food Systems Biology at TUM (Leibniz-LSB@TUM) in Freising, Germany. His academic foundation includes a Diploma with distinction in Computer Science, Applied Mathematics and Operations Research from the University of Bonn (1981-1986), followed by a summa cum laude Doctorate in Computer Science and Applied Mathematics from CAU Kiel in 1990, where he received dual honors: the CAU Dissertation Award and Best Dissertation Award. Zimmer's research pioneers the integration of bioinformatics, systems biology, and machine learning to decode molecular food-consumer interactions. His group develops causal system models for biological networks, validated through in silico simulations and multi-omics perturbation experiments (transcriptomics/proteomics). Core methodologies include network regulation modeling, algorithmic bioinformatics, and database construction linking food compounds to biochemical networks and cellular phenotypes, with translational goals for food and biotech innovation. His 14 most recent publications (2012-2024) reveal dominant trends in multi-omics immunology and cardiovascular research, featuring computational innovations for high-throughput data analysis. Key themes include host-pathogen dynamics (viral infections), inflammatory disease mechanisms (atherosclerosis), and methodological advances in proteomics/transcriptomics, consistently bridging fundamental bioinformatics with clinical applications. Major scientific recognitions include: CAU Dissertation Award and Best Dissertation Award (1990) Director of LMU's Informatics Department (2010-2012) DFG Review Board membership for biomedical foundations (2008-2016) Leadership of the DFG Bioinformatics Munich Center (2001-2008) Academic Senate election at LMU München (2011) Zimmer directs LMU/TUM's joint B.Sc./M.Sc. bioinformatics programs since 2001 as founding architect of the DFG-funded Bioinformatics Munich initiative. His educational leadership spans spokesperson roles for international training groups (IRTG RECESS), collaborative research centers (SFB1123 Atherosclerosis), and elite programs (Data Science, Munich Center for Machine Learning). Grant stewardship includes directing the DFG Bioinformatics Munich Center and shaping national funding policy via the DFG review board. At Leibniz-LSB@TUM, his research group pioneers databases connecting food compounds to cellular phenotypes through molecular networks, collaborating with Munich universities, clinics, and biotech partners to develop high-throughput sequencing/proteomics applications for future food and health innovations.

Suyang Zhangمشاهده پروفایل

پژوهشگر

• Transcription-Coupled Alternative Splicing
• RNA Splicing
• Gene Expression Regulation
• +۳ مورد دیگر

Suyang Zhang is a Researcher at the University of Cambridge , affiliated with the MRC Laboratory of Molecular Biology (MRC-LMB). His research focuses on the molecular mechanisms underlying transcription-coupled alternative splicing, integrating structural biology and biochemical approaches to elucidate interactions between the transcription and splicing machineries. Primary institution: MRC-LMB, University of Cambridge Research group members: Jack Bowden, Yuliya Gordiyenko, Yunke Luo, Pei Wang, Helen Zhang Research Interests: Dr. Zhang investigates how RNA polymerase II (Pol II) transcription and pre-mRNA splicing are mechanistically coupled. His work aims to uncover the structural basis for splice site selection and the functional interplay between the transcription and splicing machineries, with implications for understanding gene regulation in eukaryotic systems. Recent Publications: His group has published high-impact structural studies on Pol II complexes with spliceosomal components (U1 snRNP) and regulatory factors (DSIF, SPT6), as well as mechanistic insights into APC/C activation and translation initiation complexes. These studies leverage cryo-EM, biochemical reconstitution, and RNA sequencing to bridge structural and functional gaps. 2025: Structural basis of RECQL5-induced Pol II transcription braking 2025: Pol II-DSIF-SPT6-U1 snRNP complex architecture 2021: Pol II-U1 snRNP interaction mechanisms 2019: Cyclin A2 degradation pathways 2016: APC/C activation dynamics 2014: Translation initiation complex structure Methodologies: The lab employs multidisciplinary approaches, including cryo-EM, biochemical assays, and in vivo RNA sequencing, to dissect molecular mechanisms at atomic resolution.

G. Petur Nielsenمشاهده پروفایل

استاد

• Bone and Soft Tissue Pathology
• Molecular Genetics of Bone Tumors
• Chordoma Research
• +۵ مورد دیگر

G. Petur Nielsen, MD is a Professor of Pathology at Harvard Medical School and serves as Subspecialty Head, Bone and Soft Tissue Pathology at Massachusetts General Hospital . With a clinical focus on bone and soft tissue tumors, his expertise spans diagnostic pathology, molecular genetics of neoplasms, and ancillary testing applications. Research interests center on Pathology and biology of bone/soft tissue tumors Molecular genetics of bone and soft tissue neoplasms Chordoma and sarcoma research Epithelioid vascular tumor differentiation Mesenchymal tumors of the female genital tract His work includes landmark studies on tumor misdiagnosis rates, immunohistochemical profiling, and genomic analysis of chordomas. Scientific contributions appear in leading journals like Nature and American Journal of Surgical Pathology , with major emphasis on Molecular tumor classification Mutational signature analysis Translational oncology Diagnostic accuracy improvement Genomic instability mechanisms

Lara Urbanمشاهده پروفایل

استاد پژوهشی

• Molecular Biology
• Artificial Intelligence
• Environmental Health
• +۳ مورد دیگر

Dr. Lara Urban is a Principal Investigator at Helmholtz Munich and Helmholtz AI, and a TUM Junior Fellow at the Technical University of Munich's Life Sciences School. Her research integrates genomics and artificial intelligence to address One Health challenges, focusing on environmental health, biodiversity conservation, and pathogen surveillance. She holds a PhD from EMBL-EBI and the University of Cambridge (2019) and Master's degrees from Julius-Maximilians-University of Würzburg (2015). Her work leverages portable genomic technologies for real-time data analysis in clinical, environmental, and conservation contexts. Key areas include studying bioaerosols, pathogen detection, and genomic diversity in endangered species like the kākāpō. Awards include the Young Scientist of the Year 2022 and Humboldt Research Fellowship. Her team has published on nanopore sequencing applications, antibiotic resistance, and conservation genomics. Collaborations span institutions like the University of Zurich and ETH Zurich, funded by EU Horizon Europe, BMBF, and Helmholtz grants. Current initiatives include fieldwork in Chile and advancing genomic equity through democratized tools.

• Computational Genomics
• Gene Regulation
• RNA Biology
• +۴ مورد دیگر

Susanne Bornelöv is a Professor in the Department of Biochemistry at the University of Cambridge. Her research focuses on computational genomics and gene regulation, particularly exploring posttranscriptional mechanisms such as codon optimality-mediated mRNA decay and transposon silencing. She uses computational methods, ribosome profiling, and Drosophila models to study how codon usage, tRNA availability, and RNA modifications influence gene regulation and genome evolution. Her work integrates artificial intelligence (AI) and comparative genomics to model gene regulatory processes and design novel regulatory elements. Key research areas include piRNA clusters' roles in suppressing retroviruses, codon usage bias in pluripotent stem cells, and the interplay between mRNA methylation and protein synthesis. The Bornelöv Group collaborates widely, including with institutions like Cold Spring Harbor Laboratory, to advance understanding of fundamental gene expression principles. Publications highlight contributions to topics like deep learning in genomics, evolutionary conserved piRNA mechanisms, and transcriptional regulation. She leads a group open to interns, students, and researchers, fostering interdisciplinary approaches to address complex biological questions.